Latest & greatest articles for nsaids

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Top results for nsaids

101. Blood pressure destabilization and related healthcare utilization among hypertensive patients using nonspecific NSAIDs and COX-2-specific inhibitors

Blood pressure destabilization and related healthcare utilization among hypertensive patients using nonspecific NSAIDs and COX-2-specific inhibitors Blood pressure destabilization and related healthcare utilization among hypertensive patients using nonspecific NSAIDs and COX-2-specific inhibitors Blood pressure destabilization and related healthcare utilization among hypertensive patients using nonspecific NSAIDs and COX-2-specific inhibitors Zhao S Z, Burke T A, Whelton A, von Allmen H (...) , Henderson S C Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The authors compared patients treated with celecoxib, rofecoxib, ibuprofen, diclofenac, or naproxen. The latter three treatments are nonsteroidal anti-inflammatory drugs

NHS Economic Evaluation Database.2002

102. Role of initial NSAID choice and patient risk factors in the prevention of NSAID gastropathy: a decision analysis

Role of initial NSAID choice and patient risk factors in the prevention of NSAID gastropathy: a decision analysis Role of initial NSAID choice and patient risk factors in the prevention of NSAID gastropathy: a decision analysis Role of initial NSAID choice and patient risk factors in the prevention of NSAID gastropathy: a decision analysis Fendrick A M, Bandekar R R, Chernew M E, Scheiman J M Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of NSAID gastropathy. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The hypothetical population comprised long-term users of NSAIDs without risk factors

NHS Economic Evaluation Database.2002

103. Non-steroidal anti-inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults.

Non-steroidal anti-inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults. BACKGROUND: Lateral elbow pain, or tennis elbow, is a common condition causing pain in the elbow and forearm and lack of strength and function of the elbow and wrist. It is often treated with non-steroidal anti-inflammatory drugs (NSAIDs), either orally or by topical application. OBJECTIVES: To assess effectiveness of NSAIDs (oral or topical) in the treatment of adults with lateral elbow pain with respect (...) to symptom (pain) reduction, improvement in function, grip strength and adverse effects. SEARCH STRATEGY: We searched the Musculoskeletal Review Group's trials register database, the Cochrane Clinical Trials Register (Cochrane Library issue 2, 2001), MEDLINE, CINAHL, EMBASE and SCISEARCH up to June 2001. SELECTION CRITERIA: Randomised and pseudo randomised trials in all languages of NSAIDs (oral or topical) compared to placebo or another intervention, or comparing two NSAIDs (oral or topical) to each

Cochrane2002

104. Helicobacter pylori screening for individuals requiring chronic NSAID therapy: a decision analysis

Helicobacter pylori screening for individuals requiring chronic NSAID therapy: a decision analysis Helicobacter pylori screening for individuals requiring chronic NSAID therapy: a decision analysis Helicobacter pylori screening for individuals requiring chronic NSAID therapy: a decision analysis Scheiman J M, Bandekar R R, Chernew M E, Fendrick A M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief (...) summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of Helicobacter pylori (Hp) screening for chronic users of non-steroidal anti-inflammatory drugs (NSAIDs). Type of intervention Screening. Economic study type Cost-effectiveness analysis. Study population The study population included all NSAID users at an average risk of peptic ulcer disease. More detailed characteristics

NHS Economic Evaluation Database.2001

105. Incremental cost-effectiveness analysis comparing rofecoxib with nonselective NSAIDs in osteoarthritis: Ontario Ministry of Health perspective

Incremental cost-effectiveness analysis comparing rofecoxib with nonselective NSAIDs in osteoarthritis: Ontario Ministry of Health perspective Incremental cost-effectiveness analysis comparing rofecoxib with nonselective NSAIDs in osteoarthritis: Ontario Ministry of Health perspective Incremental cost-effectiveness analysis comparing rofecoxib with nonselective NSAIDs in osteoarthritis: Ontario Ministry of Health perspective Marshall J K, Pellissier J M, Attard C L, Kong S X, Marentette M (...) published over a number of years. The price year was 1999. Source of effectiveness data The effectiveness evidence came from a review of the literature and authors' assumptions. Modelling A decision tree model was constructed to compare the costs and benefits of the two alternative treatments reflecting practice in the Canadian setting. The model referred to a hypothetical cohort of patients with OA who were treated with either rofecoxib or NSAIDs over a period of one year. Patients could develop GI

NHS Economic Evaluation Database.2001

106. Local infiltration with NSAIDs for postoperative analgesia: evidence for a peripheral analgesic action

Local infiltration with NSAIDs for postoperative analgesia: evidence for a peripheral analgesic action Local infiltration with NSAIDs for postoperative analgesia: evidence for a peripheral analgesic action Local infiltration with NSAIDs for postoperative analgesia: evidence for a peripheral analgesic action Romsing J, Moiniche S, Ostergaard D, Dahl JB Authors' objectives To investigate the evidence for a peripheral analgesic effect of local infiltration with non-steroidal anti-inflammatory (...) drugs (NSAIDs) in post-operative pain. Searching MEDLINE was searched from 1966 to September 1999, EMBASE from 1989 to August 1999, and the Cochrane library in 1999, using the search terms 'NSAID', 'non-steroidal anti-inflammatory drug', individual drug names, 'postoperative pain', 'local infiltration', 'intra-articular', 'regional' and 'surgical site'. There were no restrictions on publication language. Additional studies were identified from the references lists of retrieved reports. Abstracts

DARE.2000

107. Quantitative estimation of rare adverse events which follow a biological progression: a new model applied to chronic NSAID use

Quantitative estimation of rare adverse events which follow a biological progression: a new model applied to chronic NSAID use Quantitative estimation of rare adverse events which follow a biological progression: a new model applied to chronic NSAID use Quantitative estimation of rare adverse events which follow a biological progression: a new model applied to chronic NSAID use Tramer M R, Moore R A, Reynolds D J, McQuay H J Authors' objectives To estimate the incidence of death from (...) gastroduodenal complications with chronic use of non-steroidal anti-inflammatory drugs (NSAIDs). Searching MEDLINE and EMBASE (up to December 1996) were searched for articles published in any language, using the following free text terms either alone or in combination: 'non-steroidal anti-inflammatory drug', 'aspirin', 'ulcer', 'bleeding', 'haemorrhage', 'perforation' and 'death'. Additional studies were identified by handsearching reference lists from retrieved reports, review articles on NSAIDs, relevant

DARE.2000

108. Prevention of chronic NSAID induced upper gastrointestinal toxicity.

Prevention of chronic NSAID induced upper gastrointestinal toxicity. BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are important agents in the management of arthritic and inflammatory conditions, and are among the most frequently prescribed medications in North America and Europe. However, there is overwhelming evidence linking these agents to a variety of gastrointestinal (GI) toxicities. OBJECTIVES: To review the effectiveness of common interventions for the prevention of NSAID (...) : Randomized controlled clinical trials (RCTs) of prostaglandin analogues (PA), H2-receptor antagonists (H2RA) or proton pump inhibitors (PPI) for the prevention of chronic NSAID induced upper GI toxicity were included. DATA COLLECTION AND ANALYSIS: Two independent reviewers extracted data regarding population characteristics, study design, methodological quality and number of patients with endoscopic ulcers, ulcer complications, symptoms, overall drop-outs, drop outs due to symptoms. Dichotomous data

Cochrane2000

109. Prevention of NSAID-induced gastroduodenal ulcers.

Prevention of NSAID-induced gastroduodenal ulcers. BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are important agents in the management of arthritic and inflammatory conditions, and are among the most frequently prescribed medications in North America and Europe. However, there is overwhelming evidence linking these agents to a variety of gastrointestinal (GI) toxicities. OBJECTIVES: To review the effectiveness of common interventions for the prevention of NSAID induced upper GI (...) controlled clinical trials (RCTs) of prostaglandin analogues (PA), H2-receptor antagonists (H2RA) or proton pump inhibitors (PPI) for the prevention of chronic NSAID induced upper GI toxicity were included. DATA COLLECTION AND ANALYSIS: Two independent reviewers extracted data regarding population characteristics, study design, methodological quality and number of patients with endoscopic ulcers, ulcer complications, symptoms, overall drop-outs, drop outs due to symptoms. Dichotomous data was pooled

Cochrane2000

110. Choice of NSAID and management strategy in rheumatoid arthritis and osteoarthritis: the impact on costs and outcomes in the UK

Choice of NSAID and management strategy in rheumatoid arthritis and osteoarthritis: the impact on costs and outcomes in the UK Choice of NSAID and management strategy in rheumatoid arthritis and osteoarthritis: the impact on costs and outcomes in the UK Choice of NSAID and management strategy in rheumatoid arthritis and osteoarthritis: the impact on costs and outcomes in the UK McCabe C J, Akehurst R L, Kirsch J, Whitfield M, Backhouse M, Woolf A D, Scott D L, Emery P, Haslock I Record Status (...) This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Non-steroidal anti-inflammatory drugs (NSAIDs) for the management of rheumatoid arthritis and osteoarthritis: nabumetone (between 1,000 and 2,000 mg per day), diclofenac (100-200 mg per day), ibuprofen (1,200

NHS Economic Evaluation Database.1998

111. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group.

A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group. 9494148 1998 03 12 1998 03 12 2013 11 21 0028-4793 338 11 1998 Mar 12 The New England journal of medicine N. Engl. J. Med. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus (...) Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group. 719-26 Suppressing acid secretion is thought o reduce the risk of ulcers associated with regular use of nonsteroidal antiinflammatory drugs (NSAIDs), but the best means of accomplishing this is uncertain. We studied 541 patients who required continuous treatment with NSAIDs and who had ulcers or more than 10 erosions in either the stomach or duodenum. Patients were randomly assigned to double-blind treatment with omeprazole, 20 mg

NEJM1998

112. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group.

Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. 9494149 1998 03 12 1998 03 12 2013 11 21 0028-4793 338 11 1998 Mar 12 The New England journal of medicine N. Engl. J. Med. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group (...) . 727-34 Misoprostol is effective for ulcers associated with the use of nonsteroidal antiinflammatory drugs (NSAIDs) but is often poorly tolerated because of diarrhea and abdominal pain. We compared the efficacy of omeprazole and misoprostol in healing and preventing ulcers associated with NSAIDs. In a double-blind study, we randomly assigned 935 patients who required continuous NSAID therapy and who had ulcers or more than 10 erosions in the stomach or duodenum (or both) to receive 20 mg or 40 mg

NEJM1998

113. Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP NSAIDs study. Helicobacter Eradication for Lesion Prevention.

Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP NSAIDs study. Helicobacter Eradication for Lesion Prevention. 9759744 1998 10 15 1998 10 15 2015 06 16 0140-6736 352 9133 1998 Sep 26 Lancet (London, England) Lancet Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP NSAIDs study. Helicobacter Eradication for Lesion Prevention. 1016-21 The effect (...) of Helicobacter pylori in patients receiving non-steroidal anti-inflammatory drugs (NSAIDs) is unclear. We investigated the effects of H. pylori eradication in patients with current or previous peptic ulceration, dyspepsia, or both who continued to use NSAIDs. 285 patients were randomly assigned omeprazole 20 mg, amoxycillin 1000 mg, and clarithromycin 500 mg, twice daily (n=142, H. pylori eradication treatment), or omeprazole with placebo antibiotics (n=143, controls) for 1 week. All patients received

Lancet1998

114. The efficacy of non-steroidal anti-inflammatory drugs (NSAIDS) for shoulder complaints: a systematic review

The efficacy of non-steroidal anti-inflammatory drugs (NSAIDS) for shoulder complaints: a systematic review The efficacy of non-steroidal anti-inflammatory drugs (NSAIDS) for shoulder complaints: a systematic review The efficacy of non-steroidal anti-inflammatory drugs (NSAIDS) for shoulder complaints: a systematic review van der Windt D A, van der Heijden G J, Scholten R J, Koes B W, Bouter L M Authors' objectives To examine the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) for (...) designs of evaluations included in the review Randomised controlled trials (RCTs) were included. Specific interventions included in the review NSAIDs, either compared to placebo or to other treatment modalities, or to another NSAID. A variety of drugs were studied including naproxen, diclofenac and flurbiprofen. Participants included in the review At least 90% of the study population had to be patients with intrinsic shoulder complaints which included bursitis, tendinitis, periarthritis and capsulitis

DARE.1995

115. [Cost-effectiveness of misoprostol administration in the prevention of NSAID-induced gastric ulcer]

[Cost-effectiveness of misoprostol administration in the prevention of NSAID-induced gastric ulcer] Die Kosten-Effektivitat der Misoprostoltherapie in der Pravention NSAR-induzierter Magenulzera [Cost-effectiveness of misoprostol administration in the prevention of NSAID-induced gastric ulcer] Die Kosten-Effektivitat der Misoprostoltherapie in der Pravention NSAR-induzierter Magenulzera [Cost-effectiveness of misoprostol administration in the prevention of NSAID-induced gastric ulcer] Schwarz B (...) Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The administration of misoprostol, a prostaglandin E analog, to patients already taking non-steroidal anti-inflammatory drugs (NSAID) in order to prevent the incidence of gastric

NHS Economic Evaluation Database.1995

116. Duodenal and gastric ulcer prevention with misoprostol in arthritis patients taking NSAIDs. Misoprostol Study Group.

Duodenal and gastric ulcer prevention with misoprostol in arthritis patients taking NSAIDs. Misoprostol Study Group. Duodenal and gastric ulcer preven... preview & related info | Mendeley E-mail address Password ( ) Remember me …or sign in with Search Main Navigation › Short URL Annals of Internal Medicine ( 1993 ) Volume: 119 , Issue: 4 , Pages: 257-262 PubMed: Available from or Find this paper at: Abstract OBJECTIVES: To determine the efficacy of misoprostol for the prevention (...) of nonsteroidal anti-inflammatory drug (NSAID)-induced duodenal and gastric ulcers in arthritis patients receiving NSAID therapy. DESIGN: A randomized, double-blind, multicenter, placebo-controlled trial. SETTING: Six hundred thirty-eight private, Veterans Affairs, health maintenance, and academic practices. PATIENTS: Six hundred thirty-eight patients with chronic inflammatory or noninflammatory arthritis who were taking an NSAID but who did not have a gastric or duodenal ulcer on screening endoscopy received treatment

Annals of Internal Medicine1993

117. Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial.

Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. 2904006 1988 12 30 1988 12 30 2015 06 16 0140-6736 2 8623 1988 Dec 03 Lancet (London, England) Lancet Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. 1277-80 A double-blind, placebo-controlled study was carried out to see whether the synthetic E prostaglandin, misoprostol, would prevent gastric ulcer induced by non (...) -steroidal anti-inflammatory drugs (NSAIDs). 420 patients with osteoarthritis and NSAID-associated abdominal pain were studied; they were receiving ibuprofen, piroxicam, or naproxen. Endoscopy was done at entry and after 1, 2, and 3 months of continuous treatment with 100 micrograms or 200 micrograms misoprostol or placebo, given four times daily with meals and at bedtime, concurrently with the NSAID. Abdominal pain was rated independently by patients and physicians. A treatment failure was defined

Lancet1988