Latest & greatest articles for overdiagnosis

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Top results for overdiagnosis

21. Influence of study features and methods on overdiagnosis estimates in breast and prostate cancer screening. Full Text available with Trip Pro

Influence of study features and methods on overdiagnosis estimates in breast and prostate cancer screening. Knowledge of the likelihood that a screening-detected case of cancer has been overdiagnosed is vitally important to make treatment decisions and develop screening policy. An overdiagnosed case is an excess case detected by screening. Estimates of the frequency of overdiagnosis in breast and prostate cancer screening vary greatly across studies. This article identifies features (...) of overdiagnosis studies that influence results and shows their effect by using published research. First, different ways to define and measure overdiagnosis are considered. Second, contextual features and how they affect overdiagnosis estimates are examined. Third, the effect of estimation approach is discussed. Many studies use excess incidence under screening as a proxy for overdiagnosis. Others use statistical models to make inferences about lead time or natural history and then derive the corresponding

2013 Annals of Internal Medicine

22. Overdiagnosis in screening mammography in Denmark: population based cohort study. Full Text available with Trip Pro

Overdiagnosis in screening mammography in Denmark: population based cohort study. To use data from two longstanding, population based screening programmes to study overdiagnosis in screening mammography.Population based cohort study.Copenhagen municipality (from 1991) and Funen County (from 1993), Denmark.57,763 women targeted by organised screening, aged 56-69 when the screening programmes started, and followed up to 2009.Overdiagnosis of breast cancer in women targeted by screening, assessed (...) for Copenhagen and 1.02 for Funen; for participants followed for at least eight years after the end of screening, they were 1.05 and 1.01. A pooled estimate gave 1.040 (0.99 to 1.09) for all targeted women and 1.023 (0.97 to 1.08) for targeted women followed for at least eight years after the end of screening.On the basis of combined data from the two screening programmes, this study indicated that overdiagnosis most likely amounted to 2.3% (95% confidence interval -3% to 8%) in targeted women. Among

2013 BMJ

23. Women's views on overdiagnosis in breast cancer screening: a qualitative study. Full Text available with Trip Pro

Women's views on overdiagnosis in breast cancer screening: a qualitative study. To elicit women's responses to information about the nature and extent of overdiagnosis in mammography screening (detecting disease that would not present clinically during the woman's lifetime) and explore how awareness of overdiagnosis might influence attitudes and intentions about screening.Qualitative study using focus groups that included a presentation explaining overdiagnosis, incorporating different (...) published estimates of its rate (1-10%, 30%, 50%) and information on the mortality benefit of screening, with guided group discussionsSydney, AustraliaFifty women aged 40-79 years with no personal history of breast cancer and with varying levels of education and participation in screening.Prior awareness of breast cancer overdiagnosis was minimal. Women generally reacted with surprise, but most came to understand the issue. Responses to overdiagnosis and the different estimates of its magnitude were

2013 BMJ

24. Observational study: Mammography screening in Norway caused substantial overdiagnosis and did not reduce late-stage breast cancers

Observational study: Mammography screening in Norway caused substantial overdiagnosis and did not reduce late-stage breast cancers Mammography screening in Norway caused substantial overdiagnosis and did not reduce late-stage breast cancers | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Mammography screening in Norway caused substantial overdiagnosis and did not reduce late-stage breast cancers Article Text Online articles Observational

2013 Evidence-Based Medicine

25. Estimating overdiagnosis in low-dose computed tomography screening for lung cancer: a cohort study. (Abstract)

Estimating overdiagnosis in low-dose computed tomography screening for lung cancer: a cohort study. Lung cancer screening may detect cancer that will never become symptomatic (overdiagnosis), leading to overtreatment. Changes in size on sequential low-dose computed tomography (LDCT) screening, expressed as volume-doubling time (VDT), may help to distinguish aggressive cancer from cases that are unlikely to become symptomatic.To assess VDT for screening-detected lung cancer as an indicator (...) were stage I, for which survival was good.This is a retrospective study. Volume-doubling time can only indicate overdiagnosis and was estimated for new cancer from 1 measurement (a diameter of 2 mm assumed the previous year).Slow-growing or indolent cancer comprised approximately 25% of incident cases, many of which may have been overdiagnosed. To limit overtreatment in these cases, minimally invasive limited resection and nonsurgical treatments should be investigated.Italian Association for Cancer

2012 Annals of Internal Medicine

26. Overdiagnosis of invasive breast cancer due to mammography screening: results from the norwegian screening program. (Abstract)

Overdiagnosis of invasive breast cancer due to mammography screening: results from the norwegian screening program. Precise quantification of overdiagnosis of breast cancer (defined as the percentage of cases of cancer that would not have become clinically apparent in a woman's lifetime without screening) due to mammography screening has been hampered by lack of valid comparison groups that identify incidence trends attributable to screening versus those due to temporal trends in incidence.To (...) estimate the percentage of overdiagnosis of breast cancer attributable to mammography screening.Comparison of invasive breast cancer incidence with and without screening.A nationwide mammography screening program in Norway (inviting women aged 50 to 69 years), gradually implemented from 1996 to 2005.The Norwegian female population.Concomitant incidence of invasive breast cancer from 1996 to 2005 in counties where the screening program was implemented compared with that in counties where the program

2012 Annals of Internal Medicine

27. Overdiagnosis from non-progressive cancer detected by screening mammography: stochastic simulation study with calibration to population based registry data. Full Text available with Trip Pro

Overdiagnosis from non-progressive cancer detected by screening mammography: stochastic simulation study with calibration to population based registry data. To quantify the magnitude of overdiagnosis from non-progressive disease detected by screening mammography, after adjustment for the potential for lead time bias, secular trend in the underlying risk of breast cancer, and opportunistic screening.Approximate bayesian computation analysis with a stochastic simulation model designed (...) to replicate standardised incidence rates of breast cancer. The model components included the lifetime probability of breast cancer, the natural course of breast cancer, and participation in organised and opportunistic mammography screening.Isère, a French administrative region with nearly 1.2 million inhabitants.All women living in Isère and aged 50-69 during 1991-2006.Overdiagnosis, defined as the proportion of non-progressive cancers among all cases of invasive cancer and carcinoma in situ detected 1991

2011 BMJ

28. Overdiagnosis in publicly organised mammography screening programmes: systematic review of incidence trends. Full Text available with Trip Pro

Overdiagnosis in publicly organised mammography screening programmes: systematic review of incidence trends. To estimate the extent of overdiagnosis (the detection of cancers that will not cause death or symptoms) in publicly organised screening programmes.Systematic review of published trends in incidence of breast cancer before and after the introduction of mammography screening.PubMed (April 2007), reference lists, and authors. Review methods One author extracted data on incidence of breast (...) both screened and non-screened age groups, were available from the United Kingdom; Manitoba, Canada; New South Wales, Australia; Sweden; and parts of Norway. The implementation phase with its prevalence peak was excluded and adjustment made for changing background incidence and compensatory drops in incidence among older, previously screened women. Overdiagnosis was estimated at 52% (95% confidence interval 46% to 58%). Data from three countries showed a drop in incidence as the women exceeded

2009 BMJ

29. Overdiagnosis in publicly organised mammography screening programmes: systematic review of incidence trends

Overdiagnosis in publicly organised mammography screening programmes: systematic review of incidence trends Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

30. Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study. Full Text available with Trip Pro

Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study. To study the diagnosis and outcomes in people admitted to hospital with a diagnosis of severe malaria in areas with differing intensities of malaria transmission.Prospective observational study of children and adults over the course a year.10 hospitals in north east Tanzania.17,313 patients were admitted to hospital; of these 4474 (2851 children aged under 5 years) fulfilled criteria for severe

2004 BMJ