Latest & greatest articles for otitis media

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Top results for otitis media

121. Screening children in the first four years of life to undergo early treatment for otitis media with effusion.

Screening children in the first four years of life to undergo early treatment for otitis media with effusion. BACKGROUND: Otitis media with effusion (OME) is the most common cause of acquired hearing loss in childhood and has been associated with delayed language development and behavioural problems. This condition has a prevalence of about 20% at the age of two years, a time of rapid language development. It is most often asymptomatic. Effective treatment exists for clearing effusions. Some

Cochrane2003

122. Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media.

Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media. CONTEXT: Chronic otitis media with effusion (OME) has long been considered to be a sterile inflammatory process. The previous application of molecular diagnostic technologies to OME suggests that viable bacteria are present in complex communities known as mucosal biofilms; however, direct imaging evidence of mucosal biofilms associated with OM is lacking. OBJECTIVE: To determine whether biofilm formation (...) occurs in middle-ear mucosa in an experimental model of otitis media. DESIGN AND MATERIALS: A total of 48 research-grade, young adult chinchillas weighing 500 g were used for 2 series of animal experiments: one to obtain specimens for scanning electron microscopy and the other to obtain specimens for confocal laser scanning microscopy using vital dyes. In each series, 21 animals were bilaterally injected with viable Haemophilus influenzae bacteria and 1 was inoculated to account for expected

JAMA2002

123. Ventilation tubes after surgery for otitis media with effusion or acute otitis media and swimming: systematic review and meta-analysis

Ventilation tubes after surgery for otitis media with effusion or acute otitis media and swimming: systematic review and meta-analysis Ventilation tubes after surgery for otitis media with effusion or acute otitis media and swimming: systematic review and meta-analysis Ventilation tubes after surgery for otitis media with effusion or acute otitis media and swimming: systematic review and meta-analysis Carbonell R, Ruiz-Garcia V Authors' objectives To determine whether swimming using ear (...) protection, swimming without ear protection and not swimming affects the risk of acute otitis media (AOM) in children with ventilation tubes. Searching MEDLINE (from 1966 to June 2001), EMBASE (from 1980 to June 2001) and the Cochrane Library (to June 2001) were searched without language restriction. In addition, the reference lists from identified studies were checked. Experts were not contacted and grey literature was not sought. A brief summary of the search strategy was reported in the review. Study

DARE.2002

124. Predictors of poor outcome and benefits from antibiotics in children with acute otitis media: pragmatic randomised trial.

Predictors of poor outcome and benefits from antibiotics in children with acute otitis media: pragmatic randomised trial. 12098725 2002 07 05 2002 07 26 2014 06 12 1756-1833 325 7354 2002 Jul 06 BMJ (Clinical research ed.) BMJ Predictors of poor outcome and benefits from antibiotics in children with acute otitis media: pragmatic randomised trial. 22; discussion 22 To identify which children with acute otitis media are at risk of poor outcome and to assess benefit from antibiotics (...) or vomiting, immediate antibiotics made little difference to distress by day three (15% v 19%, chi2=0.74; P=0.39) or night disturbance (20% v 27%, chi2=1.6; P=0.20). Addition of cough did not significantly improve prediction of benefit. In children with otitis media but without fever and vomiting antibiotic treatment has little benefit and a poor outcome is unlikely. Little Paul P Community Clinical Sciences (Primary Medical Care Group), University of Southampton, Aldermoor Health Centre, Southampton SO15

BMJ2002 Full Text: Link to full Text with Trip Pro

125. Pneumococcal vaccines for preventing otitis media.

Pneumococcal vaccines for preventing otitis media. BACKGROUND: Acute otitis media (AOM) is one of the most common diseases in early infancy and childhood. Long term effects of recurrent episodes of otitis media, rapid emergence of drug resistant bacteria associated with AOM worldwide and huge estimated direct and indirect annual costs associated with otitis media have emphasized the need for an effective vaccination program to prevent episodes of AOM. OBJECTIVES: The object of this review (...) is not recommended. The results of currently ongoing trials could provide more information whether pneumococcal vaccines are effective in specific high-risk (otitis-prone) populations.

Cochrane2002

126. Decongestants and antihistamines for acute otitis media in children.

Decongestants and antihistamines for acute otitis media in children. BACKGROUND: Acute otitis media (AOM) is a common and important source of morbidity in children, although most cases resolve spontaneously. While frequently recommended, decongestant and antihistamine therapy is of unclear benefit. OBJECTIVES: To determine the efficacy of decongestant and antihistamine therapy in children with AOM on outcomes of AOM resolution, medication side effects, and complications of AOM. SEARCH STRATEGY

Cochrane2002

127. Management of acute otitis media

Management of acute otitis media Management of acute otitis media Management of acute otitis media Marcy M, Takata G, Chan L S Shekelle P, Mason W, Wachsman L, Ernst R, Hay J W, Corley P M, Morphew T, Ramicone E, Nicholson C Authors' objectives To analyse the evidence on the initial management of uncomplicated acute otitis media (AOM) in children, and to assess the following three questions. What is the natural history of AOM without antibiotic treatment? Are antibiotics effective in preventing (...) to establish differences in antibiotic efficacy. In addition, future studies should address the issue of bacterial resistance. Bibliographic details Marcy M, Takata G, Chan L S Shekelle P, Mason W, Wachsman L, Ernst R, Hay J W, Corley P M, Morphew T, Ramicone E, Nicholson C. Management of acute otitis media. Rockville, MD, USA: Agency for Healthcare Research and Quality. Evidence Report/Technology Assessment; 15. 2001 Original Paper URL Other publications of related interest Jadad AR, Moore RA, Carroll D

DARE.2001

128. Evidence assessment of management of acute otitis media - I. The role of antibiotics in treatment of uncomplicated acute otitis media

Evidence assessment of management of acute otitis media - I. The role of antibiotics in treatment of uncomplicated acute otitis media Evidence assessment of management of acute otitis media - I. The role of antibiotics in treatment of uncomplicated acute otitis media Evidence assessment of management of acute otitis media - I. The role of antibiotics in treatment of uncomplicated acute otitis media Takata G S, Chan L S, Shekelle P, Morton S C, Mason W, Marcy S M Authors' objectives (...) To synthesise the literature on the natural history of acute otitis media (AOM), the effectiveness of antibiotic treatment in uncomplicated AOM, and the relative effectiveness of specific antibiotic regimens. Searching The following sources were searched: MEDLINE from 1966 to March 1999; the Cochrane Library (to March 1999); HealthSTAR from 1975 to March 1999; International Pharmaceutical Abstracts from 1970 to March 1999; CINAHL from 1982 to March 1999; BIOSIS Previews from 1970 to March 1999; and EMBASE

DARE.2001

129. Azithromycin vs. clarithromycin and co-amoxiclav: clinical and economic comparison in the treatment of acute otitis media in children

Azithromycin vs. clarithromycin and co-amoxiclav: clinical and economic comparison in the treatment of acute otitis media in children Azithromycin vs. clarithromycin and co-amoxiclav: clinical and economic comparison in the treatment of acute otitis media in children Azithromycin vs. clarithromycin and co-amoxiclav: clinical and economic comparison in the treatment of acute otitis media in children Kawalski H, Blacha E, Kopacz M, Mos M, Cierpiol-Tracz E, Welniak M, Dudziak B, Bojda S, Kossowska (...) B, Gatniejewska E, Ligacz M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of azithromycin, clarithromycin and co-amoxiclav in the treatment of children with acute otitis media (AOM). Azithromycin was administered

NHS Economic Evaluation Database.2001

130. Management of acute otitis media

Management of acute otitis media Management of acute otitis media Management of acute otitis media Agency for Healthcare Research and Quality (AHRQ) Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Agency for Healthcare Research and Quality (AHRQ). Management of acute otitis media. Rockville: Agency for Healthcare Research and Quality (...) (AHRQ). Evidence Report/Technology Assessment No. 15. 2001 Authors' objectives The objective of this report is to analyze the evidence on the initial management of uncomplicated acute otitis media (AOM) in children. Authors' conclusions There is a wide range of reported clinical failure rates in the first week in children with AOM who are not treated with antibiotics. The pooled estimates indicate that a majority of these children have clinical resolution within the first week after presentation

Health Technology Assessment (HTA) Database.2001

131. Effect of recolonisation with "interfering" alpha streptococci on recurrences of acute and secretory otitis media in children: randomised placebo controlled trial.

Effect of recolonisation with "interfering" alpha streptococci on recurrences of acute and secretory otitis media in children: randomised placebo controlled trial. 11159619 2001 02 22 2001 03 08 2014 07 28 0959-8138 322 7280 2001 Jan 27 BMJ (Clinical research ed.) BMJ Effect of recolonisation with "interfering" alpha streptococci on recurrences of acute and secretory otitis media in children: randomised placebo controlled trial. 210-2 To study the effect of recolonisation with alpha (...) streptococci with the ability to inhibit the growth of otopathogens ("interfering" activity) on the recurrence of acute otitis media in susceptible children and the effect on the frequency of secretory otitis media. Double blind, randomised, placebo controlled study. Ear, nose, and throat clinic with three doctors. 130 children prone to otitis media aged between 6 months and 6 years, 108 of whom were eligible and followed for 3 months. Recurrence of otitis media during follow up and a normal tympanic

BMJ2001 Full Text: Link to full Text with Trip Pro

132. Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media.

Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media. 11159657 2001 02 22 2001 03 29 2014 07 28 0959-8138 322 7282 2001 Feb 10 BMJ (Clinical research ed.) BMJ Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media. 336-42 To compare immediate with delayed prescribing of antibiotics for acute otitis media. Open randomised controlled trial. General practices in south west England. 315 children aged (...) between 6 months and 10 years presenting with acute otitis media. Two treatment strategies, supported by standardised advice sheets-immediate antibiotics or delayed antibiotics (antibiotic prescription to be collected at parents' discretion after 72 hours if child still not improving). Symptom resolution, absence from school or nursery, paracetamol consumption. On average, symptoms resolved after 3 days. Children prescribed antibiotics immediately had shorter illness (-1.1 days (95% confidence

BMJ2001 Full Text: Link to full Text with Trip Pro

133. Efficacy of a pneumococcal conjugate vaccine against acute otitis media.

Efficacy of a pneumococcal conjugate vaccine against acute otitis media. 11172176 2001 01 25 2001 02 08 2015 11 19 0028-4793 344 6 2001 Feb 08 The New England journal of medicine N. Engl. J. Med. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. 403-9 Ear infections are a common cause of illness during the first two years of life. New conjugate vaccines may be able to prevent a substantial portion of cases of acute otitis media caused by Streptococcus pneumoniae. We (...) enrolled 1662 infants in a randomized, double-blind efficacy trial of a heptavalent pneumococcal polysaccharide conjugate vaccine in which the carrier protein is the nontoxic diphtheria-toxin analogue CRM197. The children received either the study vaccine or a hepatitis B vaccine as a control at 2, 4, 6, and 12 months of age. The clinical diagnosis of acute otitis media was based on predefined criteria, and the bacteriologic diagnosis was based on a culture of middle-ear fluid obtained by myringotomy

NEJM2001

134. Effect of early or delayed insertion of tympanostomy tubes for persistent otitis media on developmental outcomes at the age of three years.

Effect of early or delayed insertion of tympanostomy tubes for persistent otitis media on developmental outcomes at the age of three years. 11309632 2001 04 05 2001 05 03 2007 11 14 0028-4793 344 16 2001 Apr 19 The New England journal of medicine N. Engl. J. Med. Effect of early or delayed insertion of tympanostomy tubes for persistent otitis media on developmental outcomes at the age of three years. 1179-87 A main indication for the insertion of tympanostomy tubes in infants and young children (...) is persistent otitis media with effusion, reflecting concern that this condition may cause lasting impairments of speech, language, cognitive, and psychosocial development. However, evidence of such relations is inconclusive, and evidence is lacking that the insertion of tympanostomy tubes prevents developmental impairment. We enrolled 6350 healthy infants from 2 to 61 days of age and evaluated them regularly for middle-ear effusion. Before the age of three years 429 children with persistent effusion were

NEJM2001

135. Decongestants and antihistamines for acute otitis media in children.

Decongestants and antihistamines for acute otitis media in children. BACKGROUND: Acute otitis media (AOM) is a common and important source of morbidity in children, although most cases resolve spontaneously. While frequently recommended, decongestant and antihistamine therapy is of unclear benefit. OBJECTIVES: To determine the efficacy of decongestant and antihistamine therapy in children with AOM on outcomes of AOM resolution, medication side effects, and complications of AOM. SEARCH STRATEGY

Cochrane2001

136. Childhood vaccination against pneumococcal otitis media and pneumonia: an analysis of benefits and costs

Childhood vaccination against pneumococcal otitis media and pneumonia: an analysis of benefits and costs Childhood vaccination against pneumococcal otitis media and pneumonia: an analysis of benefits and costs Childhood vaccination against pneumococcal otitis media and pneumonia: an analysis of benefits and costs Weycker D, Richardson E, Oster G Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief (...) summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of a heptavalent pneumococcal conjugate vaccine (PNCRM7) in children aged younger than 5 years, for the prevention of acute otitis media (AOM), community-acquired pneumonia (CAP), and tympanostomy and related procedures (TRP). Type of intervention Primary prevention (paediatric vaccination). Economic study type Cost

NHS Economic Evaluation Database.2000

137. Primary care based randomised, double blind trial of amoxicillin versus placebo for acute otitis media in children aged under 2 years.

Primary care based randomised, double blind trial of amoxicillin versus placebo for acute otitis media in children aged under 2 years. 10657332 2000 03 09 2000 03 09 2014 06 15 0959-8138 320 7231 2000 Feb 05 BMJ (Clinical research ed.) BMJ Primary care based randomised, double blind trial of amoxicillin versus placebo for acute otitis media in children aged under 2 years. 350-4 To determine the effect of antibiotic treatment for acute otitis media in children between 6 months and 2 years of age (...) . Practice based, double blind, randomised, placebo controlled trial. 53 general practices in the Netherlands. 240 children aged 6 months to 2 years with the diagnosis of acute otitis media. Amoxicillin 40 mg/kg/day in three doses. Persistent symptoms at day four and duration of fever and pain or crying, or both. Otoscopy at days four and 11, tympanometry at six weeks, and use of analgesic. Persistent symptoms at day four were less common in the amoxicillin group (risk difference 13%; 95% confidence

BMJ2000 Full Text: Link to full Text with Trip Pro

138. Treatment of acute otitis media with an antiadhesive oligosaccharide: a randomised, double-blind, placebo-controlled trial.

Treatment of acute otitis media with an antiadhesive oligosaccharide: a randomised, double-blind, placebo-controlled trial. 11052582 2000 11 22 2000 11 22 2015 06 16 0140-6736 356 9239 2000 Oct 21 Lancet (London, England) Lancet Treatment of acute otitis media with an antiadhesive oligosaccharide: a randomised, double-blind, placebo-controlled trial. 1398-402 Antiadhesive compounds are promising candidates for prevention or treatment of infections. We have investigated the efficacy (...) of such an agent, 3'-sialyllacto-N-neotetraose (NE-1530), given intranasally for prophylaxis of acute otitis media and for effect on nasopharyngeal carriage of bacteria. We did a randomised, double-blind placebo-controlled study at one study site. 507 healthy children were randomly assigned either NE-1530 (n=254) or placebo (253) as intranasal sprays twice daily during 3 months. The children were examined by the study physicians once a month and during illness. Treatment efficacy was estimated from Cox

Lancet2000

139. Antibiotics for acute otitis media in children.

Antibiotics for acute otitis media in children. BACKGROUND: Acute otitis media is one of the most common diseases in early infancy and childhood. Antibiotic use for acute otitis media varies from 31% in the Netherlands to 98% in the USA and Australia. OBJECTIVES: The objective of this review was to assess the effects of antibiotics for children with acute otitis media. SEARCH STRATEGY: We searched the Cochrane Controlled Trials Register, MEDLINE, Index Medicus, Current Contents and reference (...) lists of articles from 1958 to January 1999. SELECTION CRITERIA: Randomised trials comparing antimicrobial drugs with placebo in children with acute otitis media. DATA COLLECTION AND ANALYSIS: Three reviewers independently assessed trial quality and extracted data. MAIN RESULTS: Nine trials were eligible but only six trials, with a total of 1,962 children, included patient-relevant outcomes. The methodological quality of the included trials was generally high. All trials were from developed

Cochrane2000

140. Short course antibiotics for acute otitis media.

Short course antibiotics for acute otitis media. BACKGROUND: Otitis media is a common pediatric problem, for which antibiotics are frequently prescribed. OBJECTIVES: To determine the effectiveness of a short course of antibiotics (less than seven days) in comparison to a longer course (seven days or greater) for the treatment of acute otitis media in children. SEARCH STRATEGY: The medical literature was searched for randomized controlled studies of the treatment of ear infections in children

Cochrane2000