Latest & greatest articles for otitis media

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on otitis media or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on otitis media and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for otitis media

181. Randomised study of myringotomy, amoxycillin/clavulanate, or both for acute otitis media in infants. (PubMed)

Randomised study of myringotomy, amoxycillin/clavulanate, or both for acute otitis media in infants. In a prospective study, 105 infants aged 3-12 months with acute otitis media were randomly assigned to one of three treatment groups: amoxycillin/clavulanate ('Augmentin') alone (36 patients), myringotomy plus placebo (35 patients), or augmentin plus myringotomy (34 patients). The last two groups were double-blinded. Bacterial pathogens, mainly Haemophilus influenzae (of which 20% were beta

1989 Lancet Controlled trial quality: uncertain

182. Effectiveness of adenoidectomy and tympanostomy tubes in the treatment of chronic otitis media with effusion. (PubMed)

Effectiveness of adenoidectomy and tympanostomy tubes in the treatment of chronic otitis media with effusion. To study the effectiveness of adenoidectomy and of the placement of tympanostomy tubes in the treatment of chronic otitis media with effusion, we randomly assigned 578 children, aged four through eight years, to receive bilateral myringotomy and no additional treatment (Group 1), placement of tympanostomy tubes (Group 2), adenoidectomy (Group 3), or adenoidectomy and placement (...) be considered when surgical therapy is indicated in children four to eight years old who are severely affected by chronic otitis media with effusion.

1987 NEJM Controlled trial quality: uncertain

183. Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. Results of a double-blind, randomized trial. (PubMed)

Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. Results of a double-blind, randomized trial. In a randomized, double-blind, placebo-controlled trial involving 518 infants and children who had otitis media with effusion ("secretory" otitis media), we evaluated the efficacy of a two-week course of amoxicillin (40 mg per kilogram of body weight per day) with and without a four-week course of an oral decongestant-antihistamine (...) and children with otitis media with effusion, amoxicillin treatment increases to some extent the likelihood of resolution.

Full Text available with Trip Pro

1987 NEJM Controlled trial quality: predicted high

184. Lack of efficacy of a decongestant-antihistamine combination for otitis media with effusion ("secretory" otitis media) in children. Results of a double-blind, randomized trial. (PubMed)

Lack of efficacy of a decongestant-antihistamine combination for otitis media with effusion ("secretory" otitis media) in children. Results of a double-blind, randomized trial. In a double-blind, randomized trial of 553 infants and children who had otitis media with effusion ("secretory" otitis media), we compared the efficacy of a four-week course of an oral decongestant-antihistamine combination (pseudoephedrine hydrochloride, 4 mg per kilogram of body weight per day, and chlorpheniramine (...) -antihistamine combinations do not appear to be indicated for the treatment of otitis media with effusion in infants and children.

1983 NEJM Controlled trial quality: uncertain

185. Therapy of acute otitis media: myringotomy, antibiotics, or neither? A double-blind study in children. (PubMed)

Therapy of acute otitis media: myringotomy, antibiotics, or neither? A double-blind study in children. In a double-blind study 171 children with acute otitis media (239 affected ears) were treated by four different methods: neither antibiotics nor myringotomy; myringotomy only; antibiotics only; or both antibiotics and myringotomy. All received symptomatic treatment. There were no significant differences in clinical course (pain, temperature, duration of discharge, otoscopic appearances (...) , audiography, recurrence rate) between the four groups. In the groups treated without antibiotics, the ears discharge for slightly longer and the eardrums took a little longer to heal; these differences were not significant. No complications were seen. Symptomatic therapy with nosedrops and analgesics seems a reasonable initial approach to acute otitis media in children. Myringotomy and antibiotics can be reserved for cases in which the course of otitis is irregular, there are complications

1981 Lancet Controlled trial quality: uncertain

186. Pneumococcal vaccine and otitis media. (PubMed)

Pneumococcal vaccine and otitis media. After an acute attack of otitis media 827 children aged 3 months to 6 years were assigned randomly to receive either 14-valent pneumococcal polysaccharide vaccine or a control vaccine (Haemophilus influenzae type b capsular polysaccharide). In children older than 6 months serum antibody responses to most of the vaccine polysaccharides were satisfactory. The response to type 6A was poor. Correspondingly, no clinical protection was seen below 6 months of age (...) or against otitis media caused by group 6 pneumococci. Among the children more than 6 months old, the first 6 months after vaccination saw significantly (p < 0.001) fewer attacks caused by the pneumococal types represented in the vaccine (group 6 excepted) in those who received the pneumococcal vaccine than in those who received the control vaccine. Protection against type 19F was statistically significant (p < 0.01). The overall protective efficacy was 58%--somewhat better in children older than 2 years

1980 Lancet Controlled trial quality: uncertain

187. Persistence of middle-ear effusion after acute otitis media in children. (PubMed)

Persistence of middle-ear effusion after acute otitis media in children. We observed the frequent occurrence of persistent middle-ear effusion in children with acute otitis media and followed them according to standard procedures for otologic diagnosis. We performed a life-table analysis to identify risk factors for such persistent disease. Sixty-two patients were free of middle-ear effusion at one or more clinic visits two to 13 weeks after presentation and were considered cured; 45 had (...) may be associated with impaired hearing and appears to be the most important sequela of otitis media.

1979 NEJM Controlled trial quality: uncertain

188. Ampicillin compared to other antimicrobials in acute otitis media. (PubMed)

Ampicillin compared to other antimicrobials in acute otitis media. 4964192 1967 12 21 2016 10 17 0098-7484 202 8 1967 Nov 20 JAMA JAMA Ampicillin compared to other antimicrobials in acute otitis media. 697-702 Bass J W JW Cohen S H SH Corless J D JD Mamunes P P eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 0 Anti-Infective Agents 17R794ESYN Penicillin G Procaine 740T4C525W Sulfisoxazole 7C782967RD Ampicillin RIT82F58GK (...) Penicillin G Benzathine X20I9EN955 Oxytetracycline Z61I075U2W Penicillin V AIM IM Ampicillin therapeutic use Anti-Infective Agents therapeutic use Child Child, Preschool Humans Infant Otitis Media drug therapy Oxytetracycline therapeutic use Penicillin G Benzathine therapeutic use Penicillin G Procaine therapeutic use Penicillin V therapeutic use Sulfisoxazole therapeutic use 1967 11 20 1967 11 20 0 1 1967 11 20 0 0 ppublish 4964192

1967 JAMA Controlled trial quality: uncertain

189. Myringotomy in acute otitis media. A controlled study. (PubMed)

Myringotomy in acute otitis media. A controlled study. 4161606 1966 10 17 2016 10 17 0098-7484 197 11 1966 Sep 12 JAMA JAMA Myringotomy in acute otitis media. A controlled study. 849-53 Roddey O F OF Jr Earle R R Jr Haggerty R R eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 0 Nasal Decongestants 0 Sympathomimetics 17R794ESYN Penicillin G Procaine 1WS297W6MV Phenylephrine 740T4C525W Sulfisoxazole Q42T66VG0C Penicillin G (...) RIT82F58GK Penicillin G Benzathine AIM IM Audiometry Bacteria isolation & purification Child Child, Preschool Humans Infant Infant, Newborn Myringoplasty Nasal Decongestants therapeutic use Otitis Media cytology drug therapy surgery Penicillin G surgery Penicillin G Benzathine therapeutic use Penicillin G Procaine therapeutic use Phenylephrine therapeutic use Sulfisoxazole therapeutic use Sympathomimetics therapeutic use 1966 9 12 2001 3 28 10 1 1966 9 12 0 0 ppublish 4161606

1966 JAMA Controlled trial quality: uncertain