Latest & greatest articles for nitroglycerin

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on nitroglycerin or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on nitroglycerin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for nitroglycerin

21. Meta-analysis of the use of glyceryl trinitrate ointment after haemorrhoidectomy as an analgesic and in promoting wound healing

Meta-analysis of the use of glyceryl trinitrate ointment after haemorrhoidectomy as an analgesic and in promoting wound healing Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

22. Nitroglycerin in the prevention of post-ERCP pancreatitis: a meta-analysis

Nitroglycerin in the prevention of post-ERCP pancreatitis: a meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

23. A meta-analysis for the effect of prophylactic GTN on the incidence of post-ERCP pancreatitis and on the successful rate of cannulation of bile ducts

A meta-analysis for the effect of prophylactic GTN on the incidence of post-ERCP pancreatitis and on the successful rate of cannulation of bile ducts Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

24. Topical glyceryl trinitrate for rotator cuff disease. (Abstract)

Topical glyceryl trinitrate for rotator cuff disease. Rotator cuff disease is a common cause of shoulder pain. Topical glyceryl trinitrate is a possible new treatment.To determine the effectiveness and safety of topical glyceryl trinitrate for rotator cuff disease.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, SPORTDiscus, PEDro, the Australian Clinical Trials Registry, Current Controlled Trials (to October 2007) and the references (...) and citations of included studies.We included randomised controlled trials and controlled clinical trials of people with rotator cuff disease who received topical glyceryl trinitrate, alone or in combination, compared to placebo or active therapy.Two authors independently assessed risk of bias and extracted data.Three small studies, one at moderate risk of bias and two at high risk of bias, were included. Meta-analysis was precluded due to different interventions and outcome measures. Study participants

2009 Cochrane

25. MQX-503, a novel formulation of nitroglycerin, improves the severity of Raynaud`s phenomenon: A randomized, controlled trial (Abstract)

MQX-503, a novel formulation of nitroglycerin, improves the severity of Raynaud`s phenomenon: A randomized, controlled trial Raynaud's phenomenon (RP) affects 3-9% of the general population and >90% of patients with systemic sclerosis. Nitrates are often prescribed for the treatment of RP, but currently available formulations are limited by side effects, particularly headaches, dizziness, and skin irritation. The purpose of this study was to evaluate the tolerability and efficacy of a novel (...) formulation of topical nitroglycerin, MQX-503, in the treatment of RP in an ambulatory setting.We conducted a multicenter, randomized, placebo-controlled study with a 2-week single-blind run-in period to determine baseline severity, followed by a 4-week double-blind treatment phase. Two hundred nineteen adult patients with a clinical diagnosis of primary or secondary RP received 0.9% MQX-503 gel or matching placebo during the treatment period. Gel was applied immediately before or within 5 minutes

2009 EvidenceUpdates Controlled trial quality: predicted high

26. Glyceryl trinitrate for prevention of pancreatitis after endoscopic retrograde cholangiopancreatography: a meta-analysis of randomized, double-blind, placebo-controlled trials

Glyceryl trinitrate for prevention of pancreatitis after endoscopic retrograde cholangiopancreatography: a meta-analysis of randomized, double-blind, placebo-controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

27. Randomized comparison of intravenous terbutaline vs nitroglycerin for acute intrapartum fetal resuscitation. (Abstract)

Randomized comparison of intravenous terbutaline vs nitroglycerin for acute intrapartum fetal resuscitation. The purpose of this study was to compare terbutaline and nitroglycerin for acute intrapartum fetal resuscitation.Women between 32-, 42 weeks' gestation were assigned randomly to 250 microg of terbutaline or 400 microg nitroglycerin intravenously for nonreassuring fetal heart rate tracings in labor. The rate of successful acute intrapartum fetal resuscitation and the maternal hemodynamic (...) changes were compared. Assuming a 50% failure rate in the terbutaline arm, we calculated that a total of 110 patients would be required to detect a 50% reduction in failure in the nitroglycerin group (50% to 25%), with an alpha value of .05, a beta value of .20, and a power of 80%.One hundred ten women had nonreassuring fetal heart rate tracings in labor; 57 women received terbutaline, and 53 women received nitroglycerin. Successful acute resuscitation rates were similar (terbutaline 71.9

2007 EvidenceUpdates Controlled trial quality: uncertain

28. Drugs - Glyceryl Trinitrate (GTN and Suscard)

Drugs - Glyceryl Trinitrate (GTN and Suscard) Glyceryl Trinitrate (GTN, Suscard) GTN Drugs October 2006 Page 1 of 2 Drugs PRESENTATION Metered dose spray containing 400 micrograms glyceryl trinitrate per dose. Tablets containing glyceryl trinitrate 2, 3 or 5 milligrams for buccal administration (depends on local ordering). ACTIONS A potent vasodilator drug resulting in: • dilatation of coronary arteries/relief of coronary spasm. • dilatation of systemic veins resulting in lower pre-load (...) effects are mainly related to a generalised vasodilation effect of this drug and are usually transient. GTN Glyceryl Trinitrate (GTN, Suscard) Page 2 of 2 October 2006 Drugs Drugs

2007 Joint Royal Colleges Ambulance Liaison Committee

29. Glyceryl Trinitrate (GTN and Suscard)

Glyceryl Trinitrate (GTN and Suscard) Glyceryl Trinitrate (GTN, Suscard) GTN Drugs October 2006 Page 1 of 2 Drugs PRESENTATION Metered dose spray containing 400 micrograms glyceryl trinitrate per dose. Tablets containing glyceryl trinitrate 2, 3 or 5 milligrams for buccal administration (depends on local ordering). ACTIONS A potent vasodilator drug resulting in: • dilatation of coronary arteries/relief of coronary spasm. • dilatation of systemic veins resulting in lower pre-load. • reduced (...) related to a generalised vasodilation effect of this drug and are usually transient. GTN Glyceryl Trinitrate (GTN, Suscard) Page 2 of 2 October 2006 Drugs Drugs

2006 Joint Royal Colleges Ambulance Liaison Committee

30. Chest pain relief by nitroglycerin does not predict active coronary artery disease. (Abstract)

Chest pain relief by nitroglycerin does not predict active coronary artery disease. The belief that chest pain relief with nitroglycerin indicates the presence of active coronary artery disease is common. However, this hypothesis has not been tested.To define the diagnostic and prognostic value of chest pain relief with nitroglycerin.Prospective observational cohort study.Urban community teaching hospital.459 consecutive patients with chest pain admitted through the emergency department who (...) received nitroglycerin from emergency services personnel or an emergency department nurse. Follow-up was obtained by telephone contact at 4 months.Chest pain relief was defined as a decrease of at least 50% in patients' self-reported pain within 5 minutes of the initial dose of sublingual or spray nitroglycerin. Active coronary artery disease was defined as any elevated serum enzyme levels, coronary angiography demonstrating a 70% or greater stenosis, or a positive exercise test result.Nitroglycerin

2003 Annals of Internal Medicine

31. Nitroglycerin in septic shock after intravascular volume resuscitation. (Abstract)

Nitroglycerin in septic shock after intravascular volume resuscitation. In patients with septic shock, oxygen consumption is increased, but oxygen delivery and extraction is impaired, partly because of microcirculatory shutdown and shunting. Orthogonal polarisation spectral (OPS) imaging allows visualisation of the microcirculation. We used this technique to assess microcirculatory flow in septic-shock patients who had a mean arterial blood pressure of more than 60 mm Hg and central venous (...) pressure greater than 12 mm Hg. The infusion of 0.5 mg of nitroglycerin intravenously then resulted in a marked increase in microvascular flow on OPS imaging. Improved recruitment of the microcirculation could be a new resuscitation endpoint in septic shock.

2002 Lancet

32. Intravenous nesiritide vs nitroglycerin for treatment of decompensated congestive heart failure: a randomized controlled trial. (Abstract)

Intravenous nesiritide vs nitroglycerin for treatment of decompensated congestive heart failure: a randomized controlled trial. Decompensated congestive heart failure (CHF) is the leading hospital discharge diagnosis in patients older than 65 years.To compare the efficacy and safety of intravenous nesiritide, intravenous nitroglycerin, and placebo.Randomized, double-blind trial of 489 inpatients with dyspnea at rest from decompensated CHF, including 246 who received pulmonary artery (...) catheterization, that was conducted at 55 community and academic hospitals between October 1999 and July 2000.Intravenous nesiritide (n = 204), intravenous nitroglycerin (n = 143), or placebo (n = 142) added to standard medications for 3 hours, followed by nesiritide (n = 278) or nitroglycerin (n = 216) added to standard medication for 24 hours.Change in pulmonary capillary wedge pressure (PCWP) among catheterized patients and patient self-evaluation of dyspnea at 3 hours after initiation of study drug among

2002 JAMA Controlled trial quality: predicted high

33. Nitroglycerin as a uterine relaxant: a systematic review

Nitroglycerin as a uterine relaxant: a systematic review Nitroglycerin as a uterine relaxant: a systematic review Nitroglycerin as a uterine relaxant: a systematic review Morgan P J, Kung R, Tarshis J Authors' objectives To evaluate the effectiveness of nitroglycerin as a uterine relaxant. Searching The authors searched PubMed (from 1966 to 2001), the Cochrane Controlled Trials Register, the International Journal of Obstetric Anesthesia, and the reference lists of identified articles. They also (...) in the review Randomised controlled trials (RCTs) were eligible for the review. Two of the included studies used a crossover design. Specific interventions included in the review Studies using nitroglycerin as a uterine relaxant were potentially eligible. In the included studies, nitroglycerin was used in obstetrics and gynaecology for induction, version, foetal extraction, pre-eclampsia, tocolysis, cervical dilation, embryo transfer and dysmenorrhoea. The dose and application (intravenous, vaginal or skin

2002 DARE.

34. Modelling the economic impact of managing a chronic anal fissure with a proprietary formulation of nitroglycerin (Rectogesic) compared to lateral internal sphincterotomy in the United Kingdom

(Rectogesic) compared to lateral internal sphincterotomy in the United Kingdom Christie A, Guest J F Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of nitroglycerin (0.2% glycerine nitrate, GTN) (Rectogesic) for the treatment (...) Modelling the economic impact of managing a chronic anal fissure with a proprietary formulation of nitroglycerin (Rectogesic) compared to lateral internal sphincterotomy in the United Kingdom Modelling the economic impact of managing a chronic anal fissure with a proprietary formulation of nitroglycerin (Rectogesic) compared to lateral internal sphincterotomy in the United Kingdom Modelling the economic impact of managing a chronic anal fissure with a proprietary formulation of nitroglycerin

2002 NHS Economic Evaluation Database.

35. Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm

Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm Shapira O M, Alkon J D, Macron D S F, Keaney J F, Vita J A, Aldea G S, Shemin R J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief (...) summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study focused on the use of two conduit vasodilators in the prevention of arterial conduit spasm after coronary bypass grafting (CABG). Patients received a 24-hour intravenous infusion of either nitroglycerin (0.1 microgram.kg-1.min-1) or diltiazem (0.1 mg/kg during 20 minutes and then 0.1 mg.kg-1.min-1), followed by 6 months

2000 NHS Economic Evaluation Database.

36. Glyceryl trinitrate for chronic anal fissures

) 1999 Authors' objectives To assess the effectiveness and cost-effectiveness of glyceryl trinitrate for chronic anal fissures Authors' conclusions 0.2% glyceryl trinitrate (GTN) ointment is an unlicensed treatment for chronic anal fissures. The Committee agreed that GTN has a clinically important effect on healing and is a simple and cheap treatment. It often avoids the need for surgery, as well as the delay in waiting for surgical treatment. Evidence for the use of this treatment comes from 2 RCTs (...) Glyceryl trinitrate for chronic anal fissures Glyceryl trinitrate for chronic anal fissures Glyceryl trinitrate for chronic anal fissures Chase D, Milne R Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Chase D, Milne R. Glyceryl trinitrate for chronic anal fissures. Southampton: Wessex Institute for Health Research and Development (WIHRD

1999 Health Technology Assessment (HTA) Database.

37. A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. (Abstract)

A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. Lateral internal sphincterotomy, the most common treatment for chronic anal fissure, may cause permanent injury to the anal sphincter, which can lead to fecal incontinence. We compared two nonsurgical treatments that avert the risk of fecal incontinence. We randomly assigned 50 adults with symptomatic chronic posterior anal fissures to receive treatment with either a total (...) of 20 U of botulinum toxin injected into the internal anal sphincter on each side of the anterior midline or 0.2 percent nitroglycerin ointment applied twice daily for six weeks.After two months, the fissures were healed in 24 of the 25 patients (96 percent) in the botulinum-toxin group and in 15 of the 25 (60 percent) in the nitroglycerin group (P=0.005). No patient in either group had fecal incontinence. At some time during treatment, five patients in the nitroglycerin group had transient

1999 NEJM Controlled trial quality: uncertain

38. A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. (Abstract)

A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Anal fissure is most commonly treated surgically by internal anal sphincterotomy. However, there is some concern over the effects of this procedure on continence. Nitric oxide donors such as glyceryl trinitrate (GTN) have been shown to cause a reversible chemical sphincterotomy capable of healing fissures in a small series of cases. This study reports a prospective (...) , randomised, double-blind, placebo-controlled trial to test the hypothesis that topical GTN is the best first-line treatment for chronic anal fissure.80 consecutive patients were randomised to receive treatments with topical 0.2% GTN ointment or placebo. Maximum anal resting pressure (MARP) was measured with a constantly perfused side-hole catheter before and after the first application of trial ointment. Anodermal blood flow was measured during manometry by laser Doppler flowmetry. After initial

1997 Lancet Controlled trial quality: predicted high

39. Randomised, double-blind trial of intravenous diltiazem versus glyceryl trinitrate for unstable angina pectoris. (Abstract)

Randomised, double-blind trial of intravenous diltiazem versus glyceryl trinitrate for unstable angina pectoris. The effect of dihydropyridines in patients with unstable angina is discouraging. To find out the effect of the non-dihydropyridine-like calcium-channel blocker diltiazem, a randomised, double-blind trial was conducted comparing diltiazem with glyceryl trinitrate, both given intravenously, in 129 patients with unstable angina. The endpoints were refractory angina or myocardial (...) infarction, individually and as a composite endpoint. Refractory angina alone or together with myocardial infarction occurred significantly less commonly in the diltiazem group. While patients were on the trial drugs the numbers with refractory angina were 6 (10%) in the diltiazem group versus 17 (28%) in the glyceryl trinitrate group (relative risk 0.36, p = 0.02), and the numbers with refractory angina and myocardial infarction were 9 (15%) versus 23 (38%) (relative risk 0.40, p = 0.007). Over 48 h

1996 Lancet Controlled trial quality: uncertain

40. Early administration of terlipressin plus glyceryl trinitrate to control active upper gastrointestinal bleeding in cirrhotic patients. (Abstract)

combined with glyceryl trinitrate (TER-GTN), administered as early as possible to 76 patients with cirrhosis who had active GIB (84 bleeding episodes). Infusion was done at the patient's home by the physician on the emergency team (a mobile intensive care unit) if the patient had GIB and a history and clinical signs of cirrhosis. Patients received either an intravenous injection (1 to 2 mg) of TER-GTN or a double-placebo injection, and then another injection at 4 and 8 h. Control of bleeding (...) Early administration of terlipressin plus glyceryl trinitrate to control active upper gastrointestinal bleeding in cirrhotic patients. Upper gastrointestinal bleeding (GIB) is a major complication in cirrhotic patients. Endoscopy and oesophageal sclerosis are reference treatments and must be done as soon as possible. However, such treatment is not possible unless the patient is admitted to hospital. In a prospective, randomised, double-blind trial, we compared the efficacy of terlipressin

1995 Lancet Controlled trial quality: predicted high