Latest & greatest articles for morphine

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Top results for morphine

121. Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials

Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

122. Morphine, gabapentin, or their combination for neuropathic pain. (PubMed)

Morphine, gabapentin, or their combination for neuropathic pain. The available drugs to treat neuropathic pain have incomplete efficacy and dose-limiting adverse effects. We compared the efficacy of a combination of gabapentin and morphine with that of each as a single agent in patients with painful diabetic neuropathy or postherpetic neuralgia.In this randomized, double-blind, active placebo-controlled, four-period crossover trial, patients received daily active placebo (lorazepam), sustained (...) -release morphine, gabapentin, and a combination of gabapentin and morphine--each given orally for five weeks. The primary outcome measure was mean daily pain intensity in patients receiving a maximal tolerated dose; secondary outcomes included pain (rated according to the Short-Form McGill Pain Questionnaire), adverse effects, maximal tolerated doses, mood, and quality of life.Of 57 patients who underwent randomization (35 with diabetic neuropathy and 22 with postherpetic neuralgia), 41 completed

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2005 NEJM Controlled trial quality: predicted high

123. Morphine sulphate analgesia did not affect diagnostic accuracy in undifferentiated abdominal pain

Morphine sulphate analgesia did not affect diagnostic accuracy in undifferentiated abdominal pain Morphine sulphate analgesia did not affect diagnostic accuracy in undifferentiated abdominal pain | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Morphine sulphate analgesia did not affect diagnostic accuracy in undifferentiated abdominal pain Article Text Therapeutics Morphine sulphate analgesia did not affect diagnostic accuracy

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2004 Evidence-Based Medicine (Requires free registration)

124. Efficacy of oral rofecoxib versus intravenous ketoprofen as an adjuvant to PCA morphine after urologic surgery

Efficacy of oral rofecoxib versus intravenous ketoprofen as an adjuvant to PCA morphine after urologic surgery Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2004 NHS Economic Evaluation Database.

125. Patient-controlled transdermal fentanyl hydrochloride vs intravenous morphine pump for postoperative pain: a randomized controlled trial. (PubMed)

Patient-controlled transdermal fentanyl hydrochloride vs intravenous morphine pump for postoperative pain: a randomized controlled trial. Patient-controlled analgesia (PCA) with morphine is commonly used to provide acute postoperative pain control after major surgery. The fentanyl hydrochloride patient-controlled transdermal system eliminates the need for venous access and complicated programming of pumps.To assess the efficacy and safety of an investigational patient-controlled iontophoretic (...) transdermal system using fentanyl hydrochloride compared with a standard intravenous morphine patient-controlled pump.Prospective randomized controlled parallel-group trial conducted between September 2000 and March 2001 at 33 North American hospitals, enrolling 636 adult patients who had just undergone major surgery.In surgical recovery rooms, patients were randomly assigned to intravenous morphine (1-mg bolus every 5 minutes; maximum of 10 mg/h) by a patient-controlled analgesia pump (n = 320

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2004 JAMA Controlled trial quality: predicted high

126. Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial. (PubMed)

Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial. Opioid analgesia is commonly used during neonatal intensive care. We undertook the Neurologic Outcomes and Pre-emptive Analgesia in Neonates (NEOPAIN) trial to investigate whether pre-emptive morphine analgesia decreases the rate of a composite primary outcome of neonatal death, severe intraventricular haemorrhage (IVH), and periventricular leucomalacia (PVL) in preterm (...) neonates.Ventilated preterm neonates (n=898) from 16 centres were randomly assigned masked placebo (n=449) or morphine (n=449) infusions. After a loading dose (100 microg/kg), morphine infusions (23-26 weeks of gestation 10 microg kg(-1) h(-1); 27-29 weeks 20 microg kg(-1) h(-1); 30-32 weeks 30 microg kg(-1) h(-1)) were continued as long as clinically justified (maximum 14 days). Open-label morphine could be given on clinical judgment (placebo group 242/443 [54.6%], morphine group 202/446 [45.3%]). Analyses were

2004 Lancet Controlled trial quality: predicted high

127. A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain

A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain Frei A, Andersen S, Hole P, Jensen N Record Status This is a critical abstract (...) of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study examined two treatments for chronic non-cancer pain. One was the fentanyl transdermal therapeutic system (fentanyl-TTS) and the other was oral sustained-release (SR) morphine. Monthly medication use was reported for patients

2003 NHS Economic Evaluation Database.

128. Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. (PubMed)

Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. To determine the efficacy of oral morphine in relieving the sensation of breathlessness in patients in whom the underlying aetiology is maximally treated.Randomised, double blind, placebo controlled crossover study.Four outpatient clinics at a hospital in South Australia.48 participants who had not previously been treated with opioids (mean age 76, SD 5 (...) ) with predominantly chronic obstructive pulmonary disease (42, 88%) were randomised to four days of 20 mg oral morphine with sustained release followed by four days of identically formulated placebo, or vice versa. Laxatives were provided as needed.Dyspnoea in the morning and evening as shown on a 100 mm visual analogue scale, quality of sleep, wellbeing, performance on physical exertion, and side effects as measured at the end of the four day treatment period.38 participants completed the study; three withdrew

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2003 BMJ Controlled trial quality: predicted high

129. Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. (PubMed)

Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. Newborns admitted to neonatal intensive care units (NICUs) undergo a variety of painful procedures and stressful events. Because the effect of continuous morphine infusion in preterm neonates has not been investigated systematically, there is confusion regarding whether morphine should be used routinely in this setting.To evaluate the effects of continuous intravenous morphine infusion (...) malformations, and administration of neuromuscular blockers).Intravenous morphine (100 microg/kg and 10 microg/kg per hour) or placebo infusion was given for 7 days (or less because of clinical necessity in several cases).The analgesic effect of morphine, as assessed using validated scales; the effect of morphine on the incidence of IVH; and poor neurologic outcome.The analgesic effect did not differ between the morphine and placebo groups, judging from the following median (interquartile range) pain scores

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2003 JAMA Controlled trial quality: predicted high

130. Nebulised morphine for severe interstitial lung disease. (PubMed)

Nebulised morphine for severe interstitial lung disease. The evidence to support the use of nebulized morphine to improve dyspnoea and exercise limitation in terminally ill patients with chronic lung disease is conflicting.To assess the effectiveness of nebulized morphine in reducing dyspnoea in patients with end-stage interstitial lung diseaseRCTs and good quality CCTs were identified by searching Medline, Embase, Cinahl as well as the Cochrane controlled clinical trial register. The following (...) search terms were used: (inhaled OR nebulised)/AND/morphine AND/Idiopathic pulmonary fibrosis/or/pulmonary fibrosis/or/idiopathic interstitial pneumonia/or/nonspecific interstitial pneumonia/or/non-specific interstitial pneumonia/or/usual interstitial pneumonia/or/desquamative interstitial pneumonia/or/cryptogenic fibrosing alveolitis/or/interstitial pneumonia/or/idiopathic interstitial lung disease/or/chronic interstitial pneumoniaAny RCT and adequate quality CCT in adult patients with ILD

2002 Cochrane

131. No pain, no gain: clinical excellence and scientific rigour: lessons learned from IA morphine

No pain, no gain: clinical excellence and scientific rigour: lessons learned from IA morphine No pain, no gain: clinical excellence and scientific rigour: lessons learned from IA morphine No pain, no gain: clinical excellence and scientific rigour: lessons learned from IA morphine Kalso E, Smith L, McQuay HJ, Moore RA Authors' objectives To include all evaluable studies on intra-articular morphine, to set simple criteria for study sensitivity, to analyse factors that can render studies (...) insensitive, and to analyse the effectiveness of intra-articular morphine. Searching MEDLINE (from 1966 to March 2000), EMBASE (from 1980 to March 2000), the Cochrane Library (Issue 3, 2000) and the Oxford Pain Relief Database (from 1950 to 1994) were searched. There was no restriction on the language of publication. The search terms were not reported. The reference lists of retrieved articles and reviews were examined for additional trials. Abstracts, review articles and unpublished reports were

2002 DARE.

132. A systematic review of the peripheral analgesic effects of intraarticular morphine

A systematic review of the peripheral analgesic effects of intraarticular morphine A systematic review of the peripheral analgesic effects of intraarticular morphine A systematic review of the peripheral analgesic effects of intraarticular morphine Gupta A, Bodin L, Holmstrom B, Berggren L Authors' objectives The authors state that the primary aim of this systematic review was to establish whether morphine injected intra-articularly has an analgesic effect when compared with placebo (...) . The secondary aims were to assess whether this is a dose-dependent effect, and if so, whether it is a systemic effect or occurs via peripheral receptors. Searching MEDLINE was searched between 1986 and 2000 for original publications, review articles, abstracts, case reports and letters to the editor. The keywords used were 'opiate/opioids', 'morphine', 'articular', 'arthroscopy', 'analgesia', 'pain' and 'postoperative'. In addition, the Cochrane Library, EMBASE, and the reference lists of all articles

2001 DARE.

133. Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review

Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review Hirayama T, Ishii F, Yago (...) K, Ogata H Authors' objectives To conduct a meta-analysis of the randomised controlled trials (RCTs) on the use of prophylactic drug therapy for post-operative nausea and vomiting (PONV), in patients receiving morphine for the treatment of post-operative pain. Searching MEDLINE (from 1966 to February 2000) and the Cochrane Library (Issue 1, 2000) were searched for relevant papers. Details of the search terms used are given in the original paper. The search was restricted to English language

2001 DARE.

134. Randomised crossover trial of transdermal fentanyl and sustained release oral morphine for treating chronic non-cancer pain. (PubMed)

Randomised crossover trial of transdermal fentanyl and sustained release oral morphine for treating chronic non-cancer pain. To compare patients' preference for transdermal fentanyl or sustained release oral morphine, their level of pain control, and their quality of life after treatment.Randomised, multicentre, international, open label, crossover trial.35 centres in Belgium, Canada, Denmark, Finland, the United Kingdom, the Netherlands, and South Africa.256 patients (aged 26-82 years (...) ) with chronic non-cancer pain who had been treated with opioids.Patients' preference for transdermal fentanyl or sustained release oral morphine, pain control, quality of life, and safety assessments.Of 212 patients, 138 (65%) preferred transdermal fentanyl, whereas 59 (28%) preferred sustained release oral morphine and 15 (7%) expressed no preference. Better pain relief was the main reason for preference for fentanyl given by 35% of patients. More patients considered pain control as being "good" or "very

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2001 BMJ Controlled trial quality: uncertain

135. Peripheral opioids: a systematic review of intra-articular morphine

Peripheral opioids: a systematic review of intra-articular morphine Peripheral opioids: a systematic review of intra-articular morphine Peripheral opioids: a systematic review of intra-articular morphine Kalso E Authors' objectives To assess the analgesic effect of intra-articular morphine. Searching MEDLINE (from 1966 to September 1998), EMBASE and the Oxford Pain Relief Database (1950 to 1994) were searched for reports in any language. The search terms included 'intra-articular', 'opiates (...) ', 'opioids', 'morphine' and 'random'. The reference lists of the retrieved reports and review articles were examined. Unpublished reports, abstracts and reviews were not included. Study selection Study designs of evaluations included in the review Randomised controlled trials (RCTs) with ten or more patients per treatment group were eligible. Specific interventions included in the review Studies that compared intra-articular morphine with placebo (saline) or different doses of intra-articular morphine

2000 DARE.

136. Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial

Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial Rainer T H, Jacobs P, Ng Y C, Cheung N K, Tam M, Lam P K, Wong R (...) , Cocks R A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Pain relief/management for patients with limb injuries. Specifically intravenous ketorolac and morphine were examined. Type of intervention Treatment; Pain relief. Economic

2000 NHS Economic Evaluation Database.

137. Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial

Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2000 PedsCCM Evidence-Based Journal Club

138. Effects of intrathecal morphine on the ventilatory response to hypoxia. (PubMed)

Effects of intrathecal morphine on the ventilatory response to hypoxia. Intrathecal administration of morphine produces intense analgesia, but it depresses respiration, an effect that can be life-threatening. Whether intrathecal morphine affects the ventilatory response to hypoxia, however, is not known.We randomly assigned 30 men to receive one of three study treatments in a double-blind fashion: intravenous morphine (0.14 mg per kilogram of body weight) with intrathecal placebo; intrathecal (...) morphine (0.3 mg) with intravenous placebo; or intravenous and intrathecal placebo. The selected doses of intravenous and intrathecal morphine produce similar degrees of analgesia. The ventilatory response to hypercapnia, the subsequent response to acute hypoxia during hypercapnic breathing (targeted end-tidal partial pressures of expired oxygen and carbon dioxide, 45 mm Hg), and the plasma levels of morphine and morphine metabolites were measured at base line (before drug administration) and 1, 2, 4

2000 NEJM Controlled trial quality: uncertain

139. Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. (PubMed)

Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. To investigate the cost effectiveness of intravenous ketorolac compared with intravenous morphine in relieving pain after blunt limb injury in an accident and emergency department.Double blind, randomised, controlled study and cost consequences analysis.Emergency department of a university hospital in the New Territories of Hong Kong.148 adult patients (...) with painful isolated limb injuries (limb injuries without other injuries).Primary outcome measure was a cost consequences analysis comparing the use of ketorolac with morphine; secondary outcome measures were pain relief at rest and with limb movement, adverse events, patients' satisfaction, and time spent in the emergency department.No difference was found in the median time taken to achieve pain relief at rest between the group receiving ketorolac and the group receiving morphine, but with movement

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2000 BMJ Controlled trial quality: predicted high

140. Injected morphine in postoperative pain: a quantitative systematic review

Injected morphine in postoperative pain: a quantitative systematic review Injected morphine in postoperative pain: a quantitative systematic review Injected morphine in postoperative pain: a quantitative systematic review McQuay H J, Carroll D, Moore R A Authors' objectives To compare the efficacy of single-dose subcutaneous, intramuscular or intravenous morphine with placebo in the control of post operative pain. Searching A number of different search strategies were conducted of MEDLINE (1966 (...) if they were full journal publications and reported data from which TOTPAR, SSPID, VASTOTPAR OR VASSPID could be calculated. Specific interventions included in the review Single doses of placebo were compared with single doses of morphine given intramuscularly or intravenously in doses of 5 mg, 8 mg, 10 mg, 12.5 mg and 20 mg. Participants included in the review Adult patients experiencing non-surgical pain (due to acute trauma) or undergoing the following types of surgery with baseline pain of moderate

1999 DARE.