Latest & greatest articles for morphine

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Top results for morphine

61. The efficacy of 2 doses of epidural morphine for postcesarean delivery analgesia: a randomized noninferiority trial (PubMed)

The efficacy of 2 doses of epidural morphine for postcesarean delivery analgesia: a randomized noninferiority trial A single dose of epidural morphine is effective in reducing pain after cesarean delivery but is associated with adverse effects. In this study, we sought to establish whether half the traditional dose of epidural morphine, when administered as part of a multimodal analgesia regimen after cesarean delivery, was associated with noninferior analgesia and fewer adverse effects.Ninety (...) term parturients undergoing cesarean delivery under epidural anesthesia were enrolled in this randomized, double-blinded, noninferiority study. Patients were randomly allocated to receive either 3 mg epidural morphine or, half this dose, 1.5 mg epidural morphine. In addition, subjects received regular systemic ketorolac and acetaminophen. Rescue analgesia (oral oxycodone) was administered for breakthrough pain. The primary outcome was the difference between groups in total opioid consumption

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2013 EvidenceUpdates Controlled trial quality: predicted high

62. Oral morphine for cancer pain. (PubMed)

Oral morphine for cancer pain. This is the second updated version of a Cochrane review first published in Issue 4, 2003 of The Cochrane Library and first updated in 2007. Morphine has been used for many years to relieve pain. Oral morphine in either immediate release or modified release form remains the analgesic of choice for moderate or severe cancer pain.To determine the efficacy of oral morphine in relieving cancer pain, and assess the incidence and severity of adverse effects.We searched (...) the following databases: Cochrane Pain, Palliative and Supportive Care Group Trials Register (June 2013); Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2013, Issue 5, May); MEDLINE (1966 to June 2013); and EMBASE (1974 to June 2013).Published randomised controlled trials (RCTs) using placebo or active comparators reporting on the analgesic effect of oral morphine in adults and children with cancer pain. Trials with fewer than ten participants were excluded.One review author

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2013 Cochrane

63. Is Pain After TKA Better with Periarticular Injection or Intrathecal Morphine? (PubMed)

Is Pain After TKA Better with Periarticular Injection or Intrathecal Morphine? Postoperative pain after TKA is a major concern to patients. The best technique to control pain is still controversial. Intrathecal morphine or periarticular multimodal drug injection are both commonly used and both appear to provide better pain control than placebo, but it is unclear whether one or the other provides better pain control.We asked whether intrathecal morphine or periarticular multimodal drug injection (...) provides better pain control with fewer adverse events.In a prospective, double-blind, randomized controlled trial we randomized 57 patients with osteoarthritic knees who underwent TKAs into two groups. Group M (n = 28) received 0.2 mg intrathecal morphine while Group I (n = 29) received periarticular multimodal drug injection. Postoperative pain was managed with patient-controlled analgesia using ketorolac. The outcomes were pain levels, the amount of analgesic drug used, and drug-related side effects

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2013 EvidenceUpdates Controlled trial quality: predicted high

64. Morphine Sulfate Injection

Morphine Sulfate Injection Drug Approval Package: Brand Name (Generic Name) NDA # Drug Approval Package U.S. Food & Drug Administration Search FDA Drug Approval Package - Morphine Sulfate Injection Company: BD Rx Inc. Application No.: 204223 Approval Date: 10/30/2013 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) Date created: March 6, 2014 Vision impaired

2013 FDA - Drug Approval Package

65. Randomised controlled trial: Intravenous analgesia for out-of-hospital traumatic pain in adults: ketamine gives a greater reduction in pain than morphine but causes more adverse effects

Randomised controlled trial: Intravenous analgesia for out-of-hospital traumatic pain in adults: ketamine gives a greater reduction in pain than morphine but causes more adverse effects Intravenous analgesia for out-of-hospital traumatic pain in adults: ketamine gives a greater reduction in pain than morphine but causes more adverse effects | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via (...) traumatic pain in adults: ketamine gives a greater reduction in pain than morphine but causes more adverse effects Article Text Pain management Randomised controlled trial Intravenous analgesia for out-of-hospital traumatic pain in adults: ketamine gives a greater reduction in pain than morphine but causes more adverse effects William Paul McKay Statistics from Altmetric.com Commentary on: Jennings PA , Cameron P , Bernard S , et al . Morphine and ketamine is superior to morphine alone for out

2013 Evidence-Based Nursing

66. Codeine for analgesia: restricted use in children because of reports of morphine toxicity

Codeine for analgesia: restricted use in children because of reports of morphine toxicity Codeine for analgesia: restricted use in children because of reports of morphine toxicity - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Codeine for analgesia: restricted use in children because of reports of morphine toxicity Codeine should only be used to relieve acute moderate pain in children older than 12 years and only if it cannot be relieved by other painkillers (...) and is considered to be suitable for persistent pain of up to moderate intensity. It is commonly used in combination with other drugs—mainly paracetamol, but also aspirin, caffeine, or ibuprofen. However, despite its established use, there remains substantial lack of knowledge about its safety and efficacy—particularly in the paediatric population. Metabolism Codeine is converted to morphine in the liver by the CYP2D6 enzyme. There are many genetic variations of CYP2D6, which affect the extent

2013 MHRA Drug Safety Update

67. Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis

Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2013 DARE.

68. Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial. (PubMed)

Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial. Continuous morphine infusion as standard postoperative analgesic therapy in young infants is associated with unwanted adverse effects such as respiratory depression.To determine whether intravenous paracetamol (acetaminophen) would significantly (>30%) reduce morphine requirements in neonates and infants after major surgery.Single (...) -center, randomized, double-blind study conducted in a level 3 pediatric intensive care unit in Rotterdam, The Netherlands. Patients were 71 neonates or infants younger than 1 year undergoing major thoracic (noncardiac) or abdominal surgery between March 2008 and July 2010, with follow-up of 48 hours.All patients received a loading dose of morphine 30 minutes before the end of surgery, followed by continuous morphine or intermittent intravenous paracetamol up to 48 hours postsurgery. Infants in both

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2013 JAMA Controlled trial quality: predicted high

69. Dexamethasone for the prophylaxis of postoperative nausea and vomiting associated with neuraxial morphine administration: a systematic review and meta-analysis

Dexamethasone for the prophylaxis of postoperative nausea and vomiting associated with neuraxial morphine administration: a systematic review and meta-analysis Dexamethasone for the prophylaxis of postoperative nausea and vomiting associated with neuraxial morphine administration: a systematic review and meta-analysis Dexamethasone for the prophylaxis of postoperative nausea and vomiting associated with neuraxial morphine administration: a systematic review and meta-analysis Allen TK, Jones CA (...) , Habib AS CRD summary The authors concluded that a single dose of intravenous dexamethasone 5mg to 10mg was an effective antiemetic in women receiving neuraxial morphine for caesarean delivery or abdominal hysterectomy. Possible publication bias suggested the findings should be interpreted with caution. The evidence base was generally small and the authors’ recommendation to interpret the findings with caution seems appropriate. Authors' objectives To assess the prophylactic efficacy of an antiemetic

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2012 DARE.

70. Effect of perioperative systemic alpha-2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials

Effect of perioperative systemic alpha-2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

71. Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial (PubMed)

Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial We designed a randomized double-blind placebo-controlled trial to assess the role of a single prophylactic dose of vitamin C (2 g) po in reducing the consumption of opioids postoperatively in patients undergoing laparoscopic cholecystectomy.Eighty adult patients were allocated to receive 2 g vitamin C po or placebo approximately one hour prior to induction of anesthesia. Following laparoscopic (...) cholecystectomy, patients received morphine patient-controlled analgesia for 24 hr. The following data were assessed postoperatively in the postanesthesia care unit at two, four, six, 12, and 24 hr: morphine consumption, verbal numerical rating scale scores for incisional pain and nausea/vomiting, and pruritus and sedation scores. The primary outcome measure was 24-hr morphine consumption. Patient satisfaction was assessed before hospital discharge.Morphine consumption was significantly lower in the vitamin C

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2012 EvidenceUpdates Controlled trial quality: predicted high

72. Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain

Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

73. Watchful dosing of morphine or morphine equivalent dosing in the treatment of chronic non-cancer pain: a review of the clinical evidence

Watchful dosing of morphine or morphine equivalent dosing in the treatment of chronic non-cancer pain: a review of the clinical evidence Watchful dosing of morphine or morphine equivalent dosing in the treatment of chronic non-cancer pain: a review of the clinical evidence Watchful dosing of morphine or morphine equivalent dosing in the treatment of chronic non-cancer pain: a review of the clinical evidence CADTH Record Status This is a bibliographic record of a published health technology (...) assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Watchful dosing of morphine or morphine equivalent dosing in the treatment of chronic non-cancer pain: a review of the clinical evidence. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). 2012 Authors' conclusions The evidence base around a watchful dose threshold for morphine or equivalent opioid dosing was limited in both quality and quantity

2012 Health Technology Assessment (HTA) Database.

74. Watchful Dosing of Morphine or Morphine Equivalent Dosing in the Treatment of Chronic Non-Cancer Pain: A Review of the Clinical Evidence

Watchful Dosing of Morphine or Morphine Equivalent Dosing in the Treatment of Chronic Non-Cancer Pain: A Review of the Clinical Evidence Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources and a summary of the best evidence on the topic that CADTH could identify using (...) -commercial purposes, provided that attribution is given to CADTH. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions. TITLE: Watchful Dosing of Morphine or Morphine Equivalent Dosing in the Treatment of Chronic Non-Cancer Pain: A Review of the Clinical Evidence DATE: 06 June 2012 CONTEXT AND POLICY

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

75. Morphine and Ketamine Is Superior to Morphine Alone for Out-of-Hospital Trauma Analgesia: A Randomized Controlled Trial (PubMed)

Morphine and Ketamine Is Superior to Morphine Alone for Out-of-Hospital Trauma Analgesia: A Randomized Controlled Trial We assess the efficacy of intravenous ketamine compared with intravenous morphine in reducing pain in adults with significant out-of-hospital traumatic pain.This study was an out-of-hospital, prospective, randomized, controlled, open-label study. Patients with trauma and a verbal pain score of greater than 5 after 5 mg intravenous morphine were eligible for enrollment (...) . Patients allocated to the ketamine group received a bolus of 10 or 20 mg, followed by 10 mg every 3 minutes thereafter. Patients allocated to the morphine alone group received 5 mg intravenously every 5 minutes until pain free. Pain scores were measured at baseline and at hospital arrival.A total of 135 patients were enrolled between December 2007 and July 2010. There were no differences between the groups at baseline. After the initial 5-mg dose of intravenous morphine, patients allocated to ketamine

2012 EvidenceUpdates Controlled trial quality: predicted high

76. Postoperative Analgesic and Behavioral Effects of Intranasal Fentanyl, Intravenous Morphine, and Intramuscular Morphine in Pediatric Patients Undergoing Bilateral Myringotomy and Placement of Ventilating Tubes (PubMed)

Postoperative Analgesic and Behavioral Effects of Intranasal Fentanyl, Intravenous Morphine, and Intramuscular Morphine in Pediatric Patients Undergoing Bilateral Myringotomy and Placement of Ventilating Tubes Bilateral myringotomy and placement of ventilating tubes (BMT) is one of the most common pediatric surgical procedures in the United States. Many children who undergo BMT develop behavioral changes in the postanesthesia care unit (PACU) and require rescue pain medication. The incidence (...) randomized into 1 of 3 groups: group 1-nasal fentanyl 2 μg/kg with IV and IM saline placebo; group 2-IV morphine 0.1 mg/kg with nasal and IM placebo; or group 3-IM morphine 0.1 mg/kg with nasal and IV placebo. All subjects received a standardized general anesthetic with sevoflurane, N(2)O, and O(2) and similar postoperative care. The primary end point of the study was the pain scores measured by the Faces, Legs, Activity, Cry, and Consolability (FLACC) scale in the PACU.There were no significant

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2012 EvidenceUpdates Controlled trial quality: predicted high

77. Ropivacaine continuous wound infusion versus epidural morphine for postoperative analgesia after cesarean delivery: a randomized controlled trial (PubMed)

Ropivacaine continuous wound infusion versus epidural morphine for postoperative analgesia after cesarean delivery: a randomized controlled trial The infusion of local anesthetic in the surgical wound is helpful in the multimodal management of postoperative pain. We hypothesized that local anesthetic wound infusion after cesarean delivery would provide better pain control than epidural morphine analgesia.Healthy, term women scheduled for elective cesarean delivery were included in this assessor (...) -blinded, randomized study. Patients were randomly assigned to receive analgesia through a multiorifice wound catheter placed below the fascia and connected to a 5 mL/h ropivacaine 2 mg/mL infusion or an epidural bolus of morphine 2 mg every 12 hours. Both analgesic regimens were continued for 48 hours. The primary outcome was pain at rest at 24 hours postoperatively using the verbal rating score for pain (0-10 scale). Pain intensity, rescue analgesia consumption, and side effects were assessed at 2, 6

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2012 EvidenceUpdates Controlled trial quality: predicted high

78. Cost-effectiveness of tapentadol prolonged release compared with oxycodone controlled release in the UK in patients with severe non-malignant chronic pain who failed 1st line treatment with morphine

Cost-effectiveness of tapentadol prolonged release compared with oxycodone controlled release in the UK in patients with severe non-malignant chronic pain who failed 1st line treatment with morphine Cost-effectiveness of tapentadol prolonged release compared with oxycodone controlled release in the UK in patients with severe non-malignant chronic pain who failed 1st line treatment with morphine Cost-effectiveness of tapentadol prolonged release compared with oxycodone controlled release (...) in the UK in patients with severe non-malignant chronic pain who failed 1st line treatment with morphine Ikenberg R, Hertel N, Moore RA, Obradovic M, Baxter G, Conway P, Liedgens H Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study

2012 NHS Economic Evaluation Database.

79. Is intranasal fentanyl better than parenteral morphine for managing acute pain in children?

Is intranasal fentanyl better than parenteral morphine for managing acute pain in children? BestBets: Is intranasal fentanyl better than parenteral morphine for managing acute pain in children? Is intranasal fentanyl better than parenteral morphine for managing acute pain in children? Report By: Sandeep Rahul Kusre - Senior House Officer Search checked by Jonathan Costello - Consultant A&E Institution: Royal Free Hospital Current web editor: Stewart Teece - Clinical Research Fellow Date (...) Submitted: 5th April 2009 Date Completed: 30th November 2011 Last Modified: 30th November 2011 Status: Green (complete) Three Part Question In [children presenting to Accident & Emergency in acute pain] is [intranasal fentanyl a better analgesic than intravenous or intramuscular morphine] at [reducing pain] Clinical Scenario A child presents to the paediatric emergency department in acute pain but you cannot give him intranasal diamorphine due to both a departmental and nationwide shortage. You are able

2011 BestBETS

80. Fentanyl Pectin Nasal Spray reduces breakthrough cancer pain intensity compared with placebo in people taking at least 60 mg daily oral morphine or equivalent. (PubMed)

Fentanyl Pectin Nasal Spray reduces breakthrough cancer pain intensity compared with placebo in people taking at least 60 mg daily oral morphine or equivalent. 21561853 2011 10 26 2011 06 10 1468-9618 14 3 2011 Jul Evidence-based nursing Evid Based Nurs Fentanyl Pectin Nasal Spray reduces breakthrough cancer pain intensity compared with placebo in people taking at least 60 mg daily oral morphine or equivalent. 90-1 10.1136/ebn1150 Curtiss Carol P CP Tufts University Medical School, Boston

2011 Evidence-Based Nursing Controlled trial quality: uncertain