Latest & greatest articles for opioid

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Top results for opioid

4. Opioid drugs are no better than standard painkillers for long-term back and joint pain

Opioid drugs are no better than standard painkillers for long-term back and joint pain Opioid drugs are no better than standard painkillers for long-term back and joint pain Dissemination Centre Discover Portal NIHR DC Discover Opioid drugs are no better than standard painkillers for long-term back and joint pain Published on 3 July 2018 doi: People with long-term back pain, or osteoarthritis of their hips or knees, do not get better pain relief from opioid drugs and are more likely to get side (...) effects than those who take paracetamol or non-steroidal anti-inflammatory drugs (NSAIDs), like naproxen or ibuprofen. A US study assigned 240 patients to either opioid or non-opioid pain relief drugs and measured their pain over 12 months. Those who were assigned opioid drugs had less relief of their pain and also were more likely to have side-effects related to their medication. The findings may surprise some doctors and patients with long-term pain, because of the widely held belief that opioids

NIHR Dissemination Centre2018

5. Naloxone for opioid-exposed newborn infants.

Naloxone for opioid-exposed newborn infants. BACKGROUND: Naloxone, a specific opioid antagonist, is available for the treatment of newborn infants with cardiorespiratory or neurological depression that may be due to intrauterine exposure to opioid. It is unclear whether newborn infants may benefit from this therapy and whether naloxone has any harmful effects. OBJECTIVES: To determine the effect of naloxone on the need for and duration of neonatal unit stay in infants of mothers who received (...) opioid analgesia prior to delivery or of mothers who have used a prescribed or non-prescribed opioid during pregnancy. SEARCH METHODS: We searched the following databases in February 2018: the Cochrane Central Register of Controlled Trials (the Cochrane Library 2018, Issue 1), MEDLINE (OvidSP), MEDLINE In process & Other Non-Indexed Citations (OvidSP), Embase (OvidSP), CINAHL (EBSCO), Maternity and Infant Care (OvidSP), and PubMed. We searched for ongoing and completed trials in the WHO

Cochrane2018

6. Receipt of Overlapping Opioid and Benzodiazepine Prescriptions Among Veterans Dually Enrolled in Medicare Part D and the Department of Veterans Affairs: A Cross-sectional Study.

Receipt of Overlapping Opioid and Benzodiazepine Prescriptions Among Veterans Dually Enrolled in Medicare Part D and the Department of Veterans Affairs: A Cross-sectional Study. Background: Overlapping use of opioids and benzodiazepines is associated with increased risk for overdose. Veterans receiving medications concurrently from the U.S. Department of Veterans Affairs (VA) and Medicare may be at higher risk for such overlap. Objective: To assess the association between dual use of VA (...) and Medicare drug benefits and receipt of overlapping opioid and benzodiazepine prescriptions. Design: Cross-sectional. Setting: VA and Medicare. Participants: All veterans enrolled in VA and Medicare Part D who filled at least 2 opioid prescriptions in 2013 (n = 368 891). Measurements: Outcomes were the proportion of patients with a Pharmacy Quality Alliance (PQA) measure of opioid-benzodiazepine overlap (≥2 filled prescriptions for benzodiazepines with ≥30 days of overlap with opioids) and the proportion

Annals of Internal Medicine2018

7. Transdermal fentanyl patches: life-threatening and fatal opioid toxicity from accidental exposure, particularly in children

Transdermal fentanyl patches: life-threatening and fatal opioid toxicity from accidental exposure, particularly in children Transdermal fentanyl patches: life-threatening and fatal opioid toxicity from accidental exposure, particularly in children - GOV.UK GOV.UK uses cookies to make the site simpler. Search Transdermal fentanyl patches: life-threatening and fatal opioid toxicity from accidental exposure, particularly in children Provide clear information to patients and caregivers about how (...) to minimise the risk of accidental exposure and the importance of appropriate disposal of patches. We continue to receive reports of unintentional opioid toxicity and overdose of fentanyl due to accidental exposure to patches. Published 11 October 2018 From: Therapeutic area: , , , Contents Advice for healthcare professionals: always fully inform patients and their caregivers about directions for safe use for fentanyl patches, including the importance of: not exceeding the prescribed dose following

MHRA Drug Safety Update2018

8. Location, Location, Location: Treating patients with opioid use disorder in primary care

Location, Location, Location: Treating patients with opioid use disorder in primary care

Tools for Practice2018

9. Medications for Alcohol and Opioid Use Disorders and Risk of Suicidal Behavior, Accidental Overdoses, and Crime

Medications for Alcohol and Opioid Use Disorders and Risk of Suicidal Behavior, Accidental Overdoses, and Crime 30068260 2018 10 05 1535-7228 175 10 2018 Oct 01 The American journal of psychiatry Am J Psychiatry Medications for Alcohol and Opioid Use Disorders and Risk of Suicidal Behavior, Accidental Overdoses, and Crime. 970-978 10.1176/appi.ajp.2018.17101112 The authors examined associations between medications for alcohol and opioid use disorders (acamprosate, naltrexone, methadone (...) ., violent, nonviolent, and substance-related) as well as reduction in accidental overdoses (hazard ratio=0.75, 95% CI=0.60, 0.93). For methadone, there were significant reductions in the rate of suicidal behaviors (hazard ratio=0.60, 95% CI=0.40-0.88) as well as reductions in all crime categories. However, there was an increased risk for accidental overdoses among individuals taking methadone (hazard ratio=1.25, 95% CI=1.13, 1.38). Medications currently used to treat alcohol and opioid use disorders

EvidenceUpdates2018

10. Opioid overdose

Opioid overdose Opioid overdose - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Opioid overdose Last reviewed: August 2018 Last updated: September 2018 Summary The patient's history from bystanders/friends/family can assist diagnosis. Signs include central nervous system (CNS) and respiratory depression, miosis, and apnoea. Initial treatment consists of ensuring adequate ventilation followed by administration (...) of the opioid antagonist naloxone. Monitor patients for re-sedation and repeat antidote dose if necessary. Definition An opioid is any synthetic or natural agent that stimulates opioid receptors and produces opium-like effects. Opiates are opioids naturally derived from the opium poppy, Papaver somniferum , and include morphine and codeine. Opioids are used in the treatment of pain but are often sold illicitly and abused for their euphoric effects. An overdose occurs when larger quantities than physically

BMJ Best Practice2018

12. Preoperative Opioid Use Is Associated with Higher Readmission and Revision Rates in Total Knee and Total Hip Arthroplasty

Preoperative Opioid Use Is Associated with Higher Readmission and Revision Rates in Total Knee and Total Hip Arthroplasty 30020122 2018 07 18 1535-1386 100 14 2018 Jul 18 The Journal of bone and joint surgery. American volume J Bone Joint Surg Am Preoperative Opioid Use Is Associated with Higher Readmission and Revision Rates in Total Knee and Total Hip Arthroplasty. 1171-1176 10.2106/JBJS.17.01414 Prescription opioid use is epidemic in the U.S. Recently, an association was demonstrated between (...) preoperative opioid use and increased health-care utilization following abdominal surgeries. Given that primary total knee arthroplasty (TKA) and total hip arthroplasty (THA) are 2 of the most common surgical procedures in the U.S., we examined the association of preoperative opioid use with 30-day readmission and early revision rates. We reviewed 2003 to 2014 data from 2 Truven Health MarketScan databases (commercial insurance and Medicare plus commercial supplemental insurance). Subjects were included

EvidenceUpdates2018

13. A Systematic Review and Meta-analysis of Ketamine as an Alternative to Opioids for Acute Pain in the Emergency Department

A Systematic Review and Meta-analysis of Ketamine as an Alternative to Opioids for Acute Pain in the Emergency Department 30019434 2018 07 18 1553-2712 2018 Jul 17 Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Acad Emerg Med A Systematic Review and Meta-analysis of Ketamine as an Alternative to Opioids for Acute Pain in the Emergency Department. 10.1111/acem.13502 Opioids are commonly prescribed in the emergency department (ED) for the treatment (...) of acute pain. Analgesic alternatives are being explored in response to an epidemic of opioid misuse. Low-dose ketamine (LDK) is one opioid alternative for the treatment of acute pain in the ED. This systematic review and meta-analysis sought to quantify whether LDK is an effective and safe opioid alternative for acute pain reduction in adults in the ED setting. (PROSPERO Registration Number CRD42017065303). This was a systematic review of randomized controlled trials comparing intravenous opioids

EvidenceUpdates2018

14. Contributions of prescribed and non-prescribed opioids to opioid related deaths: population based cohort study in Ontario, Canada.

Contributions of prescribed and non-prescribed opioids to opioid related deaths: population based cohort study in Ontario, Canada. OBJECTIVE: To describe the contributions of prescribed and non-prescribed opioids to opioid related deaths. DESIGN: Population based cohort study. SETTING: Ontario, Canada, from 1 January 2013 to 31 December 2016. PARTICIPANTS: All Ontarians who died of an opioid related cause. EXPOSURE: Active opioid prescriptions, defined as those with a duration overlapping (...) the date of death, and recent opioid prescriptions, defined as those dispensed in the 30 and 180 days preceding death. Postmortem toxicology results from the Drug and Drug/Alcohol Related Death database were used to characterise deaths on the basis of presence of prescribed and non-prescribed (that is, diverted or illicit) opioids, overall and stratified by year and age. RESULTS: 2833 opioid related deaths occurred. An active opioid prescription on the date of death was relatively common but declined

BMJ2018

15. Opioid Prescribing in the United States Before and After the Centers for Disease Control and Prevention's 2016 Opioid Guideline.

Opioid Prescribing in the United States Before and After the Centers for Disease Control and Prevention's 2016 Opioid Guideline. Background: In response to adverse outcomes from prescription opioids, the Centers for Disease Control and Prevention (CDC) released the Guideline for Prescribing Opioids for Chronic Pain in March 2016. Objective: To test the hypothesis that the CDC guideline release corresponded to declines in specific opioid prescribing practices. Design: Interrupted time series (...) analysis of monthly prescribing measures from the IQVIA transactional data warehouse and Real-World Data Longitudinal Prescriptions population-level estimates based on retail pharmacy data. Population size was determined by U.S. Census monthly estimates. Setting: United States, 2012 to 2017. Patients: Persons prescribed opioid analgesics. Measurements: Outcomes included opioid dosage, days supplied, overlapping benzodiazepine prescriptions, and the overall rate of prescribing. Results: The rate of high

Annals of Internal Medicine2018

16. Sustained Preoperative Opioid Use Is a Predictor of Continued Use Following Spine Surgery

Sustained Preoperative Opioid Use Is a Predictor of Continued Use Following Spine Surgery 29870441 2018 06 05 1535-1386 100 11 2018 Jun 06 The Journal of bone and joint surgery. American volume J Bone Joint Surg Am Sustained Preoperative Opioid Use Is a Predictor of Continued Use Following Spine Surgery. 914-921 10.2106/JBJS.17.00862 Preoperative opioid use is known to increase the likelihood of complications and inferior outcomes following spine surgery. We evaluated the association (...) of preoperative opioid use and other risk factors with postoperative opioid use. We queried 2006-2014 TRICARE insurance claims to identify adults who underwent lumbar interbody arthrodesis, lumbar discectomy, lumbar decompression, or lumbar posterolateral arthrodesis. The duration of preoperative opioid use was categorized as acute exposure, exposed without sustained use, intermediate sustained use, and chronic sustained use. Cox proportional-hazard models that adjusted for demographic factors, preoperative

EvidenceUpdates2018

18. Opioid

Opioid Top results for opioid - Trip Database or use your Google+ account Find evidence fast My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button (...) . An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for opioid The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical

Trip Latest and Greatest2018

19. Trends in opioid use in commercially insured and Medicare Advantage populations in 2007-16: retrospective cohort study.

Trends in opioid use in commercially insured and Medicare Advantage populations in 2007-16: retrospective cohort study. OBJECTIVE: To describe trends in the rate and daily dose of opioids used among commercial and Medicare Advantage beneficiaries from 2007 to 2016. DESIGN: Retrospective cohort study of administrative claims data. SETTING: National database of medical and pharmacy claims for commercially insured and Medicare Advantage beneficiaries in the United States. PARTICIPANTS: 48 million (...) individuals with any period of insurance coverage between 1 January 2007 and 31 December 2016, including commercial beneficiaries, Medicare Advantage beneficiaries aged 65 years and over, and Medicare Advantage beneficiaries under age 65 years (eligible owing to permanent disability). MAIN ENDPOINTS: Proportion of beneficiaries with any opioid prescription per quarter, average daily dose in milligram morphine equivalents (MME), and proportion of opioid use episodes that represented long term use. RESULTS

BMJ2018