Latest & greatest articles for nsaids

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Top results for nsaids

1. Non-steroidal anti-inflammatory drug (NSAID) therapy in patients with hypertension, cardiovascular, renal or gastrointestinal comorbidities: joint APAGE/APLAR/APSDE/APSH/APSN/PoA recommendations

Non-steroidal anti-inflammatory drug (NSAID) therapy in patients with hypertension, cardiovascular, renal or gastrointestinal comorbidities: joint APAGE/APLAR/APSDE/APSH/APSN/PoA recommendations Non-steroidal Anti-Inflammatory Drug (NSAID) Therapy in Patients With Hypertension, Cardiovascular, Renal or Gastrointestinal Comorbidities: Joint APAGE/APLAR/APSDE/APSH/APSN/PoA Recommendations - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set (...) to Collections Create a new collection Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Gut Actions 2020 Jan 14 [Online ahead of print] Non-steroidal Anti-Inflammatory Drug (NSAID) Therapy in Patients With Hypertension, Cardiovascular, Renal

2020 EvidenceUpdates

2. Does NSAID use increase the risk for progression of CKD?

Does NSAID use increase the risk for progression of CKD? Chiefs’ Inquiry Corner – 12/23/19 – Clinical Correlations Search Chiefs’ Inquiry Corner – 12/23/19 December 23, 2019 2 min read Nonsteroidal anti-inflammatory (NSAIDs) drugs have a low, but real risk of acute kidney injury, exacerbating hypertension and contributing to electrolyte disturbances. However, the impact of NSAID use on progression of chronic kidney disease (CKD) had previously been unclear. A systematic review and meta-analysis (...) of patients with moderate to severe CKD did not find an association between NSAID use and progression of CKD. However, a subgroup analysis of patients with “high dose NSAID use” (defined as the top quintile or decile of patients included in the respective study) did have a significant association with progression of CKD. As such, NSAIDs are now thought to have a cumulative dose effect on the risk of CKD progression, and an argument can be made for the cautious use of NSAIDs in patients with CKD

2020 Clinical Correlations

3. COVID-19: NSAIDs in Acute Respiratory Infection

COVID-19: NSAIDs in Acute Respiratory Infection NSAIDs in Acute Respiratory Infection - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website NSAIDs in Acute Respiratory Infection Access Evidence Inventory Carl Heneghan, Jon Brassey Verdict: there is a need for caution when using NSAIDs in the context of acute respiratory infections (ARI). Pre-existing medications and conditions need to be taken account of when (...) deciding to prescribe NSAIDs for symptomatic ARI. The lowest effective dose should be prescribed for the shortest period of time.Parenteral use of NSAIDs during an ARI should be avoided. Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used by patients with ARI or common cold for pain and fever relief. Their use needs to be balanced with the risks and benefits. Current research evidence in coronavirus is lacking and therefore evidence from acute respiratory infections have been used to inform

2020 Oxford COVID-19 Evidence Service

4. Gliptins: joint pain and exposure to NSAIDs

Gliptins: joint pain and exposure to NSAIDs Prescrire IN ENGLISH - Spotlight ''Gliptins: joint pain and exposure to NSAIDs'', 1 November 2019 {1} {1} {1} | | > > > Gliptins: joint pain and exposure to NSAIDs Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight In the November issue of Prescrire International - Gliptins: joint pain and exposure (...) to NSAIDs FREE DOWNLOAD In the Adverse Effects section of the November issue, the results of a study by the independent French medical journal Prescrire, based on data from France's national health insurance system. Full text available for free download. Summary Joint and muscle pain are part of the adverse effect profile of gliptins. In France, Prescrire carried out a study, using data from the mandatory national health insurance system, showing that patients taking gliptins are more frequently exposed

2019 Prescrire

5. Acute gout: Oral steroids work as well as NSAIDs

Acute gout: Oral steroids work as well as NSAIDs Acute gout: Oral steroids work as well as NSAIDs Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Acute gout: Oral steroids work as well as NSAIDs View/ Open Date 2008-10 Format Metadata Abstract Use a short course of oral steroids (prednisone 30-40mg/d for 5 days (...) ) for treatment of acute gout when nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated. Steroids are also a reasonable choice as first-line treatment. Stength of recommendation: B: 2 good-quality, randomized controlled trials (RCTs). URI Part of Citation Journal of Family Practice, 57(10) 2008: 655-657. Rights OpenAccess. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. Collections hosted by hosted by

2019 PURLS

6. Comparison of intravenous NSAIDs and trigger point injection for low back pain in ED: A prospective randomized study (Abstract)

Comparison of intravenous NSAIDs and trigger point injection for low back pain in ED: A prospective randomized study Low back pain (LBP) is a common complaint originating from muscles Myofascial pain syndrome (MPS) is mainly associated with trigger points (TrP) in the muscle tissue. We compared the intravenously administered non-steroidal anti-inflammatory drug (NSAID) and trigger point injection (TPI) in the treatment of LBP patients admitted to the emergency department due to pain caused (...) by TrPs.After randomization, NSAID was administered intravenously in group 1 and TPIs were performed as specified by Travell and Simons in group 2. The TrPs were identified with the anamnesis and physical examination Demographic characteristics and vital signs of the patients were recorded. Pain scores were measured with the Visual Analogue Scale (VAS) at admission; and in minutes 5, 10, 15, 30, and 60.There were 32 patients in group 1 and 22 patients in group 2. The demographics, vital signs, and pain

2019 EvidenceUpdates

7. Acute gout: Oral steroids work as well as NSAIDs

Acute gout: Oral steroids work as well as NSAIDs Acute gout: Oral steroids work as well as NSAIDs Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Acute gout: Oral steroids work as well as NSAIDs View/ Open Date 2008-10 Format Metadata Abstract Use a short course of oral steroids (prednisone 30-40mg/d for 5 days (...) ) for treatment of acute gout when nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated. Steroids are also a reasonable choice as first-line treatment. Stength of recommendation: B: 2 good-quality, randomized controlled trials (RCTs). URI Part of Citation Journal of Family Practice, 57(10) 2008: 655-657. Rights OpenAccess. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. Collections hosted by hosted by

2019 PURLS

8. Omega-3 PUFA vs. NSAIDs for Preventing Cardiac Inflammation Full Text available with Trip Pro

Omega-3 PUFA vs. NSAIDs for Preventing Cardiac Inflammation 30406113 2018 11 14 2297-055X 5 2018 Frontiers in cardiovascular medicine Front Cardiovasc Med Omega-3 PUFA vs. NSAIDs for Preventing Cardiac Inflammation. 146 10.3389/fcvm.2018.00146 Ye Jiayu J Irving K. Barber School of Arts and Sciences (IKBSAS), Department of Biology, University of University of British Columbia, Kelowna, BC, Canada. Ghosh Sanjoy S Irving K. Barber School of Arts and Sciences (IKBSAS), Department of Biology (...) , University of University of British Columbia, Kelowna, BC, Canada. eng Journal Article 2018 10 23 Switzerland Front Cardiovasc Med 101653388 2297-055X EPA NSAIDs aspirin docosahexaenoic acid (DHA) inflammation 2018 04 26 2018 10 01 2018 11 9 6 0 2018 11 9 6 0 2018 11 9 6 1 epublish 30406113 10.3389/fcvm.2018.00146 PMC6205954 J Am Coll Nutr. 2002 Dec;21(6):495-505 12480795 J Nutr. 2002 Dec;132(12):3566-76 12468590 N Engl J Med. 1991 Jul 11;325(2):87-91 2052056 J Assoc Physicians India. 2002 Aug;50:1028-33

2018 Frontiers in cardiovascular medicine

9. NSAIDs

NSAIDs Top results for nsaids - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading (...) history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for nsaids The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest

2018 Trip Latest and Greatest

10. NSAIDs are superior to paracetamol for osteoarthritic pain and function in a network meta-analysis. (Abstract)

NSAIDs are superior to paracetamol for osteoarthritic pain and function in a network meta-analysis. 29367329 2018 12 14 2018 12 14 2515-4478 23 1 2018 02 BMJ evidence-based medicine BMJ Evid Based Med NSAIDs are superior to paracetamol for osteoarthritic pain and function in a network meta-analysis. 40-41 10.1136/ebmed-2017-110878 Rasmussen Sten S 0000-0002-8664-352X Department of Orthopaedic Surgery, Aalborg University Hospital, Aalborg, Denmark. Department of Clinical Medicine, Aalborg

2018 BMJ evidence-based medicine

11. NSAIDs: Are They All the Same?

NSAIDs: Are They All the Same? NSAIDs: Are They All the Same? – Clinical Correlations Search NSAIDs: Are They All the Same? February 1, 2018 5 min read By Vishal Shah, MD Peer Reviewed Nonsteroidal antiinflammatory drugs (NSAIDs) are a heterogenous group of non-opioid analgesics and anti-inflammatory agents. Their use is ubiquitous, from treating a simple tension headache to a sprained ankle. NSAIDs are available over the counter and in prescription form. NSAID use in the United States (...) of opioids and addictive nature of these agents, . 3 NSAIDs inhibit cyclooxygenase (COX), an enzyme involved in the production of prostaglandins. Although COX-1 is present in most tissues, it plays a crucial role in gastric cytoprotection and platelet aggregation. COX-2 is primarily involved in the inflammatory response, with additional role in vasoprotection and regulation of renal blood flow. Based on their COX-2 selectivity, NSAIDs can be grouped into 3 categories: Non-selective (ibuprofen, naproxen

2018 Clinical Correlations

12. Perioperative Use of NSAIDs: Safety and Guidelines

Perioperative Use of NSAIDs: Safety and Guidelines Perioperative Use of NSAIDs: Safety and Guidelines | CADTH.ca Find the information you need Perioperative Use of NSAIDs: Safety and Guidelines Perioperative Use of NSAIDs: Safety and Guidelines Last updated: April 5, 2018 Project Number: RB1205-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical evidence regarding the safety and harms of the perioperative use of nonsteroidal (...) anti-inflammatory drugs (NSAIDs)? What are the evidence-based guidelines regarding the perioperative use of NSAIDs? Key Message Eight systematic reviews (six with meta-analyses), six randomized controlled trials, 21 non-randomized studies, and three evidence-based guidelines were identified regarding the perioperative use of NSAIDs. Files Rapid Response Summary of Abstracts Published : April 5, 2018 Related Content Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

13. Vonoprazan prevents ulcer recurrence during long-term NSAID therapy: randomised, lansoprazole-controlled non-inferiority and single-blind extension study Full Text available with Trip Pro

Vonoprazan prevents ulcer recurrence during long-term NSAID therapy: randomised, lansoprazole-controlled non-inferiority and single-blind extension study To assess the non-inferiority of vonoprazan to lansoprazole for secondary prevention of non-steroidal anti-inflammatory drug (NSAID)-induced peptic ulcer (PU) and the safety of vonoprazan during extended use.A phase 3, 24-week, multicenter, randomised, double-blind (DB), active-controlled study, followed by a phase 3, ≥28 week, multicenter (...) , single-blind, parallel-group extension study (EXT) in outpatients (n=642) receiving long-term NSAID therapy who are at risk of PU recurrence. The patients received vonoprazan (10 mg or 20 mg) or lansoprazole 15 mg once daily. For DB, non-inferiority of the proportion of patients with recurrent PU within 24 weeks was analysed by Farrington and Manning test (significance level 2.5%, non-inferiority margin 8.3%; primary endpoint), recurrent PU within 12 weeks, bleeding and time-to-event of PU (secondary

2017 EvidenceUpdates

14. Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. Full Text available with Trip Pro

Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most parts of the world. While in the past pain was largely dismissed (...) ) is a major health concern. Chronic pain (that is pain lasting three months or longer) can arise in the paediatric population in a variety of pathophysiological classifications (nociceptive, neuropathic, or idiopathic) from genetic conditions, nerve damage pain, chronic musculoskeletal pain, and chronic abdominal pain, as well as for other unknown reasons.Non-steroidal anti-inflammatory drugs (NSAIDs) are used to treat pain, reduce fever, and for their anti-inflammation properties. They are commonly used

2017 Cochrane

15. Non-steroidal anti-inflammatory drugs (NSAIDs) for cancer-related pain in children and adolescents. Full Text available with Trip Pro

Non-steroidal anti-inflammatory drugs (NSAIDs) for cancer-related pain in children and adolescents. Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization (WHO) guidelines for pharmacological treatments for persisting pain in children acknowledge that pain in children is a major public health concern of high significance in most parts of the world. Views on children's pain have changed over time (...) treatments, or mucositis. However, this review focused on pain caused directly by the tumour itself such as nerve infiltration, external nerve compression, and other inflammatory events.Non-steroidal anti-inflammatory drugs (NSAIDs) are used to treat pain, reduce fever, and for their anti-inflammatory properties. They are commonly used within paediatric pain management. NSAIDs are currently licensed for use in western countries, however not approved for infants aged under three months. Primary adverse

2017 Cochrane

16. Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults. Full Text available with Trip Pro

Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults. Pain is a common symptom with cancer, and 30% to 50% of all people with cancer will experience moderate to severe pain that can have a major negative impact on their quality of life. Non-opioid drugs are commonly used to treat cancer pain, and are recommended for this purpose in the World Health Organization (WHO) cancer pain treatment ladder, either alone or in combination with opioids.A previous Cochrane review (...) that examined the evidence for nonsteroidal anti-inflammatory drugs (NSAIDs) or paracetamol, alone or combined with opioids, for cancer pain was withdrawn in 2015 because it was out of date; the date of the last search was 2005. This review, and another on paracetamol, updates the evidence.To assess the efficacy of oral NSAIDs for cancer pain in adults, and the adverse events reported during their use in clinical trials.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE

2017 Cochrane

17. NSAIDs for Chronic Low Back Pain. (Abstract)

NSAIDs for Chronic Low Back Pain. Are nonsteroidal anti-inflammatory drugs (NSAIDs) associated with greater pain relief than placebo, other drugs, and nondrug treatments for patients with chronic low back pain?Compared with placebo, NSAIDs are associated with a small but significant improvement in pain and disability in patients with chronic low back pain, although this difference became nonsignificant when studies with high risk for bias were excluded. The associated benefits were smaller than

2017 JAMA Controlled trial quality: uncertain

18. Unborn children still exposed to NSAIDs

Unborn children still exposed to NSAIDs Prescrire IN ENGLISH - Spotlight ''In the April issue of Prescrire International: unborn children still exposed to NSAIDs'', 1 April 2017 {1} {1} {1} | | > > > In the April issue of Prescrire International: unborn children still exposed to NSAIDs Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight In the April (...) issue of Prescrire International: unborn children still exposed to NSAIDs FREE DOWNLOAD In the Adverse Effects section of the April edition: results of a French study showing that around 5% of unborn children in France are exposed to prescribed NSAIDs, including about 1% from the 6th month of pregnancy. And these numbers exclude self-medication. Authorities need to send out a stronger message: "NEVER USE NSAIDs DURING PREGNANCY". Full text available for free download. Summary A study based on data

2017 Prescrire

19. NSAIDs are Caspase Inhibitors Full Text available with Trip Pro

NSAIDs are Caspase Inhibitors Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs in the world. While the role of NSAIDs as cyclooxygenase (COX) inhibitors is well established, other targets may contribute to anti-inflammation. Here we report caspases as a new pharmacological target for NSAID family drugs such as ibuprofen, naproxen, and ketorolac at physiologic concentrations both in vitro and in vivo. We characterize caspase activity in both in vitro (...) and in cell culture, and combine computational modeling and biophysical analysis to determine the mechanism of action. We observe that inhibition of caspase catalysis reduces cell death and the generation of pro-inflammatory cytokines. Further, NSAID inhibition of caspases is COX independent, representing a new anti-inflammatory mechanism. This finding expands upon existing NSAID anti-inflammatory behaviors, with implications for patient safety and next-generation drug design.Copyright © 2017 Elsevier Ltd

2017 Cell chemical biology

20. Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses. Full Text available with Trip Pro

Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses. Non-steroidal anti-inflammatory drugs (NSAIDs), such as non-selective NSAIDs (nsNSAIDs) or selective cyclooxygenase-2 (COX-2) inhibitors, are commonly prescribed for arthritic pain relief in patients with osteoarthritis (OA), rheumatoid arthritis (RA), or ankylosing spondylitis (AS). Treatment guidelines for chronic NSAID therapy (...) include the consideration for gastroprotection for those at risk of gastric ulcers (GUs) associated with the chronic NSAID therapy. The United States Food and Drug Administration has approved naproxen/esomeprazole magnesium tablets for the relief of signs and symptoms of OA, RA, and AS, and to decrease the risk of developing GUs in patients at risk of developing NSAID-associated GUs. The European Medical Association has approved this therapy for the symptomatic treatment of OA, RA, and AS in patients

2017 Open access rheumatology : research and reviews