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Latest & greatest articles for nitroglycerin
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Randomized comparison of intravenous terbutaline vs nitroglycerin for acute intrapartum fetal resuscitation. The purpose of this study was to compare terbutaline and nitroglycerin for acute intrapartum fetal resuscitation.Women between 32-, 42 weeks' gestation were assigned randomly to 250 microg of terbutaline or 400 microg nitroglycerin intravenously for nonreassuring fetal heart rate tracings in labor. The rate of successful acute intrapartum fetal resuscitation and the maternal hemodynamic (...) changes were compared. Assuming a 50% failure rate in the terbutaline arm, we calculated that a total of 110 patients would be required to detect a 50% reduction in failure in the nitroglycerin group (50% to 25%), with an alpha value of .05, a beta value of .20, and a power of 80%.One hundred ten women had nonreassuring fetal heart rate tracings in labor; 57 women received terbutaline, and 53 women received nitroglycerin. Successful acute resuscitation rates were similar (terbutaline 71.9
Chest pain relief by nitroglycerin does not predict active coronary artery disease. The belief that chest pain relief with nitroglycerin indicates the presence of active coronary artery disease is common. However, this hypothesis has not been tested.To define the diagnostic and prognostic value of chest pain relief with nitroglycerin.Prospective observational cohort study.Urban community teaching hospital.459 consecutive patients with chest pain admitted through the emergency department who (...) received nitroglycerin from emergency services personnel or an emergency department nurse. Follow-up was obtained by telephone contact at 4 months.Chest pain relief was defined as a decrease of at least 50% in patients' self-reported pain within 5 minutes of the initial dose of sublingual or spray nitroglycerin. Active coronary artery disease was defined as any elevated serum enzyme levels, coronary angiography demonstrating a 70% or greater stenosis, or a positive exercise test result.Nitroglycerin
Nitroglycerin in septic shock after intravascular volume resuscitation. In patients with septic shock, oxygen consumption is increased, but oxygen delivery and extraction is impaired, partly because of microcirculatory shutdown and shunting. Orthogonal polarisation spectral (OPS) imaging allows visualisation of the microcirculation. We used this technique to assess microcirculatory flow in septic-shock patients who had a mean arterial blood pressure of more than 60 mm Hg and central venous (...) pressure greater than 12 mm Hg. The infusion of 0.5 mg of nitroglycerin intravenously then resulted in a marked increase in microvascular flow on OPS imaging. Improved recruitment of the microcirculation could be a new resuscitation endpoint in septic shock.
Nitroglycerin as a uterine relaxant: a systematic review Nitroglycerin as a uterine relaxant: a systematic review Nitroglycerin as a uterine relaxant: a systematic review Morgan P J, Kung R, Tarshis J Authors' objectives To evaluate the effectiveness of nitroglycerin as a uterine relaxant. Searching The authors searched PubMed (from 1966 to 2001), the Cochrane Controlled Trials Register, the International Journal of Obstetric Anesthesia, and the reference lists of identified articles. They also (...) in the review Randomised controlled trials (RCTs) were eligible for the review. Two of the included studies used a crossover design. Specific interventions included in the review Studies using nitroglycerin as a uterine relaxant were potentially eligible. In the included studies, nitroglycerin was used in obstetrics and gynaecology for induction, version, foetal extraction, pre-eclampsia, tocolysis, cervical dilation, embryo transfer and dysmenorrhoea. The dose and application (intravenous, vaginal or skin
Modelling the economic impact of managing a chronic anal fissure with a proprietary formulation of nitroglycerin (Rectogesic) compared to lateral internal sphincterotomy in the United Kingdom Modelling the economic impact of managing a chronic anal fissure with a proprietary formulation of nitroglycerin (Rectogesic) compared to lateral internal sphincterotomy in the United Kingdom Modelling the economic impact of managing a chronic anal fissure with a proprietary formulation of nitroglycerin (...) (Rectogesic) compared to lateral internal sphincterotomy in the United Kingdom Christie A, Guest J F Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of nitroglycerin (0.2% glycerine nitrate, GTN) (Rectogesic) for the treatment
Intravenous nesiritide vs nitroglycerin for treatment of decompensated congestive heart failure: a randomized controlled trial. Decompensated congestive heart failure (CHF) is the leading hospital discharge diagnosis in patients older than 65 years.To compare the efficacy and safety of intravenous nesiritide, intravenous nitroglycerin, and placebo.Randomized, double-blind trial of 489 inpatients with dyspnea at rest from decompensated CHF, including 246 who received pulmonary artery (...) catheterization, that was conducted at 55 community and academic hospitals between October 1999 and July 2000.Intravenous nesiritide (n = 204), intravenous nitroglycerin (n = 143), or placebo (n = 142) added to standard medications for 3 hours, followed by nesiritide (n = 278) or nitroglycerin (n = 216) added to standard medication for 24 hours.Change in pulmonary capillary wedge pressure (PCWP) among catheterized patients and patient self-evaluation of dyspnea at 3 hours after initiation of study drug among
Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm Shapira O M, Alkon J D, Macron D S F, Keaney J F, Vita J A, Aldea G S, Shemin R J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief (...) summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study focused on the use of two conduit vasodilators in the prevention of arterial conduit spasm after coronary bypass grafting (CABG). Patients received a 24-hour intravenous infusion of either nitroglycerin (0.1 microgram.kg-1.min-1) or diltiazem (0.1 mg/kg during 20 minutes and then 0.1 mg.kg-1.min-1), followed by 6 months
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. Lateral internal sphincterotomy, the most common treatment for chronic anal fissure, may cause permanent injury to the anal sphincter, which can lead to fecal incontinence. We compared two nonsurgical treatments that avert the risk of fecal incontinence. We randomly assigned 50 adults with symptomatic chronic posterior anal fissures to receive treatment with either a total (...) of 20 U of botulinum toxin injected into the internal anal sphincter on each side of the anterior midline or 0.2 percent nitroglycerin ointment applied twice daily for six weeks.After two months, the fissures were healed in 24 of the 25 patients (96 percent) in the botulinum-toxin group and in 15 of the 25 (60 percent) in the nitroglycerin group (P=0.005). No patient in either group had fecal incontinence. At some time during treatment, five patients in the nitroglycerin group had transient
Effects of intracoronary streptokinase and intracoronary nitroglycerin infusion on coronary angiographic patterns and mortality in patients with acute myocardial infarction. We randomly assigned patients with a clinical diagnosis of acute myocardial infarction to one of four treatment groups: intracoronary streptokinase, intracoronary nitroglycerin, intracoronary streptokinase and intracoronary nitroglycerin, or conventional therapy without initial angiography. Of 124 patients 122 sustained (...) acute myocardial infarction. Initial angiography revealed total occlusion of the coronary artery responsible for infarction in 67 per cent (61 of 91). Acute recanalization occurred in 74 per cent (32 of 43) of patients receiving streptokinase but in only 6 per cent (1 of 18) of patients treated with nitroglycerin alone (P less than 0.01). At angiography of all four groups on Day 10 to 14 the vessel responsible for acute myocardial infarction was patent in 77 per cent (71 of 92) of patients