Latest & greatest articles for nsaids

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Top results for nsaids

81. Risk of serious NSAID-related gastrointestinal events during long-term exposure: a systematic review

Risk of serious NSAID-related gastrointestinal events during long-term exposure: a systematic review Risk of serious NSAID-related gastrointestinal events during long-term exposure: a systematic review Risk of serious NSAID-related gastrointestinal events during long-term exposure: a systematic review Schaffer D, Florin T, Eagle C, Marschner I, Singh G, Grobler M, Fenn C, Schou M, Curnow K M CRD summary This review investigated whether the occurrence of serious gastrointestinal events decrease (...) over time in studies of long-term use of non-steroidal anti-inflammatory drugs (NSAIDs). The authors found that the probability of having a serious NSAID-related ulcer bleed, perforation or hospitalisation did not meaningfully decline over time. The use of meta-regression with few studies implies cautious interpretation of these results. Authors' objectives To assess whether the occurrence of serious gastrointestinal (GI) events reduces over time in studies of long-term use of non-steroidal anti

DARE.2006

82. NSAID-analgesia, pain control and morbidity in cardiothoracic surgery

NSAID-analgesia, pain control and morbidity in cardiothoracic surgery NSAID-analgesia, pain control and morbidity in cardiothoracic surgery NSAID-analgesia, pain control and morbidity in cardiothoracic surgery Bainbridge D, Cheng D C, Martin J E, Novick R CRD summary This review assessed the effects of non-steroidal anti-inflammatory drugs (NSAIDs) combined with narcotic or regional analgesia in patients undergoing cardiothoracic surgery. It concluded that NSAID use reduced pain and narcotic (...) consumption, but that there were no significant differences in side-effects and hospital length of stay. The conclusions of this well-conducted review appear reliable. Authors' objectives To assess whether non-steroidal anti-inflammatory drugs (NSAIDs), adjunctive to either opioid or regional analgesia, can reduce post-operative pain, narcotic requirements, morbidity and resource utilisation in patients undergoing cardiothoracic surgery. Searching MEDLINE, the Cochrane CENTRAL Register, EMBASE, DARE, NEED

DARE.2006

83. A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience

A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience Goldkind L, Laine L CRD summary The authors concluded that there were limited safety data from controlled clinical trials (...) about the withdrawn non-steroidal anti-inflammatory drugs bromfenac, benoxaprofen and ibufenac. The authors' conclusions about such limited data appear to be supported by the evidence presented, but poor reporting means it is not possible to assess the reliability of these conclusions. Authors' objectives To evaluate clinical trial data on the hepatotoxicity of three non-steroidal anti-inflammatory drugs (NSAIDs) that have been withdrawn from the market due to hepatotoxicity: bromfenac, benoxaprofen

DARE.2006

84. Coxibs versus combination NSAID and PPI therapy for chronic pain: an exploration of the risks, benefits, and costs

Coxibs versus combination NSAID and PPI therapy for chronic pain: an exploration of the risks, benefits, and costs Coxibs versus combination NSAID and PPI therapy for chronic pain: an exploration of the risks, benefits, and costs Coxibs versus combination NSAID and PPI therapy for chronic pain: an exploration of the risks, benefits, and costs Hur C, Chan A T, Tramontano A C, Gazelle G S CRD summary This review compared cyclooxygenase-2 inhibitors (coxibs) with non-selective non-steroidal anti (...) -selective non-steroidal anti-inflammatory drugs (NSAIDs) and proton-pump inhibitor (PPI) therapy for chronic musculoskeletal pain. Searching MEDLINE (1985 to November 2005) and the Cochrane Library were searched for relevant studies published in the English language; the search terms were reported. References lists were screened for further articles of interest. Study selection Study designs of evaluations included in the review Clinical trials were eligible for inclusion in the review. Specific

DARE.2006

87. Review: selective COX 2 inhibitors increase vascular events more than placebo and naproxen but not more than other NSAIDs

Review: selective COX 2 inhibitors increase vascular events more than placebo and naproxen but not more than other NSAIDs Review: selective COX 2 inhibitors increase vascular events more than placebo and naproxen but not more than other NSAIDs | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user (...) name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: selective COX 2 inhibitors increase vascular events more than placebo and naproxen but not more than other NSAIDs Article Text Therapeutics Review: selective COX 2 inhibitors increase vascular events more than placebo and naproxen but not more than other

Evidence-Based Medicine (Requires free registration)2006

88. Review: paracetamol reduces pain in osteoarthritis but is less effective than NSAIDs

Review: paracetamol reduces pain in osteoarthritis but is less effective than NSAIDs Review: paracetamol reduces pain in osteoarthritis but is less effective than NSAIDs | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search (...) for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: paracetamol reduces pain in osteoarthritis but is less effective than NSAIDs Article Text Treatment Review: paracetamol reduces pain in osteoarthritis but is less effective than NSAIDs Free Cathy R Kessenich , RN, DSN, ARNP Statistics from Altmetric.com No Altmetric data available

Evidence-Based Mental Health2006

89. Review: topical NSAIDs reduce pain in osteoarthritis only during the first 2 weeks of use

Review: topical NSAIDs reduce pain in osteoarthritis only during the first 2 weeks of use Review: topical NSAIDs reduce pain in osteoarthritis only during the first 2 weeks of use | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword (...) Search for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: topical NSAIDs reduce pain in osteoarthritis only during the first 2 weeks of use Article Text Treatment Review: topical NSAIDs reduce pain in osteoarthritis only during the first 2 weeks of use Free Cathy R Kessenich , RN, DSN, ARNP Statistics from Altmetric.com No Altmetric

Evidence-Based Mental Health2006

90. NSAIDS or paracetamol, alone or combined with opioids, for cancer pain.

NSAIDS or paracetamol, alone or combined with opioids, for cancer pain. BACKGROUND: NSAIDs are widely applied to treat cancer pain and are frequently combined with opioids in combination preparations for this purpose. However, it is unclear which agent is most clinically efficacious for relieving cancer-related pain, or even what may be the additional benefit of combining an NSAID with an opioid in this setting. OBJECTIVES: To assess the effects of NSAIDs, alone or combined with opioids (...) , for the treatment of cancer pain. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (Issue 2, 2002), MEDLINE (January 1966 to March 2003), EMBASE (January 1980 to December 2001), LILACS (January 1984 to December 2001) and reference list of articles. SELECTION CRITERIA: Randomized controlled trials and controlled clinical trials that compared NSAID versus placebo; NSAID versus NSAID; NSAID versus NSAID plus opioid; opioid versus opioid plus NSAID; or NSAID versus opioid. DATA

Cochrane2005

91. Meta-analysis: role of Helicobacter pylori eradication in the prevention of peptic ulcer in NSAID users

Meta-analysis: role of Helicobacter pylori eradication in the prevention of peptic ulcer in NSAID users Meta-analysis: role of Helicobacter pylori eradication in the prevention of peptic ulcer in NSAID users Meta-analysis: role of Helicobacter pylori eradication in the prevention of peptic ulcer in NSAID users Vergara M, Catalan M, Gisbert J P, Calvet X CRD summary This review compared Helicobacter pylori eradication with either no eradication or treatment with a proton-pump inhibitor (PPI) in (...) H. pylori-infected patients requiring non-steroidal anti-inflammatory drugs (NSAIDs). The authors concluded that eradication is more effective than no eradication, but is less effective than PPI treatment for preventing NSAID-associated ulcers. The conclusions appear generally reliable. Authors' objectives To determine whether the eradication of Helicobacter pylori (H. pylori) prevents peptic ulcer in users of non-steroidal anti-inflammatory drugs (NSAIDs). Searching MEDLINE, EMBASE

DARE.2005

92. Effect of preoperative Cox-II-selective NSAIDs (coxibs) on postoperative outcomes: a systematic review of randomized studies

Effect of preoperative Cox-II-selective NSAIDs (coxibs) on postoperative outcomes: a systematic review of randomized studies Effect of preoperative Cox-II-selective NSAIDs (coxibs) on postoperative outcomes: a systematic review of randomized studies Effect of preoperative Cox-II-selective NSAIDs (coxibs) on postoperative outcomes: a systematic review of randomized studies Straube S, Derry S, McQuay H J, Moore R A CRD summary This review evaluated the effect of pre-operative cyclooxygenase-2 (...) and economic analysis. The authors went on to state that studies need to discriminate between pre-operative coxibs alone and in combination with post-operative coxibs. Funding Pain Research; Oxford Pain Relief Trust. Bibliographic details Straube S, Derry S, McQuay H J, Moore R A. Effect of preoperative Cox-II-selective NSAIDs (coxibs) on postoperative outcomes: a systematic review of randomized studies. Acta Anaesthesiologica Scandinavica 2005; 49(5): 601-613 PubMedID DOI Indexing Status Subject indexing

DARE.2005

93. Cost-effectiveness analysis of NSAIDs, NSAIDs with concomitant therapy to prevent gastrointestinal toxicity, and COX-2 specific inhibitors in the treatment of rheumatoid arthritis

Cost-effectiveness analysis of NSAIDs, NSAIDs with concomitant therapy to prevent gastrointestinal toxicity, and COX-2 specific inhibitors in the treatment of rheumatoid arthritis Cost-effectiveness analysis of NSAIDs, NSAIDs with concomitant therapy to prevent gastrointestinal toxicity, and COX-2 specific inhibitors in the treatment of rheumatoid arthritis Cost-effectiveness analysis of NSAIDs, NSAIDs with concomitant therapy to prevent gastrointestinal toxicity, and COX-2 specific inhibitors (...) in the treatment of rheumatoid arthritis Yun H R, Bae S C Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study examined the use of non-steroidal anti-inflammatory agents (NSAIDs) with and without concomitant therapy to prevent

NHS Economic Evaluation Database.2005

94. Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of osteoarthritis and rheumatoid arthritis patients in the UK

Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of osteoarthritis and rheumatoid arthritis patients in the UK Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of osteoarthritis and rheumatoid arthritis patients in the UK Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of osteoarthritis and rheumatoid arthritis patients in the UK Moore A, Phillips C, Hunsche E, Pellissier J, Crespi S Record Status (...) was derived from a synthesis of completed studies. Modelling A decision tree model was used to assess the expected costs and consequences of ETO, compared with different options of non-selective NSAIDs, in a hypothetical cohort of 10,000 patients. GI events, major (clinically evident gastroduodenal perforations, symptomatic gastroduodenal ulcers or upper GI bleeding) and minor (those that could lead to treatment), were calculated and entered into the model to derive the total costs associated with each

NHS Economic Evaluation Database.2004

95. Nonsteroidal anti-inflammatory drugs (NSAIDs) versus opioids for acute renal colic.

Nonsteroidal anti-inflammatory drugs (NSAIDs) versus opioids for acute renal colic. BACKGROUND: Renal colic is a common cause of acute severe pain. Both opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are recommended for treatment, but the relative efficacy of these drugs is uncertain. OBJECTIVES: To examine the benefits and disadvantages of NSAIDs and opioids for the management of pain in acute renal colic. SEARCH STRATEGY: We searched the Cochrane Renal Group's specialised register (...) (May 2003), the Cochrane Central Register of Randomised Controlled Trials (CENTRAL - The Cochrane Library issue 2, 2003), MEDLINE (1966 - 31 January 2003), EMBASE (1980 - 31 January 2003) and handsearched reference lists of retrieved articles. SELECTION CRITERIA: Randomised controlled trials (RCTs) comparing any opioid with any NSAID, regardless of dose or route of administration were included. DATA COLLECTION AND ANALYSIS: Data was extracted and quality assessed independently by two reviewers

Cochrane2004

96. Non steroidal anti-inflammatory drugs (NSAID) and Aspirin for preventing colorectal adenomas and carcinomas.

Non steroidal anti-inflammatory drugs (NSAID) and Aspirin for preventing colorectal adenomas and carcinomas. BACKGROUND: There is evidence from experimental animals studies, prospective and retrospective observational studies that nonsteroidal anti-inflammatory drugs (NSAIDS) may reduce the development of sporadic colorectal adenomas (CRAs) and cancer (CRC) and may induce the regression of adenomas in familial adenomatous polyposis (FAP). OBJECTIVES: To conduct a systematic review to determine (...) the effect of NSAIDS for the prevention or regression of CRAs and CRC. SEARCH STRATEGY: Randomized controlled trials (RCTs) up to September 2003 were identified. SELECTION CRITERIA: NSAIDS and aspirin (ASA) were the interventions. The primary outcomes were the number of subjects with at least one CRA, the change in polyp burden, and CRC. The secondary outcome was adverse events. DATA COLLECTION AND ANALYSIS: Two reviewers independently extracted data and assessed trial quality. Dichotomous outcomes were

Cochrane2004

97. Epidemiology overview of gastrointestinal and renal toxicity of NSAIDs

Epidemiology overview of gastrointestinal and renal toxicity of NSAIDs Epidemiology overview of gastrointestinal and renal toxicity of NSAIDs Epidemiology overview of gastrointestinal and renal toxicity of NSAIDs Henry D, McGettigan P CRD summary This review assessed the risk of serious gastrointestinal complications with non-steroidal anti-inflammatory drugs (NSAIDs). The authors concluded that, at low doses, the risk is lower with ibuprofen than with other NSAIDs. Wide variation in (...) the estimate of risk between different studies of the same drugs, which the authors were unable to explain, casts doubt on the reliability of the conclusion. Authors' objectives The objectives were three-fold: to update previous systematic reviews; to determine the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on the risk of serious gastrointestinal complications; and to examine the place of drug dose in explaining the variation in this risk. Searching MEDLINE, EMBASE, the Cochrane Library

DARE.2003

98. Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review

Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review Hyllested M, Jones S, Pedersen J L, Kehlet H Authors' objectives To compare the safety and efficacy of paracetamol, non-steroidal anti (...) -inflammatory drugs (NSAIDs), and their combinations in post-operative pain management. Searching MEDLINE (from 1966 to January 2001) and the Cochrane Library (January 2001) were searched for articles published in full in the English language. The search strategy used pain terms combined with the keywords 'paracetamol', 'acetaminophen', 'proparacetamol', 'non-steroidal anti-inflammatory drugs (NSAID)', or individual drug names. The reference lists from identified studies were also examined. Study selection

DARE.2002

99. Blood pressure destabilization and related healthcare utilization among hypertensive patients using nonspecific NSAIDs and COX-2-specific inhibitors

Blood pressure destabilization and related healthcare utilization among hypertensive patients using nonspecific NSAIDs and COX-2-specific inhibitors Blood pressure destabilization and related healthcare utilization among hypertensive patients using nonspecific NSAIDs and COX-2-specific inhibitors Blood pressure destabilization and related healthcare utilization among hypertensive patients using nonspecific NSAIDs and COX-2-specific inhibitors Zhao S Z, Burke T A, Whelton A, von Allmen H (...) , Henderson S C Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The authors compared patients treated with celecoxib, rofecoxib, ibuprofen, diclofenac, or naproxen. The latter three treatments are nonsteroidal anti-inflammatory drugs

NHS Economic Evaluation Database.2002

100. Role of initial NSAID choice and patient risk factors in the prevention of NSAID gastropathy: a decision analysis

Role of initial NSAID choice and patient risk factors in the prevention of NSAID gastropathy: a decision analysis Role of initial NSAID choice and patient risk factors in the prevention of NSAID gastropathy: a decision analysis Role of initial NSAID choice and patient risk factors in the prevention of NSAID gastropathy: a decision analysis Fendrick A M, Bandekar R R, Chernew M E, Scheiman J M Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of NSAID gastropathy. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The hypothetical population comprised long-term users of NSAIDs without risk factors

NHS Economic Evaluation Database.2002