Latest & greatest articles for penicillin

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on penicillin or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on penicillin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for penicillin

1. Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study. (PubMed)

Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study. To determine whether total exposure to penicillin V can be reduced while maintaining adequate clinical efficacy when treating pharyngotonsillitis caused by group A streptococci.Open label, randomised controlled non-inferiority study.17 primary healthcare centres in Sweden between September (...) 2015 and February 2018.Patients aged 6 years and over with pharyngotonsillitis caused by group A streptococci and three or four Centor criteria (fever ≥38.5°C, tender lymph nodes, coatings of the tonsils, and absence of cough).Penicillin V 800 mg four times daily for five days (total 16 g) compared with the current recommended dose of 1000 mg three times daily for 10 days (total 30 g).Primary outcome was clinical cure five to seven days after the end of antibiotic treatment. The non-inferiority

2019 BMJ

2. Evaluation and Management of Penicillin Allergy: A Review. (PubMed)

Evaluation and Management of Penicillin Allergy: A Review. β-Lactam antibiotics are among the safest and most effective antibiotics. Many patients report allergies to these drugs that limit their use, resulting in the use of broad-spectrum antibiotics that increase the risk for antimicrobial resistance and adverse events.Approximately 10% of the US population has reported allergies to the β-lactam agent penicillin, with higher rates reported by older and hospitalized patients. Although many (...) patients report that they are allergic to penicillin, clinically significant IgE-mediated or T lymphocyte-mediated penicillin hypersensitivity is uncommon (<5%). Currently, the rate of IgE-mediated penicillin allergies is decreasing, potentially due to a decreased use of parenteral penicillins, and because severe anaphylactic reactions to oral amoxicillin are rare. IgE-mediated penicillin allergy wanes over time, with 80% of patients becoming tolerant after a decade. Cross-reactivity between penicillin

2019 JAMA

3. Diagnostic accuracy of penicillin skin testing at predicting IgE-mediated reaction to aminopenicillins and natural penicillins in patients with a history of penicillin allergy

Diagnostic accuracy of penicillin skin testing at predicting IgE-mediated reaction to aminopenicillins and natural penicillins in patients with a history of penicillin allergy Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

4. Penicillin

Penicillin Top results for penicillin - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for penicillin The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms

2018 Trip Latest and Greatest

5. Risk of meticillin resistant <i>Staphylococcus aureus</i> and <i>Clostridium difficile</i> in patients with a documented penicillin allergy: population based matched cohort study. (PubMed)

Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study. To evaluate the relation between penicillin allergy and development of meticillin resistant Staphylococcus aureus (MRSA) and C difficile.Population based matched cohort study.United Kingdom general practice (1995-2015).301 399 adults without previous MRSA or C difficile enrolled in the Health Improvement Network (...) database: 64 141 had a penicillin allergy and 237 258 comparators matched on age, sex, and study entry time.The primary outcome was risk of incident MRSA and C difficile. Secondary outcomes were use of β lactam antibiotics and β lactam alternative antibiotics.Among 64 141 adults with penicillin allergy and 237 258 matched comparators, 1365 developed MRSA (442 participants with penicillin allergy and 923 comparators) and 1688 developed C difficile (442 participants with penicillin allergy and 1246

Full Text available with Trip Pro

2018 BMJ

6. Impacts of Penicillin Binding Protein 2 Inactivation on β-Lactamase Expression and Muropeptide Profile in Stenotrophomonas maltophilia (PubMed)

Impacts of Penicillin Binding Protein 2 Inactivation on β-Lactamase Expression and Muropeptide Profile in Stenotrophomonas maltophilia Penicillin binding proteins (PBPs) are involved in peptidoglycan synthesis, and their inactivation is linked to β-lactamase expression in ampR-β-lactamase module-harboring Gram-negative bacteria. There are seven annotated PBP genes, namely, mrcA, mrcB, pbpC, mrdA, ftsI, dacB, and dacC, in the Stenotrophomonas maltophilia genome, and these genes encode PBP1a

Full Text available with Trip Pro

2017 mSystems

7. Penicillin Allergy Is Not Necessarily Forever (PubMed)

Penicillin Allergy Is Not Necessarily Forever 28672303 2017 08 22 2018 11 13 1538-3598 318 1 2017 Jul 04 JAMA JAMA Penicillin Allergy Is Not Necessarily Forever. 82-83 10.1001/jama.2017.6510 Trubiano Jason A JA Department of Infectious Diseases, Austin Hospital, Melbourne, Victoria, Australia2Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Adkinson N Franklin NF John Hopkins Asthma and Allergy Centre, Baltimore, Maryland. Phillips Elizabeth Jane (...) EJ Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee5Institute for Immunology and Infectious Diseases, Murdoch University, Western Australia, Australia. eng P50 GM115305 GM NIGMS NIH HHS United States Journal Article United States JAMA 7501160 0098-7484 0 Penicillins 37341-29-0 Immunoglobulin E AIM IM JAMA. 2017 Nov 7;318(17 ):1714 29114824 Diagnosis, Differential Drug Hypersensitivity diagnosis immunology Exanthema chemically induced Humans Immunoglobulin E

Full Text available with Trip Pro

2017 JAMA

9. Removal of Penicillin G by combination of sonolysis and Photocatalytic (sonophotocatalytic) process from aqueous solution: process optimization using RSM (Response Surface Methodology) (PubMed)

Removal of Penicillin G by combination of sonolysis and Photocatalytic (sonophotocatalytic) process from aqueous solution: process optimization using RSM (Response Surface Methodology) Penicillin G (PG) is used in a variety of infectious diseases, extensively. Generally, when antibiotics are introduced into the food chain, they pose a threat to the environment and can risk health outcomes. The aim of the present study was the removal of Penicillin G from an aqueous solution through (...) an integrated system of UV/ZnO and UV/WO3 with Ultrasound pretreatment.In this descriptive-analytical work dealing with the removal of Penicillin G from an aqueous solution, four significant variables, contact time (60-120 min), Penicillin G concentration (50-150 mg/L), ZnO dose (200-400 mg/L), and WO3 dose (100-200 mg/L) were investigated. Experiments were performed in a Pyrex reactor (batch, 1 Lit) with an artificial UV 100-Watt medium pressure mercury lamp, coupled with ultrasound (100 W, 40 KHz) for PG

Full Text available with Trip Pro

2016 Electronic physician

10. ASCIA Penicillin Allergy Guide for health professionals

ASCIA Penicillin Allergy Guide for health professionals • In severe penicillin allergy (e.g. anaphylaxis, bronchospasm, urticaria, angioedema), avoid ALL penicillins, cephalosporins and other beta-lactam antibiotics • In non-severe penicillin allergy (e.g. mild rash) use cephalosporins and carbapenems with caution • Some reactions (e.g. nausea) are not considered allergies and do not warrant prohibiting penicillin use Contraindicated At all times where reasonable evidence of penicillin allergy (...) exists Caution Avoid if severe penicillin allergy (e.g. anaphylaxis) Use with caution if non-severe allergy (e.g. minor rash) Seek specialist advice Considered Safe In the absence of other contraindications Cefaclor Cefepime Cefotaxime Cefoxitin Ceftazidime Ceftriaxone Cefuroxime Cephalexin Cephazolin Doripenem, ertapenem, imipenem, meropenem Aztreonam Azithromycin, erythromycin, roxithromycin, clarithromycin Ciprofloxacin, norfloxacin, moxifloxacin Clindamycin, lincomycin Doxycycline, minocycline

2016 Australasian Society of Clinical Immunology and Allergy

11. Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis

Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing (...) boards Evidence Education * Associated Topics Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis Shukan Kanuga, DDS, MSD . Overview Systematic Review Conclusion Three to 6 days of short-term late-generation antibiotics have comparable treatment efficacy as a 10-day course of oral penicillin in children with acute group A β-hemolytic streptococcus (GABHS) pharyngitis. Critical Summary Assessment On the basis of good

2015 ADA Center for Evidence-Based Dentistry

12. Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis

Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing (...) boards Evidence Education * Associated Topics Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis Shukan Kanuga, DDS, MSD . Overview Systematic Review Conclusion Three to 6 days of short-term late-generation antibiotics have comparable treatment efficacy as a 10-day course of oral penicillin in children with acute group A β-hemolytic streptococcus (GABHS) pharyngitis. Critical Summary Assessment On the basis of good

2015 ADA Center for Evidence-Based Dentistry

13. Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis

Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing (...) boards Evidence Education * Associated Topics Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis Shukan Kanuga, DDS, MSD . Overview Systematic Review Conclusion Three to 6 days of short-term late-generation antibiotics have comparable treatment efficacy as a 10-day course of oral penicillin in children with acute group A β-hemolytic streptococcus (GABHS) pharyngitis. Critical Summary Assessment On the basis of good

2015 ADA Center for Evidence-Based Dentistry

14. Systematic review: Penicillin is the drug of choice to treat all stages of syphilis despite a paucity of clinical trials data for the treatment of some stages, pregnant women and HIV-infected people

Systematic review: Penicillin is the drug of choice to treat all stages of syphilis despite a paucity of clinical trials data for the treatment of some stages, pregnant women and HIV-infected people Penicillin is the drug of choice to treat all stages of syphilis despite a paucity of clinical trials data for the treatment of some stages, pregnant women and HIV-infected people | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you (...) Penicillin is the drug of choice to treat all stages of syphilis despite a paucity of clinical trials data for the treatment of some stages, pregnant women and HIV-infected people Article Text Therapeutics/Prevention Systematic review Penicillin is the drug of choice to treat all stages of syphilis despite a paucity of clinical trials data for the treatment of some stages, pregnant women and HIV-infected people Susan Tuddenham , Khalil G Ghanem Statistics from Altmetric.com Commentary on : Clement ME

2015 Evidence-Based Medicine (Requires free registration)

15. Low-dose penicillin for recurrent cellulitis?

Low-dose penicillin for recurrent cellulitis? Low-dose penicillin for recurrent cellulitis? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Low-dose penicillin for recurrent cellulitis? View/ Open Date 2014-01 Format Metadata Abstract Practice changer: Prescribe low-dose penicillin to patients with recurrent leg

2014 PURLS

16. Penicillins

Penicillins USE OF PENICILLINS IN PREGNANCY 0344 892 0909 USE OF PENICILLINS IN PREGNANCY (Date of issue: June 2017 , Version: 2.2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary The penicillins; benzylpenicillin (penicillin G (...) ), phenoxymethylpenicillin (penicillin V), amoxicillin, co-amoxiclav (amoxicillin/clavulanic acid), ampicillin, flucloxacillin, temocillin, ticarcillin, piperacillin and pivmecillinam are broad-spectrum antibacterial agents indicated in the treatment of a wide range of mild to moderately severe infections caused by susceptible micro-organisms. Penicillins may be used in pregnancy if clinically indicated. The vast majority of the large amount of available data shows no increased risk of congenital malformation

2014 UK Teratology Information Service

17. Penicillin to prevent recurrent leg cellulitis. (PubMed)

Penicillin to prevent recurrent leg cellulitis. Cellulitis of the leg is a common bacterial infection of the skin and underlying tissue. We compared prophylactic low-dose penicillin with placebo for the prevention of recurrent cellulitis.We conducted a double-blind, randomized, controlled trial involving patients with two or more episodes of cellulitis of the leg who were recruited in 28 hospitals in the United Kingdom and Ireland. Randomization was performed according to a computer-generated (...) code, and study medications (penicillin [250 mg twice a day] or placebo for 12 months) were dispensed by a central pharmacy. The primary outcome was the time to a first recurrence. Participants were followed for up to 3 years. Because the risk of recurrence was not constant over the 3-year period, the primary hypothesis was tested during prophylaxis only.A total of 274 patients were recruited. Baseline characteristics were similar in the two groups. The median time to a first recurrence

Full Text available with Trip Pro

2013 NEJM Controlled trial quality: predicted high

18. Are Short-Term Late-Generation Antibiotics Equivalent to Standard Penicillin Therapy in the Resolution of Symptoms in Acute Strep Throat in Children?

Are Short-Term Late-Generation Antibiotics Equivalent to Standard Penicillin Therapy in the Resolution of Symptoms in Acute Strep Throat in Children? Systematic Review Snapshot TAKE-HOME MESSAGE Although antibiotics are not the best agent for symptomatic management of streptococcal pharyngitis, according to limited data, short-course antibiotics appear to reduce the duration of symptoms more effectively than longer-course therapy. Are Short-Term Late-Generation Antibiotics Equivalent (...) to Standard Penicillin Therapy in the Resolution of Symptoms in Acute Strep Throat in Children? EBEM Commentators Anand Swaminathan, MD, MPH New York University School of Medicine/Bellevue Hospital Center Department of Emergency Medicine New York, NY Jeffrey Hom, MD, MPH Stony Brook University School of Medicine Departments of Pediatrics (Emergency) and Emergency Medicine Stony Brook, NY Results Table 1. Short (3 days) versus standard (7 days) antibiotic course. Symptom Number of Subjects Difference

2013 Annals of Emergency Medicine Systematic Review Snapshots

19. Use of penicillin and other antibiotics and risk of multiple sclerosis: a population-based case-control study (PubMed)

Use of penicillin and other antibiotics and risk of multiple sclerosis: a population-based case-control study A 2006 study from the United Kingdom found that penicillin use may decrease the risk of multiple sclerosis (MS). To confirm this finding, the authors conducted a nationwide case-control study in Denmark, using the Danish Multiple Sclerosis Registry to identify 3,259 patients with MS onset from 1996 to 2008, and selected 10 population controls per case (n = 32,590), matched on sex (...) and age. Through the National Prescription Database, prescriptions for antibiotics redeemed from 1995 to 2008 and before the date of first MS symptom/index date were identified. Conditional logistic regression analysis was used to compute odds ratios associating antibiotic use with MS occurrence. In total, 1,922 patients (59%) redeemed penicillin prescriptions before the index date and 2,292 (70%) redeemed any type of antibiotic prescription. Penicillin use was associated with an increased risk of MS

Full Text available with Trip Pro

2011 EvidenceUpdates

20. Anaphylactic Cross-Reactivity Between Penicillin and Cephalosporin

Anaphylactic Cross-Reactivity Between Penicillin and Cephalosporin UTCAT848, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Minimal Risk Of Severe Type 1 Hypersensitivity Reaction To Third Generation Cephalosporin In Patients Who Experience Type 1 Hypersensitivity Reaction And Allergy To Penicillin Clinical Question Do patients who experience a severe type 1 hypersensitivity reaction to penicillin and demonstrate (...) an allergy to cephalosporin experience a severe type 1 hypersensitivity reaction to the cephalosporin? Clinical Bottom Line It appears that patients who have a severe type 1 hypersensitivity reaction to penicillin do not have an increased risk of anaphylaxis to cephalosporins. This evidence may be skewed however by adherence to the recommendation not to give cephalosporins to individuals with a history of penicillin anaphylaxis. (See Comments on the CAT below) Best Evidence (you may view more info

2011 UTHSCSA Dental School CAT Library