Latest & greatest articles for nsaids

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Top results for nsaids

21. Nonsteroidal anti-inflammatory drugs(NSAIDs) alone or in combination with opioids for the treatment of acute renal colic

Nonsteroidal anti-inflammatory drugs(NSAIDs) alone or in combination with opioids for the treatment of acute renal colic Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence

2018 PROSPERO

22. NSAIDs alone or in combination with other modalities for prevention of post-ERCP pancreatitis: an updated systematic review and meta-analysis

NSAIDs alone or in combination with other modalities for prevention of post-ERCP pancreatitis: an updated systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2018 PROSPERO

23. Comparison of the effect of exercise therapy, non-steroidal anti-inflammatory drugs (NSAIDs), and opioids on knee osteoarthritis pain: a network meta-analysis

Comparison of the effect of exercise therapy, non-steroidal anti-inflammatory drugs (NSAIDs), and opioids on knee osteoarthritis pain: a network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr

2018 PROSPERO

24. In adult patients with common cold, is Ma-Xing-Gan-Shi-Tang effective rather than nonsteroidal anti-inflammatory drugs (NSAIDs) and antibiotic treatment or non-treatment in resolving respiratory symptoms?

In adult patients with common cold, is Ma-Xing-Gan-Shi-Tang effective rather than nonsteroidal anti-inflammatory drugs (NSAIDs) and antibiotic treatment or non-treatment in resolving respiratory symptoms? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files

2018 PROSPERO

25. Paracetamol, NSAIDS and opioid analgesics for chronic low back pain: a network meta-analysis [Cochrane protocol]

Paracetamol, NSAIDS and opioid analgesics for chronic low back pain: a network meta-analysis [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence

2018 PROSPERO

26. Efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) and cytokine inhibitors in depression: a systematic review and network meta-analysis

Efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) and cytokine inhibitors in depression: a systematic review and network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2018 PROSPERO

27. Perioperative use of non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids and the risk of anastomotic leakage (AL) in colorectal surgery for malignant or benign disease

Perioperative use of non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids and the risk of anastomotic leakage (AL) in colorectal surgery for malignant or benign disease Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2018 PROSPERO

28. Perioperative Use of NSAIDs: Safety and Guidelines

Perioperative Use of NSAIDs: Safety and Guidelines Perioperative Use of NSAIDs: Safety and Guidelines | CADTH.ca Find the information you need Perioperative Use of NSAIDs: Safety and Guidelines Perioperative Use of NSAIDs: Safety and Guidelines Last updated: April 5, 2018 Project Number: RB1205-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical evidence regarding the safety and harms of the perioperative use of nonsteroidal (...) anti-inflammatory drugs (NSAIDs)? What are the evidence-based guidelines regarding the perioperative use of NSAIDs? Key Message Eight systematic reviews (six with meta-analyses), six randomized controlled trials, 21 non-randomized studies, and three evidence-based guidelines were identified regarding the perioperative use of NSAIDs. Files Rapid Response Summary of Abstracts Published : April 5, 2018 Related Content Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

29. Vonoprazan prevents ulcer recurrence during long-term NSAID therapy: randomised, lansoprazole-controlled non-inferiority and single-blind extension study Full Text available with Trip Pro

Vonoprazan prevents ulcer recurrence during long-term NSAID therapy: randomised, lansoprazole-controlled non-inferiority and single-blind extension study To assess the non-inferiority of vonoprazan to lansoprazole for secondary prevention of non-steroidal anti-inflammatory drug (NSAID)-induced peptic ulcer (PU) and the safety of vonoprazan during extended use.A phase 3, 24-week, multicenter, randomised, double-blind (DB), active-controlled study, followed by a phase 3, ≥28 week, multicenter (...) , single-blind, parallel-group extension study (EXT) in outpatients (n=642) receiving long-term NSAID therapy who are at risk of PU recurrence. The patients received vonoprazan (10 mg or 20 mg) or lansoprazole 15 mg once daily. For DB, non-inferiority of the proportion of patients with recurrent PU within 24 weeks was analysed by Farrington and Manning test (significance level 2.5%, non-inferiority margin 8.3%; primary endpoint), recurrent PU within 12 weeks, bleeding and time-to-event of PU (secondary

2017 EvidenceUpdates

30. Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. Full Text available with Trip Pro

Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most parts of the world. While in the past pain was largely dismissed (...) ) is a major health concern. Chronic pain (that is pain lasting three months or longer) can arise in the paediatric population in a variety of pathophysiological classifications (nociceptive, neuropathic, or idiopathic) from genetic conditions, nerve damage pain, chronic musculoskeletal pain, and chronic abdominal pain, as well as for other unknown reasons.Non-steroidal anti-inflammatory drugs (NSAIDs) are used to treat pain, reduce fever, and for their anti-inflammation properties. They are commonly used

2017 Cochrane

31. Non-steroidal anti-inflammatory drugs (NSAIDs) for cancer-related pain in children and adolescents. Full Text available with Trip Pro

Non-steroidal anti-inflammatory drugs (NSAIDs) for cancer-related pain in children and adolescents. Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization (WHO) guidelines for pharmacological treatments for persisting pain in children acknowledge that pain in children is a major public health concern of high significance in most parts of the world. Views on children's pain have changed over time (...) treatments, or mucositis. However, this review focused on pain caused directly by the tumour itself such as nerve infiltration, external nerve compression, and other inflammatory events.Non-steroidal anti-inflammatory drugs (NSAIDs) are used to treat pain, reduce fever, and for their anti-inflammatory properties. They are commonly used within paediatric pain management. NSAIDs are currently licensed for use in western countries, however not approved for infants aged under three months. Primary adverse

2017 Cochrane

32. Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults. Full Text available with Trip Pro

Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults. Pain is a common symptom with cancer, and 30% to 50% of all people with cancer will experience moderate to severe pain that can have a major negative impact on their quality of life. Non-opioid drugs are commonly used to treat cancer pain, and are recommended for this purpose in the World Health Organization (WHO) cancer pain treatment ladder, either alone or in combination with opioids.A previous Cochrane review (...) that examined the evidence for nonsteroidal anti-inflammatory drugs (NSAIDs) or paracetamol, alone or combined with opioids, for cancer pain was withdrawn in 2015 because it was out of date; the date of the last search was 2005. This review, and another on paracetamol, updates the evidence.To assess the efficacy of oral NSAIDs for cancer pain in adults, and the adverse events reported during their use in clinical trials.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE

2017 Cochrane

33. Should PPIs be routinely co-prescribed with long-term NSAIDs?

Should PPIs be routinely co-prescribed with long-term NSAIDs? Should PPIs be routinely co-prescribed with long-term NSAIDs? – Morsels of Evidence \t\t\t\r\n\t\t\t \t\t\t\r\n\t\t\t Like this: Like Loading... ","author":{"@type":"Person","name":"Michael Tam"},"image":["https:\/\/evidencebasedmedicine.com.au\/wp-content\/uploads\/2017\/07\/mo2017-7-ee-cover.png"]} Toggle search form Toggle navigation Evidence-based medicine for general practitioners Jul 03 2017 Should PPIs be routinely co (...) -prescribed with long-term NSAIDs? By in , , Journal reference: Rostom A, Dube C, Wells G, et al. Prevention of NSAID-induced gastroduodenal ulcers. Cochrane database of systematic reviews 2002(4):CD002296. Link: Published: June 2011 Evidence cookie says… Proton-pump inhibitors (PPIs) protect against the development of ulcers seen on endoscopy, in patients taking longer-term NSAIDs little data exists on clinical outcomes prophylaxis should be considered for patients at increased risk of gastrointestinal

2017 Morsels of Evidence

34. Should PPIs be routinely co-prescribed with long-term NSAIDs?

Should PPIs be routinely co-prescribed with long-term NSAIDs? Should PPIs be routinely co-prescribed with long-term NSAIDs? – Morsels of Evidence \t\t\t\r\n\t\t\t \t\t\t\r\n\t\t\t Like this: Like Loading... ","author":{"@type":"Person","name":"Michael Tam"},"image":["https:\/\/evidencebasedmedicine.com.au\/wp-content\/uploads\/2017\/07\/mo2017-7-ee-cover.png"]} Toggle search form Toggle navigation Evidence-based medicine for general practitioners Jul 03 2017 Should PPIs be routinely co (...) -prescribed with long-term NSAIDs? By in , , Journal reference: Rostom A, Dube C, Wells G, et al. Prevention of NSAID-induced gastroduodenal ulcers. Cochrane database of systematic reviews 2002(4):CD002296. Link: Published: June 2011 Evidence cookie says… Proton-pump inhibitors (PPIs) protect against the development of ulcers seen on endoscopy, in patients taking longer-term NSAIDs little data exists on clinical outcomes prophylaxis should be considered for patients at increased risk of gastrointestinal

2017 Morsels of Evidence

35. NSAIDs for Chronic Low Back Pain. (Abstract)

NSAIDs for Chronic Low Back Pain. Are nonsteroidal anti-inflammatory drugs (NSAIDs) associated with greater pain relief than placebo, other drugs, and nondrug treatments for patients with chronic low back pain?Compared with placebo, NSAIDs are associated with a small but significant improvement in pain and disability in patients with chronic low back pain, although this difference became nonsignificant when studies with high risk for bias were excluded. The associated benefits were smaller than

2017 JAMA Controlled trial quality: uncertain

36. NSAIDs as treatment for uncomplicated urinary tract infections

NSAIDs as treatment for uncomplicated urinary tract infections NSAIDs as treatment for uncomplicated urinary tract infections – Morsels of Evidence \t\t\t\r\n\t\t\t \t\t\t\r\n\t\t\t Like this: Like Loading... ","author":{"@type":"Person","name":"Michael Tam"},"image":["https:\/\/evidencebasedmedicine.com.au\/wp-content\/uploads\/2017\/06\/mo2017-5.png"]} Toggle search form Toggle navigation Evidence-based medicine for general practitioners Jun 09 2017 NSAIDs as treatment for uncomplicated (...) urinary tract infections By in , , Journal reference: Gagyor I, Bleidorn J, Kochen MM, Schmiemann G, Wegscheider K, Hummers-Pradier E. Ibuprofen versus fosfomycin for uncomplicated urinary tract infection in women: randomised controlled trial. Bmj 2015 Dec 23;351:h6544. Link: Published: December 2015 Evidence cookie says… NSAIDs should not be recommended as a first line treatment for uncomplicated UTIs in women compared with women who received empirical antibiotics, those who received regular

2017 Morsels of Evidence

37. NSAIDs as treatment for uncomplicated urinary tract infections

NSAIDs as treatment for uncomplicated urinary tract infections NSAIDs as treatment for uncomplicated urinary tract infections – Morsels of Evidence \t\t\t\r\n\t\t\t \t\t\t\r\n\t\t\t Like this: Like Loading... ","author":{"@type":"Person","name":"Michael Tam"},"image":["https:\/\/evidencebasedmedicine.com.au\/wp-content\/uploads\/2017\/06\/mo2017-5.png"]} Toggle search form Toggle navigation Evidence-based medicine for general practitioners Jun 09 2017 NSAIDs as treatment for uncomplicated (...) urinary tract infections By in , , Journal reference: Gagyor I, Bleidorn J, Kochen MM, Schmiemann G, Wegscheider K, Hummers-Pradier E. Ibuprofen versus fosfomycin for uncomplicated urinary tract infection in women: randomised controlled trial. Bmj 2015 Dec 23;351:h6544. Link: Published: December 2015 Evidence cookie says… NSAIDs should not be recommended as a first line treatment for uncomplicated UTIs in women compared with women who received empirical antibiotics, those who received regular

2017 Morsels of Evidence

38. Unborn children still exposed to NSAIDs

Unborn children still exposed to NSAIDs Prescrire IN ENGLISH - Spotlight ''In the April issue of Prescrire International: unborn children still exposed to NSAIDs'', 1 April 2017 {1} {1} {1} | | > > > In the April issue of Prescrire International: unborn children still exposed to NSAIDs Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight In the April (...) issue of Prescrire International: unborn children still exposed to NSAIDs FREE DOWNLOAD In the Adverse Effects section of the April edition: results of a French study showing that around 5% of unborn children in France are exposed to prescribed NSAIDs, including about 1% from the 6th month of pregnancy. And these numbers exclude self-medication. Authorities need to send out a stronger message: "NEVER USE NSAIDs DURING PREGNANCY". Full text available for free download. Summary A study based on data

2017 Prescrire

39. NSAIDs are Caspase Inhibitors Full Text available with Trip Pro

NSAIDs are Caspase Inhibitors Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs in the world. While the role of NSAIDs as cyclooxygenase (COX) inhibitors is well established, other targets may contribute to anti-inflammation. Here we report caspases as a new pharmacological target for NSAID family drugs such as ibuprofen, naproxen, and ketorolac at physiologic concentrations both in vitro and in vivo. We characterize caspase activity in both in vitro (...) and in cell culture, and combine computational modeling and biophysical analysis to determine the mechanism of action. We observe that inhibition of caspase catalysis reduces cell death and the generation of pro-inflammatory cytokines. Further, NSAID inhibition of caspases is COX independent, representing a new anti-inflammatory mechanism. This finding expands upon existing NSAID anti-inflammatory behaviors, with implications for patient safety and next-generation drug design.Copyright © 2017 Elsevier Ltd

2017 Cell chemical biology

40. Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses. Full Text available with Trip Pro

Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses. Non-steroidal anti-inflammatory drugs (NSAIDs), such as non-selective NSAIDs (nsNSAIDs) or selective cyclooxygenase-2 (COX-2) inhibitors, are commonly prescribed for arthritic pain relief in patients with osteoarthritis (OA), rheumatoid arthritis (RA), or ankylosing spondylitis (AS). Treatment guidelines for chronic NSAID therapy (...) include the consideration for gastroprotection for those at risk of gastric ulcers (GUs) associated with the chronic NSAID therapy. The United States Food and Drug Administration has approved naproxen/esomeprazole magnesium tablets for the relief of signs and symptoms of OA, RA, and AS, and to decrease the risk of developing GUs in patients at risk of developing NSAID-associated GUs. The European Medical Association has approved this therapy for the symptomatic treatment of OA, RA, and AS in patients

2017 Open access rheumatology : research and reviews