Latest & greatest articles for morphine

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Top results for morphine

61. Sufentanil is not superior to morphine for the treatment of acute traumatic pain in an emergency setting: a randomized, double-blind, out-of-hospital trial

Sufentanil is not superior to morphine for the treatment of acute traumatic pain in an emergency setting: a randomized, double-blind, out-of-hospital trial 20382445 2010 11 01 2010 11 12 2013 11 21 1097-6760 56 5 2010 Nov Annals of emergency medicine Ann Emerg Med Sufentanil is not superior to morphine for the treatment of acute traumatic pain in an emergency setting: a randomized, double-blind, out-of-hospital trial. 509-16 10.1016/j.annemergmed.2010.03.020 We determine the best intravenous (...) opioid titration protocol by comparing morphine and sufentanil for adult patients with severe traumatic acute pain in an out-of-hospital setting, with a physician providing care. In this double-blind randomized clinical trial, patients were eligible for inclusion if aged 18 years or older, with acute severe pain (defined as a numeric rating scale score ≥ 6/10) caused by trauma. They were assigned to receive either intravenous 0.15 μg/kg sufentanil, followed by 0.075 μg/kg every 3 minutes

EvidenceUpdates2010

62. NMDA-receptor antagonist and morphine decrease CRPS-pain and cerebral pain representation

NMDA-receptor antagonist and morphine decrease CRPS-pain and cerebral pain representation 20630656 2010 09 13 2010 12 28 2013 11 21 1872-6623 151 1 2010 Oct Pain Pain NMDA-receptor antagonist and morphine decrease CRPS-pain and cerebral pain representation. 69-76 10.1016/j.pain.2010.06.022 A combination therapy of morphine with an NMDA-receptor antagonist might be more effective than morphine without a NMDA-receptor antagonist for the relief of neuropathic pain in patients with complex regional (...) pain syndrome (CRPS). In order to test the efficacy of this combination therapy we performed a double-blind randomized placebo-controlled study on patients suffering from CRPS of the upper extremity. We used functional magnetic resonance imaging during movement of the affected and unaffected upper hand before and after a treatment regimen of 49 days that contrasted morphine and an NMDA-receptor antagonist with morphine and placebo. We postulated superior pain relief for the combination therapy

EvidenceUpdates2010

63. Intranasal fentanyl or diamorphine versus intravenous morphine for analgesia in adults

Intranasal fentanyl or diamorphine versus intravenous morphine for analgesia in adults BestBets: Intranasal fentanyl or diamorphine versus intravenous morphine for analgesia in adults Intranasal fentanyl or diamorphine versus intravenous morphine for analgesia in adults Report By: Lee Helliwell - SpR Emergency Medicine Search checked by Catherine Jackson - ST5, Emergency Medicine Institution: Lancashire Teaching Hospitals NHS Trust Current web editor: Richard Body - Clinical Research Fellow (...) Date Submitted: 8th December 2009 Date Completed: 7th September 2010 Last Modified: 8th September 2010 Status: Green (complete) Three Part Question In [adults presenting to the Emergency Department in pain] is [intranasal fentanyl superior to intravenous morphine] at [reducing pain]? Clinical Scenario It is 7:45am and you are just winding down with a coffee before the end of a shift and the doors to the Emergency Department (ED) burst open. Lying on a stretcher is a young, obese lady who

BestBETS2010

64. The analgesic efficacy of subarachnoid morphine in comparison with ultrasound-guided transversus abdominis plane block after cesarean delivery: a randomized controlled trial

The analgesic efficacy of subarachnoid morphine in comparison with ultrasound-guided transversus abdominis plane block after cesarean delivery: a randomized controlled trial 20488929 2010 07 28 2010 08 26 2016 11 25 1526-7598 111 2 2010 Aug Anesthesia and analgesia Anesth. Analg. The analgesic efficacy of subarachnoid morphine in comparison with ultrasound-guided transversus abdominis plane block after cesarean delivery: a randomized controlled trial. 475-81 10.1213/ANE.0b013e3181e30b9f (...) Ultrasound-guided transversus abdominis plane block is an effective method of providing pain relief after cesarean delivery. Neuraxial morphine is currently the "gold standard" treatment for pain after cesarean delivery. In this study we tested the hypothesis that subarachnoid morphine would provide more prolonged and superior analgesia than would transversus abdominis plane block in patients undergoing elective cesarean delivery. In this prospective, double-blind study, 57 patients were randomly

EvidenceUpdates2010

65. ALO-01 (morphine sulfate and naltrexone hydrochloride) extended-release capsules in the treatment of chronic pain of osteoarthritis of the hip or knee: pharmacokinetics, efficacy, and safety

ALO-01 (morphine sulfate and naltrexone hydrochloride) extended-release capsules in the treatment of chronic pain of osteoarthritis of the hip or knee: pharmacokinetics, efficacy, and safety 19944650 2010 03 30 2010 07 01 2013 11 21 1528-8447 11 4 2010 Apr The journal of pain : official journal of the American Pain Society J Pain ALO-01 (morphine sulfate and naltrexone hydrochloride) extended-release capsules in the treatment of chronic pain of osteoarthritis of the hip or knee (...) : pharmacokinetics, efficacy, and safety. 303-11 10.1016/j.jpain.2009.07.017 ALO-01 (EMBEDA [morphine sulfate and naltrexone hydrochloride] extended-release capsules [King Pharmaceuticals, Inc, Bridgewater, NJ]), indicated for chronic moderate-to-severe pain, is designed to release naltrexone upon tampering (eg, by crushing), reducing morphine-induced subjective effects. This multicenter, randomized, double-blind, crossover study assessed pharmacokinetics, efficacy, and safety of ALO-01 and compared them

EvidenceUpdates2010

67. A randomized, double-blind, placebo-controlled trial of epidural morphine analgesia after vaginal delivery

A randomized, double-blind, placebo-controlled trial of epidural morphine analgesia after vaginal delivery 19910627 2009 12 21 2010 01 12 2013 11 21 1526-7598 110 1 2010 Jan 01 Anesthesia and analgesia Anesth. Analg. A randomized, double-blind, placebo-controlled trial of epidural morphine analgesia after vaginal delivery. 159-64 10.1213/ANE.0b013e3181c30f78 Pain after vaginal delivery can interfere with the activities of daily living. We hypothesized that epidural medication administered after (...) delivery would be of benefit for acute postpartum pain management. The objective of this study was to assess whether epidural morphine after vaginal delivery would reduce the analgesic requirements for perineal pain. This randomized, double-blind, placebo-controlled trial included 228 parturients who received epidural morphine, 2.5 mg, or epidural saline within 1 h of delivery. The primary outcome was the proportion of women who received additional analgesics in the first 24 h postpartum. We also

EvidenceUpdates2010

68. Morphine use after combat injury in Iraq and post-traumatic stress disorder.

Morphine use after combat injury in Iraq and post-traumatic stress disorder. BACKGROUND: Post-traumatic stress disorder (PTSD) is a common adverse mental health outcome among seriously injured civilians and military personnel who are survivors of trauma. Pharmacotherapy in the aftermath of serious physical injury or exposure to traumatic events may be effective for the secondary prevention of PTSD. METHODS: We identified 696 injured U.S. military personnel without serious traumatic brain injury (...) from the Navy-Marine Corps Combat Trauma Registry Expeditionary Medical Encounter Database. Complete data on medications administered were available for all personnel selected. The diagnosis of PTSD was obtained from the Career History Archival Medical and Personnel System and verified in a review of medical records. RESULTS: Among the 696 patients studied, 243 received a diagnosis of PTSD and 453 did not. The use of morphine during early resuscitation and trauma care was significantly associated

NEJM2010

69. Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side-effects after major surgery: a systematic review

Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side-effects after major surgery: a systematic review Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side-effects after major surgery: a systematic review Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side (...) -effects after major surgery: a systematic review McDaid C, Maund E, Rice S, Wright K, Jenkins B, Woolacott N Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation McDaid C, Maund E, Rice S, Wright K, Jenkins B, Woolacott N. Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related

Health Technology Assessment (HTA) Database.2010

70. Analgesic efficacy and adverse effects of epidural morphine compared to parenteral opioids after elective caesarean section: a systematic review

Analgesic efficacy and adverse effects of epidural morphine compared to parenteral opioids after elective caesarean section: a systematic review Analgesic efficacy and adverse effects of epidural morphine compared to parenteral opioids after elective caesarean section: a systematic review Analgesic efficacy and adverse effects of epidural morphine compared to parenteral opioids after elective caesarean section: a systematic review Bonnet MP, Mignon A, Mazoit JX, Ozier Y, Marret E CRD summary (...) The authors concluded that epidural morphine after caesarean section increased the time to first request for a rescue analgesic (limited to the first postoperative day) and decreased pain postoperatively, but increased the risks of nausea and pruritus. Apart from some limitations in reporting of the review process, the authors' conclusions reflect the reasonable quality evidence presented and seem reliable. Authors' objectives To evaluate the analgesic effectiveness and side effects of epidural morphine

DARE.2010

71. Intravenous paracetamol or morphine for the treatment of renal colic: a randomized, placebo-controlled trial

Intravenous paracetamol or morphine for the treatment of renal colic: a randomized, placebo-controlled trial 19647342 2009 09 22 2009 10 08 2013 11 21 1097-6760 54 4 2009 Oct Annals of emergency medicine Ann Emerg Med Intravenous paracetamol or morphine for the treatment of renal colic: a randomized, placebo-controlled trial. 568-74 10.1016/j.annemergmed.2009.06.501 This randomized, placebo-controlled trial evaluates the analgesic efficacy and safety of intravenous single-dose paracetamol (...) and morphine for the treatment of renal colic. We conducted a randomized, double-blind, placebo-controlled clinical trial comparing single intravenous doses of paracetamol (1 g), morphine (0.1 mg/kg), and placebo (normal saline solution) for patients presenting to the emergency department (ED) with suspected renal colic. Subjects with inadequate pain relief at 30 minutes received rescue fentanyl (0.75 microg/kg). We compared changes in pain intensity 30 minutes after treatment among the 3 arms, as well

EvidenceUpdates2010

72. A randomized controlled trial of pentazocine versus ondansetron for the treatment of intrathecal morphine-induced pruritus in patients undergoing cesarean delivery

A randomized controlled trial of pentazocine versus ondansetron for the treatment of intrathecal morphine-induced pruritus in patients undergoing cesarean delivery 19843798 2009 10 21 2009 11 05 2013 11 21 1526-7598 109 5 2009 Nov Anesthesia and analgesia Anesth. Analg. A randomized controlled trial of pentazocine versus ondansetron for the treatment of intrathecal morphine-induced pruritus in patients undergoing cesarean delivery. 1606-11 10.1213/ANE.0b013e3181b72e93 Ondansetron is effective (...) for the treatment of intrathecal morphine-induced pruritus. There is evidence that kappa-opioid receptor agonists have antipruritic activity. Pentazocine is an agonist of kappa-opioid receptors and partial agonist at mu-opioid receptors. We therefore performed a randomized, double-blind trial to compare the efficacy of pentazocine and ondansetron for the treatment of pruritus associated with intrathecal injection of morphine in patients undergoing cesarean delivery. Two hundred eight parturients who developed

EvidenceUpdates2010

73. Morphine-based cardiac anesthesia provides superior early recovery compared with fentanyl in elective cardiac surgery patients

Morphine-based cardiac anesthesia provides superior early recovery compared with fentanyl in elective cardiac surgery patients 19608797 2009 07 17 2009 07 30 2014 11 20 1526-7598 109 2 2009 Aug Anesthesia and analgesia Anesth. Analg. Morphine-based cardiac anesthesia provides superior early recovery compared with fentanyl in elective cardiac surgery patients. 311-9 10.1213/ane.0b013e3181a90adc Experimental and clinical data suggest that morphine possesses unique cardioprotective (...) and antiinflammatory properties. In this clinical investigation, we sought to determine whether the choice of intraoperative opioid (morphine or fentanyl) influences early recovery after cardiac surgery. Ninety patients undergoing cardiac surgery with cardiopulmonary bypass were randomized to receive either morphine (40 mg) or fentanyl (600 mug) as part of a standardized opioid-isoflurane anesthetic. Quality of recovery was assessed using the QoR-40 questionnaire administered preoperatively and daily

EvidenceUpdates2009

74. The interaction between epidural 2-chloroprocaine and morphine: a randomized controlled trial of the effect of drug administration timing on the efficacy of morphine analgesia

The interaction between epidural 2-chloroprocaine and morphine: a randomized controlled trial of the effect of drug administration timing on the efficacy of morphine analgesia 19535707 2009 06 18 2009 07 21 2013 11 21 1526-7598 109 1 2009 Jul Anesthesia and analgesia Anesth. Analg. The interaction between epidural 2-chloroprocaine and morphine: a randomized controlled trial of the effect of drug administration timing on the efficacy of morphine analgesia. 168-73 10.1213/ane.0b013e3181a40cf6 (...) The efficacy and duration of epidural morphine analgesia is diminished when administered after 2-chloroprocaine compared with lidocaine. The mechanism of the interaction between 2-chloroprocaine and morphine is unknown. Possible explanations include differences in the latency and duration of action of the two drugs or opioid receptor antagonism. We hypothesized that administration of epidural morphine 30 min before the initiation of 2-chloroprocaine anesthesia would result in postoperative analgesia of

EvidenceUpdates2009

75. The efficacy of intrathecal morphine with or without clonidine for postoperative analgesia after radical prostatectomy

The efficacy of intrathecal morphine with or without clonidine for postoperative analgesia after radical prostatectomy 19448230 2009 05 18 2009 06 05 2013 11 21 1526-7598 108 6 2009 Jun Anesthesia and analgesia Anesth. Analg. The efficacy of intrathecal morphine with or without clonidine for postoperative analgesia after radical prostatectomy. 1954-7 10.1213/ane.0b013e3181a30182 In this randomized study, we compared intrathecal (i.t.) morphine with or without clonidine and i.v. postoperative (...) patient-controlled analgesia (PCA) morphine for analgesia after radical retropubic prostatectomy. Fifty patients were randomly divided into three groups. They were allocated to receive i.t. morphine (4 microg/kg) (M group), i.t. morphine and clonidine (1 microg/kg) (MC group), or PCA (PCA group). Each patient was given morphine PCA for postoperative analgesia. The primary objective was the quantity of morphine required during the first 48 postoperative hours. The first request for morphine, numeric

EvidenceUpdates2009

76. Morphine with adjuvant ketamine vs. Higher doses of morphine alone for immediate post-thoracotomy analgesia

Morphine with adjuvant ketamine vs. Higher doses of morphine alone for immediate post-thoracotomy analgesia 18753471 2009 07 08 2009 08 05 2014 07 30 1931-3543 136 1 2009 Jul Chest Chest Morphine with adjuvant ketamine vs higher dose of morphine alone for immediate postthoracotomy analgesia. 245-52 10.1378/chest.08-0246 Thoracotomy is associated with severe pain. We hypothesized that the concomitant use of a subanesthetic dose of ketamine plus a two-third-standard morphine dose might provide (...) more effective analgesia with fewer side effects than a standard morphine dose for early pain control. We conducted a 6-month randomized, double-blind study in patients undergoing thoracotomy for minimally invasive direct coronary artery bypass or for lung tumor resection. After extubation, when objectively awake (>or= 5/10 visual analogue scale [VAS]) and complaining of pain (>or= 5/10 VAS), patients were connected to patient-controlled IV analgesia delivering 1.5 mg of morphine plus saline

EvidenceUpdates2009

77. Reduced hospital stay, morphine consumption, and pain intensity with local infiltration analgesia after unicompartmental knee arthroplasty

Reduced hospital stay, morphine consumption, and pain intensity with local infiltration analgesia after unicompartmental knee arthroplasty 19404806 2009 04 30 2009 05 04 2016 12 15 1745-3682 80 2 2009 Apr Acta orthopaedica Acta Orthop Reduced hospital stay, morphine consumption, and pain intensity with local infiltration analgesia after unicompartmental knee arthroplasty. 213-9 10.3109/17453670902930008 The degree of postoperative pain is usually moderate to severe following knee arthroplasty (...) were given. 21 hours postoperatively, 150 mg ropivacain, 30 mg ketorolac, and 0.1 mg epinephrine were injected intraarticularly via a catheter in group A, whereas patients in group P were injected with the same volume of saline (22 mL). Median hospital stay was shorter in group A than in group P: 1 (1-6) days as opposed to 3 (1-6) days (p < 0.001). Postoperative pain in group A was statistically significantly lower at rest after 6 h and 27 h and on movement after 6, 12, 22, and 27 h. Morphine

EvidenceUpdates2009 Full Text: Link to full Text with Trip Pro

78. Extended-release epidural morphine sulfate (Depodur) - relief of postoperative pain following major orthopaedic, abdominal or pelvic surgery

Extended-release epidural morphine sulfate (Depodur) - relief of postoperative pain following major orthopaedic, abdominal or pelvic surgery Scottish Medicines Consortium Briefing Note - extended-release epidural morphine sulfate (Depodur) NHS SCOTLAND Providing advice about the status of all newly licensed medicines Useful Liks Resize text: | | | | | | NHS Scotland Site Search: You are here: > > > > Briefing Note - extended-release epidural morphine sulfate (Depodur) Briefing Note - extended (...) -release epidural morphine sulfate (Depodur) SMC did not recommend extended-release epidural morphine (EREM) for the relief of postoperative pain following major orthopaedic, abdominal or pelvic surgery. Major surgery can result in the patient experiencing significant pain and therefore requiring pain relief medication. The epidural space is the area outside the spinal cord but inside the vertebral canal of the spinal column. The epidural space is used for drug administration as it allows the drug

Scottish Medicines Consortium2009

79. Ketamine and lornoxicam for preventing a fentanyl-induced increase in postoperative morphine requirement

Ketamine and lornoxicam for preventing a fentanyl-induced increase in postoperative morphine requirement 19020155 2008 11 21 2008 12 30 2013 11 21 1526-7598 107 6 2008 Dec Anesthesia and analgesia Anesth. Analg. Ketamine and lornoxicam for preventing a fentanyl-induced increase in postoperative morphine requirement. 2032-7 10.1213/ane.0b013e3181888061 N-methyl-D-aspartate receptor antagonists and nonsteroidal anti-inflammatory drugs are believed to prevent opioid-induced hyperalgesia (...) and/or acute opioid tolerance, which could cause an increase in postoperative opioid requirement. In this randomized, double-blind, placebo-controlled study, we investigated whether co-administration of ketamine or lornoxicam and fentanyl could prevent the increase of postoperative morphine requirement induced by fentanyl alone. Ninety females undergoing total abdominal hysterectomy with spinal anesthesia were randomly assigned to six groups consisting of placebo (normal saline, C), fentanyl (three bolus

EvidenceUpdates2009

80. Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis

Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting (...) in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis George RB, Allen TK, Habib AS CRD summary This review found that prophylactic serotonin (5-HT 3 ) receptor antagonists did not reduce pruritus incidence, but significantly reduced severity and need for pruritus treatment, postoperative nausea and vomiting and need for antiemetic therapy, and effectively treated established pruritus, in women who received intrathecal morphine for caesarean delivery

DARE.2009