Latest & greatest articles for morphine

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Top results for morphine

101. Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial.

Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial. 15158628 2004 05 25 2004 06 10 2015 06 16 1474-547X 363 9422 2004 May 22 Lancet (London, England) Lancet Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial. 1673-82 Opioid analgesia is commonly used during neonatal intensive care. We undertook the Neurologic Outcomes and Pre-emptive Analgesia in Neonates (NEOPAIN) trial (...) to investigate whether pre-emptive morphine analgesia decreases the rate of a composite primary outcome of neonatal death, severe intraventricular haemorrhage (IVH), and periventricular leucomalacia (PVL) in preterm neonates. Ventilated preterm neonates (n=898) from 16 centres were randomly assigned masked placebo (n=449) or morphine (n=449) infusions. After a loading dose (100 microg/kg), morphine infusions (23-26 weeks of gestation 10 microg kg(-1) h(-1); 27-29 weeks 20 microg kg(-1) h(-1); 30-32 weeks 30

Lancet2004

102. Patient-controlled transdermal fentanyl hydrochloride vs intravenous morphine pump for postoperative pain: a randomized controlled trial.

Patient-controlled transdermal fentanyl hydrochloride vs intravenous morphine pump for postoperative pain: a randomized controlled trial. 15026400 2004 03 17 2004 03 22 2016 10 17 1538-3598 291 11 2004 Mar 17 JAMA JAMA Patient-controlled transdermal fentanyl hydrochloride vs intravenous morphine pump for postoperative pain: a randomized controlled trial. 1333-41 Patient-controlled analgesia (PCA) with morphine is commonly used to provide acute postoperative pain control after major surgery (...) . The fentanyl hydrochloride patient-controlled transdermal system eliminates the need for venous access and complicated programming of pumps. To assess the efficacy and safety of an investigational patient-controlled iontophoretic transdermal system using fentanyl hydrochloride compared with a standard intravenous morphine patient-controlled pump. Prospective randomized controlled parallel-group trial conducted between September 2000 and March 2001 at 33 North American hospitals, enrolling 636 adult

JAMA2004

103. A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain

A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain Frei A, Andersen S, Hole P, Jensen N Record Status This is a critical abstract (...) of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study examined two treatments for chronic non-cancer pain. One was the fentanyl transdermal therapeutic system (fentanyl-TTS) and the other was oral sustained-release (SR) morphine. Monthly medication use was reported for patients

NHS Economic Evaluation Database.2003

104. Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea.

Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. 12958109 2003 09 05 2003 09 15 2014 06 11 1756-1833 327 7414 2003 Sep 06 BMJ (Clinical research ed.) BMJ Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. 523-8 To determine the efficacy of oral morphine in relieving the sensation of breathlessness in patients in whom (...) the underlying aetiology is maximally treated. Randomised, double blind, placebo controlled crossover study. Four outpatient clinics at a hospital in South Australia. 48 participants who had not previously been treated with opioids (mean age 76, SD 5) with predominantly chronic obstructive pulmonary disease (42, 88%) were randomised to four days of 20 mg oral morphine with sustained release followed by four days of identically formulated placebo, or vice versa. Laxatives were provided as needed. Dyspnoea

BMJ2003 Full Text: Link to full Text with Trip Pro

105. Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial.

Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. 14612478 2003 11 12 2003 11 25 2016 10 17 1538-3598 290 18 2003 Nov 12 JAMA JAMA Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. 2419-27 Newborns admitted to neonatal intensive care units (NICUs) undergo a variety of painful procedures and stressful events. Because the effect of continuous morphine infusion in preterm (...) neonates has not been investigated systematically, there is confusion regarding whether morphine should be used routinely in this setting. To evaluate the effects of continuous intravenous morphine infusion on pain responses, incidence of intraventricular hemorrhage (IVH), and poor neurologic outcome (severe IVH, periventricular leukomalacia, or death). A randomized, double-blind, placebo-controlled trial conducted between December 2000 and October 2002 in 2 level III NICUs in the Netherlands of 150

JAMA2003

106. Oral morphine for cancer pain.

Oral morphine for cancer pain. BACKGROUND: Morphine has been used to relieve pain for many years. Oral morphine in either immediate release or sustained release form remains the analgesic of choice for moderate or severe cancer pain. OBJECTIVES: To determine the efficacy of oral morphine in relieving cancer pain. To assess the incidence and severity of adverse effects. SEARCH STRATEGY: The following databases were searched: The Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane (...) Library, Issue 4, 2002; the trials register of the Cochrane Pain, Palliative and Supportive Care group (February 2002); MEDLINE 1966 to December 2002; EMBASE 1988 to December 2002; and the Oxford Pain Relief database 1950 to 1994. SELECTION CRITERIA: Published randomised controlled trials (full reports) reporting on the analgesic effect of oral morphine in adults and children with cancer pain. Any comparator trials were considered. Trials with fewer than 10 subjects were excluded. DATA COLLECTION

Cochrane2003

107. No pain, no gain: clinical excellence and scientific rigour: lessons learned from IA morphine

No pain, no gain: clinical excellence and scientific rigour: lessons learned from IA morphine No pain, no gain: clinical excellence and scientific rigour: lessons learned from IA morphine No pain, no gain: clinical excellence and scientific rigour: lessons learned from IA morphine Kalso E, Smith L, McQuay HJ, Moore RA Authors' objectives To include all evaluable studies on intra-articular morphine, to set simple criteria for study sensitivity, to analyse factors that can render studies (...) insensitive, and to analyse the effectiveness of intra-articular morphine. Searching MEDLINE (from 1966 to March 2000), EMBASE (from 1980 to March 2000), the Cochrane Library (Issue 3, 2000) and the Oxford Pain Relief Database (from 1950 to 1994) were searched. There was no restriction on the language of publication. The search terms were not reported. The reference lists of retrieved articles and reviews were examined for additional trials. Abstracts, review articles and unpublished reports were

DARE.2002

108. Nebulised morphine for severe interstitial lung disease.

Nebulised morphine for severe interstitial lung disease. BACKGROUND: The evidence to support the use of nebulized morphine to improve dyspnoea and exercise limitation in terminally ill patients with chronic lung disease is conflicting. OBJECTIVES: To assess the effectiveness of nebulized morphine in reducing dyspnoea in patients with end-stage interstitial lung disease SEARCH STRATEGY: RCTs and good quality CCTs were identified by searching Medline, Embase, Cinahl as well as the Cochrane (...) controlled clinical trial register. The following search terms were used: (inhaled OR nebulised)/AND/morphine AND/Idiopathic pulmonary fibrosis/or/pulmonary fibrosis/or/idiopathic interstitial pneumonia/or/nonspecific interstitial pneumonia/or/non-specific interstitial pneumonia/or/usual interstitial pneumonia/or/desquamative interstitial pneumonia/or/cryptogenic fibrosing alveolitis/or/interstitial pneumonia/or/idiopathic interstitial lung disease/or/chronic interstitial pneumonia SELECTION CRITERIA

Cochrane2002

109. Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review

Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review Hirayama T, Ishii F, Yago (...) K, Ogata H Authors' objectives To conduct a meta-analysis of the randomised controlled trials (RCTs) on the use of prophylactic drug therapy for post-operative nausea and vomiting (PONV), in patients receiving morphine for the treatment of post-operative pain. Searching MEDLINE (from 1966 to February 2000) and the Cochrane Library (Issue 1, 2000) were searched for relevant papers. Details of the search terms used are given in the original paper. The search was restricted to English language

DARE.2001

110. A systematic review of the peripheral analgesic effects of intraarticular morphine

A systematic review of the peripheral analgesic effects of intraarticular morphine A systematic review of the peripheral analgesic effects of intraarticular morphine A systematic review of the peripheral analgesic effects of intraarticular morphine Gupta A, Bodin L, Holmstrom B, Berggren L Authors' objectives The authors state that the primary aim of this systematic review was to establish whether morphine injected intra-articularly has an analgesic effect when compared with placebo (...) . The secondary aims were to assess whether this is a dose-dependent effect, and if so, whether it is a systemic effect or occurs via peripheral receptors. Searching MEDLINE was searched between 1986 and 2000 for original publications, review articles, abstracts, case reports and letters to the editor. The keywords used were 'opiate/opioids', 'morphine', 'articular', 'arthroscopy', 'analgesia', 'pain' and 'postoperative'. In addition, the Cochrane Library, EMBASE, and the reference lists of all articles

DARE.2001

111. Randomised crossover trial of transdermal fentanyl and sustained release oral morphine for treating chronic non-cancer pain.

Randomised crossover trial of transdermal fentanyl and sustained release oral morphine for treating chronic non-cancer pain. 11348910 2001 05 11 2001 06 14 2014 07 28 0959-8138 322 7295 2001 May 12 BMJ (Clinical research ed.) BMJ Randomised crossover trial of transdermal fentanyl and sustained release oral morphine for treating chronic non-cancer pain. 1154-8 To compare patients' preference for transdermal fentanyl or sustained release oral morphine, their level of pain (...) control, and their quality of life after treatment. Randomised, multicentre, international, open label, crossover trial. 35 centres in Belgium, Canada, Denmark, Finland, the United Kingdom, the Netherlands, and South Africa. 256 patients (aged 26-82 years) with chronic non-cancer pain who had been treated with opioids. Patients' preference for transdermal fentanyl or sustained release oral morphine, pain control, quality of life, and safety assessments. Of 212 patients, 138 (65%) preferred transdermal fentanyl, whereas

BMJ2001 Full Text: Link to full Text with Trip Pro

112. Peripheral opioids: a systematic review of intra-articular morphine

Peripheral opioids: a systematic review of intra-articular morphine Peripheral opioids: a systematic review of intra-articular morphine Peripheral opioids: a systematic review of intra-articular morphine Kalso E Authors' objectives To assess the analgesic effect of intra-articular morphine. Searching MEDLINE (from 1966 to September 1998), EMBASE and the Oxford Pain Relief Database (1950 to 1994) were searched for reports in any language. The search terms included 'intra-articular', 'opiates (...) ', 'opioids', 'morphine' and 'random'. The reference lists of the retrieved reports and review articles were examined. Unpublished reports, abstracts and reviews were not included. Study selection Study designs of evaluations included in the review Randomised controlled trials (RCTs) with ten or more patients per treatment group were eligible. Specific interventions included in the review Studies that compared intra-articular morphine with placebo (saline) or different doses of intra-articular morphine

DARE.2000

113. Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial

Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial Rainer T H, Jacobs P, Ng Y C, Cheung N K, Tam M, Lam P K, Wong R (...) , Cocks R A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Pain relief/management for patients with limb injuries. Specifically intravenous ketorolac and morphine were examined. Type of intervention Treatment; Pain relief. Economic

NHS Economic Evaluation Database.2000

114. Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial

Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2000

115. Effects of intrathecal morphine on the ventilatory response to hypoxia.

Effects of intrathecal morphine on the ventilatory response to hypoxia. 11071674 2000 10 16 2000 10 26 2016 11 24 0028-4793 343 17 2000 Oct 26 The New England journal of medicine N. Engl. J. Med. Effects of intrathecal morphine on the ventilatory response to hypoxia. 1228-34 Intrathecal administration of morphine produces intense analgesia, but it depresses respiration, an effect that can be life-threatening. Whether intrathecal morphine affects the ventilatory response to hypoxia, however (...) , is not known. We randomly assigned 30 men to receive one of three study treatments in a double-blind fashion: intravenous morphine (0.14 mg per kilogram of body weight) with intrathecal placebo; intrathecal morphine (0.3 mg) with intravenous placebo; or intravenous and intrathecal placebo. The selected doses of intravenous and intrathecal morphine produce similar degrees of analgesia. The ventilatory response to hypercapnia, the subsequent response to acute hypoxia during hypercapnic breathing (targeted

NEJM2000

116. Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial.

Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. 11082083 2000 12 11 2001 01 04 2014 06 15 0959-8138 321 7271 2000 Nov 18 BMJ (Clinical research ed.) BMJ Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. 1247-51 To investigate the cost effectiveness of intravenous ketorolac compared with intravenous (...) morphine in relieving pain after blunt limb injury in an accident and emergency department. Double blind, randomised, controlled study and cost consequences analysis. Emergency department of a university hospital in the New Territories of Hong Kong. 148 adult patients with painful isolated limb injuries (limb injuries without other injuries). Primary outcome measure was a cost consequences analysis comparing the use of ketorolac with morphine; secondary outcome measures were pain relief at rest

BMJ2000 Full Text: Link to full Text with Trip Pro

117. Injected morphine in postoperative pain: a quantitative systematic review

Injected morphine in postoperative pain: a quantitative systematic review Injected morphine in postoperative pain: a quantitative systematic review Injected morphine in postoperative pain: a quantitative systematic review McQuay H J, Carroll D, Moore R A Authors' objectives To compare the efficacy of single-dose subcutaneous, intramuscular or intravenous morphine with placebo in the control of post operative pain. Searching A number of different search strategies were conducted of MEDLINE (1966 (...) if they were full journal publications and reported data from which TOTPAR, SSPID, VASTOTPAR OR VASSPID could be calculated. Specific interventions included in the review Single doses of placebo were compared with single doses of morphine given intramuscularly or intravenously in doses of 5 mg, 8 mg, 10 mg, 12.5 mg and 20 mg. Participants included in the review Adult patients experiencing non-surgical pain (due to acute trauma) or undergoing the following types of surgery with baseline pain of moderate

DARE.1999

118. Determination of an effective dose of intrathecal morphine for pain relief after cesarean delivery

Determination of an effective dose of intrathecal morphine for pain relief after cesarean delivery Determination of an effective dose of intrathecal morphine for pain relief after cesarean delivery Determination of an effective dose of intrathecal morphine for pain relief after cesarean delivery Gerancher J C, Floyd H, Eisenach J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Administering intrathecal (IT) morphine along with oral hydrocodone/acetaminophen and other commonly prescribed drugs for pain relief after cesarean delivery. The method of administration of IT morphine was up-down sequential allocation of doses. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population

NHS Economic Evaluation Database.1999

119. A randomized comparison of ketorolac tromethamine and morphine for postoperative analgesia in critically ill children.

A randomized comparison of ketorolac tromethamine and morphine for postoperative analgesia in critically ill children. PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club1999

120. Pain relief from intra-articular morphine after knee surgery: a qualitative systematic review

Pain relief from intra-articular morphine after knee surgery: a qualitative systematic review Pain relief from intra-articular morphine after knee surgery: a qualitative systematic review Pain relief from intra-articular morphine after knee surgery: a qualitative systematic review Kalso E, Tramer MR, Carroll D, McQuay HJ, Moore RA Authors' objectives To investigate the evidence for an analgesic effect of intra-articular morphine and to examine those features of trial methodology which influence (...) or with different doses of intra-articular morphine, were included. Specific interventions included in the review Intra-articular morphine, intravenous morphine, intramuscular morphine, intra-articular bupivacaine. Participants included in the review Patients, all of whom had undergone knee surgery. Outcomes assessed in the review Pain intensity was assessed during two time periods: early (up to six hours from intra-articular injection) and late (from six to 24 hours). The total consumption of rescue analgesics

DARE.1997