Latest & greatest articles for parkinson's disease

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Top results for parkinson's disease

1. Trunk Exercises Improve Gait Symmetry in Parkinson Disease: A Blind Phase II Randomized Controlled Trial. (PubMed)

Trunk Exercises Improve Gait Symmetry in Parkinson Disease: A Blind Phase II Randomized Controlled Trial. 29095706 2019 02 15 2019 02 15 1537-7385 97 3 2018 03 American journal of physical medicine & rehabilitation Am J Phys Med Rehabil Trunk Exercises Improve Gait Symmetry in Parkinson Disease: A Blind Phase II Randomized Controlled Trial. 151-159 10.1097/PHM.0000000000000858 Deficits in step-to-step symmetry and trunk muscle activations have been linked to falls in Parkinson disease. Given (...) such symptoms are poorly managed with anti-parkinsonian medications, alternate therapies are needed. This blind phase II randomized controlled trial sought to establish whether exercise can improve step-to-step symmetry in Parkinson disease. Twenty-four Parkinson disease patients with a falls history completed baseline assessments of symptom severity, balance confidence, mobility, and quality of life. Step-to-step symmetry was assessed by deriving harmonic ratios from three-dimensional accelerations

2019 American journal of physical medicine & rehabilitation

2. Path Finder for freezing of gait in people with Parkinson?s disease

Path Finder for freezing of gait in people with Parkinson?s disease P Path Finder for freezing of gait in people with ath Finder for freezing of gait in people with P Parkinson arkinson’s disease ’s disease Medtech innovation briefing Published: 25 January 2019 nice.org.uk/guidance/mib170 pathways Summary Summary The technology technology described in this briefing is Path Finder laser shoe attachment. It is used as a walking aid and is designed to help prevent freezing of gait in people (...) with Parkinson's disease. The inno innovativ vative aspects e aspects are that it is currently the only hands-free visual-cueing device for people with Parkinson's disease available in the UK. The intended place in ther place in therap apy y would be in place of other visual-cue walking aids but together with a reduced number of physiotherapy sessions, depending on the individuals' disease stage and personal preference. It would be used by the patient in their home or in the physiotherapy clinic. It may also

2019 National Institute for Health and Clinical Excellence - Advice

3. Safety and efficacy of CVT-301 (levodopa inhalation powder) on motor function during off periods in patients with Parkinson`s disease: a randomised, double-blind, placebo-controlled phase 3 trial

Safety and efficacy of CVT-301 (levodopa inhalation powder) on motor function during off periods in patients with Parkinson`s disease: a randomised, double-blind, placebo-controlled phase 3 trial 30663606 2019 01 21 1474-4465 18 2 2019 Feb The Lancet. Neurology Lancet Neurol Safety and efficacy of CVT-301 (levodopa inhalation powder) on motor function during off periods in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled phase 3 trial. 145-154 S1474-4422(18 (...) )30405-8 10.1016/S1474-4422(18)30405-8 Patients with Parkinson's disease chronically treated with levodopa commonly have delayed or unpredictable onset of its benefits after oral intake. In this study, we assessed the safety and efficacy of CVT-301, a self-administered levodopa oral inhalation powder, for the treatment of patients with Parkinson's disease during off periods. In this randomised, double-blind, placebo-controlled, phase 3 trial, patients were recruited at 65 sites in Canada, Poland

2019 EvidenceUpdates

4. ‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease

‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease Signal - ‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease Dissemination Centre Discover Portal NIHR DC Discover ‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease Published on 23 March 2016 Physiotherapy and occupational therapy do (...) not help people with mild to moderate Parkinson’s disease to lead more independent lives. This NIHR-funded randomised controlled trial of adults with Parkinson’s disease did not find any difference between the therapy group and a no-therapy control group at up to 15 months in any of the four measures of activities of daily living: mobility, kitchen activities, domestic tasks or leisure activities. The average ‘dose’ of the therapies was four sessions of 58 minutes over eight weeks for both therapies

2019 NIHR Dissemination Centre

5. A randomized controlled study of whether setting specific goals improves the effectiveness of therapy in people with Parkinson`s disease

A randomized controlled study of whether setting specific goals improves the effectiveness of therapy in people with Parkinson`s disease 30501396 2018 12 03 1477-0873 2018 Dec 03 Clinical rehabilitation Clin Rehabil A randomized controlled study of whether setting specific goals improves the effectiveness of therapy in people with Parkinson's disease. 269215518815217 10.1177/0269215518815217 To evaluate the effects of an intervention based on a specific set of goals on goal attainment, manual (...) dexterity, hand grip strength and finger prehension force compared to a standardized approach in patients with Parkinson's disease. Randomized controlled trial. Home-based. Fifty patients with a clinical diagnosis of Parkinson's disease acknowledging impaired manual ability were randomized into two groups. Patients in the experimental group ( n = 25) were included in an intervention focused on task components that involved goals proposed by participants. Patients in the control group ( n = 25) received

2019 EvidenceUpdates

6. Effects of Qigong Exercise on Non-Motor Symptoms and Inflammatory Status in Parkinson's Disease: A Protocol for a Randomized Controlled Trial. (PubMed)

Effects of Qigong Exercise on Non-Motor Symptoms and Inflammatory Status in Parkinson's Disease: A Protocol for a Randomized Controlled Trial. 30669324 2019 01 23 2305-6320 6 1 2019 Jan 18 Medicines (Basel, Switzerland) Medicines (Basel) Effects of Qigong Exercise on Non-Motor Symptoms and Inflammatory Status in Parkinson's Disease: A Protocol for a Randomized Controlled Trial. E13 10.3390/medicines6010013 Background: Non-motor symptoms such as sleep disturbance, cognitive decline, fatigue (...) , anxiety, and depression in Parkinson's disease (PD) impact quality of life. Increased levels of pro-inflammatory cytokines in individuals with PD have been reported, which may contribute to non-motor symptoms. A mind-body exercise, Qigong, has demonstrated benefits across different medical conditions. However, a lack of evidence causes clinicians and patients to be uncertain about the effects of Qigong in individuals with PD. This study will examine the effects of Qigong on non-motor symptoms

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2019 Medicines (Basel, Switzerland)

7. Early predictors of mortality in parkinsonism and Parkinson disease: A population-based study

Early predictors of mortality in parkinsonism and Parkinson disease: A population-based study 30381367 2018 11 27 1526-632X 91 22 2018 Nov 27 Neurology Neurology Early predictors of mortality in parkinsonism and Parkinson disease: A population-based study. e2045-e2056 10.1212/WNL.0000000000006576 To examine mortality and associated risk factors, including possible effects of mild cognitive impairment, imaging, and CSF abnormalities, in a community-based population with incident parkinsonism (...) and Parkinson disease. One hundred eighty-two patients with new-onset, idiopathic parkinsonism were diagnosed from January 2004 through April 2009, in a catchment area of 142,000 inhabitants in Sweden. Patients were comprehensively investigated according to a multimodal research protocol and followed prospectively for up to 13.5 years. A total of 109 patients died. Mortality rates in the general Swedish population were used to calculate standardized mortality ratio and expected survival, and Cox

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2018 EvidenceUpdates

8. Cost-effectiveness of the HiBalance training program for elderly with Parkinson`s disease: analysis of data from a randomized controlled trial

Cost-effectiveness of the HiBalance training program for elderly with Parkinson`s disease: analysis of data from a randomized controlled trial 30246557 2018 09 24 1477-0873 2018 Sep 24 Clinical rehabilitation Clin Rehabil Cost-effectiveness of the HiBalance training program for elderly with Parkinson's disease: analysis of data from a randomized controlled trial. 269215518800832 10.1177/0269215518800832 To determine the cost-effectiveness of the HiBalance training program for managing (...) Parkinson's disease (PD)-related balance and gait disorders. Cost comparison design following the randomized controlled trial comparing a novel balance training intervention with care as usual. A total of 100 participants with mild-moderate PD were randomized to either the intervention ( n = 51) or the control group ( n = 49). A 10-week (three times per week), group-based, progressive balance training program, led by two physical therapists. All program costs were collected for both groups. Cost-utility

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2018 EvidenceUpdates

9. Antibody biomarker for de novo Parkinson disease: attempted validation (PubMed)

Antibody biomarker for de novo Parkinson disease: attempted validation 30211310 2018 11 14 2373-8057 4 2018 NPJ Parkinson's disease NPJ Parkinsons Dis Antibody biomarker for de novo Parkinson disease: attempted validation. 28 10.1038/s41531-018-0064-2 Parkinson disease (PD) is a progressive neurodegenerative disease with motor symptoms that result from degeneration of midbrain dopaminergic neurons. Biomarker research seeks to identify the disease during the pre-symptomatic phase, which (...) higher in PD vs. control serum. In that study we used samples from the NINDS Parkinson's Disease Biomarker Program. The current study sought to validate that finding using serum samples from de novo and control subjects in the Parkinson's Progression Markers Initiative study. We found no difference in levels of antibodies captured by the PD2 peptoid in the de novo PD vs. control subjects, and no difference in IgG3 serum levels in the two groups. The failure to replicate our previous study appears

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2018 NPJ Parkinson's disease

10. Parkinson Disease. (PubMed)

Parkinson Disease. Parkinson disease is a common neurodegenerative disorder that causes progressive motor and nonmotor disability. It is diagnosed clinically and requires a detailed history and neurologic examination to exclude alternative diagnoses. Although disease-modifying therapies do not exist for Parkinson disease, effective symptomatic therapies, including dopaminergic medications and surgery, allow patients to maintain good quality of life for many years. Nonmotor symptoms, including (...) mood, cognitive, sleep, autonomic, and gastrointestinal symptoms, should be managed by a multidisciplinary team of clinicians. Recent advances include new diagnostic criteria from the Movement Disorder Society and the addition of new symptomatic therapies for treating motor complications and nonmotor symptoms in advanced disease.

2018 Annals of Internal Medicine

11. Parkinson?s disease

Parkinson?s disease Top results for parkinson's disease - Trip Database or use your Google+ account Liberating the literature My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box (...) and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for parkinson's disease The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical

2018 Trip Latest and Greatest

12. Long-term effects of highly challenging balance training in Parkinson's disease-a randomized controlled trial

Long-term effects of highly challenging balance training in Parkinson's disease-a randomized controlled trial 29962227 2018 07 02 1477-0873 2018 Jun 01 Clinical rehabilitation Clin Rehabil Long-term effects of highly challenging balance training in Parkinson's disease-a randomized controlled trial. 269215518784338 10.1177/0269215518784338 To determine long-term effects of a highly challenging training program in people with Parkinson's disease, as well as describe how initially observed (...) improvements of the program deteriorated over time. Long-term follow-up of previously reported outcomes at 10 weeks of a randomized controlled trial. University hospital setting. One-hundred elderly with mild-to-moderate (Hoehn and Yahr 2-3) Parkinson's disease. Participants in the training group ( n = 51) received 10 weeks (three times/week) of balance and gait exercises, incorporating dual-tasks, while the control group ( n = 49) received care as usual. Balance control (Mini-Balance Evaluation System

2018 EvidenceUpdates

13. Non-pharmacological therapies for sleep disturbances in people with Parkinson's disease: A systematic review

Non-pharmacological therapies for sleep disturbances in people with Parkinson's disease: A systematic review 29700848 2018 05 31 1365-2648 2018 Apr 27 Journal of advanced nursing J Adv Nurs Non-pharmacological therapies for sleep disturbances in people with Parkinson's disease: A systematic review. 10.1111/jan.13694 To determine the effectiveness of non-pharmacological therapies for sleep disturbances in people with Parkinson's disease (PD). Sleep disturbances, which are common in people (...) . Journal of Advanced Nursing Published by John Wiley & Sons Ltd. Lee JuHee J http://orcid.org/0000-0002-2805-1622 Mo-Im Kim Nursing Research Institute, College of Nursing, Yonsei University, Seoul, Korea. Kim Yonji Y Graduate School, College of Nursing, Yonsei University, Seoul, Korea. Kim Yie Lin YL Graduate School, College of Nursing, Yonsei University, Seoul, Korea. eng Journal Article Review 2018 04 27 England J Adv Nurs 7609811 0309-2402 Parkinson's disease non-pharmacological sleep systematic

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2018 EvidenceUpdates

14. Parkinson's disease

Parkinson's disease Autosynthesis - Trip Database or use your Google+ account Liberating the literature My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing (...) to (we will only get better by constructive feedback). For a list of known issues . Also read , explaining issues with the system. To get started, type a condition/disease into the search box above. Here are some examples to get you started: Performing Autosynthesis X Axis Alphabetically Risk of bias No. Articles Sample Size Risk of bias any low Minimum sample size Apply Follow us: © 2017 Trip Database Ltd. company number 04316414. Trip is proud to be made in the UK.

2018 Trip Evidence Maps

15. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Subthalamic Nucleus and Globus Pallidus Internus Deep Brain Stimulation for the Treatment of Patients with Parkinson?s Disease

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Subthalamic Nucleus and Globus Pallidus Internus Deep Brain Stimulation for the Treatment of Patients with Parkinson?s Disease

2018 Congress of Neurological Surgeons

16. Inflammatory bowel disease increases the risk of Parkinson's disease: a Danish nationwide cohort study 1977-2014

Inflammatory bowel disease increases the risk of Parkinson's disease: a Danish nationwide cohort study 1977-2014 29785965 2018 05 22 1468-3288 2018 May 21 Gut Gut Inflammatory bowel disease increases the risk of Parkinson's disease: a Danish nationwide cohort study 1977-2014. gutjnl-2017-315666 10.1136/gutjnl-2017-315666 Intestinal inflammation has been suggested to play a role in development of Parkinson's disease (PD) and multiple system atrophy (MSA). To test the hypothesis that IBD is (...) of PD as compared with non-IBD individuals (HR=1.22; 95% CI 1.09 to 1.35). The increased risk was present independently of age at IBD diagnosis, gender or length of follow-up. The overall incidence of MSA was low in our study, and the regression analysis suggested a tendency towards higher risk of developing MSA in patients with IBD as compared with non-IBD individuals (HR=1.41; 95% CI 0.82 to 2.44). Estimates were similar for women and men. The increased risk of parkinsonism was significantly

2018 EvidenceUpdates

17. Multiple Microelectrode Recordings in STN‐DBS Surgery for Parkinson's Disease: A Randomized Study (PubMed)

Multiple Microelectrode Recordings in STN‐DBS Surgery for Parkinson's Disease: A Randomized Study 30009214 2018 11 14 2330-1619 5 3 2018 May-Jun Movement disorders clinical practice Mov Disord Clin Pract Multiple Microelectrode Recordings in STN-DBS Surgery for Parkinson's Disease: A Randomized Study. 296-305 10.1002/mdc3.12621 Subthalamic nucleus deep brain stimulation improves motor symptoms and fluctuations in advanced Parkinson's disease, but the degree of clinical improvement depends (...) of subthalamic nucleus stimulation. Sixty patients were included in this double-blind, randomized study, 30 in each group. Primary outcome measures were the difference from baseline to 12 months in the MDS-UPDRS motor score (part III) in the off-medication state and quality of life using the Parkinson's Disease Questionnaire-39 (PDQ-39) scores. The mean reduction of the MDS-UPDRS III off score was 35 (SD 12) in the group investigated with multiple simultaneous microelectrodes compared to 26 (SD 10

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2018 Movement disorders clinical practice

18. The Effects of Functional Training, Bicycle Exercise, and Exergaming on Walking Capacity of Elderly Patients With Parkinson Disease: A Pilot Randomized Controlled Single-blinded Trial

The Effects of Functional Training, Bicycle Exercise, and Exergaming on Walking Capacity of Elderly Patients With Parkinson Disease: A Pilot Randomized Controlled Single-blinded Trial 29337023 2018 04 27 1532-821X 99 5 2018 May Archives of physical medicine and rehabilitation Arch Phys Med Rehabil The Effects of Functional Training, Bicycle Exercise, and Exergaming on Walking Capacity of Elderly Patients With Parkinson Disease: A Pilot Randomized Controlled Single-blinded Trial. 826-833 S0003 (...) -9993(18)30009-1 10.1016/j.apmr.2017.12.014 To compare the effects of functional training, bicycle exercise, and exergaming on walking capacity of elderly with Parkinson disease (PD). A pilot randomized, controlled, single-blinded trial. A state reference health care center for elderly, a public reference outpatient clinic for the elderly. Elderly individuals (≥60 years of age; N=62) with idiopathic PD (stage 2 to 3 of modified Hoehn and Yahr staging scale) according to the London Brain Bank

2018 EvidenceUpdates

19. A Kinematic Sensor and Algorithm to Detect Motor Fluctuations in Parkinson Disease: Validation Study Under Real Conditions of Use (PubMed)

A Kinematic Sensor and Algorithm to Detect Motor Fluctuations in Parkinson Disease: Validation Study Under Real Conditions of Use 29695377 2018 11 14 2369-2529 5 1 2018 Apr 25 JMIR rehabilitation and assistive technologies JMIR Rehabil Assist Technol A Kinematic Sensor and Algorithm to Detect Motor Fluctuations in Parkinson Disease: Validation Study Under Real Conditions of Use. e8 10.2196/rehab.8335 A new algorithm has been developed, which combines information on gait bradykinesia (...) and dyskinesia provided by a single kinematic sensor located on the waist of Parkinson disease (PD) patients to detect motor fluctuations (On- and Off-periods). The goal of this study was to analyze the accuracy of this algorithm under real conditions of use. This validation study of a motor-fluctuation detection algorithm was conducted on a sample of 23 patients with advanced PD. Patients were asked to wear the kinematic sensor for 1 to 3 days at home, while simultaneously keeping a diary

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2018 JMIR rehabilitation and assistive technologies

20. ‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease

‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease NIHR DC | Signal - ‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal ‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease Published on 23 March 2016 Physiotherapy and (...) occupational therapy do not help people with mild to moderate Parkinson’s disease to lead more independent lives. This NIHR-funded randomised controlled trial of adults with Parkinson’s disease did not find any difference between the therapy group and a no-therapy control group at up to 15 months in any of the four measures of activities of daily living: mobility, kitchen activities, domestic tasks or leisure activities. The average ‘dose’ of the therapies was four sessions of 58 minutes over eight weeks

2018 NIHR Dissemination Centre