Latest & greatest articles for opioid

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on opioid or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on opioid and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for opioid

41. Efficacy of opioids versus placebo in chronic pain: a systematic review and meta-analysis of enriched enrollment randomized withdrawal trials

Efficacy of opioids versus placebo in chronic pain: a systematic review and meta-analysis of enriched enrollment randomized withdrawal trials 29765246 2018 05 18 1178-7090 11 2018 Journal of pain research J Pain Res Efficacy of opioids versus placebo in chronic pain: a systematic review and meta-analysis of enriched enrollment randomized withdrawal trials. 923-934 10.2147/JPR.S160255 Opioids have been used for millennia for the treatment of pain. However, the long-term efficacy of opioids (...) to treat chronic non-cancer pain continues to be debated. To evaluate opioids' efficacy in chronic non-cancer pain, we performed a meta-analysis of published clinical trials for μ-opioid receptor agonists performed for US Food and Drug Administration approval. MEDLINE and Cochrane trial register were searched for enriched enrollment randomized withdrawal studies (before June 2016). Selection criteria included: adults, ≥10 subjects per arm, any chronic pain condition, double-blind treatment period

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

42. Recent opioid use and fall-related injury among older patients with trauma

Recent opioid use and fall-related injury among older patients with trauma 29685910 2018 05 03 1488-2329 190 16 2018 Apr 23 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Recent opioid use and fall-related injury among older patients with trauma. E500-E506 10.1503/cmaj.171286 Evidence for an association between opioid use and risk of falls or fractures in older adults is inconsistent. We examine the association between recent opioid use (...) and the risk, as well as the clinical outcomes, of fall-related injuries in a large trauma population of older adults. In a retrospective, observational, multicentre cohort study conducted on registry data, we included all patients aged 65 years and older who were admitted (hospital stay > 2 d) for injury in 57 trauma centres in the province of Quebec, Canada, between 2004 and 2014. We looked at opioid prescriptions filled in the 2 weeks preceding the trauma in patients who sustained a fall, compared

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

43. Patterns of Potential Opioid Misuse and Subsequent Adverse Outcomes in Medicare, 2008 to 2012.

Patterns of Potential Opioid Misuse and Subsequent Adverse Outcomes in Medicare, 2008 to 2012. Background: Providers are increasingly being expected to examine their patients' opioid treatment histories before writing new opioid prescriptions. However, little evidence exists on how patterns of potential opioid misuse are associated with subsequent adverse outcomes nationally. Objective: To estimate how a range of patterns of potential opioid misuse relate to adverse outcomes during (...) the subsequent year. Design: Observational study comparing outcomes for Medicare enrollees with potential opioid misuse patterns versus those for beneficiaries with no such patterns, adjusting for patient characteristics. Setting: Medicare, 2008 to 2012. Patients: A 5% sample of beneficiaries who had an opioid prescription without a cancer diagnosis. Measurements: Several measures for opioid misuse were defined on the basis of drug quantity, overlapping prescriptions, use of multiple prescribers

Annals of Internal Medicine2018

44. Managing infants born to mothers who have used opioids during pregnancy

Managing infants born to mothers who have used opioids during pregnancy The incidence of infant opioid withdrawal has grown rapidly in many countries, including Canada, in the last decade, presenting significant health and early brain development concerns. Increased prenatal exposure to opioids reflects rising prescription opioid use as well as the presence of both illegal opiates and opioid-substitution therapies. Infants are at high risk for experiencing symptoms of abstinence (...) or withdrawal that may require assessment and treatment. This practice point focuses specifically on the effect(s) of opioid withdrawal and current management strategies in the care of infants born to mothers with opioid dependency. Keywords: Discharge planning; Management; NAS; NPI; Treatment strategies

Canadian Paediatric Society2018

45. Neer Award 2018: the effect of preoperative education on opioid consumption in patients undergoing arthroscopic rotator cuff repair: a prospective, randomized clinical trial

Neer Award 2018: the effect of preoperative education on opioid consumption in patients undergoing arthroscopic rotator cuff repair: a prospective, randomized clinical trial 29599038 2018 05 20 1532-6500 27 6 2018 Jun Journal of shoulder and elbow surgery J Shoulder Elbow Surg Neer Award 2018: the effect of preoperative education on opioid consumption in patients undergoing arthroscopic rotator cuff repair: a prospective, randomized clinical trial. 962-967 S1058-2746(18)30120-4 10.1016/j.jse (...) .2018.02.039 Opioids are commonly administered for the treatment of acute and chronic pain symptoms. The current health care system is struggling to deal with increasing medication abuse and rising mortality rates from overdose. Preoperative patient-targeted education on opioid use is an avenue yet to be explored. The purpose of the study was to determine whether preoperative narcotics education reduces consumption after arthroscopic rotator cuff repair (ARCR). Patients undergoing primary ARCR at our

EvidenceUpdates2018

46. Management of opioid use disorders: a national clinical practice guideline

Management of opioid use disorders: a national clinical practice guideline 29507156 2018 03 14 1488-2329 190 9 2018 Mar 05 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Management of opioid use disorders: a national clinical practice guideline. E247-E257 10.1503/cmaj.170958 Bruneau Julie J Centre hospitalier de l'Université de Montréal (Bruneau), Université de Montréal; Département de médecine de famille et de médecine d'urgence (Bruneau, Goyer

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

47. Impact of Preadmission Opioid Treatment on 1-Year Mortality Following Nonsurgical Intensive Care

Impact of Preadmission Opioid Treatment on 1-Year Mortality Following Nonsurgical Intensive Care 29528945 2018 03 12 1530-0293 2018 Mar 09 Critical care medicine Crit. Care Med. Impact of Preadmission Opioid Treatment on 1-Year Mortality Following Nonsurgical Intensive Care. 10.1097/CCM.0000000000003080 Compare all-cause mortality following nonsurgical ICU admission for opioid users with nonusers. Nationwide register-based cohort study. All 43 ICUs in Denmark (7,028,668 citizens cumulatively (...) during the study period). The Danish National Health Service provides universal healthcare, guaranteeing equal access to healthcare along with partial reimbursement for prescribed drugs. All 118,388 nonsurgical patients admitted to an ICU from 2005 to 2014. Patients were categorized according to timing of last redeemed opioid prescription before admission: current user (prior 0-30 d), recent user (prior 31-365 d), former user (prior 365+ d), or nonuser (no prescription since 1994). All-cause

EvidenceUpdates2018

49. Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial.

Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial. Importance: Limited evidence is available regarding long-term outcomes of opioids compared with nonopioid medications for chronic pain. Objective: To compare opioid vs nonopioid medications over 12 months on pain-related function, pain intensity, and adverse effects. Design, Setting, and Participants: Pragmatic, 12-month (...) , randomized trial with masked outcome assessment. Patients were recruited from Veterans Affairs primary care clinics from June 2013 through December 2015; follow-up was completed December 2016. Eligible patients had moderate to severe chronic back pain or hip or knee osteoarthritis pain despite analgesic use. Of 265 patients enrolled, 25 withdrew prior to randomization and 240 were randomized. Interventions: Both interventions (opioid and nonopioid medication therapy) followed a treat-to-target strategy

JAMA2018 Full Text: Link to full Text with Trip Pro

50. Management of opioid use disorders: a national clinical practice guideline

Management of opioid use disorders: a national clinical practice guideline © 2018 Joule Inc. or its licensors CMAJ | MARCH 5, 2018 | VOLUME 190 | ISSUE 9 E247 O pioid use disorder is one of the most challenging forms of addiction facing the Canadian health care system, and a major contributor to the marked rises in opioid- related morbidity and death that Canada has been seeing in recent years. The evolving landscape of nonmedical opioid use has become increasingly dominated by prescription (...) opioids diverted from the medical system and, more recently, by highly potent, illicitly manufactured synthetic opioids (e.g., fentanyl and its analogues, including carfentanil). 1 The mean national rate of hospital admissions related to opioid poisonings increased from 9 hospital admissions per day in 2007/08 to more than 13 admissions per day in 2014/15. 2 A corre- sponding rise in injection of prescription opioids has been observed among people who inject drugs in Canada, 3,4 and has been

CMA Infobase (Canada)2018

51. Opioid Analgesic Use and Risk for Invasive Pneumococcal Diseases: A Nested Case-Control Study.

Opioid Analgesic Use and Risk for Invasive Pneumococcal Diseases: A Nested Case-Control Study. Background: Although certain opioid analgesics have immunosuppressive properties and increase the risk for infections in animals, the clinical effects of prescription opioid use on infection risk among humans are unknown. Objective: To test the hypothesis that prescription opioid use is an independent risk factor for invasive pneumococcal disease (IPD). Design: Nested case-control study. Setting (...) : Tennessee Medicaid database linked to Medicare and Active Bacterial Core surveillance system databases (1995 to 2014). Patients: 1233 case patients with IPD aged 5 years and older matched to 24 399 control participants by diagnosis date, age, and county of residence. Measurements: Opioid use was measured on the basis of pharmacy prescription fills. Invasive pneumococcal disease was defined by the isolation of Streptococcus pneumoniae from a normally sterile site. The odds of current opioid use were

Annals of Internal Medicine2018

52. A Systematic Review and Meta-analysis Comparing the Efficacy of Nonsteroidal Anti-inflammatory Drugs, Opioids, and Paracetamol in the Treatment of Acute Renal Colic

A Systematic Review and Meta-analysis Comparing the Efficacy of Nonsteroidal Anti-inflammatory Drugs, Opioids, and Paracetamol in the Treatment of Acute Renal Colic 29174580 2018 02 06 1873-7560 2017 Nov 22 European urology Eur. Urol. A Systematic Review and Meta-analysis Comparing the Efficacy of Nonsteroidal Anti-inflammatory Drugs, Opioids, and Paracetamol in the Treatment of Acute Renal Colic. S0302-2838(17)30977-6 10.1016/j.eururo.2017.11.001 Renal colic is a common, acute presentation (...) of urolithiasis that requires immediate pain relief. European Association of Urology guidelines recommend nonsteroidal anti-inflammatory drugs (NSAIDs) as the preferred analgesia. However, the fear of NSAID adverse effects and the uncertainty about superior analgesic effect have maintained the practice of advocating intravenous opioids as the initial analgesia. The objective of this systematic review and meta-analysis was to compare the safety and efficacy of NSAIDs with opioids and paracetamol (acetaminophen

EvidenceUpdates2018

53. Effect of Perioperative Gabapentin on Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort: A Randomized Clinical Trial

Effect of Perioperative Gabapentin on Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort: A Randomized Clinical Trial 29238824 2018 02 07 2168-6262 2017 Dec 13 JAMA surgery JAMA Surg Effect of Perioperative Gabapentin on Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort: A Randomized Clinical Trial. 10.1001/jamasurg.2017.4915 Guidelines recommend using gabapentin to decrease postoperative pain and opioid use, but significant variation (...) exists in clinical practice. To determine the effect of perioperative gabapentin on remote postoperative time to pain resolution and opioid cessation. A randomized, double-blind, placebo-controlled trial of perioperative gabapentin was conducted at a single-center, tertiary referral teaching hospital. A total of 1805 patients aged 18 to 75 years scheduled for surgery (thoracotomy, video-assisted thoracoscopic surgery, total hip replacement, total knee replacement, mastectomy, breast lumpectomy, hand

EvidenceUpdates2018

54. Buprenorphine extended-release implant (Probuphine Braeburn Pharmaceuticals Inc.) for opioid use disorder

Buprenorphine extended-release implant (Probuphine Braeburn Pharmaceuticals Inc.) for opioid use disorder Buprenorphine extended-release implant (Probuphine; Braeburn Pharmaceuticals Inc.) for opioid use disorder Buprenorphine extended-release implant (Probuphine; Braeburn Pharmaceuticals Inc.) for opioid use disorder HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has (...) been made for the HTA database. Citation HAYES, Inc. Buprenorphine extended-release implant (Probuphine; Braeburn Pharmaceuticals Inc.) for opioid use disorder. Lansdale: HAYES, Inc. Healthcare Technology Brief Publication. 2017 Authors' conclusions Patients with opioid use disorder may benefit from medication-assisted treatments that include a combination of medication and behavioral therapy. Technology Description: Probuphine is an implantable system containing buprenorphine hydrochloride, which

Health Technology Assessment (HTA) Database.2018

55. Medial Open Transversus Abdominis Plane (MOTAP) Catheters Reduce Opioid Requirements and Improve Pain Control Following Open Liver Resection: A Multicenter, Blinded, Randomized Controlled Trial

Medial Open Transversus Abdominis Plane (MOTAP) Catheters Reduce Opioid Requirements and Improve Pain Control Following Open Liver Resection: A Multicenter, Blinded, Randomized Controlled Trial 29300708 2018 01 04 1528-1140 2018 Jan 03 Annals of surgery Ann. Surg. Medial Open Transversus Abdominis Plane (MOTAP) Catheters Reduce Opioid Requirements and Improve Pain Control Following Open Liver Resection: A Multicenter, Blinded, Randomized Controlled Trial. 10.1097/SLA.0000000000002657 (...) a standardized technique, 2 catheters were placed after resection: one in the plane between internal oblique and transversus abdominis and the other in the posterior rectus sheath. Patients were randomized to receive ropivacaine 0.2% (ROP) or saline (NS) through both catheters for 72 hours. All patients received IV PCA with hydromorphone as part of a multimodality analgesia program. Primary outcome was opioid use over the first 48 hours. One hundred fifty-three patients were included in the analysis (71 ROP

EvidenceUpdates2018

56. Opioid-sparing Effects of SoluMatrix Indomethacin in a Phase 3 Study in Patients With Acute Postoperative Pain

Opioid-sparing Effects of SoluMatrix Indomethacin in a Phase 3 Study in Patients With Acute Postoperative Pain 28591082 2018 01 04 1536-5409 34 2 2018 Feb The Clinical journal of pain Clin J Pain Opioid-sparing Effects of SoluMatrix Indomethacin in a Phase 3 Study in Patients With Acute Postoperative Pain. 138-144 10.1097/AJP.0000000000000525 To report the opioid-sparing effects of SoluMatrix indomethacin, developed using SoluMatrix Fine Particle Technology, in a phase 3 study in patients (...) with acute pain following bunionectomy. This phase 3, placebo-controlled study randomized 462 patients with moderate-to-severe pain following bunionectomy surgery to receive SoluMatrix indomethacin 40 mg 3 times daily, SoluMatrix indomethacin 40 mg twice daily, SoluMatrix indomethacin 20 mg 3 times daily, celecoxib 400-mg loading dose followed by 200 mg twice daily, or placebo. Patients were permitted to receive opioid-containing rescue medication throughout the study. The proportion of patients who used

EvidenceUpdates2018

57. Postsurgical prescriptions for opioid naive patients and association with overdose and misuse: retrospective cohort study.

Postsurgical prescriptions for opioid naive patients and association with overdose and misuse: retrospective cohort study. OBJECTIVE: To quantify the effects of varying opioid prescribing patterns after surgery on dependence, overdose, or abuse in an opioid naive population. DESIGN: Retrospective cohort study. SETTING: Surgical claims from a linked medical and pharmacy administrative database of 37 651 619 commercially insured patients between 2008 and 2016. PARTICIPANTS: 1 015 116 opioid naive (...) patients undergoing surgery. MAIN OUTCOME MEASURES: Use of oral opioids after discharge as defined by refills and total dosage and duration of use. The primary outcome was a composite of misuse identified by a diagnostic code for opioid dependence, abuse, or overdose. RESULTS: 568 612 (56.0%) patients received postoperative opioids, and a code for abuse was identified for 5906 patients (0.6%, 183 per 100 000 person years). Total duration of opioid use was the strongest predictor of misuse, with each

BMJ2018 Full Text: Link to full Text with Trip Pro

58. Optimization of Postoperative Intravenous Patient-Controlled Analgesia with Opioid-Dexmedetomidine Combinations: An Updated Meta-Analysis with Trial Sequential Analysis of Randomized Controlled Trials

Optimization of Postoperative Intravenous Patient-Controlled Analgesia with Opioid-Dexmedetomidine Combinations: An Updated Meta-Analysis with Trial Sequential Analysis of Randomized Controlled Trials 29149140 2017 11 17 2150-1149 20 7 2017 Nov Pain physician Pain Physician Optimization of Postoperative Intravenous Patient-Controlled Analgesia with Opioid-Dexmedetomidine Combinations: An Updated Meta-Analysis with Trial Sequential Analysis of Randomized Controlled Trials. 569-596 It is still (...) a challenge to optimize postoperative pain management. The effects of adding dexmedetomidine (DEX) to opioid-based postoperative intravenous patient-controlled analgesia (PCA) are not fully understood. The aim of this study is to assess the efficacy and safety of opioid-DEX combinations for postoperative PCA, and a trial sequential analysis (TSA) is utilized to evaluate the robustness of the current evidence. A systematic review and meta-analysis. Randomized controlled trials that compared opioid-DEX

EvidenceUpdates2018

59. Parent/Nurse-Controlled Analgesia Compared with Intravenous PRN Opioids for Postsurgical Pain Management in Children with Developmental Delay: A Randomized Controlled Trial

Parent/Nurse-Controlled Analgesia Compared with Intravenous PRN Opioids for Postsurgical Pain Management in Children with Developmental Delay: A Randomized Controlled Trial 29099960 2017 11 03 1526-4637 2017 Nov 01 Pain medicine (Malden, Mass.) Pain Med Parent/Nurse-Controlled Analgesia Compared with Intravenous PRN Opioids for Postsurgical Pain Management in Children with Developmental Delay: A Randomized Controlled Trial. 10.1093/pm/pnx257 The aim of this study was to conduct a randomized (...) , controlled comparison of outcomes associated with parent/nurse-controlled analgesia (PNCA), with and without a basal (background) opioid infusion, with intravenous (IV) opioids intermittently administered by a nurse on an "as needed" basis (IV PRN) for postoperative pain management in children with developmental delay (DD). Participants included children with DD expected to require IV opioids for at least 24 postoperative hours. Patients were randomized to one of three groups: PNCA with a basal infusion

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

60. Implementation of a risk-stratified opioid weaning protocol in a pediatric intensive care unit

Implementation of a risk-stratified opioid weaning protocol in a pediatric intensive care unit PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2018