Latest & greatest articles for morphine

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Top results for morphine

121. Treatment of intrathecal morphine-induced pruritus following Caesarean section

Treatment of intrathecal morphine-induced pruritus following Caesarean section Treatment of intrathecal morphine-induced pruritus following Caesarean section Treatment of intrathecal morphine-induced pruritus following Caesarean section Alhashemi J A, Crosby E T, Grodecki W, Duffy P J, Hull K A, Gallant C Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results (...) and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Nalbuphine and diphenhydramine in the treatment of intrathecal morphine-induced pruritus following Caesarean section. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Patients scheduled to undergo elective Caesarean section. Setting Hospital. The economic study was performed in Canada. Dates to which data relate It is not clear

NHS Economic Evaluation Database.1997

122. Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis

Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis Rockemann M G (...) followed-up until the fourth post-operative day (PO day). Five BOLUS and four PCEA patients dropped out because of inadequate analgesia with the pre-randomised regimen, occlusion or dislocation of the epidural catheter, or a systolic arterial pressure (SAP) greater than 80 mmHg. Analysis of effectiveness Drop-out patients were switched to intravenous patient-controlled opioid analgesia with morphine, and the recording of time and costs was continued; analgesia and side-effects were excluded from

NHS Economic Evaluation Database.1997

123. Cost-effectiveness of long-term intrathecal morphine therapy for pain associated with failed back surgery syndrome

Cost-effectiveness of long-term intrathecal morphine therapy for pain associated with failed back surgery syndrome Cost-effectiveness of long-term intrathecal morphine therapy for pain associated with failed back surgery syndrome Cost-effectiveness of long-term intrathecal morphine therapy for pain associated with failed back surgery syndrome de Lissovoy G, Brown R E, Halpern M, Hassenbusch S J, Ross E Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Use of intrathecal morphine therapy (IMT) administered via an implantable pump in patients suffering from intractable pain attributed to failed back surgery syndrome. Type of intervention Treatment and supportive care. Economic study type Cost-effectiveness analysis. Study

NHS Economic Evaluation Database.1997

124. A cost analysis of alfentanil + propofol vs morphine + midazolam for the sedation of critically ill patients

A cost analysis of alfentanil + propofol vs morphine + midazolam for the sedation of critically ill patients A cost analysis of alfentanil + propofol vs morphine + midazolam for the sedation of critically ill patients A cost analysis of alfentanil + propofol vs morphine + midazolam for the sedation of critically ill patients Manley N M, Fitzpatrick R W, Long T, Jones P W Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each (...) abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Alfentanil with propofol versus morphine with midazolam for the sedation of critically ill patients. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Critically ill patients admitted to the intensive care unit (ICU) and expected to need mechanical

NHS Economic Evaluation Database.1997

125. Randomised trial of epidural bupivacaine and morphine in prevention of stump and phantom pain in lower-limb amputation.

Randomised trial of epidural bupivacaine and morphine in prevention of stump and phantom pain in lower-limb amputation. 9365449 1997 12 05 1997 12 05 2015 06 16 0140-6736 350 9088 1997 Nov 08 Lancet (London, England) Lancet Randomised trial of epidural bupivacaine and morphine in prevention of stump and phantom pain in lower-limb amputation. 1353-7 Epidural analgesia before limb amputation is commonly used to reduce postamputation pain. But there have been no controlled studies with large (...) numbers of patients to prove such a pre-emptive effect. We investigated whether postamputation stump and phantom pain in the first year is reduced by preoperative epidural blockade with bupivacaine and morphine. In a randomised, double-blind trial, 60 patients scheduled for lower-limb amputation were randomly assigned epidural bupivacaine (0.25% 4-7 mL/h) and morphine (0.16-0.28 mg/h) for 18 h before and during the operation (29 patients; blockade group) or epidural saline (4-7 mL/h) and oral

Lancet1997

126. Randomised trial of oral morphine for painful episodes of sickle-cell disease in children.

Randomised trial of oral morphine for painful episodes of sickle-cell disease in children. 9365450 1997 12 05 1997 12 05 2015 06 16 0140-6736 350 9088 1997 Nov 08 Lancet (London, England) Lancet Randomised trial of oral morphine for painful episodes of sickle-cell disease in children. 1358-61 Oral controlled-release morphine can provide effective analgesia through a non-invasive route and may facilitate outpatient management of severe episodes of sickle-cell pain. We compared the clinical (...) efficacy and safety of oral morphine with continuous intravenous morphine in children with severe episodes of sickle-cell pain, by a double-blind, randomised, parallel-group design. 56 children aged 5-17 years received loading doses of intravenous morphine of up to 0.15 mg/kg, followed by randomly assigned oral morphine 1.9 mg/kg every 12 h plus intravenous placebo (saline), or intravenous morphine 0.04 mg kg-1 h-1, plus placebo tablet. Breakthrough pain was treated with oral, immediate-release

Lancet1997

127. Randomised trial of oral morphine for chronic non-cancer pain.

Randomised trial of oral morphine for chronic non-cancer pain. 8544547 1996 02 09 1996 02 09 2015 06 16 0140-6736 347 8995 1996 Jan 20 Lancet (London, England) Lancet Randomised trial of oral morphine for chronic non-cancer pain. 143-7 The use of opioid analgesics for chronic non-cancer pain is controversial. Some surveys report good pain relief and improvement in performance while others suggest a poor outcome with a propensity to psychological dependence or addiction. We undertook (...) a randomised double-blind crossover study to test the hypothesis that oral morphine relieves pain and improves the quality of life in patients with chronic regional pain of soft tissue or musculoskeletal origin who have not responded to codeine, anti-inflammatory agents, and antidepressants. Morphine was administered as a sustained-release preparation in doses up to 60 mg twice daily and compared with benztropine (active placebo) in doses up to 1 mg twice daily over three-week titration, six-week

Lancet1996

128. Morphine-augmented hepatobiliary scintigraphy: a meta-analysis

Morphine-augmented hepatobiliary scintigraphy: a meta-analysis Morphine-augmented hepatobiliary scintigraphy: a meta-analysis Morphine-augmented hepatobiliary scintigraphy: a meta-analysis Cabana M D, Alavi A, Berlin J A, Shea J A, Kim C K, Williams S V Authors' objectives To compare the sensitivity and specificity of morphine-augmented hepatobiliary scintigraphy (MA-HBS) with that of conventional hepatobiliary scintigraphy (C-HBS), in the diagnosis of acute cholecystitis. Searching MEDLINE (...) , or did not equal the sum of the patients in subgroups mentioned were excluded. Specific interventions included in the review Only studies of the diagnostic accuracy of MA-HBS and/or C-HBS were eligible for inclusion in the review. For MA-HBS a positive test had to be defined as non-visualisation of the gallbladder 20-30 min after morphine administration. For MA-HBS studies morphine augmentation had to be generally commenced 60 min after the start of the study if there was non-visualisation

DARE.1995

129. Randomised double-blind controlled trial of effect of morphine on catecholamine concentrations in ventilated pre-term babies.

Randomised double-blind controlled trial of effect of morphine on catecholamine concentrations in ventilated pre-term babies. 8101584 1993 08 26 1993 08 26 2015 06 16 0140-6736 342 8867 1993 Aug 07 Lancet (London, England) Lancet Randomised double-blind controlled trial of effect of morphine on catecholamine concentrations in ventilated pre-term babies. 324-7 A sick premature baby who requires intensive care will undergo many uncomfortable procedures. It is now accepted that such babies (...) perceive pain and need adequate analgesia, but little is known about the effects of sedation in these patients. We investigated the use of morphine to provide analgesia and sedation for ventilated preterm babies in a randomised, double-blind, placebo-controlled trial. 41 mechanically ventilated babies who had been treated with surfactant (Curosurf) for hyaline membrane disease were randomly assigned morphine in 5% dextrose (100 micrograms/kg per h for 2 h followed by 25 micrograms/kg per h continuous

Lancet1993

130. Preoperative morphine pre-empts postoperative pain.

Preoperative morphine pre-empts postoperative pain. 8100911 1993 08 09 1993 08 09 2015 06 16 0140-6736 342 8863 1993 Jul 10 Lancet (London, England) Lancet Preoperative morphine pre-empts postoperative pain. 73-5 Postoperative analgesia is usually inadequate, perhaps because conventional approaches to pain relief do not take account of underlying mechanisms. Pre-emptive analgesia may prevent nociceptive inputs generated during surgery from sensitising central neurons and, therefore, may reduce (...) postoperative pain. In a randomised, double-blind study, we compared the effect of parenteral morphine when given before or after total abdominal hysterectomy in 60 patients. 10 mg of morphine were given intramuscularly 1 hour before operation (im pre), intravenously at induction of anaesthesia (iv pre), or intravenously at closure of the peritoneum (iv post). Response was assessed by morphine consumption from patient-controlled analgesia machines which was found to be significantly reduced in the iv pre

Lancet1993

131. Halothane-morphine compared with high-dose sufentanil for anesthesia and postoperative analgesia in neonatal cardiac surgery.

Halothane-morphine compared with high-dose sufentanil for anesthesia and postoperative analgesia in neonatal cardiac surgery. 1530752 1992 01 09 1992 01 09 2013 11 21 0028-4793 326 1 1992 Jan 02 The New England journal of medicine N. Engl. J. Med. Halothane-morphine compared with high-dose sufentanil for anesthesia and postoperative analgesia in neonatal cardiac surgery. 1-9 Extreme hormonal and metabolic responses to stress are associated with increased morbidity and mortality in sick adults (...) . We hypothesized that administering deep opioid anesthesia to critically ill neonates undergoing cardiac surgery would blunt their responses to stress and might improve clinical outcomes. In a randomized trial, 30 neonates were assigned to receive deep intraoperative anesthesia with high doses of sufentanil and postoperative infusions of opiates for 24 hours; 15 neonates were assigned to receive lighter anesthesia with halothane and morphine followed postoperatively by intermittent morphine

NEJM1992

132. Morphine responsiveness of chronic pain: double-blind randomised crossover study with patient-controlled analgesia.

Morphine responsiveness of chronic pain: double-blind randomised crossover study with patient-controlled analgesia. 1350803 1992 07 06 1992 07 06 2015 06 16 0140-6736 339 8806 1992 Jun 06 Lancet (London, England) Lancet Morphine responsiveness of chronic pain: double-blind randomised crossover study with patient-controlled analgesia. 1367-71 There is controversy about whether the lack of response of some chronic pain to opioid treatment is absolute or relative. It is widely believed (...) that nociceptive pain is responsive to opioids whereas neuropathic pain tends not to be. We have used a method of patient-controlled analgesia (PCA) with simultaneous nurse-observer measurement of analgesia, mood, and adverse effects to address these issues. Ten patients with chronic pain were given morphine at two concentrations (10 and 30 mg/ml) by PCA in two separate sessions in a double-blind randomised crossover study. Before the study a clinical judgment was made as to whether each pain was nociceptive

Lancet1992

133. Analgesic effect of intraarticular morphine after arthroscopic knee surgery.

Analgesic effect of intraarticular morphine after arthroscopic knee surgery. 1653901 1991 10 16 1991 10 16 2013 11 21 0028-4793 325 16 1991 Oct 17 The New England journal of medicine N. Engl. J. Med. Analgesic effect of intraarticular morphine after arthroscopic knee surgery. 1123-6 Opioids can produce potent antinociceptive effects by interacting with local opioid receptors in inflamed peripheral tissue. In this study we examined the analgesic effects of the intraarticular, as compared (...) with intravenous, administration of morphine after arthroscopic knee surgery. In a double-blind, randomized trial, we studied 52 patients who had received one of four injections at the end of surgery. The patients in group 1 (n = 18) received 1 mg of morphine intraarticularly and saline intravenously; those in group 2 (n = 15), saline intraarticularly and 1 mg of morphine intravenously; those in group 3 (n = 10), 0.5 mg of morphine intraarticularly and saline intravenously; and those in group 4 (n = 9), 1 mg

NEJM1991

134. Epidural morphine decreases postoperative hypertension by attenuating sympathetic nervous system hyperactivity.

Epidural morphine decreases postoperative hypertension by attenuating sympathetic nervous system hyperactivity. 2724504 1989 07 10 1989 07 10 2016 10 17 0098-7484 261 24 1989 Jun 23-30 JAMA JAMA Epidural morphine decreases postoperative hypertension by attenuating sympathetic nervous system hyperactivity. 3577-81 Twenty-four adults who were undergoing operations on the abdominal aorta were enrolled in a randomized, double-blind, placebo-controlled study in which epidural morphine sulfate (6 mg (...) ) was employed to attenuate the sympathoadrenal response to surgery to evaluate the possible contribution of sympathetic nervous system hyperactivity to postoperative hypertension. Patients who received epidural morphine required less parenteral morphine in the 24 hours following surgery, had lower analogue pain scores, and had markedly lower plasma norepinephrine levels when compared with patients in the control group who received an identical volume of saline in the epidural space. Epidural morphine had

JAMA1989

135. Buccal morphine--a new route for analgesia?

Buccal morphine--a new route for analgesia? 2857025 1985 02 14 1985 02 14 2015 06 16 0140-6736 1 8420 1985 Jan 12 Lancet (London, England) Lancet Buccal morphine--a new route for analgesia? 71-3 The analgesic effects of buccal and intramuscular morphine were compared in a prospective, double-blind, double-dummy study in forty patients who experienced pain after elective orthopaedic operations. Each patient simultaneously received a buccal tablet and an intramuscular injection, only one of which (...) contained morphine sulphate (13.3 mg); the patients were randomly allocated to two equal groups so twenty patients received each active preparation. The two preparations produced a similar degree of postoperative analgesia, assessed by the mean reduction in pain score and the pain relief score. Peak plasma morphine concentrations were slightly lower after buccal than after intramuscular administration but they declined more slowly; consequently, the drug's bioavailability was 40-50% greater after buccal

Lancet1985

136. Orally administered zomepirac and parenterally administered morphine. Comparison for the treatment of postoperative pain.

Orally administered zomepirac and parenterally administered morphine. Comparison for the treatment of postoperative pain. 6776300 1981 01 29 1981 01 29 2016 10 17 0098-7484 244 20 1980 Nov 21 JAMA JAMA Orally administered zomepirac and parenterally administered morphine. Comparison for the treatment of postoperative pain. 2298-302 A double-blind study comparing the analgesic efficacy of orally administered zomepirac sodium with intramuscularly (IM) administered morphine sulfate was conducted (...) in 109 patients with acute postoperative pain. Single treatments were administered within 48 hours of surgery, and subjective responses were obtained from patients by specially employed trained nurses. Pain relief achieved with both doses of orally administered zomepirac sodium at 100 mg and 200 mg was similar, and analgesia with each dose of zomepirac was significantly better than that obtained with IM administered morphine sulfate at 8 mg. There were no unusual side effects with either drug

JAMA1980

137. Dextroamphetamine with morphine for the treatment of postoperative pain.

Dextroamphetamine with morphine for the treatment of postoperative pain. 320478 1977 04 28 1977 04 28 2013 11 21 0028-4793 296 13 1977 Mar 31 The New England journal of medicine N. Engl. J. Med. Dextroamphetamine with morphine for the treatment of postoperative pain. 712-5 In a double-blind, single-dose study, dextroamphetamine combined with morphine was compared with morphine alone to determine the relative efficacy of the combination given intramuscularly for postoperative pain. Each of 450 (...) patients received one treatment of morphine sulfate (3, 6 or 12 mg) with dextroamphetamine (0, 5 or 10 mg). Analgesia, as measured by the patients' subjective responses to questions about relief of pain, was augmented when dextroamphetamine was given with morphine; the combination of dextroamphetamine, 10 mg, with morphine was twice as potent as morphine alone, and the combination with 5 mg was 1 1/2 times as potent as morphine. In simple performance tests, and in measures of side effects

NEJM1977