Latest & greatest articles for obesity

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on obesity or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on obesity and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for obesity

101. Contribution of sex and body constitution to three-dimensional lower extremity alignment for healthy, elderly, non-obese humans in a Japanese population Full Text available with Trip Pro

Contribution of sex and body constitution to three-dimensional lower extremity alignment for healthy, elderly, non-obese humans in a Japanese population Humans support their bodies exclusively by vertical balance in bipedal locomotion, and the body, especially the lower extremity, generally changes with age. Sex and body constitution are assumed to be associated with lower extremity alignment, but this association remains to be elucidated. This study sought to clarify this association (...) in healthy, elderly, non-obese humans in a Japanese population.The present study investigated 55 healthy volunteers (mean age: 70 ± 6 years). A 3D extremity alignment system was applied under weight-bearing conditions on biplane long lower extremities X-rays using a 3D-to-2D image registration technique. The evaluation parameters included 3D hip-knee-ankle angle (3DHKA) alignment in the coronal (coronal alignment) and sagittal planes (sagittal alignment) and rotational alignment between the femur

2018 Journal of experimental orthopaedics

102. Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial. (Abstract)

Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial. Obesity is a major public health issue, and new pharmaceuticals for weight management are needed. Therefore, we evaluated the efficacy and safety of the glucagon-like peptide-1 (GLP-1) analogue semaglutide in comparison with liraglutide and a placebo in promoting weight loss.We did a randomised

2018 Lancet Controlled trial quality: predicted high

103. Obesity

on Clinical Cardiology https://doi.org/10.1161/CIR.0b013e3182a5cfb3 Circulation. 2013; 128: 1689-1712 2013 3. Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight. BACKGROUND: The global prevalence of childhood and adolescent obesity is high. Lifestyle changes towards a healthy diet, increased physical activity and reduced sedentary activities are recommended to prevent and treat obesity . Evidence (...) . executive functions) and/or future success in children and adolescents with obesity or overweight 2018 4. The West Midlands ActiVe lifestyle and healthy Eating in School children (WAVES) study: a cluster randomised controlled trial testing the clinical effectiveness and cost-effectiveness of a multifaceted obesity prevention intervention programme targeted at The West Midlands ActiVe lifestyle and healthy Eating in School children (WAVES) study: a cluster randomised controlled trial testing the clinical

2018 Trip Latest and Greatest

104. Perioperative Management of Obstructive Sleep Apnea and Obesity Hypoventilation Syndrome: A Workshop Report

Perioperative Management of Obstructive Sleep Apnea and Obesity Hypoventilation Syndrome: A Workshop Report AMERICANTHORACICSOCIETY DOCUMENTS KnowledgeGapsinthePerioperativeManagementofAdultswith ObstructiveSleepApneaandObesityHypoventilationSyndrome An Of?cial American Thoracic Society Workshop Report Najib T. Ayas, Cheryl R. Laratta, John M. Coleman, Anthony G. Doufas, Matthias Eikermann, Peter C. Gay, Daniel J. Gottlieb, Indira Gurubhagavatula, David R. Hillman, Roop Kaw, Atul Malhotra (...) ?cientevidencetoguidescreeningandoptimizationofOSAand OHSintheperioperativesettingtoachievetheseobjectives.Patients whoareatgreatestriskofrespiratoryorcardiaccomplicationsrelated toOSAandOHSarenotwellde?ned,andtheeffectivenessof monitoringandotherinterventionsremainstobedetermined. Centersinvolvedinsleepresearchneedtodevelopcollaborative networkstoallowmulticenterstudiestoaddresstheknowledgegaps identi?edbelow. Keywords: obstructive sleep apnea; perioperative care; obesity hypoventilation syndrome; risk assessment; postoperative complications Ann

2018 American Thoracic Society

105. Comparing the image quality of tissue harmonic and conventional B-mode ultrasound of kidney in over-obese individuals Full Text available with Trip Pro

Comparing the image quality of tissue harmonic and conventional B-mode ultrasound of kidney in over-obese individuals Increased subcutaneous fat thickness and depth of target organs in over-obese patients, results in weak signals and inadequate images. Tissue harmonic imaging has been used widely in obese patients and is believed to result in higher quality images. This superiority is not proved in modern machines with improved image quality in conventional mode.To compare the image quality (...) between conventional and tissue harmonic ultrasound images.This cross-sectional study was carried out from March 2015 to June 2016. Seventy-six over-obese patients referred to Ghaem Hospital (Mashhad, Iran) for weight-correction surgeries, were enrolled into the study. Conventional and tissue harmonic images of their kidneys were blinded and compared back-to-back by four expert radiologists. Data were analyzed by SPSS version 16, using Cochrane's Q test.All raters reported image quality to be better

2018 Electronic physician

106. Tackling obesity in mental health secure units: a mixed method synthesis of available evidence Full Text available with Trip Pro

Tackling obesity in mental health secure units: a mixed method synthesis of available evidence The prevalence and incidence of obesity are high in people with severe mental illness (SMI). In England, around 6000 people with SMI access care from secure mental health units. There is currently no specific guidance on how to reduce the risk of obesity-related morbidity and mortality in this population.To identify international evidence that addresses the issue of obesity in mental health secure (...) units.A mixed method review of evidence (published 2000-2015) was carried out to assess obesity prevalence, intervention and policy change, as well as barriers to change.Evidence from 22 mainly small, non-comparator studies (reported in 21 papers) using a range of methods was reviewed. Dietary, physical activity and cultural interventions being implemented within secure units to address the problem of obesity showed some promising outcomes for physical health and health education. These were

2018 BJPsych open

107. Obesity, mental health, and sexual dysfunction: A critical review Full Text available with Trip Pro

, systematic reviews, and meta-analyses of obesity, overweight, sexual function, sexual dysfunction, psychological health, mental health, and weight loss. Research demonstrates an association between obesity, mental health, and sexual functioning, but has failed to identify casual pathways between these conditions. Clarifying such pathways is necessary to inform treatment guidelines for clinical practice. (...) Obesity, mental health, and sexual dysfunction: A critical review Obesity has profound medical, psychological, and emotional consequences and is associated with sexual difficulties. Little is known regarding the interrelationship between obesity and sexual functioning from a psychological perspective, and less is known regarding treatment options. This review examines these issues and considers various treatments. Literature searches were conducted to locate original research, reviews

2018 Health psychology open

108. Preconceptional health behavior change in women with overweight and obesity: prototype for SMART strong healthy women intervention Full Text available with Trip Pro

Preconceptional health behavior change in women with overweight and obesity: prototype for SMART strong healthy women intervention The prevalence of maternal perinatal obesity is rising, and in turn, increases health risks and morbidity for both mother and child. Past evidence suggests the preconceptional Strong Healthy Women (SHW) intervention can reduce multiple biobehavioral risk factors for adverse perinatal health. The SHW intervention, however, was time- and resource-intensive to deliver (...) to supplement the curriculum, and presenting on-screen information in a concise format. In designing the final prototype, 87% of participant preferences were able to be incorporated.Smartphone devices can enhance the reach of face-to-face behavioral interventions by reducing implementation burden. Engaging end-users (in this case, preconceptional women with overweight/obesity) in the mHealth design process through semi-structured focus groups is a feasible and useful approach. Eliciting and leveraging user

2018 mHealth

109. Association between maternal adherence to healthy lifestyle practices and risk of obesity in offspring: results from two prospective cohort studies of mother-child pairs in the United States. Full Text available with Trip Pro

Association between maternal adherence to healthy lifestyle practices and risk of obesity in offspring: results from two prospective cohort studies of mother-child pairs in the United States. To examine the association between an overall maternal healthy lifestyle (characterized by a healthy body mass index, high quality diet, regular exercise, no smoking, and light to moderate alcohol intake) and the risk of developing obesity in offspring.Prospective cohort studies of mother-child (...) pairs.Nurses' Health Study II (NHSII) and Growing Up Today Study (GUTS) in the United States.24 289 GUTS participants aged 9-14 years at baseline who were free of obesity and born to 16 945 NHSII women.Obesity in childhood and adolescence, defined by age and sex specific cutoff points from the International Obesity Task Force. Risk of offspring obesity was evaluated by multivariable log-binomial regression models with generalized estimating equations and an exchangeable correlation structure.1282 (5.3

2018 BMJ

110. Effects of clomiphene citrate on male obesity-associated hypogonadism: a randomized, double-blind, placebo-controlled study (Abstract)

Effects of clomiphene citrate on male obesity-associated hypogonadism: a randomized, double-blind, placebo-controlled study Obesity causes secondary hypogonadism (HG) in men. Standard testosterone (T) replacement therapy improves metabolic parameters but leads to infertility.To evaluate clomiphene citrate (CC) treatment of adult men with male obesity-associated secondary hypogonadism (MOSH).Single-center, randomized, double-blind, placebo-controlled trial.Seventy-eight men aged 36.5 ± 7.8 years

2018 EvidenceUpdates

111. Obesity

Obesity Evidence Maps - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading

2018 Trip Evidence Maps

112. VEGF-mTOR signaling links obesity and endometrial cancer Full Text available with Trip Pro

VEGF-mTOR signaling links obesity and endometrial cancer 30035172 2018 11 14 2331-4737 5 5-6 2018 May Oncoscience Oncoscience VEGF-mTOR signaling links obesity and endometrial cancer. 150-151 10.18632/oncoscience.430 Sahoo Subhransu S SS Gynecology Oncology Group, University of Newcastle, Callaghan, NSW 2308, Australia. Tanwar Pradeep S PS Gynecology Oncology Group, University of Newcastle, Callaghan, NSW 2308, Australia. eng Editorial 2018 06 27 United States Oncoscience 101636666 2331-4737

2018 Oncoscience

113. Comparing the efficacy of therapeutic packages in Persian Medicine with Classical Medicine in overweight patients: a randomized clinical trial Full Text available with Trip Pro

Comparing the efficacy of therapeutic packages in Persian Medicine with Classical Medicine in overweight patients: a randomized clinical trial Obesity is a major risk factor for many diseases. In Persian Medicine, much emphasis has been put on the balanced weight that maintains health. Therefore, the treatment of obesity is a top priority for health care in Persian and Classical Medicine.To compare the efficacy of therapeutic packages in Persian Medicine with Classical Medicine in overweight (...) treatment.This randomized clinical trial was conducted at Ghaem Hospital in Mashhad, Iran, from August 22, 2016 to December 20, 2016. Sixty-nine overweight women with body mass index (BMI) of 27-29.9 and waist circumference more than 88 cm based on inclusion and exclusion criteria, were included in the study. To control bias in sampling, with considering that the age variable is an interventional factor in the process of effective treatment, in addition to using the random allocation method, the population

2018 Electronic physician Controlled trial quality: uncertain

114. MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study. (Abstract)

MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study. Weight loss is often key in the management of obese or overweight patients with type 2 diabetes, yet few treatments for diabetes achieve clinically meaningful weight loss. We aimed to assess the efficacy, tolerability, and safety of treatment with MEDI0382, a balanced glucagon-like peptide-1 and glucagon receptor (...) in the MEDI0382 group vs 23 [88%] of 26 in the placebo group); gastrointestinal disorders (18 [72%] vs 13 [40%]) and decreased appetite (five [20%] vs none) occurred more frequently with MEDI0382 than placebo. No participants in the MEDI0382 group had a grade 3 or worse TEAE (vs two [8%] in the placebo group).MEDI0382 has the potential to deliver clinically meaningful reductions in blood glucose and bodyweight in obese or overweight individuals with type 2 diabetes.MedImmune.Copyright © 2018 Elsevier Ltd. All

2018 Lancet Controlled trial quality: predicted high

115. Differences in Obesity Prevalence by Demographics and Urbanization in US Children and Adolescents, 2013-2016. Full Text available with Trip Pro

Differences in Obesity Prevalence by Demographics and Urbanization in US Children and Adolescents, 2013-2016. Differences in childhood obesity by demographics and urbanization have been reported.To present data on obesity and severe obesity among US youth by demographics and urbanization and to investigate trends by urbanization.Measured weight and height among youth aged 2 to 19 years in the 2001-2016 National Health and Nutrition Examination Surveys, which are serial, cross-sectional (...) , nationally representative surveys of the civilian, noninstitutionalized population.Sex, age, race and Hispanic origin, education of household head, and urbanization, as assessed by metropolitan statistical areas (MSAs; large: ≥ 1 million population).Prevalence of obesity (body mass index [BMI] ≥95th percentile of US Centers for Disease Control and Prevention [CDC] growth charts) and severe obesity (BMI ≥120% of 95th percentile) by subgroups in 2013-2016 and trends by urbanization between 2001-2004

2018 JAMA

116. Differences in Obesity Prevalence by Demographic Characteristics and Urbanization Level Among Adults in the United States, 2013-2016. Full Text available with Trip Pro

Differences in Obesity Prevalence by Demographic Characteristics and Urbanization Level Among Adults in the United States, 2013-2016. Differences in obesity by sex, age group, race and Hispanic origin among US adults have been reported, but differences by urbanization level have been less studied.To provide estimates of obesity by demographic characteristics and urbanization level and to examine trends in obesity prevalence by urbanization level.Serial cross-sectional analysis of measured (...) height and weight among adults aged 20 years or older in the 2001-2016 National Health and Nutrition Examination Survey, a nationally representative survey of the civilian, noninstitutionalized US population.Sex, age group, race and Hispanic origin, education level, smoking status, and urbanization level as assessed by metropolitan statistical areas (MSAs; large: ≥1 million population).Prevalence of obesity (body mass index [BMI] ≥30) and severe obesity (BMI ≥40) by subgroups in 2013-2016 and trends

2018 JAMA

117. Transcriptomic Profiling of Obesity-Related Nonalcoholic Steatohepatitis Reveals a Core Set of Fibrosis-Specific Genes Full Text available with Trip Pro

Transcriptomic Profiling of Obesity-Related Nonalcoholic Steatohepatitis Reveals a Core Set of Fibrosis-Specific Genes Nonalcoholic steatohepatitis (NASH) is strongly associated with obesity and type 2 diabetes. The molecular factors underlying the development of inflammation and severe fibrosis in NASH remain largely unknown. The purpose of this study was to identify gene expression patterns related to obesity-related NASH inflammation and fibrosis. We performed sequencing-based mRNA profiling

2018 Journal of the Endocrine Society

118. Effect of one time high dose "stoss therapy" of vitamin D on glucose homeostasis in high risk obese adolescents. Full Text available with Trip Pro

Effect of one time high dose "stoss therapy" of vitamin D on glucose homeostasis in high risk obese adolescents. To study the effect of using a one time high dose "stoss therapy" of vitamin D2 (ergocalciferol: VD2) on indices of insulin sensitivity {whole body sensitivity index: WBISI} and secretion {insulinogenic index: IGI} measured during an oral glucose tolerance test (OGTT) in obese adolescents with VDD (25 OHD; serum metabolite of vit D: < 30 ng/dL).In a randomized placebo controlled (...) cross over design 20 obese adolescents with vitamin D deficiency (VDD) had baseline OGTT. Arm A received one time high dose 300,000 IU of ergocalciferol and Arm B received placebo. After 6 weeks the adolescents were reassigned to Arm A if they were in Arm B and vice versa. 25OHD, calcium, parathyroid hormone, comprehensive metabolic panel, urine calcium creatinine ratio were measured at each study visit. OGTTs to assess indices of sensitivity and secretion were done at baseline, 6 weeks and 12 weeks

2018 Archives of endocrinology and metabolism Controlled trial quality: uncertain

119. Antibiotics: repeated treatments before the age of two could be a factor in obesity

 |  Spotlight Antibiotics: repeated treatments before the age of two could be a factor in obesity Antibiotics disrupt the intestinal flora (intestinal microbiota) and could be a factor in weight gain. Prescription of antibiotics for children should not be automatic but should be evaluated on a case-by-case basis. Overweight and obesity are the result of an imbalance between energy intake and energy expenditure and can be associated with various known genetic, hormone, environmental (...) Antibiotics: repeated treatments before the age of two could be a factor in obesity Prescrire IN ENGLISH - Spotlight ''Antibiotics: repeated treatments before the age of two could be a factor in obesity'', 1 June 2018 {1} {1} {1} | | > > > Antibiotics: repeated treatments before the age of two could be a factor in obesity Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   | 

2018 Prescrire

120. Habit-based interventions for weight loss maintenance in adults with overweight and obesity: a randomized controlled trial Full Text available with Trip Pro

Habit-based interventions for weight loss maintenance in adults with overweight and obesity: a randomized controlled trial The objective of this study was to determine whether habit-based interventions are clinically beneficial in achieving long-term (12-month) weight loss maintenance and explore whether making new habits or breaking old habits is more effective.Volunteer community members aged 18-75 years who had overweight or obesity (BMI ≥ 25 kg/m2) were randomized in a single-blind, three

2018 EvidenceUpdates