Latest & greatest articles for osteoarthritis

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Top results for osteoarthritis

101. Clinical efficacy of intra-articular injections in knee osteoarthritis: a prospective randomized study comparing hyaluronic acid and betamethasone.

Clinical efficacy of intra-articular injections in knee osteoarthritis: a prospective randomized study comparing hyaluronic acid and betamethasone. 27790040 2016 10 28 2017 02 20 7 2015 Open access rheumatology : research and reviews Open Access Rheumatol Clinical efficacy of intra-articular injections in knee osteoarthritis: a prospective randomized study comparing hyaluronic acid and betamethasone. 9-18 Osteoarthritis (OA) is the most common joint disease and leading cause of disability (...) . Intra-articular (IA) administration of hyaluronic acid (HA) or corticosteroids (CS) have been previously studied, though using insufficient number of patients or short follow-up periods. We evaluate HA and CS in patients with knee OA in terms of clinical efficacy over 12 months. We used a prospective, randomized study with parallel groups. Randomized patients received IA injections of HA or betamethasone (BM). The primary outcomes were improvement in pain using Visual Analog Scale and function

Open access rheumatology : research and reviews2016 Full Text: Link to full Text with Trip Pro

102. Efficacy of a natural mineral complex in North American adults with osteoarthritis of the knee: a randomized double-blind placebo-controlled study.

Efficacy of a natural mineral complex in North American adults with osteoarthritis of the knee: a randomized double-blind placebo-controlled study. 27790038 2016 10 28 2017 02 20 6 2014 Open access rheumatology : research and reviews Open Access Rheumatol Efficacy of a natural mineral complex in North American adults with osteoarthritis of the knee: a randomized double-blind placebo-controlled study. 91-103 This study evaluated the efficacy of a hydrothermal mineral complex (HMC) supplement (...) in participants with knee osteoarthritis. This was a double-blind, placebo-controlled, 12-week crossover study with 150 participants receiving either placebo or HMC for 4 weeks, with a 4-week washout period. The primary endpoint was WOMAC™ pain, and secondary endpoints were WOMAC™ physical function and stiffness, the 36-Item Short Form Health Survey (SF-36), high-sensitivity C-reactive protein, tumor necrosis factor α, interleukin 6, and safety. There were no significant differences in WOMAC™ pain, stiffness

Open access rheumatology : research and reviews2016 Full Text: Link to full Text with Trip Pro

103. Unique aspects of pain reduction in osteoarthritis of the knee with LMWF-5A.

Unique aspects of pain reduction in osteoarthritis of the knee with LMWF-5A. 27790041 2016 10 28 2017 02 20 7 2015 Open access rheumatology : research and reviews Open Access Rheumatol Unique aspects of pain reduction in osteoarthritis of the knee with LMWF-5A. 19-22 Osteoarthritis of the knee (OAK) is a common form of arthritis that can lead to substantial pain and disability. This commentary highlights key aspects of the recently published phase 3 A Efficacy and Safety Study of Two Doses (...) of Intra-Articular Injection of Ampion™ in Adults With Pain Due to Osteoarthritis of the Knee (SPRING) study. SPRING (NCT01839331) was a multicenter, randomized, vehicle-controlled, double-blind trial that evaluated the safety and efficacy of the low-molecular-weight fraction of 5% human serum albumin (LMWF-5A) for treatment of pain, measured by the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain scale, in patients with symptomatic OAK (N=329). Patients in this study reflected

Open access rheumatology : research and reviews2016 Full Text: Link to full Text with Trip Pro

104. Gait analysis of patients with knee osteoarthritis highlights a pathological mechanical pathway and provides a basis for therapeutic interventions

Gait analysis of patients with knee osteoarthritis highlights a pathological mechanical pathway and provides a basis for therapeutic interventions 28461915 2018 11 13 2058-5241 1 10 2016 Oct EFORT open reviews EFORT Open Rev Gait analysis of patients with knee osteoarthritis highlights a pathological mechanical pathway and provides a basis for therapeutic interventions. 368-374 10.1302/2058-5241.1.000051 Knee osteoarthritis (OA) is a painful and incapacitating disease affecting a large portion (...) of the elderly population, for which no cure exists. There is a critical need to enhance our understanding of OA pathogenesis, as a means to improve therapeutic options.Knee OA is a complex disease influenced by many factors, including the loading environment. Analysing knee biomechanics during walking - the primary cyclic load-bearing activity - is therefore particularly relevant.There is evidence of meaningful differences in the knee adduction moment, flexion moment and flexion angle during walking between

EFORT open reviews2016 Full Text: Link to full Text with Trip Pro

105. Effects of High- and Low-Velocity Resistance Training on Gait Kinematics and Kinetics in Individuals with Hip Osteoarthritis: A Randomized Controlled Trial.

Effects of High- and Low-Velocity Resistance Training on Gait Kinematics and Kinetics in Individuals with Hip Osteoarthritis: A Randomized Controlled Trial. 27754998 2016 10 18 2017 05 18 1537-7385 96 6 2017 Jun American journal of physical medicine & rehabilitation Am J Phys Med Rehabil Effects of High- and Low-Velocity Resistance Training on Gait Kinematics and Kinetics in Individuals with Hip Osteoarthritis: A Randomized Controlled Trial. 417-423 10.1097/PHM.0000000000000640 The aim (...) of this study was to investigate the effects of high-velocity (HV) and low-velocity (LV) resistance training on gait kinematics and kinetics in patients with hip osteoarthritis. This was a single-blind, randomized controlled trial. Forty-six women with hip osteoarthritis were randomly allocated to the HV (n = 23) or LV (n = 23) training group. The participants underwent an 8-week home-based the HV or LV resistance-training program, involving the hip and knee muscles. Outcome measures included gait

American journal of physical medicine & rehabilitation2016

106. Occupational Exposures and Osteoarthritis

Occupational Exposures and Osteoarthritis Occupational Exposures and Osteoarthritis We use cookies on this website. By using this site, you agree that we may store and access cookies on your device. Swedish Agency for Health Technology Assessment and Assessment of Social Services Occupational Exposures and Osteoarthritis Share: Reading time approx. 3 minutes Since 2011, the Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU) has had a mandate from the Swedish (...) government to systematically assess the evidence for associations between occupational exposures and health issues. A wide range of occupational exposures were investigated, including physical work load, vibration, noise and other work-related environmental factors. Background Osteoarthritis is a chronic joint disorder characterized by pain and reduced joint function. Osteoarthritis affects more people than any other joint disease and it is a major cause of physical disability. The disease has

Swedish Council on Technology Assessement2016

107. Simultaneous anterior cruciate ligament reconstruction and dome-shaped high tibial osteotomy for severe medial compartment osteoarthritis of the knee

Simultaneous anterior cruciate ligament reconstruction and dome-shaped high tibial osteotomy for severe medial compartment osteoarthritis of the knee 29264266 2018 11 13 2214-6873 6 2016 Oct Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology Asia Pac J Sports Med Arthrosc Rehabil Technol Simultaneous anterior cruciate ligament reconstruction and dome-shaped high tibial osteotomy for severe medial compartment osteoarthritis of the knee. 7-12 10.1016/j.asmart (...) .2016.08.001 The optimal surgical procedure to address both anterior cruciate ligament (ACL) deficiency and medial compartment osteoarthritis (OA) has been controversial. A 49-year-old woman with a 30-year history of chronic anterior cruciate ligament (ACL) deficiency, medial compartment osteoarthritis, and varus deformity presented with medial knee pain and apprehension with walking and playing soccer. Her preoperative range of motion was from 0° of extension to 135° of flexion. The anterior drawer sign

Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology2016 Full Text: Link to full Text with Trip Pro

108. Basic science of osteoarthritis

Basic science of osteoarthritis 27624438 2016 09 14 2018 11 13 2197-1153 3 1 2016 Dec Journal of experimental orthopaedics J Exp Orthop Basic science of osteoarthritis. 22 10.1186/s40634-016-0060-6 Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large population worldwide and for which there is no definitive cure. This review provides critical insights into the basic knowledge on OA that may lead to innovative end efficient new therapeutic regimens. While (...) degradation of the articular cartilage is the hallmark of OA, with altered interactions between chondrocytes and compounds of the extracellular matrix, the subchondral bone has been also described as a key component of the disease, involving specific pathomechanisms controlling its initiation and progression. The identification of such events (and thus of possible targets for therapy) has been made possible by the availability of a number of animal models that aim at reproducing the human pathology

Journal of experimental orthopaedics2016 Full Text: Link to full Text with Trip Pro

110. Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study

Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study 27402605 2016 08 24 2016 08 24 1532-8406 31 9 Suppl 2016 Sep The Journal of arthroplasty J Arthroplasty Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study. 293-7 10.1016/j.arth.2016.05.015 S0883-5403(16)30153-X Knee osteoarthritis is a disabling disease (...) that costs billions of dollars to treat. Corticosteroid gives varying pain relief and costs $12 per injection, whereas ketorolac costs $2 per injection, per institutional costs. The aim of this study was to compare ketorolac with corticosteroid based on pain relief using patient outcome measures and cost data. A total of 35 patients were randomized to ketorolac or corticosteroid intra-articular knee injection in a double-blind, prospective study. Follow-up was 24 weeks. Osteoarthritis was evaluated using

EvidenceUpdates2016

111. Intra-articular interleukin-1 receptor antagonist (IL1-ra) microspheres for posttraumatic osteoarthritis: in vitro biological activity and in vivo disease modifying effect

Intra-articular interleukin-1 receptor antagonist (IL1-ra) microspheres for posttraumatic osteoarthritis: in vitro biological activity and in vivo disease modifying effect 27539076 2016 08 19 2018 11 13 2197-1153 3 1 2016 Dec Journal of experimental orthopaedics J Exp Orthop Intra-articular interleukin-1 receptor antagonist (IL1-ra) microspheres for posttraumatic osteoarthritis: in vitro biological activity and in vivo disease modifying effect. 18 10.1186/s40634-016-0054-4 Interleukin-1 (...) receptor antagonist (IL-1 ra) can be disease-modifying in posttraumatic osteoarthritis (PTOA). One limitation is its short joint residence time. We hypothesized that IL-1 ra encapsulation in poly (lactide-co-glycolide) (PLGA) microspheres reduces IL-1 ra systemic absorption and provides an enhanced anti-PTOA effect. IL-1 ra release kinetics and biological activity: IL-1 ra encapsulation into PLGA microsphere was performed using double emulsion solvent extraction. Lyophilized PLGA IL-1 ra microspheres

Journal of experimental orthopaedics2016 Full Text: Link to full Text with Trip Pro

112. Functional outcome measures in a surgical model of hip osteoarthritis in dogs

Functional outcome measures in a surgical model of hip osteoarthritis in dogs 27525982 2016 08 16 2018 11 13 2197-1153 3 1 2016 Dec Journal of experimental orthopaedics J Exp Orthop Functional outcome measures in a surgical model of hip osteoarthritis in dogs. 17 10.1186/s40634-016-0053-5 The hip is one of the most common sites of osteoarthritis in the body, second only to the knee in prevalence. However, current animal models of hip osteoarthritis have not been assessed using many (...) of the functional outcome measures used in orthopaedics, a characteristic that could increase their utility in the evaluation of therapeutic interventions. The canine hip shares similarities with the human hip, and functional outcome measures are well documented in veterinary medicine, providing a baseline for pre-clinical evaluation of therapeutic strategies for the treatment of hip osteoarthritis. The purpose of this study was to evaluate a surgical model of hip osteoarthritis in a large laboratory animal

Journal of experimental orthopaedics2016 Full Text: Link to full Text with Trip Pro

113. Brief time-based activity pacing instruction as a singular behavioral intervention was not effective in participants with symptomatic osteoarthritis

Brief time-based activity pacing instruction as a singular behavioral intervention was not effective in participants with symptomatic osteoarthritis 26963847 2016 06 18 2017 03 13 2017 03 13 1872-6623 157 7 2016 07 Pain Pain Brief time-based activity pacing instruction as a singular behavioral intervention was not effective in participants with symptomatic osteoarthritis. 1563-73 10.1097/j.pain.0000000000000549 Osteoarthritis (OA) of the lower extremities is a prevalent cause of disability (...) in which symptoms interfere with mobility and activity participation. Behavioral self-management for OA symptomatology is commonly recommended; but these interventions are underutilized, unstandardized in application, and at times, unavailable in the context of clinical care. For people with chronic pain, rehabilitation professionals may select to apply activity pacing instruction as one behavioral strategy to manage symptoms. Activity pacing is widely used in combination with other pharmacological

EvidenceUpdates2016

114. Unloading Shoes for Self-Management of Knee Osteoarthritis: A Randomized Trial.

Unloading Shoes for Self-Management of Knee Osteoarthritis: A Randomized Trial. BACKGROUND: Appropriate footwear is recommended for self-management of knee osteoarthritis. Shoes that reduce harmful knee loads are available, but symptomatic effects are uncertain. OBJECTIVE: To evaluate the efficacy of unloading shoes in alleviating knee osteoarthritis symptoms. DESIGN: Participant- and assessor-blinded comparative effectiveness randomized, controlled trial. (Australian New Zealand Clinical (...) Trials Registry: ACTRN12613000851763). SETTING: Community. PARTICIPANTS: 164 persons with medial knee osteoarthritis. INTERVENTION: Walking shoes with triple-density, variable-stiffness midsoles and mild lateral-wedge insoles designed to unload the medial knee and worn daily (intervention) versus conventional walking shoes (comparator). MEASUREMENTS: Primary outcomes were pain with walking (assessed on a numerical rating scale [NRS]) and physical function (Western Ontario and McMaster Universities

Annals of Internal Medicine2016

115. Exploring Fatigue Trajectories in Early Symptomatic Knee and Hip Osteoarthritis: 6-year Results from the CHECK Study

Exploring Fatigue Trajectories in Early Symptomatic Knee and Hip Osteoarthritis: 6-year Results from the CHECK Study 27182065 2016 07 02 2016 07 02 0315-162X 43 7 2016 Jul The Journal of rheumatology J. Rheumatol. Exploring Fatigue Trajectories in Early Symptomatic Knee and Hip Osteoarthritis: 6-year Results from the CHECK Study. 1413-20 10.3899/jrheum.150820 To examine whether different groups of fatigue trajectories can be identified among patients with early symptomatic osteoarthritis (OA (...) ) of the knee or hip, to describe the level of fatigue severity within each of these fatigue groups, and to investigate the involvement of age, sex, use of medication, comorbidity, and OA severity in relation to group membership. Six years of followup data on fatigue (Medical Outcomes Study Short Form-36 Vitality scale) came from the Cohort Hip and Cohort Knee (CHECK) cohort. Growth mixture modeling was applied to identify distinct fatigue trajectories as well as to take into account the effects

EvidenceUpdates2016

116. Efficacy of Elaeagnus Angustifolia extract in the treatment of knee osteoarthritis: a randomized controlled trial.

Efficacy of Elaeagnus Angustifolia extract in the treatment of knee osteoarthritis: a randomized controlled trial. 27330526 2016 06 22 2016 06 22 2017 02 20 15 2016 EXCLI journal EXCLI J Efficacy of Elaeagnus Angustifolia extract in the treatment of knee osteoarthritis: a randomized controlled trial. 203-10 10.17179/excli2015-639 Osteoarthritis (OA) is one of the most common musculoskeletal disorders all over the world. Available anti-arthritic medications have only partial efficacy (...) and their long-term use is associated with adverse events. Elaeagnus Angustifolia (EA) is a medicinal plant with analgesic and anti-inflammatory properties. The present study evaluated the impact of two doses of EA extract compared with ibuprofen on the severity of disease in patients with knee OA. This study was designed as a randomized, double blind, active-controlled and parallel group trial. Patients with OA were randomized to receive 300 mg/day (n=33) or 600 mg/day (n=32) of EA aqueous extract, or 800

EXCLI journal2016 Full Text: Link to full Text with Trip Pro

117. Naproxen (Stirlescent) - treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute musculoskeletal disorders, dysmenorrhoea and acute gout in adults

Naproxen (Stirlescent) - treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute musculoskeletal disorders, dysmenorrhoea and acute gout in adults Published 13 June 2106 Product Update: naproxen 250mg effervescent tablets (Stirlescent ® ) SMC No. (1154/16) Stirling Anglian Pharmaceuticals Ltd. 06 May 2016 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs (...) ) on its use in NHS Scotland. The advice is summarised as follows: ADVICE: following an abbreviated submission naproxen 250mg effervescent tablets (Stirlescent ® ) are accepted for restricted use within NHS Scotland. Indication under review: treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute musculoskeletal disorders, dysmenorrhoea and acute gout in adults. SMC restriction: use in patients unable to swallow naproxen tablets. Naproxen 250mg effervescent tablets (Stirlescent

Scottish Medicines Consortium2016

118. Physical Therapist-Delivered Pain Coping Skills Training and Exercise for Knee Osteoarthritis: Randomized Controlled Trial

Physical Therapist-Delivered Pain Coping Skills Training and Exercise for Knee Osteoarthritis: Randomized Controlled Trial 26417720 2016 04 27 2016 04 27 2151-4658 68 5 2016 May Arthritis care & research Arthritis Care Res (Hoboken) Physical Therapist-Delivered Pain Coping Skills Training and Exercise for Knee Osteoarthritis: Randomized Controlled Trial. 590-602 10.1002/acr.22744 To investigate whether a 12-week physical therapist-delivered combined pain coping skills training (PCST (...) ) and exercise (PCST/exercise) is more efficacious and cost effective than either treatment alone for knee osteoarthritis (OA). This was an assessor-blinded, 3-arm randomized controlled trial in 222 people (73 PCST/exercise, 75 exercise, and 74 PCST) ages ≥50 years with knee OA. All participants received 10 treatments over 12 weeks plus a home program. PCST covered pain education and training in cognitive and behavioral pain coping skills, exercise comprised strengthening exercises, and PCST/exercise

EvidenceUpdates2016

119. Comparative Effectiveness of Tai Chi Versus Physical Therapy for Knee Osteoarthritis: A Randomized Trial.

Comparative Effectiveness of Tai Chi Versus Physical Therapy for Knee Osteoarthritis: A Randomized Trial. 27183035 2016 07 19 2017 05 01 2017 05 01 1539-3704 165 2 2016 Jul 19 Annals of internal medicine Ann. Intern. Med. Comparative Effectiveness of Tai Chi Versus Physical Therapy for Knee Osteoarthritis: A Randomized Trial. 77-86 10.7326/M15-2143 Few remedies effectively treat long-term pain and disability from knee osteoarthritis. Studies suggest that Tai Chi alleviates symptoms (...) , but no trials have directly compared Tai Chi with standard therapies for osteoarthritis. To compare Tai Chi with standard physical therapy for patients with knee osteoarthritis. Randomized, 52-week, single-blind comparative effectiveness trial. (ClinicalTrials.gov: NCT01258985). An urban tertiary care academic hospital. 204 participants with symptomatic knee osteoarthritis (mean age, 60 years; 70% women; 53% white). Tai Chi (2 times per week for 12 weeks) or standard physical therapy (2 times per week for 6

Annals of Internal Medicine2016

120. Low-dose Spironolactone: Treatment for Osteoarthritis-related Knee Effusion. A Prospective Clinical and Sonographic-based Study

Low-dose Spironolactone: Treatment for Osteoarthritis-related Knee Effusion. A Prospective Clinical and Sonographic-based Study 27036390 2016 06 02 2016 06 02 0315-162X 43 6 2016 Jun The Journal of rheumatology J. Rheumatol. Low-dose Spironolactone: Treatment for Osteoarthritis-related Knee Effusion. A Prospective Clinical and Sonographic-based Study. 1114-20 10.3899/jrheum.151200 To evaluate the effectiveness of spironolactone as a treatment for osteoarthritis (OA)-related knee effusion (...) in comparison to ibuprofen, cold compresses, and placebo. This study was carried out on 200 patients, aged 40 years or older, attending the outpatient clinic of the Rheumatology Department of Sohag University Hospital with unilateral knee effusion related to OA based on clinical examination, musculoskeletal ultrasonography (US), and synovial fluid analysis. In group 1, 50 patients received spironolactone 25 mg daily for 2 weeks; in group 2, 50 patients took ibuprofen 1200 mg daily for 2 weeks; in group 3

EvidenceUpdates2016