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Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. Misoprostol is effective for ulcers associated with the use of nonsteroidal antiinflammatory drugs (NSAIDs) but is often poorly tolerated because of diarrhea and abdominal pain. We compared the efficacy of omeprazole and misoprostol in healing and preventing ulcers associated with NSAIDs.In a double-blind (...) study, we randomly assigned 935 patients who required continuous NSAID therapy and who had ulcers or more than 10 erosions in the stomach or duodenum (or both) to receive 20 mg or 40 mg of omeprazole orally in the morning or 200 microg of misoprostol orally four times daily. Patients were treated for four weeks or, in the absence of healing, eight weeks. Treatment success was defined as the absence of ulcers and the presence of fewer than five erosions at each site and not more than mild dyspepsia
Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP NSAIDs study. Helicobacter Eradication for Lesion Prevention. The effect of Helicobacter pylori in patients receiving non-steroidal anti-inflammatory drugs (NSAIDs) is unclear. We investigated the effects of H. pylori eradication in patients with current or previous peptic ulceration, dyspepsia, or both who continued to use NSAIDs.285 patients were randomly assigned (...) omeprazole 20 mg, amoxycillin 1000 mg, and clarithromycin 500 mg, twice daily (n=142, H. pylori eradication treatment), or omeprazole with placebo antibiotics (n=143, controls) for 1 week. All patients received omeprazole 20 mg once daily for 3 weeks until endoscopy, and, if the ulcer was not healed, 40 mg once daily until repeat endoscopy at 8 weeks. Ulcer-free patients with mild dyspepsia continued NSAIDs but not antiulcer treatment. We investigated ulcers with endoscopy at 1, 3, and 6 months
1998LancetControlled trial quality: predicted high
Meta-analysis of risk of gastrointestinal complications with NSAIDs. Authors should not have included data from one study. 9040415 1997 03 31 2008 11 20 0959-8138 314 7078 1997 Feb 08 BMJ (Clinical research ed.) BMJ Meta-analysis of risk of gastrointestinal complications with NSAIDs. Authors should not have included data from one study. 445 Henry D D eng Comment Letter England BMJ 8900488 0959-8138 0 Anti-Inflammatory Agents, Non-Steroidal AIM IM BMJ. 1996 Jun 22;312(7046):1563-6 8664664 Anti
Meta-analysis of risk of gastrointestinal complications with NSAIDs. Narrative review should have been used. 9040416 1997 03 31 2008 11 20 0959-8138 314 7078 1997 Feb 08 BMJ (Clinical research ed.) BMJ Meta-analysis of risk of gastrointestinal complications with NSAIDs. Narrative review should have been used. 445-6 Kaufman D W DW Shapiro S S eng Comment Letter England BMJ 8900488 0959-8138 0 Anti-Inflammatory Agents, Non-Steroidal AIM IM BMJ. 1996 Jun 22;312(7046):1563-6 8664664 BMJ. 1997 Jun
[Cost-effectiveness of misoprostol administration in the prevention of NSAID-induced gastric ulcer] Die Kosten-Effektivitat der Misoprostoltherapie in der Pravention NSAR-induzierter Magenulzera [Cost-effectiveness of misoprostol administration in the prevention of NSAID-induced gastric ulcer] Die Kosten-Effektivitat der Misoprostoltherapie in der Pravention NSAR-induzierter Magenulzera [Cost-effectiveness of misoprostol administration in the prevention of NSAID-induced gastric ulcer] Schwarz B (...) Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The administration of misoprostol, a prostaglandin E analog, to patients already taking non-steroidal anti-inflammatory drugs (NSAID) in order to prevent the incidence of gastric
The efficacy of non-steroidal anti-inflammatory drugs (NSAIDS) for shoulder complaints: a systematic review The efficacy of non-steroidal anti-inflammatory drugs (NSAIDS) for shoulder complaints: a systematic review The efficacy of non-steroidal anti-inflammatory drugs (NSAIDS) for shoulder complaints: a systematic review van der Windt D A, van der Heijden G J, Scholten R J, Koes B W, Bouter L M Authors' objectives To examine the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs (...) designs of evaluations included in the review Randomised controlled trials (RCTs) were included. Specific interventions included in the review NSAIDs, either compared to placebo or to other treatment modalities, or to another NSAID. A variety of drugs were studied including naproxen, diclofenac and flurbiprofen. Participants included in the review At least 90% of the study population had to be patients with intrinsic shoulder complaints which included bursitis, tendinitis, periarthritis and capsulitis
Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. A double-blind, placebo-controlled study was carried out to see whether the synthetic E prostaglandin, misoprostol, would prevent gastric ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs). 420 patients with osteoarthritis and NSAID-associated abdominal pain were studied; they were receiving ibuprofen, piroxicam, or naproxen. Endoscopy was done at entry and after 1, 2 (...) , and 3 months of continuous treatment with 100 micrograms or 200 micrograms misoprostol or placebo, given four times daily with meals and at bedtime, concurrently with the NSAID. Abdominal pain was rated independently by patients and physicians. A treatment failure was defined as development of a gastric ulcer. Gastric ulcers (0.3 cm in diameter or greater) occurred less frequently (p less than 0.001) in both misoprostol treatment groups (5.6% 100 micrograms and 1.4% 200 micrograms) than