Latest & greatest articles for morphine

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Top results for morphine

81. Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis (PubMed)

Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis We performed a systematic review to determine the overall efficacy of serotonin (5-HT3) receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women receiving spinal anesthesia with intrathecal morphine for cesarean delivery.Reports of randomized, controlled (...) in reducing the incidence of pruritus, they significantly reduced the severity and the need for treatment of pruritus, the incidence of postoperative nausea and vomiting, and the need for rescue antiemetic therapy in parturients who received intrathecal morphine for cesarean delivery. They were also effective for the treatment of established pruritus. Although more studies are warranted, the current data suggest that the routine prophylactic use of those drugs should be considered in this patient

2009 EvidenceUpdates

82. The interaction between epidural 2-chloroprocaine and morphine: a randomized controlled trial of the effect of drug administration timing on the efficacy of morphine analgesia (PubMed)

The interaction between epidural 2-chloroprocaine and morphine: a randomized controlled trial of the effect of drug administration timing on the efficacy of morphine analgesia The efficacy and duration of epidural morphine analgesia is diminished when administered after 2-chloroprocaine compared with lidocaine. The mechanism of the interaction between 2-chloroprocaine and morphine is unknown. Possible explanations include differences in the latency and duration of action of the two drugs (...) or opioid receptor antagonism. We hypothesized that administration of epidural morphine 30 min before the initiation of 2-chloroprocaine anesthesia would result in postoperative analgesia of similar duration and quality to that achieved by epidural morphine after the initiation of lidocaine anesthesia in patients undergoing postpartum tubal ligation.Subjects undergoing bilateral postpartum tubal ligation after vaginal delivery with epidural analgesia were randomized to one of three groups. Subjects

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2009 EvidenceUpdates

83. Morphine with adjuvant ketamine vs. Higher doses of morphine alone for immediate post-thoracotomy analgesia (PubMed)

Morphine with adjuvant ketamine vs. Higher doses of morphine alone for immediate post-thoracotomy analgesia Thoracotomy is associated with severe pain. We hypothesized that the concomitant use of a subanesthetic dose of ketamine plus a two-third-standard morphine dose might provide more effective analgesia with fewer side effects than a standard morphine dose for early pain control.We conducted a 6-month randomized, double-blind study in patients undergoing thoracotomy for minimally invasive (...) direct coronary artery bypass or for lung tumor resection. After extubation, when objectively awake (>or= 5/10 visual analogue scale [VAS]) and complaining of pain (>or= 5/10 VAS), patients were connected to patient-controlled IV analgesia delivering 1.5 mg of morphine plus saline solution (MO) or 1.0 mg of morphine plus a 5-mg ketamine bolus (MK), with a 7-min lockout time. Rescue IM diclofenac, 75 mg, was available. Follow-up lasted 4 h.Forty-one patients completed the study. MO patients (n = 20

2009 EvidenceUpdates

84. The efficacy of intrathecal morphine with or without clonidine for postoperative analgesia after radical prostatectomy (PubMed)

The efficacy of intrathecal morphine with or without clonidine for postoperative analgesia after radical prostatectomy In this randomized study, we compared intrathecal (i.t.) morphine with or without clonidine and i.v. postoperative patient-controlled analgesia (PCA) morphine for analgesia after radical retropubic prostatectomy.Fifty patients were randomly divided into three groups. They were allocated to receive i.t. morphine (4 microg/kg) (M group), i.t. morphine and clonidine (1 microg/kg (...) ) (MC group), or PCA (PCA group). Each patient was given morphine PCA for postoperative analgesia. The primary objective was the quantity of morphine required during the first 48 postoperative hours. The first request for morphine, numeric pain score at rest and on coughing, the time of tracheal decannulation and adverse effects (pruritus, postoperative nausea and vomiting, respiratory depression) were recorded.Morphine consumption in the first 48 h was decreased in the M and MC groups. The numeric

2009 EvidenceUpdates

85. Reduced hospital stay, morphine consumption, and pain intensity with local infiltration analgesia after unicompartmental knee arthroplasty (PubMed)

Reduced hospital stay, morphine consumption, and pain intensity with local infiltration analgesia after unicompartmental knee arthroplasty The degree of postoperative pain is usually moderate to severe following knee arthroplasty. We investigated the efficacy of local administration of analgesics into the operating area, both intraoperatively and postoperatively.40 patients undergoing unicompartmental knee arthroplasty (UKA) were randomized into 2 groups in a double-blind study (...) in group A than in group P: 1 (1-6) days as opposed to 3 (1-6) days (p < 0.001). Postoperative pain in group A was statistically significantly lower at rest after 6 h and 27 h and on movement after 6, 12, 22, and 27 h. Morphine consumption was statistically significantly lower in group A for the first 48 h, resulting in a lower frequency of nausea, pruritus, and sedation. Postoperatively, there were improved functional scores (Oxford knee score and EQ-5D) in both groups relative to the corresponding

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2009 EvidenceUpdates

86. Ketamine and lornoxicam for preventing a fentanyl-induced increase in postoperative morphine requirement (PubMed)

Ketamine and lornoxicam for preventing a fentanyl-induced increase in postoperative morphine requirement N-methyl-D-aspartate receptor antagonists and nonsteroidal anti-inflammatory drugs are believed to prevent opioid-induced hyperalgesia and/or acute opioid tolerance, which could cause an increase in postoperative opioid requirement. In this randomized, double-blind, placebo-controlled study, we investigated whether co-administration of ketamine or lornoxicam and fentanyl could prevent (...) the increase of postoperative morphine requirement induced by fentanyl alone.Ninety females undergoing total abdominal hysterectomy with spinal anesthesia were randomly assigned to six groups consisting of placebo (normal saline, C), fentanyl (three bolus of 1 microg x kg(-1), F), ketamine (infusion of 15 microg x kg(-1) x min(-1), K), ketamine and fentanyl (infusion of 15 microg x kg(-1) x min(-1) ketamine plus three bolus of 1 microg x kg(-1) fentanyl, FK), lornoxicam (one bolus of 8 mg, L

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2009 EvidenceUpdates

87. Extended-release epidural morphine sulfate (Depodur) - relief of postoperative pain following major orthopaedic, abdominal or pelvic surgery

Extended-release epidural morphine sulfate (Depodur) - relief of postoperative pain following major orthopaedic, abdominal or pelvic surgery Medicines advice Search Medicines advice / Search Filters Know what are you looking for? Submission type British National Formulary - Chapter Pharmaceutical company From To Advice Accepted Not recommended Restricted Superseded Withdrawn Interim acceptance Process End of life/orphan Additional Details Patient Access Scheme Advanced Search SMC ID Date

2009 Scottish Medicines Consortium

88. Risks and side-effects of intrathecal morphine combined with spinal anaesthesia: a meta-analysis

Risks and side-effects of intrathecal morphine combined with spinal anaesthesia: a meta-analysis Risks and side-effects of intrathecal morphine combined with spinal anaesthesia: a meta-analysis Risks and side-effects of intrathecal morphine combined with spinal anaesthesia: a meta-analysis Gehling M, Tryba M CRD summary This review found the use of intrathecal morphine in combination with spinal anaesthesia for post-operative analgesia was associated with an increase in nausea, vomiting (...) and pruritus. The authors' conclusions reflected the evidence presented but some methodological weaknesses mean that the reliability of these conclusions is unclear. Authors' objectives To assess the frequency of side-effects in patients receiving intrathecal morphine in combination with spinal anaesthesia. Searching MEDLINE was searched from inception to 2007; search terms were reported. Reference lists of retrieved articles were also searched for additional studies. It was unclear if any language

2009 DARE.

89. Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis

Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting (...) in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis George RB, Allen TK, Habib AS CRD summary This review found that prophylactic serotonin (5-HT 3 ) receptor antagonists did not reduce pruritus incidence, but significantly reduced severity and need for pruritus treatment, postoperative nausea and vomiting and need for antiemetic therapy, and effectively treated established pruritus, in women who received intrathecal morphine for caesarean delivery

2009 DARE.

90. The side effects of morphine and hydromorphone patient-controlled analgesia (PubMed)

The side effects of morphine and hydromorphone patient-controlled analgesia Despite "clinical lore" among health care providers that treatment with hydromorphone results in improved pain control and fewer adverse side effects, morphine continues to be the first-line medication for postoperative patient-controlled analgesia (PCA). In this study, we compared the efficacy and side-effect profiles of morphine and hydromorphone at concentrations producing equivalent drug effect measured by pain (...) score and miosis.We conducted a prospective, randomized, double-blind trial of 50 general and gynecological surgery patients. Subjects were randomly assigned to receive either morphine (1 mg/mL) or hydromorphone (0.2 mg/mL) via PCA after surgery and were followed for a period of 8 h. The primary outcome was nausea. Secondary outcome variables were pruritus, vomiting, sedation, pain report, pupillary miosis, and patient satisfaction.The side effect profile was not different between drugs

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2008 EvidenceUpdates

91. Therapeutic effect of intrathecal morphine after posterior lumbar interbody fusion surgery: a prospective, double-blind, randomized study (PubMed)

Therapeutic effect of intrathecal morphine after posterior lumbar interbody fusion surgery: a prospective, double-blind, randomized study Prospective, double-blind, randomized, placebo-controlled study.To assess the efficacy and safety of 0.4 mg intrathecal morphine for postoperative pain control after posterior lumbar interbody fusion (PLIF) surgery.Multiple studies have established the technique of intrathecal morphine analgesia in a wide variety of clinical settings. Several trials were (...) conducted in patients undergoing spine surgery, generally supporting the efficacy for this type of surgery. Many exhibit methodologic problems with dosing regimes or study design.After the institutional review board-approval and written informed consent, 52 patients scheduled for PLIF-surgery were enrolled, of whom 46 could be analyzed. Patients were randomized to receive 0.4 mg morphine (M-group) or normal saline (P-group) intrathecally under direct vision before the end of surgery. Additionally, all

2008 EvidenceUpdates

92. Postoperative ketamine administration decreases morphine consumption in major abdominal surgery: a prospective, randomized, double-blind, controlled study (PubMed)

Postoperative ketamine administration decreases morphine consumption in major abdominal surgery: a prospective, randomized, double-blind, controlled study Ketamine decreases postoperative morphine consumption, but its optimal dosing and duration of administration remain unclear. In this study, we compared the effects of ketamine administration on morphine consumption limited to the intraoperative period, or continued for 48 h postoperatively.Eighty-one patients scheduled for abdominal surgery (...) were prospectively randomized under double-blind conditions to three groups: (1) PERI group receiving intraoperative and postoperative ketamine for the first 48 h after surgery (2 microg x kg(-1) x min(-1) after a 0.5 mg/kg bolus); (2) INTRA group receiving intraoperative ketamine administration only (2 microg x kg(-1) x min(-1) after a 0.5 mg/kg bolus); and (3) CTRL group receiving placebo. Morphine consumption, visual analog scale scores and side effects (sedation score, nausea-vomiting score

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2008 EvidenceUpdates

93. Intranasal fentanyl and intravenous morphine did not differ for pain relief in children with closed long-bone fractures

Intranasal fentanyl and intravenous morphine did not differ for pain relief in children with closed long-bone fractures Intranasal fentanyl and intravenous morphine did not differ for pain relief in children with closed long-bone fracturesCommentary | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using (...) your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Intranasal fentanyl and intravenous morphine did not differ for pain relief in children with closed long-bone fracturesCommentary Article Text

2008 Evidence-Based Nursing

94. Oral morphine for cancer pain. (PubMed)

Oral morphine for cancer pain. This is an updated version of a previous Cochrane review first published in Issue 4, 2003 of The Cochrane Library. Morphine has been used for many years to relieve pain. Oral morphine in either immediate release or modified release form remains the analgesic of choice for moderate or severe cancer pain.To determine the efficacy of oral morphine in relieving cancer pain and to assess the incidence and severity of adverse effects.The following databases were (...) searched: Cochrane Pain, Palliative and Supportive Care Group Trials Register (December 2006); Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2006, Issue 4); MEDLINE (1966 to December 2006); and EMBASE (1974 to December 2006).Published randomised controlled trials (RCTs) reporting on the analgesic effect of oral morphine in adults and children with cancer pain. Any comparator trials were considered. Trials with fewer than ten participants were excluded.One review author

2007 Cochrane

95. Drugs - Morphine Sulphate Oral Solution

Drugs - Morphine Sulphate Oral Solution Morphine Sulphate Oral Solution MOR Drugs October 2006 Page 1 of 3 Drugs PRESENTATION 5ml unit dose vials containing morphine sulphate 10 milligrams in 5ml (2 milligrams in 1ml). ACTIONS Morphine is a strong opioid analgesic drug for oral administration for pain relief. It is particularly useful for treating severe continuous pain of visceral or soft tissue origins. Morphine produces sedation, euphoria and analgesia; it may both depress respiration (...) and induce hypotension. Histamine is released following morphine administration, this may contribute to its vasodilatory effects and it may also cause bronchoconstriction. INDICATIONS Severe pain. The decision about which analgesia and which route should be guided by clinical judgement (see adult and child pain management guidelines). CONTRA-INDICATIONS Do NOT give oral morphine in the following circumstances: Unable to swallow or protect own airway. Cardiac pain – use intravenous morphine. Children

2007 Joint Royal Colleges Ambulance Liaison Committee

96. Drugs - Morphine Sulphate

Drugs - Morphine Sulphate Morphine Sulphate MOR Drugs October 2006 Page 1 of 4 Drugs PRESENTATION Ampoules containing Morphine Sulphate 10 milligrams in 1ml. ACTIONS Morphine is a strong opioid analgesic drug for parenteral administration for pain relief. It is particularly useful for treating severe continuous pain of visceral or soft tissue origins. Morphine produces sedation, euphoria and analgesia; it may both depress respiration and induce hypotension. Histamine is released following (...) morphine administration, this may contribute to its vasodilatory effects and it may also cause bronchoconstriction. INDICATIONS Pain associated with suspected myocardial infarction (analgesic of ?rst choice). Severe pain. The decision about which analgesia and which route should be guided by clinical judgement (refer to adult and child pain management guidelines). CONTRA-INDICATIONS Do NOT give morphine in the following circumstances: Children under 1 year of age. Respiratory depression (Adult 65 2.5

2007 Joint Royal Colleges Ambulance Liaison Committee

97. Intranasal fentanyl and intravenous morphine did not differ for pain relief in children with closed long-bone fractures

Intranasal fentanyl and intravenous morphine did not differ for pain relief in children with closed long-bone fractures Intranasal fentanyl and intravenous morphine did not differ for pain relief in children with closed long-bone fractures | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Intranasal fentanyl and intravenous morphine did not differ for pain relief in children with closed long-bone fractures Article Text Therapeutics

2007 Evidence-Based Medicine (Requires free registration)

98. Intravenous morphine and topical tetracaine for treatment of pain in [corrected] neonates undergoing central line placement. (PubMed)

Intravenous morphine and topical tetracaine for treatment of pain in [corrected] neonates undergoing central line placement. There is limited evidence of the analgesic effectiveness of opioid analgesia or topical anesthesia during central line placement in neonates, and there are no previous studies of their relative effectiveness.To determine the effectiveness and safety of topical tetracaine, intravenous morphine, or tetracaine plus morphine for alleviating pain in ventilated neonates during (...) central line placement.Randomized, double-blind, controlled trial enrolling 132 ventilated neonates (mean gestational age, 30.6 [SD, 4.6] weeks at study entry) and conducted between October 2000 and July 2005 in 2 neonatal intensive care units in Toronto, Ontario.Prior to central line insertion, neonates were randomly assigned to receive tetracaine (n = 42), morphine (n = 38), or both (n = 31); a separate nonrandomized group of 21 neonates receiving neither tetracaine nor morphine was used

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2006 JAMA

99. Morphine Sulphate Oral Solution

Morphine Sulphate Oral Solution Morphine Sulphate Oral Solution MOR Drugs October 2006 Page 1 of 3 Drugs PRESENTATION 5ml unit dose vials containing morphine sulphate 10 milligrams in 5ml (2 milligrams in 1ml). ACTIONS Morphine is a strong opioid analgesic drug for oral administration for pain relief. It is particularly useful for treating severe continuous pain of visceral or soft tissue origins. Morphine produces sedation, euphoria and analgesia; it may both depress respiration and induce (...) hypotension. Histamine is released following morphine administration, this may contribute to its vasodilatory effects and it may also cause bronchoconstriction. INDICATIONS Severe pain. The decision about which analgesia and which route should be guided by clinical judgement (see adult and child pain management guidelines). CONTRA-INDICATIONS Do NOT give oral morphine in the following circumstances: Unable to swallow or protect own airway. Cardiac pain – use intravenous morphine. Children under 1 year

2006 Joint Royal Colleges Ambulance Liaison Committee

100. Morphine Sulphate

Morphine Sulphate Morphine Sulphate MOR Drugs October 2006 Page 1 of 4 Drugs PRESENTATION Ampoules containing Morphine Sulphate 10 milligrams in 1ml. ACTIONS Morphine is a strong opioid analgesic drug for parenteral administration for pain relief. It is particularly useful for treating severe continuous pain of visceral or soft tissue origins. Morphine produces sedation, euphoria and analgesia; it may both depress respiration and induce hypotension. Histamine is released following morphine (...) administration, this may contribute to its vasodilatory effects and it may also cause bronchoconstriction. INDICATIONS Pain associated with suspected myocardial infarction (analgesic of ?rst choice). Severe pain. The decision about which analgesia and which route should be guided by clinical judgement (refer to adult and child pain management guidelines). CONTRA-INDICATIONS Do NOT give morphine in the following circumstances: Children under 1 year of age. Respiratory depression (Adult 65 2.5 milligrams 2.5ml

2006 Joint Royal Colleges Ambulance Liaison Committee