Latest & greatest articles for morphine

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Top results for morphine

101. Intranasal fentanyl and intravenous morphine did not differ for pain relief in children with closed long-bone fractures

Intranasal fentanyl and intravenous morphine did not differ for pain relief in children with closed long-bone fractures Intranasal fentanyl and intravenous morphine did not differ for pain relief in children with closed long-bone fractures | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Intranasal fentanyl and intravenous morphine did not differ for pain relief in children with closed long-bone fractures Article Text Therapeutics

2007 Evidence-Based Medicine

102. Drugs - Morphine Sulphate

Drugs - Morphine Sulphate Morphine Sulphate MOR Drugs October 2006 Page 1 of 4 Drugs PRESENTATION Ampoules containing Morphine Sulphate 10 milligrams in 1ml. ACTIONS Morphine is a strong opioid analgesic drug for parenteral administration for pain relief. It is particularly useful for treating severe continuous pain of visceral or soft tissue origins. Morphine produces sedation, euphoria and analgesia; it may both depress respiration and induce hypotension. Histamine is released following (...) morphine administration, this may contribute to its vasodilatory effects and it may also cause bronchoconstriction. INDICATIONS Pain associated with suspected myocardial infarction (analgesic of ?rst choice). Severe pain. The decision about which analgesia and which route should be guided by clinical judgement (refer to adult and child pain management guidelines). CONTRA-INDICATIONS Do NOT give morphine in the following circumstances: Children under 1 year of age. Respiratory depression (Adult 65 2.5

2007 Joint Royal Colleges Ambulance Liaison Committee

103. Drugs - Morphine Sulphate Oral Solution

Drugs - Morphine Sulphate Oral Solution Morphine Sulphate Oral Solution MOR Drugs October 2006 Page 1 of 3 Drugs PRESENTATION 5ml unit dose vials containing morphine sulphate 10 milligrams in 5ml (2 milligrams in 1ml). ACTIONS Morphine is a strong opioid analgesic drug for oral administration for pain relief. It is particularly useful for treating severe continuous pain of visceral or soft tissue origins. Morphine produces sedation, euphoria and analgesia; it may both depress respiration (...) and induce hypotension. Histamine is released following morphine administration, this may contribute to its vasodilatory effects and it may also cause bronchoconstriction. INDICATIONS Severe pain. The decision about which analgesia and which route should be guided by clinical judgement (see adult and child pain management guidelines). CONTRA-INDICATIONS Do NOT give oral morphine in the following circumstances: Unable to swallow or protect own airway. Cardiac pain – use intravenous morphine. Children

2007 Joint Royal Colleges Ambulance Liaison Committee

104. Intravenous morphine and topical tetracaine for treatment of pain in [corrected] neonates undergoing central line placement. Full Text available with Trip Pro

Intravenous morphine and topical tetracaine for treatment of pain in [corrected] neonates undergoing central line placement. There is limited evidence of the analgesic effectiveness of opioid analgesia or topical anesthesia during central line placement in neonates, and there are no previous studies of their relative effectiveness.To determine the effectiveness and safety of topical tetracaine, intravenous morphine, or tetracaine plus morphine for alleviating pain in ventilated neonates during (...) central line placement.Randomized, double-blind, controlled trial enrolling 132 ventilated neonates (mean gestational age, 30.6 [SD, 4.6] weeks at study entry) and conducted between October 2000 and July 2005 in 2 neonatal intensive care units in Toronto, Ontario.Prior to central line insertion, neonates were randomly assigned to receive tetracaine (n = 42), morphine (n = 38), or both (n = 31); a separate nonrandomized group of 21 neonates receiving neither tetracaine nor morphine was used

2006 JAMA Controlled trial quality: predicted high

105. Morphine Sulphate Oral Solution

Morphine Sulphate Oral Solution Morphine Sulphate Oral Solution MOR Drugs October 2006 Page 1 of 3 Drugs PRESENTATION 5ml unit dose vials containing morphine sulphate 10 milligrams in 5ml (2 milligrams in 1ml). ACTIONS Morphine is a strong opioid analgesic drug for oral administration for pain relief. It is particularly useful for treating severe continuous pain of visceral or soft tissue origins. Morphine produces sedation, euphoria and analgesia; it may both depress respiration and induce (...) hypotension. Histamine is released following morphine administration, this may contribute to its vasodilatory effects and it may also cause bronchoconstriction. INDICATIONS Severe pain. The decision about which analgesia and which route should be guided by clinical judgement (see adult and child pain management guidelines). CONTRA-INDICATIONS Do NOT give oral morphine in the following circumstances: Unable to swallow or protect own airway. Cardiac pain – use intravenous morphine. Children under 1 year

2006 Joint Royal Colleges Ambulance Liaison Committee

106. Morphine Sulphate

Morphine Sulphate Morphine Sulphate MOR Drugs October 2006 Page 1 of 4 Drugs PRESENTATION Ampoules containing Morphine Sulphate 10 milligrams in 1ml. ACTIONS Morphine is a strong opioid analgesic drug for parenteral administration for pain relief. It is particularly useful for treating severe continuous pain of visceral or soft tissue origins. Morphine produces sedation, euphoria and analgesia; it may both depress respiration and induce hypotension. Histamine is released following morphine (...) administration, this may contribute to its vasodilatory effects and it may also cause bronchoconstriction. INDICATIONS Pain associated with suspected myocardial infarction (analgesic of ?rst choice). Severe pain. The decision about which analgesia and which route should be guided by clinical judgement (refer to adult and child pain management guidelines). CONTRA-INDICATIONS Do NOT give morphine in the following circumstances: Children under 1 year of age. Respiratory depression (Adult 65 2.5 milligrams 2.5ml

2006 Joint Royal Colleges Ambulance Liaison Committee

107. The Paining, Part I (Morphine in acute abdomen)

The Paining, Part I (Morphine in acute abdomen) The Paining, Part I (Morphine in acute abdomen) « Sinai EM Journal Club Emergency Medicine Discussion Forum The Paining, Part I (Morphine in acute abdomen) I’m finally getting around to the some of the good articles on ED pain management that appeared this summer. The first was in the August 2006 Annals of EM, an article by Gallagher, Esses et al. entitled, “ The authors tested the oft-repeated dictum that morphine affects diagnostic accuracy (...) , measuring pain on a 0-100mm visual scale in a prospective double-blind random trial, giving 0.1 mg / kg of IV Morphine sulfate or placebo (ouch!) with an endpoint of “diagnostic accuracy” (ie, comparing the provisional diagnosis made by an emergency physician in 15 minutes after the agent is given, vs. diagnosis at six or more weeks of followup.) They randomized 78 patients into the morphine arm, 73 into the placebo group. After fifteen minutes, the patients who got morphine changed their pain rating

2006 Sinai EM Journal Club

108. The Paining 2: Too Much Pain (Morphine vs. Dilaudid)

The Paining 2: Too Much Pain (Morphine vs. Dilaudid) The Paining 2: Too Much Pain (Morphine vs. Dilaudid) « Sinai EM Journal Club Emergency Medicine Discussion Forum The Paining 2: Too Much Pain (Morphine vs. Dilaudid) We continue to make our way through the recent pain management papers, once again turning to the August Annals ( ). Chang, Gallagher et al. strike back with a second analgesia piece in this issue — from now on, Montefiore will be simply be known as the House of Pain. The paper’s (...) called Safety and Efficacy of Hydromorphone as an Analgesic Alternative to Morphine in Acute Pain: An RCT (if you’re logged into the Sinai library, full text is ). It’s full of provocative hypotheses, good study technique, and fun historical trivia… more below! While some may doubt it, surveys and chart reviews still suggest pain is not well treated in the ED — even 0.1 mg / kg of morphine (resulting in 10 mg in the heavy folks) probably isn’t sufficient. Yet docs are loathe to order 10 mg off

2006 Sinai EM Journal Club

109. Morphine, gabapentin, or their combination for neuropathic pain. Full Text available with Trip Pro

Morphine, gabapentin, or their combination for neuropathic pain. The available drugs to treat neuropathic pain have incomplete efficacy and dose-limiting adverse effects. We compared the efficacy of a combination of gabapentin and morphine with that of each as a single agent in patients with painful diabetic neuropathy or postherpetic neuralgia.In this randomized, double-blind, active placebo-controlled, four-period crossover trial, patients received daily active placebo (lorazepam), sustained (...) -release morphine, gabapentin, and a combination of gabapentin and morphine--each given orally for five weeks. The primary outcome measure was mean daily pain intensity in patients receiving a maximal tolerated dose; secondary outcomes included pain (rated according to the Short-Form McGill Pain Questionnaire), adverse effects, maximal tolerated doses, mood, and quality of life.Of 57 patients who underwent randomization (35 with diabetic neuropathy and 22 with postherpetic neuralgia), 41 completed

2005 NEJM Controlled trial quality: predicted high

110. Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials

Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials Marret E, Kurdi O, Zufferey P, Bonnet F CRD summary (...) This review assessed the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on morphine-related adverse effects in post-operative patient-controlled analgesia. The authors concluded that NSAIDs reduced post-operative nausea and vomiting and sedation, but not pruritus, urinary retention and respiratory depression. Other than the reporting of review methods, the review was well conducted and the authors' conclusions are likely to be reliable. Authors' objectives To assess the effects of non-steroidal

2005 DARE.

111. Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials

Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

112. Cost-effectiveness of thoracic patient-controlled epidural analgesia using bupivacaine with fentanyl vs. bupivacaine with morphine after thoracotomy and upper abdominal surgery

Cost-effectiveness of thoracic patient-controlled epidural analgesia using bupivacaine with fentanyl vs. bupivacaine with morphine after thoracotomy and upper abdominal surgery Cost-effectiveness of thoracic patient-controlled epidural analgesia using bupivacaine with fentanyl vs. bupivacaine with morphine after thoracotomy and upper abdominal surgery Cost-effectiveness of thoracic patient-controlled epidural analgesia using bupivacaine with fentanyl vs. bupivacaine with morphine after (...) analgesia (TPCEA), using bupivacaine with fentanyl (BF) or bupivacaine with morphine (BM). All the patients received balanced salt solution before the thoracic epidural catheter was placed at the thoracic level of 6 - 8 for thoracotomy and of 8 - 10 for upper abdominal surgery. All patients received general anaesthesia. No opioids were given intravenously during the preoperative and intraoperative period, except one dose of fentanyl (>/= 2 microg/kg) during the induction period. Intraoperative analgesia

2005 NHS Economic Evaluation Database.

113. Morphine sulphate analgesia did not affect diagnostic accuracy in undifferentiated abdominal pain Full Text available with Trip Pro

Morphine sulphate analgesia did not affect diagnostic accuracy in undifferentiated abdominal pain Morphine sulphate analgesia did not affect diagnostic accuracy in undifferentiated abdominal pain | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Morphine sulphate analgesia did not affect diagnostic accuracy in undifferentiated abdominal pain Article Text Therapeutics Morphine sulphate analgesia did not affect diagnostic accuracy

2004 Evidence-Based Medicine

114. Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial. (Abstract)

Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial. Opioid analgesia is commonly used during neonatal intensive care. We undertook the Neurologic Outcomes and Pre-emptive Analgesia in Neonates (NEOPAIN) trial to investigate whether pre-emptive morphine analgesia decreases the rate of a composite primary outcome of neonatal death, severe intraventricular haemorrhage (IVH), and periventricular leucomalacia (PVL) in preterm (...) neonates.Ventilated preterm neonates (n=898) from 16 centres were randomly assigned masked placebo (n=449) or morphine (n=449) infusions. After a loading dose (100 microg/kg), morphine infusions (23-26 weeks of gestation 10 microg kg(-1) h(-1); 27-29 weeks 20 microg kg(-1) h(-1); 30-32 weeks 30 microg kg(-1) h(-1)) were continued as long as clinically justified (maximum 14 days). Open-label morphine could be given on clinical judgment (placebo group 242/443 [54.6%], morphine group 202/446 [45.3%]). Analyses were

2004 Lancet Controlled trial quality: predicted high

115. Patient-controlled transdermal fentanyl hydrochloride vs intravenous morphine pump for postoperative pain: a randomized controlled trial. Full Text available with Trip Pro

Patient-controlled transdermal fentanyl hydrochloride vs intravenous morphine pump for postoperative pain: a randomized controlled trial. Patient-controlled analgesia (PCA) with morphine is commonly used to provide acute postoperative pain control after major surgery. The fentanyl hydrochloride patient-controlled transdermal system eliminates the need for venous access and complicated programming of pumps.To assess the efficacy and safety of an investigational patient-controlled iontophoretic (...) transdermal system using fentanyl hydrochloride compared with a standard intravenous morphine patient-controlled pump.Prospective randomized controlled parallel-group trial conducted between September 2000 and March 2001 at 33 North American hospitals, enrolling 636 adult patients who had just undergone major surgery.In surgical recovery rooms, patients were randomly assigned to intravenous morphine (1-mg bolus every 5 minutes; maximum of 10 mg/h) by a patient-controlled analgesia pump (n = 320

2004 JAMA Controlled trial quality: predicted high

116. Efficacy of oral rofecoxib versus intravenous ketoprofen as an adjuvant to PCA morphine after urologic surgery

Efficacy of oral rofecoxib versus intravenous ketoprofen as an adjuvant to PCA morphine after urologic surgery Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2004 NHS Economic Evaluation Database.

117. Oral morphine for cancer pain. (Abstract)

Oral morphine for cancer pain. Morphine has been used to relieve pain for many years. Oral morphine in either immediate release or sustained release form remains the analgesic of choice for moderate or severe cancer pain.To determine the efficacy of oral morphine in relieving cancer pain. To assess the incidence and severity of adverse effects.The following databases were searched: The Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Library, Issue 4, 2002; the trials register (...) of the Cochrane Pain, Palliative and Supportive Care group (February 2002); MEDLINE 1966 to December 2002; EMBASE 1988 to December 2002; and the Oxford Pain Relief database 1950 to 1994.Published randomised controlled trials (full reports) reporting on the analgesic effect of oral morphine in adults and children with cancer pain. Any comparator trials were considered. Trials with fewer than 10 subjects were excluded.One reviewer extracted data, and the findings were checked by two other reviewers. There were

2003 Cochrane

118. Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. Full Text available with Trip Pro

Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. To determine the efficacy of oral morphine in relieving the sensation of breathlessness in patients in whom the underlying aetiology is maximally treated.Randomised, double blind, placebo controlled crossover study.Four outpatient clinics at a hospital in South Australia.48 participants who had not previously been treated with opioids (mean age 76, SD 5 (...) ) with predominantly chronic obstructive pulmonary disease (42, 88%) were randomised to four days of 20 mg oral morphine with sustained release followed by four days of identically formulated placebo, or vice versa. Laxatives were provided as needed.Dyspnoea in the morning and evening as shown on a 100 mm visual analogue scale, quality of sleep, wellbeing, performance on physical exertion, and side effects as measured at the end of the four day treatment period.38 participants completed the study; three withdrew

2003 BMJ Controlled trial quality: predicted high

119. Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. Full Text available with Trip Pro

Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. Newborns admitted to neonatal intensive care units (NICUs) undergo a variety of painful procedures and stressful events. Because the effect of continuous morphine infusion in preterm neonates has not been investigated systematically, there is confusion regarding whether morphine should be used routinely in this setting.To evaluate the effects of continuous intravenous morphine infusion (...) malformations, and administration of neuromuscular blockers).Intravenous morphine (100 microg/kg and 10 microg/kg per hour) or placebo infusion was given for 7 days (or less because of clinical necessity in several cases).The analgesic effect of morphine, as assessed using validated scales; the effect of morphine on the incidence of IVH; and poor neurologic outcome.The analgesic effect did not differ between the morphine and placebo groups, judging from the following median (interquartile range) pain scores

2003 JAMA Controlled trial quality: predicted high

120. A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain

A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain Frei A, Andersen S, Hole P, Jensen N Record Status This is a critical abstract (...) of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study examined two treatments for chronic non-cancer pain. One was the fentanyl transdermal therapeutic system (fentanyl-TTS) and the other was oral sustained-release (SR) morphine. Monthly medication use was reported for patients

2003 NHS Economic Evaluation Database.