Latest & greatest articles for parkinson's disease

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on parkinson's disease or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on parkinson's disease and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for parkinson's disease

1. ‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease

‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease Signal - ‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease Dissemination Centre Discover Portal NIHR DC Discover ‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease Published on 23 March 2016 Physiotherapy and occupational therapy do (...) not help people with mild to moderate Parkinson’s disease to lead more independent lives. This NIHR-funded randomised controlled trial of adults with Parkinson’s disease did not find any difference between the therapy group and a no-therapy control group at up to 15 months in any of the four measures of activities of daily living: mobility, kitchen activities, domestic tasks or leisure activities. The average ‘dose’ of the therapies was four sessions of 58 minutes over eight weeks for both therapies

NIHR Dissemination Centre2019

2. A randomized controlled study of whether setting specific goals improves the effectiveness of therapy in people with Parkinson`s disease

A randomized controlled study of whether setting specific goals improves the effectiveness of therapy in people with Parkinson`s disease 30501396 2018 12 03 1477-0873 2018 Dec 03 Clinical rehabilitation Clin Rehabil A randomized controlled study of whether setting specific goals improves the effectiveness of therapy in people with Parkinson's disease. 269215518815217 10.1177/0269215518815217 To evaluate the effects of an intervention based on a specific set of goals on goal attainment, manual (...) dexterity, hand grip strength and finger prehension force compared to a standardized approach in patients with Parkinson's disease. Randomized controlled trial. Home-based. Fifty patients with a clinical diagnosis of Parkinson's disease acknowledging impaired manual ability were randomized into two groups. Patients in the experimental group ( n = 25) were included in an intervention focused on task components that involved goals proposed by participants. Patients in the control group ( n = 25) received

EvidenceUpdates2019

3. Early predictors of mortality in parkinsonism and Parkinson disease: A population-based study

Early predictors of mortality in parkinsonism and Parkinson disease: A population-based study 30381367 2018 11 27 1526-632X 91 22 2018 Nov 27 Neurology Neurology Early predictors of mortality in parkinsonism and Parkinson disease: A population-based study. e2045-e2056 10.1212/WNL.0000000000006576 To examine mortality and associated risk factors, including possible effects of mild cognitive impairment, imaging, and CSF abnormalities, in a community-based population with incident parkinsonism (...) and Parkinson disease. One hundred eighty-two patients with new-onset, idiopathic parkinsonism were diagnosed from January 2004 through April 2009, in a catchment area of 142,000 inhabitants in Sweden. Patients were comprehensively investigated according to a multimodal research protocol and followed prospectively for up to 13.5 years. A total of 109 patients died. Mortality rates in the general Swedish population were used to calculate standardized mortality ratio and expected survival, and Cox

EvidenceUpdates2018

4. Cost-effectiveness of the HiBalance training program for elderly with Parkinson`s disease: analysis of data from a randomized controlled trial

Cost-effectiveness of the HiBalance training program for elderly with Parkinson`s disease: analysis of data from a randomized controlled trial 30246557 2018 09 24 1477-0873 2018 Sep 24 Clinical rehabilitation Clin Rehabil Cost-effectiveness of the HiBalance training program for elderly with Parkinson's disease: analysis of data from a randomized controlled trial. 269215518800832 10.1177/0269215518800832 To determine the cost-effectiveness of the HiBalance training program for managing (...) Parkinson's disease (PD)-related balance and gait disorders. Cost comparison design following the randomized controlled trial comparing a novel balance training intervention with care as usual. A total of 100 participants with mild-moderate PD were randomized to either the intervention ( n = 51) or the control group ( n = 49). A 10-week (three times per week), group-based, progressive balance training program, led by two physical therapists. All program costs were collected for both groups. Cost-utility

EvidenceUpdates2018

5. Antibody biomarker for de novo Parkinson disease: attempted validation

Antibody biomarker for de novo Parkinson disease: attempted validation 30211310 2018 11 14 2373-8057 4 2018 NPJ Parkinson's disease NPJ Parkinsons Dis Antibody biomarker for de novo Parkinson disease: attempted validation. 28 10.1038/s41531-018-0064-2 Parkinson disease (PD) is a progressive neurodegenerative disease with motor symptoms that result from degeneration of midbrain dopaminergic neurons. Biomarker research seeks to identify the disease during the pre-symptomatic phase, which (...) higher in PD vs. control serum. In that study we used samples from the NINDS Parkinson's Disease Biomarker Program. The current study sought to validate that finding using serum samples from de novo and control subjects in the Parkinson's Progression Markers Initiative study. We found no difference in levels of antibodies captured by the PD2 peptoid in the de novo PD vs. control subjects, and no difference in IgG3 serum levels in the two groups. The failure to replicate our previous study appears

NPJ Parkinson's disease2018 Full Text: Link to full Text with Trip Pro

6. Parkinson Disease.

Parkinson Disease. Parkinson disease is a common neurodegenerative disorder that causes progressive motor and nonmotor disability. It is diagnosed clinically and requires a detailed history and neurologic examination to exclude alternative diagnoses. Although disease-modifying therapies do not exist for Parkinson disease, effective symptomatic therapies, including dopaminergic medications and surgery, allow patients to maintain good quality of life for many years. Nonmotor symptoms, including (...) mood, cognitive, sleep, autonomic, and gastrointestinal symptoms, should be managed by a multidisciplinary team of clinicians. Recent advances include new diagnostic criteria from the Movement Disorder Society and the addition of new symptomatic therapies for treating motor complications and nonmotor symptoms in advanced disease.

Annals of Internal Medicine2018

7. Parkinson?s disease

Parkinson?s disease Top results for parkinson's disease - Trip Database or use your Google+ account Liberating the literature My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box (...) and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for parkinson's disease The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical

Trip Latest and Greatest2018

8. Long-term effects of highly challenging balance training in Parkinson's disease-a randomized controlled trial

Long-term effects of highly challenging balance training in Parkinson's disease-a randomized controlled trial 29962227 2018 07 02 1477-0873 2018 Jun 01 Clinical rehabilitation Clin Rehabil Long-term effects of highly challenging balance training in Parkinson's disease-a randomized controlled trial. 269215518784338 10.1177/0269215518784338 To determine long-term effects of a highly challenging training program in people with Parkinson's disease, as well as describe how initially observed (...) improvements of the program deteriorated over time. Long-term follow-up of previously reported outcomes at 10 weeks of a randomized controlled trial. University hospital setting. One-hundred elderly with mild-to-moderate (Hoehn and Yahr 2-3) Parkinson's disease. Participants in the training group ( n = 51) received 10 weeks (three times/week) of balance and gait exercises, incorporating dual-tasks, while the control group ( n = 49) received care as usual. Balance control (Mini-Balance Evaluation System

EvidenceUpdates2018

9. Parkinson's disease

Parkinson's disease Autosynthesis - Trip Database or use your Google+ account Liberating the literature My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing (...) to (we will only get better by constructive feedback). For a list of known issues . Also read , explaining issues with the system. To get started, type a condition/disease into the search box above. Here are some examples to get you started: Performing Autosynthesis X Axis Alphabetically Risk of bias No. Articles Sample Size Risk of bias any low Minimum sample size Apply Follow us: © 2017 Trip Database Ltd. company number 04316414. Trip is proud to be made in the UK.

Trip Evidence Maps2018

10. Non-pharmacological therapies for sleep disturbances in people with Parkinson's disease: A systematic review

Non-pharmacological therapies for sleep disturbances in people with Parkinson's disease: A systematic review 29700848 2018 05 31 1365-2648 2018 Apr 27 Journal of advanced nursing J Adv Nurs Non-pharmacological therapies for sleep disturbances in people with Parkinson's disease: A systematic review. 10.1111/jan.13694 To determine the effectiveness of non-pharmacological therapies for sleep disturbances in people with Parkinson's disease (PD). Sleep disturbances, which are common in people (...) . Journal of Advanced Nursing Published by John Wiley & Sons Ltd. Lee JuHee J http://orcid.org/0000-0002-2805-1622 Mo-Im Kim Nursing Research Institute, College of Nursing, Yonsei University, Seoul, Korea. Kim Yonji Y Graduate School, College of Nursing, Yonsei University, Seoul, Korea. Kim Yie Lin YL Graduate School, College of Nursing, Yonsei University, Seoul, Korea. eng Journal Article Review 2018 04 27 England J Adv Nurs 7609811 0309-2402 Parkinson's disease non-pharmacological sleep systematic

EvidenceUpdates2018

11. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Subthalamic Nucleus and Globus Pallidus Internus Deep Brain Stimulation for the Treatment of Patients with Parkinson?s Disease

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Subthalamic Nucleus and Globus Pallidus Internus Deep Brain Stimulation for the Treatment of Patients with Parkinson?s Disease

Congress of Neurological Surgeons2018

12. Inflammatory bowel disease increases the risk of Parkinson's disease: a Danish nationwide cohort study 1977-2014

Inflammatory bowel disease increases the risk of Parkinson's disease: a Danish nationwide cohort study 1977-2014 29785965 2018 05 22 1468-3288 2018 May 21 Gut Gut Inflammatory bowel disease increases the risk of Parkinson's disease: a Danish nationwide cohort study 1977-2014. gutjnl-2017-315666 10.1136/gutjnl-2017-315666 Intestinal inflammation has been suggested to play a role in development of Parkinson's disease (PD) and multiple system atrophy (MSA). To test the hypothesis that IBD is (...) of PD as compared with non-IBD individuals (HR=1.22; 95% CI 1.09 to 1.35). The increased risk was present independently of age at IBD diagnosis, gender or length of follow-up. The overall incidence of MSA was low in our study, and the regression analysis suggested a tendency towards higher risk of developing MSA in patients with IBD as compared with non-IBD individuals (HR=1.41; 95% CI 0.82 to 2.44). Estimates were similar for women and men. The increased risk of parkinsonism was significantly

EvidenceUpdates2018

13. Multiple Microelectrode Recordings in STN‐DBS Surgery for Parkinson's Disease: A Randomized Study

Multiple Microelectrode Recordings in STN‐DBS Surgery for Parkinson's Disease: A Randomized Study 30009214 2018 11 14 2330-1619 5 3 2018 May-Jun Movement disorders clinical practice Mov Disord Clin Pract Multiple Microelectrode Recordings in STN-DBS Surgery for Parkinson's Disease: A Randomized Study. 296-305 10.1002/mdc3.12621 Subthalamic nucleus deep brain stimulation improves motor symptoms and fluctuations in advanced Parkinson's disease, but the degree of clinical improvement depends (...) of subthalamic nucleus stimulation. Sixty patients were included in this double-blind, randomized study, 30 in each group. Primary outcome measures were the difference from baseline to 12 months in the MDS-UPDRS motor score (part III) in the off-medication state and quality of life using the Parkinson's Disease Questionnaire-39 (PDQ-39) scores. The mean reduction of the MDS-UPDRS III off score was 35 (SD 12) in the group investigated with multiple simultaneous microelectrodes compared to 26 (SD 10

Movement disorders clinical practice2018 Full Text: Link to full Text with Trip Pro

14. The Effects of Functional Training, Bicycle Exercise, and Exergaming on Walking Capacity of Elderly Patients With Parkinson Disease: A Pilot Randomized Controlled Single-blinded Trial

The Effects of Functional Training, Bicycle Exercise, and Exergaming on Walking Capacity of Elderly Patients With Parkinson Disease: A Pilot Randomized Controlled Single-blinded Trial 29337023 2018 04 27 1532-821X 99 5 2018 May Archives of physical medicine and rehabilitation Arch Phys Med Rehabil The Effects of Functional Training, Bicycle Exercise, and Exergaming on Walking Capacity of Elderly Patients With Parkinson Disease: A Pilot Randomized Controlled Single-blinded Trial. 826-833 S0003 (...) -9993(18)30009-1 10.1016/j.apmr.2017.12.014 To compare the effects of functional training, bicycle exercise, and exergaming on walking capacity of elderly with Parkinson disease (PD). A pilot randomized, controlled, single-blinded trial. A state reference health care center for elderly, a public reference outpatient clinic for the elderly. Elderly individuals (≥60 years of age; N=62) with idiopathic PD (stage 2 to 3 of modified Hoehn and Yahr staging scale) according to the London Brain Bank

EvidenceUpdates2018

15. A Kinematic Sensor and Algorithm to Detect Motor Fluctuations in Parkinson Disease: Validation Study Under Real Conditions of Use

A Kinematic Sensor and Algorithm to Detect Motor Fluctuations in Parkinson Disease: Validation Study Under Real Conditions of Use 29695377 2018 11 14 2369-2529 5 1 2018 Apr 25 JMIR rehabilitation and assistive technologies JMIR Rehabil Assist Technol A Kinematic Sensor and Algorithm to Detect Motor Fluctuations in Parkinson Disease: Validation Study Under Real Conditions of Use. e8 10.2196/rehab.8335 A new algorithm has been developed, which combines information on gait bradykinesia (...) and dyskinesia provided by a single kinematic sensor located on the waist of Parkinson disease (PD) patients to detect motor fluctuations (On- and Off-periods). The goal of this study was to analyze the accuracy of this algorithm under real conditions of use. This validation study of a motor-fluctuation detection algorithm was conducted on a sample of 23 patients with advanced PD. Patients were asked to wear the kinematic sensor for 1 to 3 days at home, while simultaneously keeping a diary

JMIR rehabilitation and assistive technologies2018 Full Text: Link to full Text with Trip Pro

16. ‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease

‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease NIHR DC | Signal - ‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal ‘Low dose’ physiotherapy and occupational therapy found ineffective for people with mild to moderate Parkinson’s disease Published on 23 March 2016 Physiotherapy and (...) occupational therapy do not help people with mild to moderate Parkinson’s disease to lead more independent lives. This NIHR-funded randomised controlled trial of adults with Parkinson’s disease did not find any difference between the therapy group and a no-therapy control group at up to 15 months in any of the four measures of activities of daily living: mobility, kitchen activities, domestic tasks or leisure activities. The average ‘dose’ of the therapies was four sessions of 58 minutes over eight weeks

NIHR Dissemination Centre2018

17. Levodopa-carbidopa intestinal gel (Duodopa) - Parkinson?s disease

Levodopa-carbidopa intestinal gel (Duodopa) - Parkinson?s disease Final Appraisal Recommendation Advice No: 0518 – March 2018 Levodopa-carbidopa intestinal gel (Duodopa ® ) 20 mg/ml levodopa and 5 mg/ml carbidopa monohydrate Resubmission AbbVie Ltd Additional note(s): ? AWMSG considered that levodopa-carbidopa intestinal gel (Duodopa ® ) satisfied the AWMSG criteria for appraising orphan and ultra-orphan medicines and medicines developed specifically for rare disease In reaching the above (...) every three years. Recommendation of AWMSG Levodopa-carbidopa intestinal gel (Duodopa ® ) is recommended as an option for restricted use within NHS Wales. Levodopa-carbidopa intestinal gel (Duodopa ® ) should be restricted for use in the following subpopulation within its licensed indication for the treatment of advanced levodopa-responsive Parkinson’s disease with severe motor fluctuations and hyper-/dyskinesia when available combinations of Parkinson medicinal products have not given satisfactory

All Wales Medicines Strategy Group2018

18. Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson's disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial

Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson's disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial 29452685 2018 03 01 1474-4465 17 3 2018 Mar The Lancet. Neurology Lancet Neurol Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson's disease with early motor complications (EARLYSTIM trial): secondary analysis (...) of an open-label randomised trial. 223-231 S1474-4422(18)30035-8 10.1016/S1474-4422(18)30035-8 Although subthalamic stimulation is a recognised treatment for motor complications in Parkinson's disease, reports on behavioural outcomes are controversial, which represents a major challenge when counselling candidates for subthalamic stimulation. We aimed to assess changes in behaviour in patients with Parkinson's disease receiving combined treatment with subthalamic stimulation and medical therapy over a 2

EvidenceUpdates2018

19. The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease

The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease 30009211 2018 11 14 2330-1619 5 2 2018 Mar-Apr Movement disorders clinical practice Mov Disord Clin Pract The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease. 171-176 10.1002/mdc3.12591 Rapid eye movement (REM) sleep behavior disorder (RBD) is one of the most specific prodromal indicators for Parkinson's disease (PD). To test the validity of the RBD (...) JAMA Neurol. 2015 Jun;72(6):707-12 25867792 Sleep. 1986 Jun;9(2):293-308 3505730 Mov Disord. 2013 Jul;28(8):1146-9 23519694 DeNoPa cohort, prodromal marker Parkinson's disease RBDSQ REM sleep behavior disorder screening questionnaire 2017 11 14 2018 01 03 2018 01 07 2018 7 17 6 0 2018 7 17 6 0 2018 7 17 6 1 epublish 30009211 10.1002/mdc3.12591 MDC312591 PMC6033034

Movement disorders clinical practice2018 Full Text: Link to full Text with Trip Pro

20. Unilateral MRI-guided focused ultrasound thalamotomy for moderate to severe tremor in Parkinson?s disease

Unilateral MRI-guided focused ultrasound thalamotomy for moderate to severe tremor in Parkinson?s disease Unilater Unilateral MRI-guided focused ultr al MRI-guided focused ultrasound asound thalamotom thalamotomy for moder y for moderate to se ate to sev vere tremor in ere tremor in P Parkinson arkinson’s disease ’s disease Interventional procedures guidance Published: 28 February 2018 nice.org.uk/guidance/ipg606 Y Y our responsibility our responsibility This guidance represents the view (...) possible. 1 1 Recommendations Recommendations 1.1 Current evidence on the safety and efficacy of unilateral MRI-guided focused ultrasound thalamotomy for moderate to severe tremor in Parkinson's disease is © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 1 of 4inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research. 1.2 Further research, which could include randomised

National Institute for Health and Clinical Excellence - Interventional Procedures2018