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Latest & greatest articles for obesity
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on obesity or other clinical topics then use Trip today.
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The effect of the solution-focused approach on nutrition-exercise attitudes and behaviours of overweight and obese adolescents: Randomised controlled trial To assess the effect of the solution-focused approach interview technique on overweight/obese adolescents' nutrition-exercise attitudes and behaviours.Obesity is a serious health problem for all age groups, particularly adolescents; therefore, it is important for adolescents to develop healthy nutrition habits and acquire exercise behaviours (...) . Unless healthy nutrition-exercise behaviours are acquired, obesity can develop in adolescence, continue in adulthood. Focusing on solutions can be effective for overweight/obese adolescents to develop healthy nutrition-exercise behaviours.A pretest-post-test randomised controlled trial design was used.The study included 32 overweight/obese adolescents (16 for intervention group, 16 for control group) aged 12-13 years who attended a health centre and met the inclusion criteria. The solution-focused
A randomized trial of phenylephrine infusion versus bolus dosing for nausea and vomiting during Cesarean delivery in obese women Hypotension is common after spinal anesthesia for Cesarean delivery. It is associated with nausea, vomiting, and fetal acidosis. Previous research on phenylephrine excluded obese subjects. We compared the incidence of intraoperative nausea and vomiting (IONV) in obese patients who received a prophylactic phenylephrine infusion vs those who received bolus dosing (...) for the treatment of spinal-induced hypotension.In this multicentre, double-blinded randomized controlled trial, 160 obese women undergoing elective Cesarean delivery under spinal anesthesia were randomized to receive a prophylactic phenylephrine infusion initiated at 50 μg·min-1 (and titrated according to a predefined algorithm) or 100 μg phenylephrine boluses to treat hypotension. Maternal systolic blood pressure was maintained within 20% of baseline. The primary study outcome was the incidence
Whole-genome transcriptomic insights into protective molecular mechanisms in metabolically healthy obese African Americans Several clinical guidelines have been proposed to distinguish metabolically healthy obesity (MHO) from other subgroups of obesity but the molecular mechanisms by which MHO individuals remain metabolically healthy despite having a high fat mass are yet to be elucidated. We conducted the first whole blood transcriptomic study designed to identify specific sets of genes (...) that might shed novel insights into the molecular mechanisms that protect or delay the occurrence of obesity-related co-morbidities in MHO. The study included 29 African-American obese individuals, 8 MHO and 21 metabolically abnormal obese (MAO). Unbiased transcriptome-wide network analysis was carried out to identify molecular modules of co-expressed genes that are collectively associated with MHO. Network analysis identified a group of 23 co-expressed genes, including ribosomal protein genes (RPs
of obesity in a northeastern Iranian population.A TaqMan allelic discrimination assay was used to genotype LXRβ rs2695121 polymorphism in this cross-sectional study of 168 obese, 209 overweight and 76 normal-weight subjects recruited from Mashhad city in Iran. Logistic regression analyses were used to analyze alleles and genotypes distribution. Anthropometrics and clinical variables among different genotype carriers were compared by univariate analyses. All statistical analysis was performed using SPSS v (...) Genetic association of liver X receptor beta rs2695121 polymorphism with obesity-related traits in a northeastern Iranian population Liver X receptor Beta (LXRβ), located in an obesity susceptible region, has been shown to be involved in the metabolism of lipid and carbohydrates. Previous human genetic studies have suggested genetic variability of LXRβ could be associated with human obesity. Therefore, we hypothesized that LXRβ gene rs2695121 polymorphism may be associated with the risk
Obesity does not influence prostate intrafractional motion Motion of the prostate is problematic in the accurate delivery of external beam radiation therapy (EBRT) for prostate cancer. This study investigated the relationship between body mass index (BMI), an easily measured indicator of obesity, and prostate motion.Prostate motion during EBRT was assessed by measuring the displacement of fiducial markers implanted within the prostate in 130 prostate cancer patients. Interfractional motion
Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice Increasingly, evidence suggests that exposure to maternal obesity creates an inflammatory environment in utero, exerting long-lasting postnatal signatures on the juvenile innate immune system and microbiome that may predispose offspring to development of fatty liver disease. We found that exposure to a maternal Western-style diet (...) early weaning may alleviate the sustained proinflammatory environment, preventing the rapid progression of nonalcoholic fatty liver disease to nonalcoholic steatohepatitis in offspring of obese mothers. (Hepatology Communications 2018;2:313-328).
The influence of obesity on operating room time and perioperative complications in cochlear implantation The rising incidence of obesity in the United States is associated with increased healthcare expenditures and resource allocation. Obesity has been associated with prolonged operating times during surgical procedures. The primary objective of this study is to compare body mass index (BMI) to length of surgery during cochlear implantation.A retrospective case control study from a tertiary (...) academic referral center was performed. Patients included were adults who underwent primary, single-sided cochlear implantation with documented BMI and operating room (OR) times from January 2009 to July 2015. The following data were collected: BMI, total operating room time (TORT), surgical operating room time (SORT), ASA status, perioperative and postoperative complications, age, and gender.Two hundreds and thirty-four patients were included and stratified into obese (BMI >30) and non-obese (BMI < 30
Low NTâ€proBNP levels in overweight and obese patients do not rule out a diagnosis of heart failure with preserved ejection fraction Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome that presents clinicians with a diagnostic challenge. The use of natriuretic peptides to exclude a diagnosis of HFpEF has been proposed. We sought to compare HFpEF patients with N-terminal pro-brain natriuretic peptide (NT-proBNP) level above and below the proposed cut-off.Stable (...) patients (n = 30) with left ventricular (LV) ejection fraction ≥ 50% were eligible if they had a diagnosis of HF according to the European Society of Cardiology diagnostic criteria. Characteristics of patients with NT-proBNP below (≤125 pg/mL) and above (>125 pg/mL) the diagnostic criterion were compared.There were 19 (66%) women with median age 54 years. Half were African American (16, 53%), and most were obese. There were no significant differences in clinical characteristics or medication use
Reply to the letter to the editor 'Higher rate of severe toxicities in obese patients receiving dose-dense (dd) chemotherapy according to unadjusted body surface area: results of the prospectively randomized GAIN study' by Daly et al. 28368442 2018 01 18 2018 12 02 1569-8041 28 6 2017 06 01 Annals of oncology : official journal of the European Society for Medical Oncology Ann. Oncol. Reply to the letter to the editor 'Higher rate of severe toxicities in obese patients receiving dose-dense (dd (...) May 1;28(5):1161-1162 28453698 Antineoplastic Combined Chemotherapy Protocols Body Surface Area Chemotherapy, Adjuvant Humans Obesity 2017 4 4 6 0 2018 1 19 6 0 2017 4 4 6 0 ppublish 28368442 3076097 10.1093/annonc/mdx117
Reply to 'Higher rate of severe toxicities in obese patients receiving dose-dense (dd) chemotherapy according to unadjusted body surface area: results of the prospectively randomized GAIN study' by J. Furlanetto et al. 28453698 2018 01 18 2018 12 02 1569-8041 28 5 2017 05 01 Annals of oncology : official journal of the European Society for Medical Oncology Ann. Oncol. Reply to 'Higher rate of severe toxicities in obese patients receiving dose-dense (dd) chemotherapy according to unadjusted body (...) 27502721 Ann Oncol. 2017 Jun 1;28(6):1400 28368442 Antineoplastic Combined Chemotherapy Protocols Body Surface Area Chemotherapy, Adjuvant Humans Obesity 2017 4 29 6 0 2017 4 30 6 0 2018 1 19 6 0 ppublish 28453698 2981959 10.1093/annonc/mdx055
Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss at 5 Years Among Patients With Morbid Obesity: The SLEEVEPASS Randomized Clinical Trial. Laparoscopic sleeve gastrectomy for treatment of morbid obesity has increased substantially despite the lack of long-term results compared with laparoscopic Roux-en-Y gastric bypass.To determine whether laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass are equivalent for weight loss at 5 (...) years in patients with morbid obesity.The Sleeve vs Bypass (SLEEVEPASS) multicenter, multisurgeon, open-label, randomized clinical equivalence trial was conducted from March 2008 until June 2010 in Finland. The trial enrolled 240 morbidly obese patients aged 18 to 60 years, who were randomly assigned to sleeve gastrectomy or gastric bypass with a 5-year follow-up period (last follow-up, October 14, 2015).Laparoscopic sleeve gastrectomy (n = 121) or laparoscopic Roux-en-Y gastric bypass (n = 119
Association of Bariatric Surgery Using Laparoscopic Banding, Roux-en-Y Gastric Bypass, or Laparoscopic Sleeve Gastrectomy vs Usual Care Obesity Management With All-Cause Mortality. Bariatric surgery is an effective and safe approach for weight loss and short-term improvement in metabolic disorders such as diabetes. However, studies have been limited in most settings by lack of a nonsurgical group, losses to follow-up, missing data, and small sample sizes in clinical trials and observational (...) studies.To assess the association of 3 common types of bariatric surgery compared with nonsurgical treatment with mortality and other clinical outcomes among obese patients.Retrospective cohort study in a large Israeli integrated health fund covering 54% of Israeli citizens with less than 1% turnover of members annually. Obese adult patients who underwent bariatric surgery between January 1, 2005, and December 31, 2014, were selected and compared with obese nonsurgical patients matched on age, sex, body
Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss in Patients With Morbid Obesity: The SM-BOSS Randomized Clinical Trial. Sleeve gastrectomy is increasingly used in the treatment of morbid obesity, but its long-term outcome vs the standard Roux-en-Y gastric bypass procedure is unknown.To determine whether there are differences between sleeve gastrectomy and Roux-en-Y gastric bypass in terms of weight loss, changes in comorbidities, increase (...) in quality of life, and adverse events.The Swiss Multicenter Bypass or Sleeve Study (SM-BOSS), a 2-group randomized trial, was conducted from January 2007 until November 2011 (last follow-up in March 2017). Of 3971 morbidly obese patients evaluated for bariatric surgery at 4 Swiss bariatric centers, 217 patients were enrolled and randomly assigned to sleeve gastrectomy or Roux-en-Y gastric bypass with a 5-year follow-up period.Patients were randomly assigned to undergo laparoscopic sleeve gastrectomy (n
Association of Bariatric Surgery vs Medical Obesity Treatment With Long-term Medical Complications and Obesity-Related Comorbidities. The association of bariatric surgery and specialized medical obesity treatment with beneficial and detrimental outcomes remains uncertain.To compare changes in obesity-related comorbidities in patients with severe obesity (body mass index ≥40 or ≥35 and at least 1 comorbidity) undergoing bariatric surgery or specialized medical treatment.Cohort study (...) with baseline data of exposures from November 2005 through July 2010 and follow-up data from 2006 until death or through December 2015 at a tertiary care outpatient center, Vestfold Hospital Trust, Norway. Consecutive treatment-seeking adult patients (n = 2109) with severe obesity assessed (221 patients excluded and 1888 patients included).Bariatric surgery (n = 932, 92% gastric bypass) or specialized medical treatment (n = 956) including individual or group-based lifestyle intervention programs.Primary
Viewpoint: Toward Precision Approaches for the Prevention and Treatment of Obesity 29340687 2018 01 26 2018 11 13 1538-3598 319 3 2018 01 16 JAMA JAMA Toward Precision Approaches for the Prevention and Treatment of Obesity. 223-224 10.1001/jama.2017.20051 Yanovski Susan Z SZ National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. Yanovski Jack A JA Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child (...) Health and Human Development, National Institutes of Health, Bethesda, Maryland. eng Z01 HD000641-13 NULL Intramural NIH HHS United States Z99 DK999999 NULL Intramural NIH HHS United States Z99 HD999999 NULL Intramural NIH HHS United States ZIA HD000641 HD NICHD NIH HHS United States Journal Article United States JAMA 7501160 0098-7484 AIM IM JAMA. 2018 Jan 16;319(3):238-240 29340660 Humans Obesity etiology genetics prevention & control therapy Precision Medicine 2018 1 18 6 0 2018 1 18 6 0 2018 1 27
ObesityObesity - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search ObesityObesity has become common in Canada-approximately 59% of the population is overweight and 23% are obese. The obesity rate in children has risen significantly over the last 10 years. Current evidence supports the view that obesity is a disease, although it is also a societal issue. Being obese increases the risk of many chronic disease and health conditions (...) such as: coronary heart disease, stroke, hypertension, insulin resistance, type 2 diabetes, dyslipidemia, gallbladder and liver disease, osteoarthritis, and respiratory diseases. Colon cancer and hormonally related cancers such as prostate, endometrial and breast cancer, have been associated with obesity. For more information, go to: Canadian Obesity Network Webinars: Recommendations for prevention of weight gain and use of behavioural and pharmacologic interventions to manage overweight and obesity in adults
favorable findings (one for Body Mass Index z-score [BMIz] and one for combined overweight/obesity prevalence), and one reported unfavorable results for BMIz. Physical Activity Of the three studies that reported physical activity outcomes, two reported favorable findings and one reported no change in physical activity. Dietary-related Outcomes Two studies reported on consumption of fruits and vegetables, sugar-sweetened beverages, and low nutrient foods (i.e., high-energy dense foods). Findings were (...) Obesity Prevention and Control: Supporting Healthier Snack Foods and Beverages Sold or Offered Combined with Physical Activity Interventions in Schools Obesity: Snacks Plus Physical Activity in Schools | The Community Guide Welcome to The Community Guide! Let us know what you think of the website by completing this . Open Navigation or Search form Search Search The Community Guide You are here » Systematic Review Topic Insufficient Evidence October 2018 Audience Adolescents and Young Adults
results from the systematic review are available in the . The systematic review included 14 studies. Weight-related Outcomes The combined prevalence of overweight and obesity decreased by a median of 0.4 (6 studies). Students’ body mass index z-scores (BMIz) increased by a median of 0.005 units (8 ). Dietary Outcomes Fruit and Vegetable Consumption The number of servings of fruits and vegetables students consumed per day increased by 0.10 servings (6 study arms). Other outcomes related to fruit (...) :170. Marcus C, Nyberg G, Nordenfelt A, Karpmyr M, Kowalski J, Ekelund U. A 4-year, cluster-randomized, controlled childhood obesity prevention study: STOPP. International Journal of Obesity 2009;33(4):408-17. Millar L, Kremer P, de Silva-Sanigorski A, McCabe MP, Mavoa H, et al. Reduction in overweight and obesity from a 3-year community-based intervention in Australia: the 'It's Your Move!' project. Obesity Reviews 2011;12 Suppl 2:20-8. Millar L, Robertson N, Allender S, Nichols M, Bennett C
finding focuses on interventions to increase water access with physical activity interventions. Read a for school-based interventions to prevent or control obesity. Summary of Results Detailed results from the systematic review are available in the . The systematic review included one study. The single study in this review reported a decrease in consumption of sugar-sweetened beverages, and an increase in the prevalence of overweight or obese. Summary of Economic Evidence An economic review (...) Obesity Prevention and Control: Increasing Water Access Combined with Physical Activity Interventions in Schools Obesity: Water Access Plus Physical Activity in Schools | The Community Guide Welcome to The Community Guide! Let us know what you think of the website by completing this . Open Navigation or Search form Search Search The Community Guide You are here » Systematic Review Topic Insufficient Evidence April 2018 Audience Adolescents and Young Adults Children/Infants Decision-makers