Latest & greatest articles for pain

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on pain or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on pain and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for pain

181. Placebos in chronic pain: evidence, theory, ethics, and use in clinical practice. Full Text available with Trip Pro

Placebos in chronic pain: evidence, theory, ethics, and use in clinical practice. Despite their ubiquitous presence, placebos and placebo effects retain an ambiguous and unsettling presence in biomedicine. Specifically focused on chronic pain, this review examines the effect of placebo treatment under three distinct frameworks: double blind, deception, and open label honestly prescribed. These specific conditions do not necessarily differentially modify placebo outcomes. Psychological, clinical (...) , and neurological theories of placebo effects are scrutinized. In chronic pain, conscious expectation does not reliably predict placebo effects. A supportive patient-physician relationship may enhance placebo effects. This review highlights "predictive coding" and "bayesian brain" as emerging models derived from computational neurobiology that offer a unified framework to explain the heterogeneous evidence on placebos. These models invert the dogma of the brain as a stimulus driven organ to one in which

2020 BMJ

182. Comparative efficacy and safety of different drugs for the therapy of adults with neuropathic pain after spinal cord injury: a network meta-analysis Full Text available with Trip Pro

Comparative efficacy and safety of different drugs for the therapy of adults with neuropathic pain after spinal cord injury: a network meta-analysis Inplasy Protocol 525 - INPLASY.COM International Platform of Registered Systematic Review and Meta-analysis Protocols Main Menu Share this: Copyright © 2021 INPLASY.COM Powered by INPLASY.COM

2020 INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols

183. Therapeutic ultrasound for chronic low back pain. (Abstract)

Therapeutic ultrasound for chronic low back pain. This is an update of a Cochrane Review published in 2014. Chronic non-specific low back pain (LBP) has become one of the main causes of disability in the adult population around the world. Although therapeutic ultrasound is not recommended in recent clinical guidelines, it is frequently used by physiotherapists in the treatment of chronic LBP.The objective of this review was to determine the effectiveness of therapeutic ultrasound (...) in eight studies (80%), and no studies adequately assessed compliance with the intervention. There was very low-certainty evidence (downgraded for imprecision, inconsistency, and limitations in design) of little to no difference between therapeutic ultrasound and placebo for short-term pain improvement (mean difference (MD) -7.12, 95% confidence interval (CI) -17.99 to 3.75; n = 121, 3 RCTs; 0-to-100-point visual analogue scale (VAS)). There was also moderate-certainty evidence (downgraded

2020 Cochrane

184. Effectiveness and safety of transcutaneous electrical nerve stimulation (TENS) for pain relief in labour: a protocol for systematic review and meta-analysis Full Text available with Trip Pro

Effectiveness and safety of transcutaneous electrical nerve stimulation (TENS) for pain relief in labour: a protocol for systematic review and meta-analysis Inplasy Protocol 482 - INPLASY.COM International Platform of Registered Systematic Review and Meta-analysis Protocols Main Menu Share this: Copyright © 2021 INPLASY.COM Powered by INPLASY.COM

2020 INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols

185. A Rapid Review of Best Practice Guidance to Reduce the Risk of Transition from Acute to Chronic Post-surgical Pain

A Rapid Review of Best Practice Guidance to Reduce the Risk of Transition from Acute to Chronic Post-surgical Pain This research was funded by CIHR – Drug Safety and Effectiveness Network and conducted by investigators affiliated with the following institutions: Summary ? High-quality best practice guidance is lacking for interventions that are generalizable to all surgery patients to reduce the risk of acute post-surgical pain transitioning to chronic. ? Many publications recognized (...) that control of acute post-operative pain was a primary risk factor for transition to chronic pain; however, long-term outcomes such as transition to chronic pain were not provided in supporting evidence for any acute pain management recommendations. ? Specific surgical techniques have been recommended to reduce the risk of transition from acute to chronic post- surgical pain; however, no generalizable interventions for all surgical patients have been strongly recommended within available CPGs or tested

2020 Drug Safety and Effectiveness Network

186. A Rapid Review of Best Practice Guidance of the Management of Chronic Pain and Concurrent Mental Illness and/or Substance Use Disorders

A Rapid Review of Best Practice Guidance of the Management of Chronic Pain and Concurrent Mental Illness and/or Substance Use Disorders This research was funded by CIHR – Drug Safety and Effectiveness Network and conducted by investigators affiliated with the following institutions: Summary ? High quality evidence is lacking for the best practice guidance for managing chronic pain and concurrent mental illness and/or substance use conditions. ? For managing chronic pain and concurrent mental (...) illness or substance use conditions, a better understanding of the specific interventions to deliver versus what not to deliver is needed. Given the presence of broad recommendations and interventions that are not recommended for individuals with chronic pain and concurrent conditions, additional guidance for interventions that are effective within this complex population is necessary. ? For individuals with chronic pain and comorbid mental health conditions, CPGs included recommendations of providing

2020 Drug Safety and Effectiveness Network

187. Osteoarthritis pain getting you down? Duloxetine

Osteoarthritis pain getting you down? Duloxetine July 13, 2020 Osteoarthritis pain getting you down? Duloxetine Clinical Question: Do Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), specifically duloxetine, improve pain in patients with osteoarthritis? Bottom Line: Duloxetine can meaningfully reduce osteoarthritis pain scores (by at least 30%) for ~60% of patients compared to ~40% on placebo. An average pain of ~6 (scale 0-10) will be reduced by ~2.5 points, compared to 1.7 on placebo (...) . Duloxetine adverse effects lead to withdrawal in 12% of patients versus 6% on placebo. Evidence: • Six systematic reviews with 2-7 randomized controlled trials (RCTs) and 487-2102 patients. 1-6 Duloxetine 60-120mg daily versus placebo, results statistically significant unless indicated. o Proportion of patients attaining a meaningful pain reduction (generally =30% reduction in pain score): ? Systematic review (6 RCTs, 2060 patients) 1 of hip or knee osteoarthritis, over 10-18 weeks: 64% taking duloxetine

2020 Tools for Practice

188. Clinical Study of Spinal Cord Stimulation and Pulsed Radiofrequency for Management of Herpes Zoster-Related Pain Persisting Beyond Acute Phase in Elderly Patients

Clinical Study of Spinal Cord Stimulation and Pulsed Radiofrequency for Management of Herpes Zoster-Related Pain Persisting Beyond Acute Phase in Elderly Patients Clinical Study of Spinal Cord Stimulation and Pulsed Radiofrequency for Management of Herpes Zoster-Related Pain Persisting Beyond Acute Phase in Elderly Patients - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other (...) citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Pain Physician Actions . 2020 Jun;23(3):263-270. Clinical Study of Spinal Cord Stimulation and Pulsed Radiofrequency for Management of Herpes Zoster-Related Pain Persisting Beyond Acute Phase in Elderly Patients , , , , , Affiliations Expand Affiliations 1 National Pain Management and Research Center, China-Japan

2020 EvidenceUpdates

189. Emotional Awareness and Expression Therapy Achieves Greater Pain Reduction than Cognitive Behavioral Therapy in Older Adults with Chronic Musculoskeletal Pain: A Preliminary Randomized Comparison Trial

Emotional Awareness and Expression Therapy Achieves Greater Pain Reduction than Cognitive Behavioral Therapy in Older Adults with Chronic Musculoskeletal Pain: A Preliminary Randomized Comparison Trial Emotional Awareness and Expression Therapy Achieves Greater Pain Reduction than Cognitive Behavioral Therapy in Older Adults with Chronic Musculoskeletal Pain: A Preliminary Randomized Comparison Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage (...) Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Pain Med Actions . 2020 May 25;pnaa145. doi: 10.1093/pm/pnaa145. Online ahead of print. Emotional Awareness and Expression Therapy Achieves Greater Pain Reduction than Cognitive Behavioral Therapy in Older Adults with Chronic Musculoskeletal Pain

2020 EvidenceUpdates

190. Comparison of efficacy of a supervised versus non-supervised physical therapy exercise program on the pain, functionality and quality of life of patients with non-specific chronic low-back pain: a randomized controlled trial

Comparison of efficacy of a supervised versus non-supervised physical therapy exercise program on the pain, functionality and quality of life of patients with non-specific chronic low-back pain: a randomized controlled trial Comparison of efficacy of a supervised versus non-supervised physical therapy exercise program on the pain, functionality and quality of life of patients with non-specific chronic low-back pain: a randomized controlled trial - PubMed This site needs JavaScript to work (...) on the pain, functionality and quality of life of patients with non-specific chronic low-back pain: a randomized controlled trial , , , , , , Affiliations Expand Affiliations 1 Andalusian Health Service, Family Medicine and Primary Care, Distrito Sanitario Málaga, Granada, Spain. 2 Department of Nursing, Physical Therapy and Medicine, University of Almeria, Almeria, Spain. 3 Department of Physical Therapy, University of Granada, Granada, Spain. PMID: 32517498 DOI: Item in Clipboard Comparison of efficacy

2020 EvidenceUpdates

191. Efficacy and Safety of Pulsed Radiofrequency as a Method of Dorsal Root Ganglia Stimulation in Patients with Neuropathic Pain: A Systematic Review

Efficacy and Safety of Pulsed Radiofrequency as a Method of Dorsal Root Ganglia Stimulation in Patients with Neuropathic Pain: A Systematic Review Efficacy and Safety of Pulsed Radiofrequency as a Method of Dorsal Root Ganglia Stimulation in Patients with Neuropathic Pain: A Systematic Review - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Pain Med Actions . 2020 Jun 3;pnaa141. doi: 10.1093/pm/pnaa141. Online ahead of print. Efficacy and Safety of Pulsed Radiofrequency as a Method of Dorsal Root Ganglia Stimulation in Patients with Neuropathic Pain: A Systematic Review , , , , , , Affiliations Expand Affiliations 1 Laboratory for Pain Research, University of Split School of Medicine

2020 EvidenceUpdates

192. Effectiveness of a Guided Web-Based Self-help Intervention to Prevent Depression in Patients With Persistent Back Pain: The PROD-BP Randomized Clinical Trial

Effectiveness of a Guided Web-Based Self-help Intervention to Prevent Depression in Patients With Persistent Back Pain: The PROD-BP Randomized Clinical Trial Effectiveness of a Guided Web-Based Self-help Intervention to Prevent Depression in Patients With Persistent Back Pain: The PROD-BP Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced (...) management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation JAMA Psychiatry Actions . 2020 May 27;e201021. doi: 10.1001/jamapsychiatry.2020.1021. Online ahead of print. Effectiveness of a Guided Web-Based Self-help Intervention to Prevent Depression in Patients With Persistent Back Pain: The PROD-BP Randomized Clinical Trial , , , , , , , , Affiliations Expand Affiliations 1 Institute

2020 EvidenceUpdates

193. Effects of Kinesio Taping and compression stockings on pain, edema, functional capacity and quality of life in patients with chronic venous disease: a randomized controlled trial

Effects of Kinesio Taping and compression stockings on pain, edema, functional capacity and quality of life in patients with chronic venous disease: a randomized controlled trial Effects of Kinesio Taping and compression stockings on pain, edema, functional capacity and quality of life in patients with chronic venous disease: a randomized controlled trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search (...) Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Clin Rehabil Actions . 2020 Jun;34(6):783-793. doi: 10.1177/0269215520916851. Epub 2020 Apr 29. Effects of Kinesio Taping and compression stockings on pain, edema, functional capacity and quality of life in patients with chronic venous disease: a randomized controlled trial

2020 EvidenceUpdates

194. Transcutaneous Electrical Nerve Stimulation Reduces Movement-Evoked Pain and Fatigue: A Randomized, Controlled Trial Full Text available with Trip Pro

Transcutaneous Electrical Nerve Stimulation Reduces Movement-Evoked Pain and Fatigue: A Randomized, Controlled Trial Transcutaneous Electrical Nerve Stimulation Reduces Movement-Evoked Pain and Fatigue: A Randomized, Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library (...) displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Randomized Controlled Trial Arthritis Rheumatol Actions . 2020 May;72(5):824-836. doi: 10.1002/art.41170. Epub 2020 Mar 18. Transcutaneous Electrical Nerve Stimulation Reduces Movement-Evoked Pain and Fatigue: A Randomized, Controlled Trial , , , , , , , , , , , Affiliations Expand Affiliations 1 University of Iowa, Iowa City, and St. Ambrose University, Davenport, Iowa. 2 University of Iowa, Iowa City. 3 New

2020 EvidenceUpdates

195. Pain Control After Total Hip Arthroplasty: A Randomized Controlled Trial Determining Efficacy of Fascia Iliaca Compartment Blocks in the Immediate Postoperative Period

Pain Control After Total Hip Arthroplasty: A Randomized Controlled Trial Determining Efficacy of Fascia Iliaca Compartment Blocks in the Immediate Postoperative Period Pain Control After Total Hip Arthroplasty: A Randomized Controlled Trial Determining Efficacy of Fascia Iliaca Compartment Blocks in the Immediate Postoperative Period - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several (...) for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation J Arthroplasty Actions . 2020 Jun;35(6S):S241-S245. doi: 10.1016/j.arth.2020.02.020. Epub 2020 Feb 14. Pain Control After Total Hip Arthroplasty: A Randomized Controlled Trial Determining Efficacy of Fascia Iliaca Compartment Blocks in the Immediate Postoperative Period , , , , Affiliations Expand

2020 EvidenceUpdates

196. Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial

Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center for Biotechnology Information Show (...) Permalink Copy Page navigation Obstet Gynecol Actions . 2020 Jun;135(6):1289-1295. doi: 10.1097/AOG.0000000000003850. Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial , , , , , , , Affiliations Expand Affiliation 1 Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon. PMID: 32459420 DOI: Item in Clipboard Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial Alyssa Covelli Colwill et al. Obstet

2020 EvidenceUpdates

197. Parasternal Intercostal Block Complementation Contributes to Postoperative Pain Relief in Modified Radical Mastectomy Employing Pectoral Nerve Block I and Serratus-Intercostal Block: A Randomized Trial Full Text available with Trip Pro

Parasternal Intercostal Block Complementation Contributes to Postoperative Pain Relief in Modified Radical Mastectomy Employing Pectoral Nerve Block I and Serratus-Intercostal Block: A Randomized Trial Parasternal Intercostal Block Complementation Contributes to Postoperative Pain Relief in Modified Radical Mastectomy Employing Pectoral Nerve Block I and Serratus-Intercostal Block: A Randomized Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage (...) Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation J Pain Res Actions . 2020 Apr 30;13:865-871. doi: 10.2147/JPR.S237435. eCollection 2020. Parasternal Intercostal Block Complementation Contributes to Postoperative Pain Relief in Modified Radical Mastectomy Employing Pectoral Nerve Block I and Serratus

2020 EvidenceUpdates

198. Effects on shoulder pain and disability of teaching patients with shoulder pain a home-based exercise program: a randomized controlled trial

Effects on shoulder pain and disability of teaching patients with shoulder pain a home-based exercise program: a randomized controlled trial Effects on shoulder pain and disability of teaching patients with shoulder pain a home-based exercise program: a randomized controlled trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable (...) Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Clin Rehabil Actions . 2020 Jun 7;269215520930790. doi: 10.1177/0269215520930790. Online ahead of print. Effects on shoulder pain and disability of teaching patients with shoulder pain a home-based exercise program: a randomized controlled trial , , , , Affiliations Expand Affiliation 1 Department of Health Sciences, Ribeirão Preto Medical School, University

2020 EvidenceUpdates

199. A Randomized Trial to Compare Serratus Anterior Plane Block and Erector Spinae Plane Block for Pain Management Following Thoracoscopic Surgery

A Randomized Trial to Compare Serratus Anterior Plane Block and Erector Spinae Plane Block for Pain Management Following Thoracoscopic Surgery A Randomized Trial to Compare Serratus Anterior Plane Block and Erector Spinae Plane Block for Pain Management Following Thoracoscopic Surgery - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable (...) Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Pain Med Actions . 2020 Jun 1;21(6):1248-1254. doi: 10.1093/pm/pnaa101. A Randomized Trial to Compare Serratus Anterior Plane Block and Erector Spinae Plane Block for Pain Management Following Thoracoscopic Surgery , , , , , Affiliations Expand Affiliations 1 Department of Anesthesiology and Reanimation, Istanbul Medipol University, School of Medicine, Mega

2020 EvidenceUpdates

200. Analgesic efficacy of cannabinoids for acute pain management after surgery: a systematic review and meta-analysis

Analgesic efficacy of cannabinoids for acute pain management after surgery: a systematic review and meta-analysis Analgesic efficacy of cannabinoids for acute pain management after surgery: a systematic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library (...) displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Reg Anesth Pain Med Actions . 2020 Jul;45(7):509-519. doi: 10.1136/rapm-2020-101340. Epub 2020 May 28. Analgesic efficacy of cannabinoids for acute pain management after surgery: a systematic review and meta-analysis , , , Affiliations Expand Affiliations 1 Anesthesiology and Pain Medicine - North York General Hospital & The Ottawa Hospital, University of Toronto, University of Ottawa, Toronto, Ottawa, Ontario

2020 EvidenceUpdates