Latest & greatest articles for pain

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on pain or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on pain and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for pain

1. Stressed out about stress testing? The utility of stress testing after non-ACS chest pain

Stressed out about stress testing? The utility of stress testing after non-ACS chest pain Stressed out about stress testing? The utility of stress testing after non-ACS chest pain - CanadiEM Stressed out about stress testing? The utility of stress testing after non-ACS chest pain In by Vivian Tam October 15, 2019 The Case Your next patient in the acute zone of the ED is Mr. Liu, a 53-year old man presenting with one hour of acute onset atypical chest pain. He has several risk factors (...) ​ A review of the evidence on stress testing A recent disputed the commonly cited 2% ACS miss rate after ED discharge. ​4​ In the Pope et al . study, of the 10,689 patients presenting with undifferentiated chest pain, 889 patients had acute MI. ​5​ Nineteen of the confirmed MI patients were mistakenly discharged. Therefore, of all patients presenting to the ED with undifferentiated chest pain, less than 0.2% were missed (whereas the 2% figure is derived from the 19 missed MIs of the 889 patients

2019 CandiEM

2. Palmitoylethanolamide (PEA) as treatment for knee osteoarthritis pain

Palmitoylethanolamide (PEA) as treatment for knee osteoarthritis pain Palmitoylethanolamide (PEA) as treatment for knee osteoarthritis pain – Morsels of Evidence \t\t\t\r\n\t\t\t \t\t\t\r\n\t\t\t Share this: Like this: Like Loading... ","author":{"@type":"Person","name":"Michael Tam"},"image":["https:\/\/evidencebasedmedicine.com.au\/wp-content\/uploads\/2019\/10\/Screenshot-2019-10-11-at-19.51.14.png"]} Toggle search form Toggle navigation Evidence-based medicine for general practitioners Oct (...) 11 2019 Palmitoylethanolamide (PEA) as treatment for knee osteoarthritis pain By in , , 11 October 2019 Journal reference: Steels E, Venkatesh R, Steels E, Vitetta G, Vitetta L. A double-blind randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis. Inflammopharmacology 2019 Jun;27(3):475-85. Link: Published: March 2019 Evidence cookie says… Palmitoylethanolamide (PEA) cannot be recommended as a routine therapy

2019 Morsels of Evidence

3. Inhaled nitric oxide for treating pain crises in people with sickle cell disease. (PubMed)

Inhaled nitric oxide for treating pain crises in people with sickle cell disease. In people with sickle cell disease, sickled red blood cells cause the occlusion of small blood vessels which presents as episodes of severe pain known as pain crises or vaso-occlusive crises. The pain can occur in the bones, chest, or other parts of the body, and may last several hours to days. Pain relief during crises includes both pharmacologic and non-pharmacologic treatments. The efficacy of inhaled nitric (...) oxide in pain crises has been a controversial issue and hypotheses have been made suggesting a beneficial response due to its vasodilator properties. Yet no conclusive evidence has been presented.This review aims to evaluate the available randomised controlled studies which address this topic.To capture the available body of evidence evaluating the efficacy and safety of the use of inhaled nitric oxide in treating pain crises in people with sickle cell disease; and to assess the treatment's

2019 Cochrane

4. Pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome. (PubMed)

Pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common disorder in which the two main clinical features are pelvic pain and lower urinary tract symptoms. There are currently many approaches for its management, using both pharmacological and non-pharmacological interventions. The National Institute of Health - Chronic Prostatitis Symptom Index (NIH-CPSI) score is a validated measure (...) commonly used to measure CP/CPPS symptoms. We considered a 25% decrease of NIH-CPSI baseline score or a six-point reduction as MCID.To assess the effects of pharmacological therapies for chronic prostatitis/chronic pelvic pain syndrome.We performed a comprehensive search using CENTRAL, MEDLINE, Embase, PsycINFO, CINAHL, trial registries, grey literature and conference proceedings, with no restrictions on the language of publication or publication status. The date of the latest search of all databases

2019 Cochrane

5. Chest Pain – Possible Acute Coronary Syndrome

Chest Pain – Possible Acute Coronary Syndrome American College of Radiology End User License Agreement ACR Appropriateness Criteria is a registered trademark of the American College of Radiology. By accessing the ACR Appropriateness Criteria®, you expressly agree and consent to the terms and conditions as described at: http://www.acr.org/~/media/ACR/Documents/AppCriteria/TermsandConditions.pdf Personal use of material is permitted for research, scientific and/or information purposes only. You (...) may not modify or create derivative works based on American College of Radiology material. No part of any material posted on the American College of Radiology Web site may be copied, downloaded, stored in a retrieval system, or redistributed for any other purpose without the expressed written permission of American College of Radiology. Date of origin: 1995 Last review date: 2014 ACR Appropriateness Criteria ® 1 Chest Pain Suggestive of ACS American College of Radiology ACR Appropriateness

2019 American College of Radiology

6. Smaller Quantity Opioid Prescribing for Chronic Non-Cancer Pain: Clinical Effectiveness and Guidelines

Smaller Quantity Opioid Prescribing for Chronic Non-Cancer Pain: Clinical Effectiveness and Guidelines Smaller Quantity Opioid Prescribing for Chronic Non-Cancer Pain: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Smaller Quantity Opioid Prescribing for Chronic Non-Cancer Pain: Clinical Effectiveness and Guidelines Smaller Quantity Opioid Prescribing for Chronic Non-Cancer Pain: Clinical Effectiveness and Guidelines Last updated: June 28, 2019 Project Number (...) : RA1041-000 Product Line: Research Type: Drug Report Type: Reference List Result type: Report Question What is the clinical effectiveness of prescribing opioids in smaller quantities for patients with chronic non-cancer pain? What are the evidence-based guidelines associated with opioid prescribing for patients with chronic non-cancer pain? Key Message One non-randomized study and three evidence-based guidelines were identified regarding short-term prescribing of opioids for patient with chronic non

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

7. Yoga for Chronic Non-Malignant Pain Management: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines

Yoga for Chronic Non-Malignant Pain Management: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines Yoga for Chronic Non-Malignant Pain Management: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Yoga for Chronic Non-Malignant Pain Management: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines Yoga for Chronic Non-Malignant Pain Management: A Review of Clinical Effectiveness, Cost-Effectiveness (...) and Guidelines Last updated: July 8, 2019 Project Number: RC1139-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of yoga for chronic non-malignant pain in adults? What is the cost-effectiveness of yoga for chronic non-malignant pain in adults? What are the evidence-based guidelines regarding the use of yoga for chronic non-malignant pain in adults? Key Message Evidence of limited quality from one

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

8. Multidisciplinary Treatment Programs for Patients with Acute or Subacute Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Multidisciplinary Treatment Programs for Patients with Acute or Subacute Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Multidisciplinary Treatment Programs for Patients with Acute or Subacute Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Multidisciplinary Treatment Programs for Patients with Acute or Subacute Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines (...) Multidisciplinary Treatment Programs for Patients with Acute or Subacute Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Last updated: May 7, 2019 Project Number: RC1109-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of multidisciplinary treatment programs for patients with acute or subacute pain in outpatient settings? What is the cost-effectiveness

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

9. Multidisciplinary Treatment Programs for Patients with Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines – An Update

Multidisciplinary Treatment Programs for Patients with Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines – An Update Multidisciplinary Treatment Programs for Patients with Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines – An Update | CADTH.ca Find the information you need Multidisciplinary Treatment Programs for Patients with Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost (...) -effectiveness, and Guidelines – An Update Multidisciplinary Treatment Programs for Patients with Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines – An Update Last updated: May 10, 2019 Project Number: RC1110-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of multidisciplinary treatment programs for patients with chronic, non-malignant pain

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

10. Smaller Quantity Opioid Prescribing for Acute Pain: Clinical Effectiveness and Guidelines

Smaller Quantity Opioid Prescribing for Acute Pain: Clinical Effectiveness and Guidelines Smaller Quantity Opioid Prescribing for Acute Pain: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Smaller Quantity Opioid Prescribing for Acute Pain: Clinical Effectiveness and Guidelines Smaller Quantity Opioid Prescribing for Acute Pain: Clinical Effectiveness and Guidelines Last updated: June 14, 2019 Project Number: RA1039-000 Product Line: Research Type: Drug Report (...) Type: Reference List Result type: Report Question What is the clinical effectiveness of prescribing opioids in smaller quantities for patients with acute pain? What are the evidence-based guidelines associated with opioid prescribing for patients with acute pain? Key Message One systematic review of guidelines, two non-randomized studies, and four evidence-based guidelines were identified regarding smaller quantity opioid prescribing for acute pain. Files Rapid Response Reference List Published

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

11. Multidisciplinary Pain Consult Teams for Acute Care in Hospitals: Clinical Utility and Cost-Effectiveness

Multidisciplinary Pain Consult Teams for Acute Care in Hospitals: Clinical Utility and Cost-Effectiveness Multidisciplinary Pain Consult Teams for Acute Care in Hospitals: Clinical Utility and Cost-Effectiveness | CADTH.ca Find the information you need Multidisciplinary Pain Consult Teams for Acute Care in Hospitals: Clinical Utility and Cost-Effectiveness Multidisciplinary Pain Consult Teams for Acute Care in Hospitals: Clinical Utility and Cost-Effectiveness Last updated: August 16, 2019 (...) Project Number: RB1357-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What is the clinical utility of acute pain assessment by multidisciplinary pain consult teams in an inpatient setting? What is the cost-effectiveness of acute pain assessment by multidisciplinary pain consult teams in an inpatient setting? Key Message No relevant health technology assessments, systematic reviews, meta-analyses, randomized controlled trials, non

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

12. Injectable Botulinum Toxin for Pelvic Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Injectable Botulinum Toxin for Pelvic Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Injectable Botulinum Toxin for Pelvic Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Injectable Botulinum Toxin for Pelvic Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Injectable Botulinum Toxin for Pelvic Pain: A Review of Clinical Effectiveness, Cost-Effectiveness (...) , and Guidelines Last updated: August 22, 2019 Project Number: RC1170-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of injectable botulinum toxin for pelvic floor pain? What is the cost-effectiveness of injectable botulinum toxin for pelvic floor pain? What are the evidence-based guidelines regarding injectable botulinum toxin for pelvic floor pain? Key Message Two systematic reviews and three randomized

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

13. Medical Cannabis for the Treatment of Chronic Pain: A Review of Clinical Effectiveness and Guidelines

Medical Cannabis for the Treatment of Chronic Pain: A Review of Clinical Effectiveness and Guidelines Medical Cannabis for the Treatment of Chronic Pain: A Review of Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Medical Cannabis for the Treatment of Chronic Pain: A Review of Clinical Effectiveness and Guidelines Medical Cannabis for the Treatment of Chronic Pain: A Review of Clinical Effectiveness and Guidelines Last updated: July 24, 2019 Project Number: RC1153 (...) -000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of medical cannabis for the treatment of chronic pain? What are the evidence-based guidelines associated with the use of medical cannabis for the treatment of chronic pain? Key Message Based on four overviews (with overlapping systematic reviews), and one systematic review of guidelines,8 there is some suggestion of benefit with cannabis-based medicines

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

14. Wearables with Neuroreceptor Activation Patterns for Foot Neuropathy or Musculoskeletal Foot or Back Pain: Clinical Effectiveness

Wearables with Neuroreceptor Activation Patterns for Foot Neuropathy or Musculoskeletal Foot or Back Pain: Clinical Effectiveness Wearables with Neuroreceptor Activation Patterns for Foot Neuropathy or Musculoskeletal Foot or Back Pain: Clinical Effectiveness | CADTH.ca Find the information you need Wearables with Neuroreceptor Activation Patterns for Foot Neuropathy or Musculoskeletal Foot or Back Pain: Clinical Effectiveness Wearables with Neuroreceptor Activation Patterns for Foot Neuropathy (...) or Musculoskeletal Foot or Back Pain: Clinical Effectiveness Last updated: August 27, 2019 Project Number: RA1066-000 Product Line: Research Type: Devices and Systems Report Type: Reference List Result type: Report Question What is the clinical effectiveness of wearables incorporating a neuroreceptor activation sequence or pattern for foot neuropathy? What is the clinical effectiveness of wearables incorporating a neuroreceptor activation sequence or pattern for foot pain or back pain of musculoskeletal origin

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

15. Cognitive Behavioural Therapy for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness

Cognitive Behavioural Therapy for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness Cognitive Behavioural Therapy for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness | CADTH.ca Find the information you need Cognitive Behavioural Therapy for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness Cognitive Behavioural Therapy for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness Last updated: September 16, 2019 Project Number: RC1181-000 Product Line: Research (...) Type: Non-Pharma Mental Health Intervention Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of cognitive behavioural therapy for chronic non-cancer pain? Key Message There were five systematic reviews included in this report, four of which were Cochrane reviews. Four of the five included systematic reviews had one weakness in the AMSTAR critical domains. The clinical effectiveness of cognitive behavioural therapy was assessed in several

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

16. Mindfulness Training and Yoga for the Management of Chronic Non-malignant Pain: A Review of Clinical Effectiveness and Cost-effectiveness

Mindfulness Training and Yoga for the Management of Chronic Non-malignant Pain: A Review of Clinical Effectiveness and Cost-effectiveness Mindfulness Training and Yoga for the Management of Chronic Non-malignant Pain: A Review of Clinical Effectiveness and Cost-effectiveness | CADTH.ca Find the information you need Mindfulness Training and Yoga for the Management of Chronic Non-malignant Pain: A Review of Clinical Effectiveness and Cost-effectiveness Mindfulness Training and Yoga (...) for the Management of Chronic Non-malignant Pain: A Review of Clinical Effectiveness and Cost-effectiveness Last updated: September 20, 2019 Project Number: RC1185-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of mindfulness training for chronic non-malignant pain in adults? What is the clinical effectiveness of yoga for chronic non-malignant pain in adults? What is the cost-effectiveness

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

17. Manual Therapy for Persistent or Chronic Non-Specific Neck Pain: Clinical Effectiveness, Cost-Effectiveness and Guidelines

Manual Therapy for Persistent or Chronic Non-Specific Neck Pain: Clinical Effectiveness, Cost-Effectiveness and Guidelines Manual Therapy for Persistent or Chronic Non-Specific Neck Pain: Clinical Effectiveness, Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Manual Therapy for Persistent or Chronic Non-Specific Neck Pain: Clinical Effectiveness, Cost-Effectiveness and Guidelines Manual Therapy for Persistent or Chronic Non-Specific Neck Pain: Clinical Effectiveness (...) , Cost-Effectiveness and Guidelines Last updated: September 24, 2019 Project Number: RA1070-000 Product Line: Research Type: Devices and Systems Report Type: Reference List Result type: Report Question What is the clinical effectiveness of manual therapies for non-cancer, non-specific neck pain? What is the cost-effectiveness of manual therapies for non-cancer, non-specific neck pain? What are the evidence based guidelines regarding manual therapies for non-cancer, non-specific neck pain? Key Message

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

18. Strength-based Exercise for Chronic Non-Cancer Back Pain: A Review of Clinical Effectiveness

Strength-based Exercise for Chronic Non-Cancer Back Pain: A Review of Clinical Effectiveness Strength-based Exercise for Chronic Non-Cancer Back Pain: A Review of Clinical Effectiveness | CADTH.ca Find the information you need Strength-based Exercise for Chronic Non-Cancer Back Pain: A Review of Clinical Effectiveness Strength-based Exercise for Chronic Non-Cancer Back Pain: A Review of Clinical Effectiveness Last updated: September 27, 2019 Project Number: RC1193-000 Product Line: Research (...) Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of strength-based exercise for chronic non-cancer back pain? Key Message No evidence was found regarding the clinical effectiveness of strength-based exercise alone compared with pharmacological interventions for chronic non-cancer back pain in non-pregnant people. Files Rapid Response Summary with Critical Appraisal Published : September 27, 2019 Follow us: © 2019

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

19. Tiered Care for Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Tiered Care for Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Tiered Care for Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Tiered Care for Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Tiered Care for Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-Effectiveness (...) , and Guidelines Last updated: February 12, 2019 Project Number: RC1074-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of tiered or stepped care for patients with chronic, non-malignant pain in outpatient settings? What is the cost-effectiveness of tiered or stepped care for patients with chronic, non-malignant pain in outpatient settings? What are the evidence-based guidelines regarding tiered

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

20. Extracorporeal shock wave therapy (ESWT) for heel pain

Extracorporeal shock wave therapy (ESWT) for heel pain 1 Translation of the key statement of the final report N15-06 Extrakorporale Stoßwellentherapie beim Fersenschmerz (Version 1.0; Status: 29 March 2017). Please note: This document was translated by an external translator and is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. Extract IQWiG Reports – Commission No. N15-06 Extracorporeal shock (...) wave therapy (ESWT) for heel pain 1 Extract of final report N15-06 Version 1.0 ESWT for heel pain 29 March 2017 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency in Health Care Topic: Extracorporeal shock wave therapy (ESWT) for heel pain Commissioning agency: Federal Joint Committee Commission awarded on: 30 July 2015 Internal Commission No.: N15-06 Address of publisher: Institut für Qualität und Wirtschaftlichkeit

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)