Latest & greatest articles for obesity

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Top results for obesity

121. Metabolic Concomitants of Obese and Nonobese Women With Features of Polycystic Ovarian Syndrome

Metabolic Concomitants of Obese and Nonobese Women With Features of Polycystic Ovarian Syndrome 29264465 2018 11 13 2472-1972 1 12 2017 Dec 01 Journal of the Endocrine Society J Endocr Soc Metabolic Concomitants of Obese and Nonobese Women With Features of Polycystic Ovarian Syndrome. 1417-1427 10.1210/js.2017-00323 Polycystic ovarian syndrome (PCOS) is often associated with obesity and diabetes. The present study measured body fat distribution and metabolic risk factors in women with features (...) women. Nonobese PCOS and non-PCOS women had a similar body fat content and distribution, HOMA-IR, and hepatic triglyceride content. Obese PCOS women had a similar total body fat percentage compared with their non-PCOS counterparts (41.4% and 41.4% respectively). Both obese groups had similar intraperitoneal fat (1.4% of total body mass in PCOS vs 1.4% in non-PCOS). However, obese PCOS women had a greater ratio of truncal/lower body fat (1.42 vs 1.27; P < 0.016). They also had greater insulin

Journal of the Endocrine Society2017 Full Text: Link to full Text with Trip Pro

122. Nutrition and Exercise Rehabilitation in Obesity hypoventilation syndrome (NERO): a pilot randomised controlled trial

Nutrition and Exercise Rehabilitation in Obesity hypoventilation syndrome (NERO): a pilot randomised controlled trial 28971973 2017 10 03 2017 10 03 1468-3296 2017 Sep 29 Thorax Thorax Nutrition and Exercise Rehabilitation in Obesity hypoventilation syndrome (NERO): a pilot randomised controlled trial. thoraxjnl-2016-209826 10.1136/thoraxjnl-2016-209826 Respiratory management of obesity hypoventilation syndrome (OHS) focusses on the control of sleep-disordered breathing rather than (...) the treatment of obesity. Currently, there are no data from randomised trials of weight loss targeted rehabilitation programmes for patients with OHS. A 3-month multimodal hybrid inpatient-outpatient motivation, exercise and nutrition rehabilitation programme, in addition to non invasive ventilation (NIV), would result in greater per cent weight loss compared with standard care. A single-centre pilot randomised controlled trial allocated patients to either standard care or standard care plus rehabilitation

EvidenceUpdates2017

123. An experimental therapeutics test of whether adding dissonance-induction activities improves the effectiveness of a selective obesity and eating disorder prevention program

An experimental therapeutics test of whether adding dissonance-induction activities improves the effectiveness of a selective obesity and eating disorder prevention program 28990590 2017 10 09 2017 10 31 1476-5497 2017 Oct 09 International journal of obesity (2005) Int J Obes (Lond) An experimental therapeutics test of whether adding dissonance-induction activities improves the effectiveness of a selective obesity and eating disorder prevention program. 10.1038/ijo.2017.251 Compare the Healthy (...) Weight obesity and eating disorder prevention program, which promotes participant-driven gradual lifestyle changes to bring energy intake and expenditure into balance, to a new intervention, Project Health, which adds activities to create cognitive dissonance about unhealthy eating, a sedentary lifestyle, and excess body fat, and an obesity education video-control condition. College students at risk for both outcomes because of weight concerns (N=364, 72% female) were randomized to condition

EvidenceUpdates2017

124. Liraglutide and cardiovascular outcomes in adults with overweight or obesity: A post hoc analysis from SCALE randomized controlled trials

Liraglutide and cardiovascular outcomes in adults with overweight or obesity: A post hoc analysis from SCALE randomized controlled trials 28950422 2017 09 26 2017 11 02 1463-1326 2017 Sep 26 Diabetes, obesity & metabolism Diabetes Obes Metab Liraglutide and cardiovascular outcomes in adults with overweight or obesity: A post hoc analysis from SCALE randomized controlled trials. 10.1111/dom.13125 The cardiovascular safety of liraglutide, a glucagon-like peptide-1 receptor agonist approved (...) compared to comparators was 0.42 (95% confidence interval, 0.17-1.08). In this analysis, liraglutide 3.0 mg treatment was not associated with excess cardiovascular risk. However, the wide confidence intervals and retrospective adjudication of events in two of the trials are limitations of the analysis. © 2017 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. Davies M J MJ Diabetes Research Centre, University of Leicester, Leicester, UK. Aronne L J LJ Weill-Cornell

EvidenceUpdates2017 Full Text: Link to full Text with Trip Pro

125. Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based study

Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based study 29296866 2018 11 13 2473-9529 1 24 2017 Nov 14 Blood advances Blood Adv Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based study. 2186-2192 10.1182/bloodadvances.2017007609 All multiple myeloma (MM) cases are preceded by the premalignant state monoclonal gammopathy of undetermined (...) significance (MGUS). Results from previous studies show a positive association between obesity and MM; however, the association between obesity and MGUS is controversial. The aims were to determine (1) if obesity is associated with an increased risk of MGUS and light-chain MGUS (LC-MGUS) and (2) whether obesity is associated with a higher risk of progression to MM and other lymphoproliferative (LP) diseases. Data from the population-based Age, Gene/Environment Susceptibility-Reykjavik Study (N = 5764) were

Blood advances2017 Full Text: Link to full Text with Trip Pro

126. Parents’ perceptions of reasons for excess weight loss in obese children: a peer researcher approach

Parents’ perceptions of reasons for excess weight loss in obese children: a peer researcher approach 29119009 2018 11 13 2056-7529 3 2017 Research involvement and engagement Res Involv Engagem Parents' perceptions of reasons for excess weight loss in obese children: a peer researcher approach. 22 10.1186/s40900-017-0072-0 This study reports on the process of conducting participatory research by training peer researchers to conduct interviews and analyse data collected with parents (...) parents of children identified as obese through the National Child Measurement Programme (NCMP) at the start of primary school (age 4-5) but who had lost their excess weight by age 10-11; little is currently known about how this excess weight loss is achieved. Interviews were conducted by peer researchers, transcribed verbatim and analysed thematically by both peer- and university-based investigators. The peer researchers felt confident to conduct interviews after three training sessions. Recruitment

Research involvement and engagement2017 Full Text: Link to full Text with Trip Pro

127. Vitamin D receptor gene polymorphisms as a risk factor for obesity in Saudi men

Vitamin D receptor gene polymorphisms as a risk factor for obesity in Saudi men 29238479 2018 11 13 2008-5842 9 10 2017 Oct Electronic physician Electron Physician Vitamin D receptor gene polymorphisms as a risk factor for obesity in Saudi men. 5427-5433 10.19082/5427 The prevalence of obesity and vitamin D deficiency in Saudi Arabia has increased recently. Decreased physical activity might play a role in obesity. Previous studies showed an association between low vitamin D level and its (...) receptor polymorphism with obesity development. To determine association of low vitamin D level and its receptor polymorphism with obesity in Saudi men. This case control study was carried out from March 2016 through March 2017. Three hundred Saudi male students (from applied medical sciences in Taif University, Taif, Saudi Arabia) were classified according to BMI into lean, overweight and obese groups. For each individual, blood glucose, cholesterol, HDL-C, LDL-C, insulin and 25-(OH) vitamin D were

Electronic physician2017 Full Text: Link to full Text with Trip Pro

128. Prevalence of diabetes mellitus and its relation with obesity in Turaif (Saudi Arabia) in 2017

Prevalence of diabetes mellitus and its relation with obesity in Turaif (Saudi Arabia) in 2017 29238494 2018 11 13 2008-5842 9 10 2017 Oct Electronic physician Electron Physician Prevalence of diabetes mellitus and its relation with obesity in Turaif (Saudi Arabia) in 2017. 5531-5535 10.19082/5531 The significant increase in the prevalence of obesity over past decades caused the concomitant rise in the incidence of glucose intolerance and diabetes. To determine the prevalence of diabetes among (...) Saudi nationals in Turaif, Kingdom of Saudi Arabia and to examine the association between diabetes and obesity in the studied population. This study was conducted during the period from May 01 to May 31, 2017. Data was collected from 402 individuals aged between 6-63 years via a predesigned questionnaire covering medical history of diabetes, age and sex. Body weight and height was measured to calculate BMI. Data were analyzed by SPSS version 15, using descriptive statistics and Chi-Square test. Mean

Electronic physician2017 Full Text: Link to full Text with Trip Pro

129. Obesity in individuals with schizophrenia: a case controlled study in Scotland

Obesity in individuals with schizophrenia: a case controlled study in Scotland 29093827 2018 11 13 2056-4724 3 5 2017 Sep BJPsych open BJPsych Open Obesity in individuals with schizophrenia: a case controlled study in Scotland. 254-256 10.1192/bjpo.bp.116.003640 Despite extensive clinical concern about rates of obesity in patients with schizophrenia, there is little evidence of the extent of this problem at a population level. To estimate levels of obesity in a national population sample (...) by comparing patients with schizophrenia with matched controls. We calculated levels of obesity for each patient with schizophrenia from the national Primary Care Clinical Informatics Unit database (n=4658) matched with age, gender and neighbourhood controls. We demonstrated a significant increased obesity hazard for the schizophrenia group using Cox regression analysis, with odds ratio (OR) of 1.94 (95% CI 1.81-2.10) (under the assumption of missing body mass index (BMI) indicating non-obesity

BJPsych open2017 Full Text: Link to full Text with Trip Pro

130. Association between insulin resistance and preeclampsia in obese non-diabetic women receiving metformin

Association between insulin resistance and preeclampsia in obese non-diabetic women receiving metformin 29225676 2018 11 13 1753-495X 10 4 2017 Dec Obstetric medicine Obstet Med Association between insulin resistance and preeclampsia in obese non-diabetic women receiving metformin. 170-173 10.1177/1753495X17725465 To examine whether the reduced incidence of preeclampsia in non-diabetic obese pregnant women treated with metformin is mediated by changes in insulin resistance. This was a secondary (...) analysis of obese pregnant women in a randomised trial (MOP trial). Fasting plasma glucose and insulin were measured in 384 of the 400 women who participated in the MOP trial. Homeostasis model assessment of insulin resistance (HOMA-IR) was compared in the metformin and placebo groups and in those that developed preeclampsia versus those that did not develop preeclampsia. At 28 weeks, median HOMA-IR was significantly lower in the metformin group. Logistic regression analysis demonstrated

Obstetric medicine2017 Full Text: Link to full Text with Trip Pro

131. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults.

Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight (...) to obesity in children and adolescents, and to compare trends with those of adults. METHODS: We pooled 2416 population-based studies with measurements of height and weight on 128·9 million participants aged 5 years and older, including 31·5 million aged 5-19 years. We used a Bayesian hierarchical model to estimate trends from 1975 to 2016 in 200 countries for mean BMI and for prevalence of BMI in the following categories for children and adolescents aged 5-19 years: more than 2 SD below the median

Lancet2017 Full Text: Link to full Text with Trip Pro

132. Assessing and managing children at primary health-care facilities to prevent overweight and obesity in the context of the double burden of malnutrition

Assessing and managing children at primary health-care facilities to prevent overweight and obesity in the context of the double burden of malnutrition Assessing and managing children at primary health-care facilities to prevent overweight and obesity in the context of the double burden of malnutrition Guideline Updates for the Integrated Management of Childhood Illness (IMCI)GUIDELINE Assessing and managing children at primary health-care facilities to prevent overweight and obesity (...) in the context of the double burden of malnutrition UPDATES FOR THE INTEGRATED MANAGEMENT OF CHILDHOOD ILLNESS (IMCI)Guideline: assessing and managing children at primary health-care facilities to prevent overweight and obesity in the context of the double burden of malnutrition. Updates for the Integrated Management of Childhood Illness (IMCI) ISBN 978-92-4-155012-3 © World Health Organization 2017 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial- ShareAlike

World Health Organisation Guidelines2017

133. Red wine polyphenols do not improve obesity-associated insulin resistance: A randomized controlled trial

Red wine polyphenols do not improve obesity-associated insulin resistance: A randomized controlled trial 28643477 2017 06 23 2017 08 14 1463-1326 2017 Jun 23 Diabetes, obesity & metabolism Diabetes Obes Metab Red wine polyphenols do not improve obesity-associated insulin resistance: A randomized controlled trial. 10.1111/dom.13044 Preclinical studies have suggested that polyphenols extracted from red wine (RWPs) favourably affect insulin sensitivity, but there is controversy over whether RWPs (...) exert similar effects in humans. The aim of the present study was to determine whether RWPs improve insulin sensitivity in obese volunteers. Obese (body mass index >30 kg/m(2) ) volunteers were randomly allocated to RWPs 600 mg/d (n = 14) or matched placebo (n = 15) in a double-blind parallel-arm study for 8 weeks. The participants were investigated at baseline and at the end of the study. Insulin sensitivity was determined using a hyperinsulinaemic-euglycaemic clamp (M-value), a mixed-meal test

EvidenceUpdates2017

134. Setmelanotide for pro-opiomelanocortin deficiency obesity

Setmelanotide for pro-opiomelanocortin deficiency obesity Setmelanotide for pro-opiomelanocortin deficiency obesity ‐ NIHR Innovation Observatory ☰ Menu Search Filter by Specialty Filter by Year Setmelanotide for pro-opiomelanocortin deficiency obesity September 2017 Technology Description: Body fat and food intake are regulated by signals from the brain to the gut. One of the important hormones that is responsible for this is pro-opiomelanocortin (POMC). In a very small group of people (...) there is a lack of this hormone (due to a genetic mutation), referred to as POMC deficiency. This causes severe overeating which leads to obesity and high blood sugar in children. Very few adults have been observed with this condition, which may be due to high death rates in adolescence. Pale skin that does not tan and red hair are common signs of POMC deficiency obesity. Currently there are no licensed treatment options for POMC deficiency obesity, however weight loss medicines orlistat and methylcellulose

NIHR Innovation Observatory2017

135. Randomized phase III trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early breast cancer (Alliance A011401): study design

Randomized phase III trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early breast cancer (Alliance A011401): study design 28948213 2018 11 13 2374-4677 3 2017 NPJ breast cancer NPJ Breast Cancer Randomized phase III trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early breast cancer (Alliance A011401): study design. 37 10.1038/s41523-017-0040-8 Excess body weight is a poor prognostic factor (...) in women with early breast cancer, but the effect of weight loss on the risk of breast cancer recurrence and mortality in women who are overweight or obese at the time of breast cancer diagnosis has not been evaluated. The Alliance for Clinical Trials in Oncology Breast Cancer Weight Loss trial, also known as A011401, is testing the impact of a telephone-based weight loss program on invasive disease-free survival in 3136 women with a body mass index ≥27 kg/m 2 who have recently been diagnosed

NPJ breast cancer2017 Full Text: Link to full Text with Trip Pro

136. Effect of Post-Cesarean Delivery Oral Cephalexin and Metronidazole on Surgical Site Infection Among Obese Women: A Randomized Clinical Trial.

Effect of Post-Cesarean Delivery Oral Cephalexin and Metronidazole on Surgical Site Infection Among Obese Women: A Randomized Clinical Trial. Importance: The rate of obesity among US women has been increasing, and obesity is associated with increased risk of surgical site infection (SSI) following cesarean delivery. The optimal perioperative antibiotic prophylactic regimen in this high-risk population undergoing cesarean delivery is unknown. Objective: To determine rates of SSI among obese (...) women who receive prophylactic oral cephalexin and metronidazole vs placebo for 48 hours following cesarean delivery. Design, Setting, and Participants: Randomized, double-blind clinical trial comparing oral cephalexin and metronidazole vs placebo for 48 hours following cesarean delivery for the prevention of SSI in obese women (prepregnancy BMI ≥30) who had received standard intravenous preoperative cephalosporin prophylaxis. Randomization was stratified by intact vs rupture of membranes prior

JAMA2017 Full Text: Link to full Text with Trip Pro

137. Can mobile technology improve weight loss in overweight and obese patients?

Can mobile technology improve weight loss in overweight and obese patients? Can mobile technology improve weight loss in overweight and obese patients? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Can mobile technology improve weight loss in overweight and obese patients? View/ Open Date 2017-02 Format Metadata (...) Abstract Q: Can mobile technology improve weight loss in overweight and obese patients? Evidence-based answer: Yes, this technology can help in the short term. Mobile technology compared with minimal or no intervention increases short-term (<6 months) weight loss (1.4 to 2.7 kg) in overweight and obese patients (strength of recommendation [SOR]: A, meta-analysis of good quality studies and randomized controlled trials [RCTs]). Interventions that combine nonelectronic measures with mobile technology

Clinical Inquiries2017

138. Erratum: Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer

Erratum: Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer 28884144 2017 09 08 2374-4677 3 2017 NPJ breast cancer NPJ Breast Cancer Erratum: Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer. 35 10.1038/s41523-017-0030-x [This corrects the article DOI: 10.1038/s41523-017-0015-9.]. Vaysse Charlotte C The Cancer Centre, Oslo University Hospital, Oslo, Norway. 0000

NPJ breast cancer2017 Full Text: Link to full Text with Trip Pro

139. Metformin for Obesity in Prepubertal and Pubertal Children: A Randomized Controlled Trial

Metformin for Obesity in Prepubertal and Pubertal Children: A Randomized Controlled Trial 28759403 2017 07 31 2017 08 31 2017 08 31 1098-4275 140 1 2017 Jul Pediatrics Pediatrics Metformin for Obesity in Prepubertal and Pubertal Children: A Randomized Controlled Trial. e20164285 10.1542/peds.2016-4285 Metformin has shown its effectiveness in treating obesity in adults. However, little research has been conducted in children, with a lack of attention on pubertal status. The objectives were (...) to determine whether oral metformin treatment reduces BMI z score, cardiovascular risk, and inflammation biomarkers in children who are obese depending on pubertal stage and sex. This was a randomized, prospective, double-blind, placebo-controlled, multicenter trial, stratified according to pubertal stage and sex, conducted at 4 Spanish clinical hospitals. Eighty prepubertal and 80 pubertal nondiabetic children who were obese aged 7 to 14 years with a BMI >95th percentiles were recruited. The intervention

EvidenceUpdates2017

140. Effect of Internet-Based Guided Self-help vs Individual Face-to-Face Treatment on Full or Subsyndromal Binge Eating Disorder in Overweight or Obese Patients: The INTERBED Randomized Clinical Trial

Effect of Internet-Based Guided Self-help vs Individual Face-to-Face Treatment on Full or Subsyndromal Binge Eating Disorder in Overweight or Obese Patients: The INTERBED Randomized Clinical Trial 28768334 2017 08 02 2017 08 02 2168-6238 2017 Aug 02 JAMA psychiatry JAMA Psychiatry Effect of Internet-Based Guided Self-help vs Individual Face-to-Face Treatment on Full or Subsyndromal Binge Eating Disorder in Overweight or Obese Patients: The INTERBED Randomized Clinical Trial. 10.1001

EvidenceUpdates2017