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Latest & greatest articles for obesity
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Ventilatory support or respiratory muscle training as adjuncts to exercise in obese CPAP-treated patients with obstructive sleep apnoea: a randomised controlled trial 29463621 2018 03 01 1468-3296 2018 Feb 20 Thorax Thorax Ventilatory support or respiratory muscle training as adjuncts to exercise in obese CPAP-treated patients with obstructive sleep apnoea: a randomised controlled trial. thoraxjnl-2017-211152 10.1136/thoraxjnl-2017-211152 Obstructive sleep apnoea (OSA) and obesity (...) are interdependent chronic diseases sharing reduced exercise tolerance and high cardiovascular risk. A 3-month intervention with innovative training modalities would further improve functional capacity and cardiovascular health than usual cycle exercise training in already continuous positive airway pressure (CPAP)-treated obese patients with OSA. Fifty three patients (35
The West Midlands ActiVe lifestyle and healthy Eating in School children (WAVES) study: a cluster randomised controlled trial testing the clinical effectiveness and cost-effectiveness of a multifaceted obesity prevention intervention programme targeted at The West Midlands ActiVe lifestyle and healthy Eating in School children (WAVES) study: a cluster randomised controlled trial testing the clinical effectiveness and cost-effectiveness of a multifaceted obesity prevention intervention programme (...) targeted at children aged 6-7 years The West Midlands ActiVe lifestyle and healthy Eating in School children (WAVES) study: a cluster randomised controlled trial testing the clinical effectiveness and cost-effectiveness of a multifaceted obesity prevention intervention programme targeted at children aged 6-7 years Adab P, Barrett T, Bhopal R, Cade J E, Canaway A, Cheng K K, Clarke J, Daley A, Deeks J, Duda J, Ekelund U, Frew E, Gill P, Griffin T, Hemming K, Hurley K, Lancashire E R, Martin J, McGee E
Cluster randomised controlled trial and economic and process evaluation to determine the effectiveness and cost effectiveness of a novel intervention [Healthy Lifestyles Programme (HeLP)] to prevent obesity in school children Cluster randomised controlled trial and economic and process evaluation to determine the effectiveness and cost effectiveness of a novel intervention [Healthy Lifestyles Programme (HeLP)] to prevent obesity in school children Cluster randomised controlled trial (...) and economic and process evaluation to determine the effectiveness and cost effectiveness of a novel intervention [Healthy Lifestyles Programme (HeLP)] to prevent obesity in school children Wyatt K, Lloyd J, Creanor S, Green C, Dean S G, Hillsdon M, Abraham C, Tomlinson R, Pearson V, Taylor R S, Ryan E, Streeter A, McHugh C, Hurst A, Price L, Crathorne L, Krägeloh C, Siegert R & Logan S Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA
Effectiveness of a childhood obesity prevention programme delivered through schools, targeting 6 and 7 year olds: cluster randomised controlled trial (WAVES study). OBJECTIVE: To assess the effectiveness of a school and family based healthy lifestyle programme (WAVES intervention) compared with usual practice, in preventing childhood obesity. DESIGN: Cluster randomised controlled trial. SETTING: UK primary schools from the West Midlands. PARTICIPANTS: 200 schools were randomly selected from all (...) anthropometric, dietary, physical activity, or psychological measurements (including assessment of harm). CONCLUSIONS: The primary analyses suggest that this experiential focused intervention had no statistically significant effect on BMI z score or on preventing childhood obesity. Schools are unlikely to impact on the childhood obesity epidemic by incorporating such interventions without wider support across multiple sectors and environments. TRIAL REGISTRATION: Current Controlled Trials ISRCTN97000586
The West Midlands ActiVe lifestyle and healthy Eating in School children (WAVES) study: a cluster randomised controlled trial testing the clinical effectiveness and cost-effectiveness of a multifaceted obesity prevention intervention programme targeted at The West Midlands ActiVe lifestyle and healthy Eating in School children (WAVES) study: a cluster randomised controlled trial testing the clinical effectiveness and cost-effectiveness of a multifaceted obesity prevention intervention programme
A randomized trial of phenylephrine infusion versus bolus dosing for nausea and vomiting during Cesarean delivery in obese women 29209926 2018 02 28 1496-8975 65 3 2018 Mar Canadian journal of anaesthesia = Journal canadien d'anesthesie Can J Anaesth A randomized trial of phenylephrine infusion versus bolus dosing for nausea and vomiting during Cesarean delivery in obese women. 254-262 10.1007/s12630-017-1034-6 Hypotension is common after spinal anesthesia for Cesarean delivery (...) . It is associated with nausea, vomiting, and fetal acidosis. Previous research on phenylephrine excluded obese subjects. We compared the incidence of intraoperative nausea and vomiting (IONV) in obese patients who received a prophylactic phenylephrine infusion vs those who received bolus dosing for the treatment of spinal-induced hypotension. In this multicentre, double-blinded randomized controlled trial, 160 obese women undergoing elective Cesarean delivery under spinal anesthesia were randomized to receive
The effect of the solution-focused approach on nutrition-exercise attitudes and behaviours of overweight and obese adolescents: Randomised controlled trial 29278443 2018 01 24 1365-2702 2017 Dec 26 Journal of clinical nursing J Clin Nurs The effect of the solution-focused approach on nutrition-exercise attitudes and behaviours of overweight and obese adolescents: Randomised controlled trial. 10.1111/jocn.14246 To assess the effect of the solution-focused approach interview technique (...) on overweight/obese adolescents' nutrition-exercise attitudes and behaviours. Obesity is a serious health problem for all age groups, particularly adolescents; therefore, it is important for adolescents to develop healthy nutrition habits and acquire exercise behaviours. Unless healthy nutrition-exercise behaviours are acquired, obesity can develop in adolescence, continue in adulthood. Focusing on solutions can be effective for overweight/obese adolescents to develop healthy nutrition-exercise behaviours
Whole-genome transcriptomic insights into protective molecular mechanisms in metabolically healthy obese African Americans ARTICLE OPEN Whole-genome transcriptomic insights into protective molecular mechanisms in metabolically healthy obese African Americans Amadou Gaye 1 , Ayo P. Doumatey 1,2 , Sharon K. Davis 1 , Charles N. Rotimi 1,2 and Gary H. Gibbons 1,3 Several clinical guidelines have been proposed to distinguish metabolically healthy obesity (MHO) from other subgroups of obesity (...) butthemolecular mechanismsbywhichMHOindividualsremainmetabolicallyhealthydespitehavingahighfatmassareyettobe elucidated. We conducted the ?rst whole blood transcriptomic study designed to identify speci?c sets of genes that might shed novel insights into the molecular mechanisms that protect or delay the occurrence of obesity-related co-morbidities in MHO. The study included 29 African-American obese individuals, 8 MHO and 21 metabolically abnormal obese (MAO). Unbiased transcriptome-wide network analysis
Genetic association of liver X receptor beta rs2695121 polymorphism with obesity-related traits in a northeastern Iranian population Genetic association of liver X receptor beta rs2695121 polymorphism with obesity-related traits in a northeastern Iranian population Search Search... For Authors Research Reporting Guidelines: Selected Editorials , Editorial by Associate Editor Prof. Dr. Umesh Wadgave, India. November 2018 . Editorial by Associate Professor Dr. Hossein Sanaei-Zadeh, Shiraz (...) Written by Hassan Mehrad-Majd, Majid Ghayour-Mobarhan, Mohamad-Reza Zali Parent Category: Year 2018, Volume 10 Category: Abstract Background : Liver X receptor Beta (LXRβ), located in an obesity susceptible region, has been shown to be involved in the metabolism of lipid and carbohydrates. Previous human genetic studies have suggested genetic variability of LXRβ could be associated with human obesity. Therefore, we hypothesized that LXRβ gene rs2695121 polymorphism may be associated with the risk
Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice Pyrroloquinoline Quinone Prevents Developmental Programming of Microbial Dysbiosis and Macrophage Polarization to Attenuate Liver Fibrosis in Offspring of Obese Mice Jacob E. Friedman, 1 Evgenia Dobrinskikh, 2 Alba Alfonso-Garcia, 3 Alexander Fast, 3 Rachel C. Janssen, 1 Taylor K. Soderborg, 1 Aimee L. Anderson, 4 Julie A. Reisz, 5 (...) Angelo D’Alessandro, 5 Daniel N. Frank, 6 Charles E. Robertson, 6 Becky A. de la Houssaye, 1 Linda K. Johnson, 7 David J. Orlicky, 7 Xiaoxin X. Wang, 2 Moshe Levi, 2 Eric O. Potma , 3 Karim C. El Kasmi, 4 and Karen R. Jonscher 8 Increasingly, evidence suggests that exposure to maternal obesity creates an in?ammatory environment in utero, exerting long-lasting postnatal signatures on the juvenile innate immune system and microbiome that may predispose offspring to development of fatty liver disease
Low NTâ€proBNP levels in overweight and obese patients do not rule out a diagnosis of heart failure with preserved ejection fraction Low NT-proBNP levels in overweight and obese patients do not rule out a diagnosis of heart failure with preserved ejection fraction Leo F. Buckley 1 , Justin M. Canada 2,3 , Marco G. Del Buono 2 , Salvatore Carbone 2,4 , Cory R. Trankle 2 , Hayley Billingsley 2 , Dinesh Kadariya 2 , Ross Arena 5 , Benjamin W. Van Tassell 1 and Antonio Abbate 2 * 1 Department (...) ratio at peak exercise were not signi?cantly different between NT-proBNP groups. Peak oxygen consumption (VO 2 ), VO 2 at ventilatory threshold, and ventilatory ef?ciency measures were impaired in all patients and were not signi?cantly different between high and low NT-proBNP patients. Conclusions NT-proBNP was below the proposed diagnostic cut-off point of 125 pg/mL in half of this obese study cohort. Cardiac diastolic dysfunction and cardiorespiratory ?tness were not signi?cantly different between
Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss at 5 Years Among Patients With Morbid Obesity: The SLEEVEPASS Randomized Clinical Trial. Importance: Laparoscopic sleeve gastrectomy for treatment of morbid obesity has increased substantially despite the lack of long-term results compared with laparoscopic Roux-en-Y gastric bypass. Objective: To determine whether laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass (...) are equivalent for weight loss at 5 years in patients with morbid obesity. Design, Setting, and Participants: The Sleeve vs Bypass (SLEEVEPASS) multicenter, multisurgeon, open-label, randomized clinical equivalence trial was conducted from March 2008 until June 2010 in Finland. The trial enrolled 240 morbidly obese patients aged 18 to 60 years, who were randomly assigned to sleeve gastrectomy or gastric bypass with a 5-year follow-up period (last follow-up, October 14, 2015). Interventions: Laparoscopic
Association of Bariatric Surgery Using Laparoscopic Banding, Roux-en-Y Gastric Bypass, or Laparoscopic Sleeve Gastrectomy vs Usual Care Obesity Management With All-Cause Mortality. Importance: Bariatric surgery is an effective and safe approach for weight loss and short-term improvement in metabolic disorders such as diabetes. However, studies have been limited in most settings by lack of a nonsurgical group, losses to follow-up, missing data, and small sample sizes in clinical trials (...) and observational studies. Objective: To assess the association of 3 common types of bariatric surgery compared with nonsurgical treatment with mortality and other clinical outcomes among obese patients. Design, Setting, and Participants: Retrospective cohort study in a large Israeli integrated health fund covering 54% of Israeli citizens with less than 1% turnover of members annually. Obese adult patients who underwent bariatric surgery between January 1, 2005, and December 31, 2014, were selected and compared
Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss in Patients With Morbid Obesity: The SM-BOSS Randomized Clinical Trial. Importance: Sleeve gastrectomy is increasingly used in the treatment of morbid obesity, but its long-term outcome vs the standard Roux-en-Y gastric bypass procedure is unknown. Objective: To determine whether there are differences between sleeve gastrectomy and Roux-en-Y gastric bypass in terms of weight loss, changes (...) in comorbidities, increase in quality of life, and adverse events. Design, Setting, and Participants: The Swiss Multicenter Bypass or Sleeve Study (SM-BOSS), a 2-group randomized trial, was conducted from January 2007 until November 2011 (last follow-up in March 2017). Of 3971 morbidly obese patients evaluated for bariatric surgery at 4 Swiss bariatric centers, 217 patients were enrolled and randomly assigned to sleeve gastrectomy or Roux-en-Y gastric bypass with a 5-year follow-up period. Interventions
Association of Bariatric Surgery vs Medical Obesity Treatment With Long-term Medical Complications and Obesity-Related Comorbidities. Importance: The association of bariatric surgery and specialized medical obesity treatment with beneficial and detrimental outcomes remains uncertain. Objective: To compare changes in obesity-related comorbidities in patients with severe obesity (body mass index ≥40 or ≥35 and at least 1 comorbidity) undergoing bariatric surgery or specialized medical treatment (...) . Design, Setting, and Participants: Cohort study with baseline data of exposures from November 2005 through July 2010 and follow-up data from 2006 until death or through December 2015 at a tertiary care outpatient center, Vestfold Hospital Trust, Norway. Consecutive treatment-seeking adult patients (n = 2109) with severe obesity assessed (221 patients excluded and 1888 patients included). Exposures: Bariatric surgery (n = 932, 92% gastric bypass) or specialized medical treatment (n = 956) including