Latest & greatest articles for morphine

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Top results for morphine

41. Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial.

Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial. 23299606 2013 01 09 2013 01 10 2016 10 17 1538-3598 309 2 2013 Jan 09 JAMA JAMA Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial. 149-54 10.1001/jama.2012.148050 Continuous morphine infusion as standard postoperative (...) analgesic therapy in young infants is associated with unwanted adverse effects such as respiratory depression. To determine whether intravenous paracetamol (acetaminophen) would significantly (>30%) reduce morphine requirements in neonates and infants after major surgery. Single-center, randomized, double-blind study conducted in a level 3 pediatric intensive care unit in Rotterdam, The Netherlands. Patients were 71 neonates or infants younger than 1 year undergoing major thoracic (noncardiac

JAMA2013

42. Codeine for analgesia: restricted use in children because of reports of morphine toxicity

Codeine for analgesia: restricted use in children because of reports of morphine toxicity Codeine for analgesia: restricted use in children because of reports of morphine toxicity Drug Safety Update - GOV.UK GOV.UK uses cookies to make the site simpler. Search Codeine for analgesia: restricted use in children because of reports of morphine toxicity From: Published: 10 July 2013 Therapeutic area: , , , , and Codeine should only be used to relieve acute moderate pain in children older than 12 (...) relief in adults and children and is considered to be suitable for persistent pain of up to moderate intensity. It is commonly used in combination with other drugs—mainly paracetamol, but also aspirin, caffeine, or ibuprofen. However, despite its established use, there remains substantial lack of knowledge about its safety and efficacy—particularly in the paediatric population. Metabolism Codeine is converted to morphine in the liver by the CYP2D6 enzyme. There are many genetic variations of CYP2D6, which

MHRA Drug Safety Update2013

43. Randomised controlled trial: Intravenous analgesia for out-of-hospital traumatic pain in adults: ketamine gives a greater reduction in pain than morphine but causes more adverse effects

Randomised controlled trial: Intravenous analgesia for out-of-hospital traumatic pain in adults: ketamine gives a greater reduction in pain than morphine but causes more adverse effects Intravenous analgesia for out-of-hospital traumatic pain in adults: ketamine gives a greater reduction in pain than morphine but causes more adverse effects | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log (...) morphine but causes more adverse effects Article Text Pain management Randomised controlled trial Intravenous analgesia for out-of-hospital traumatic pain in adults: ketamine gives a greater reduction in pain than morphine but causes more adverse effects William Paul McKay Statistics from Altmetric.com No Altmetric data available for this article. Commentary on: Jennings PA , Cameron P , Bernard S , et al . Morphine and ketamine is superior to morphine alone for out-of-hospital trauma analgesia: a

Evidence-Based Nursing (Requires free registration)2013

44. Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis

Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis Engelman E, Marsala C CRD summary The authors concluded that the addition of intrathecal clonidine to intrathecal morphine provided small clinical benefits, but increased the frequency of hypotension. The (...) results were heavily influenced by one trial, with an additional treatment.There were some limitations in the review, but the cautious conclusions reflect the evidence presented and seem reliable. Authors' objectives To evaluate the efficacy of adding intrathecal clonidine to intrathecal morphine for acute postoperative pain. Searching Seven databases, including EMBASE and PubMed, were searched in January 2012, for relevant studies. Search terms were reported. The references of the included articles

DARE.2013

45. Morphine Sulfate Injection

Morphine Sulfate Injection Drug Approval Package: Brand Name (Generic Name) NDA # Drug Approval Package U.S. Food & Drug Administration Enter Search terms Drug Approval Package - Morphine Sulfate Injection Company: BD Rx Inc. Application No.: 204223 Approval Date: 10/30/2013 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) Date created: March 6, 2014 Vision

FDA - Drug Approval Package2013

46. Effect of perioperative systemic alpha-2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials

Effect of perioperative systemic alpha-2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials Effect of perioperative systemic alpha-2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials Effect of perioperative systemic alpha-2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis (...) of perioperative systemic alpha-2 agonists on postoperative morphine consumption and pain intensity in patients undergoing surgery under general anaesthesia. Searching MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched to March 2011 for published articles in any language. Search terms were reported and the reference lists of retrieved articles were searched. Study selection Randomised controlled trials of systemic alpha-2 agonists administered before, during or after

DARE.2012

47. Dexamethasone for the prophylaxis of postoperative nausea and vomiting associated with neuraxial morphine administration: a systematic review and meta-analysis

Dexamethasone for the prophylaxis of postoperative nausea and vomiting associated with neuraxial morphine administration: a systematic review and meta-analysis Dexamethasone for the prophylaxis of postoperative nausea and vomiting associated with neuraxial morphine administration: a systematic review and meta-analysis Dexamethasone for the prophylaxis of postoperative nausea and vomiting associated with neuraxial morphine administration: a systematic review and meta-analysis Allen TK, Jones CA (...) , Habib AS CRD summary The authors concluded that a single dose of intravenous dexamethasone 5mg to 10mg was an effective antiemetic in women receiving neuraxial morphine for caesarean delivery or abdominal hysterectomy. Possible publication bias suggested the findings should be interpreted with caution. The evidence base was generally small and the authors’ recommendation to interpret the findings with caution seems appropriate. Authors' objectives To assess the prophylactic efficacy of an antiemetic

DARE.2012

48. Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial

Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial 22402954 2012 05 07 2012 09 18 2013 11 21 1496-8975 59 6 2012 Jun Canadian journal of anaesthesia = Journal canadien d'anesthesie Can J Anaesth Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial. 538-43 10.1007/s12630-012-9692-x We designed a randomized double-blind placebo-controlled trial to assess the role of a single prophylactic dose (...) of vitamin C (2 g) po in reducing the consumption of opioids postoperatively in patients undergoing laparoscopic cholecystectomy. Eighty adult patients were allocated to receive 2 g vitamin C po or placebo approximately one hour prior to induction of anesthesia. Following laparoscopic cholecystectomy, patients received morphine patient-controlled analgesia for 24 hr. The following data were assessed postoperatively in the postanesthesia care unit at two, four, six, 12, and 24 hr: morphine consumption

EvidenceUpdates2012

49. Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain

Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain Wolff RF, Aune D, Truyers C, Hernandez AV, Misso K, Riemsma R, Kleijnen J CRD summary (...) for inclusion. Cross-over trials were eligible if they presented results for the first phase separately. Abstracts were included where full papers were not available. The primary comparator of interest was fentanyl patch, but no relevant studies were found. Other comparators were morphine controlled-release pills or capsules, oxymorphone, oxycodone, hydromorphone or methadone compared to buprenorphine or fentanyl patch. Placebo-controlled studies were eligible. Dosages for all drugs were appropriate

DARE.2012

50. Watchful dosing of morphine or morphine equivalent dosing in the treatment of chronic non-cancer pain: a review of the clinical evidence

Watchful dosing of morphine or morphine equivalent dosing in the treatment of chronic non-cancer pain: a review of the clinical evidence Watchful dosing of morphine or morphine equivalent dosing in the treatment of chronic non-cancer pain: a review of the clinical evidence Watchful dosing of morphine or morphine equivalent dosing in the treatment of chronic non-cancer pain: a review of the clinical evidence CADTH Record Status This is a bibliographic record of a published health technology (...) assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Watchful dosing of morphine or morphine equivalent dosing in the treatment of chronic non-cancer pain: a review of the clinical evidence. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). 2012 Authors' conclusions The evidence base around a watchful dose threshold for morphine or equivalent opioid dosing was limited in both quality and quantity

Health Technology Assessment (HTA) Database.2012

52. Postoperative Analgesic and Behavioral Effects of Intranasal Fentanyl, Intravenous Morphine, and Intramuscular Morphine in Pediatric Patients Undergoing Bilateral Myringotomy and Placement of Ventilating Tubes

Postoperative Analgesic and Behavioral Effects of Intranasal Fentanyl, Intravenous Morphine, and Intramuscular Morphine in Pediatric Patients Undergoing Bilateral Myringotomy and Placement of Ventilating Tubes 22669347 2012 07 24 2012 10 09 2013 11 21 1526-7598 115 2 2012 Aug Anesthesia and analgesia Anesth. Analg. Postoperative analgesic and behavioral effects of intranasal fentanyl, intravenous morphine, and intramuscular morphine in pediatric patients undergoing bilateral myringotomy (...) to indicate which route of administration is better. Our study was designed to compare the immediate postoperative analgesic and behavioral effects of 3 frequently used intraoperative techniques of postoperative pain control for patients undergoing BMT under general anesthesia. One hundred seventy-one ASA physical status I and II children scheduled for BMT were randomized into 1 of 3 groups: group 1-nasal fentanyl 2 μg/kg with IV and IM saline placebo; group 2-IV morphine 0.1 mg/kg with nasal and IM

EvidenceUpdates2012

53. Morphine and Ketamine Is Superior to Morphine Alone for Out-of-Hospital Trauma Analgesia: A Randomized Controlled Trial

Morphine and Ketamine Is Superior to Morphine Alone for Out-of-Hospital Trauma Analgesia: A Randomized Controlled Trial 22243959 2012 05 25 2012 08 09 2013 11 21 1097-6760 59 6 2012 Jun Annals of emergency medicine Ann Emerg Med Morphine and ketamine is superior to morphine alone for out-of-hospital trauma analgesia: a randomized controlled trial. 497-503 10.1016/j.annemergmed.2011.11.012 We assess the efficacy of intravenous ketamine compared with intravenous morphine in reducing pain (...) in adults with significant out-of-hospital traumatic pain. This study was an out-of-hospital, prospective, randomized, controlled, open-label study. Patients with trauma and a verbal pain score of greater than 5 after 5 mg intravenous morphine were eligible for enrollment. Patients allocated to the ketamine group received a bolus of 10 or 20 mg, followed by 10 mg every 3 minutes thereafter. Patients allocated to the morphine alone group received 5 mg intravenously every 5 minutes until pain free. Pain

EvidenceUpdates2012

54. Ropivacaine continuous wound infusion versus epidural morphine for postoperative analgesia after cesarean delivery: a randomized controlled trial

Ropivacaine continuous wound infusion versus epidural morphine for postoperative analgesia after cesarean delivery: a randomized controlled trial 22025490 2011 12 20 2012 07 16 2015 11 19 1526-7598 114 1 2012 Jan Anesthesia and analgesia Anesth. Analg. Ropivacaine continuous wound infusion versus epidural morphine for postoperative analgesia after cesarean delivery: a randomized controlled trial. 179-85 10.1213/ANE.0b013e3182368e87 The infusion of local anesthetic in the surgical wound (...) is helpful in the multimodal management of postoperative pain. We hypothesized that local anesthetic wound infusion after cesarean delivery would provide better pain control than epidural morphine analgesia. Healthy, term women scheduled for elective cesarean delivery were included in this assessor-blinded, randomized study. Patients were randomly assigned to receive analgesia through a multiorifice wound catheter placed below the fascia and connected to a 5 mL/h ropivacaine 2 mg/mL infusion

EvidenceUpdates2012

55. Cost-effectiveness of tapentadol prolonged release compared with oxycodone controlled release in the UK in patients with severe non-malignant chronic pain who failed 1st line treatment with morphine

Cost-effectiveness of tapentadol prolonged release compared with oxycodone controlled release in the UK in patients with severe non-malignant chronic pain who failed 1st line treatment with morphine Cost-effectiveness of tapentadol prolonged release compared with oxycodone controlled release in the UK in patients with severe non-malignant chronic pain who failed 1st line treatment with morphine Cost-effectiveness of tapentadol prolonged release compared with oxycodone controlled release (...) in the UK in patients with severe non-malignant chronic pain who failed 1st line treatment with morphine Ikenberg R, Hertel N, Moore RA, Obradovic M, Baxter G, Conway P, Liedgens H Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study

NHS Economic Evaluation Database.2012

56. Is intranasal fentanyl better than parenteral morphine for managing acute pain in children?

Is intranasal fentanyl better than parenteral morphine for managing acute pain in children? BestBets: Is intranasal fentanyl better than parenteral morphine for managing acute pain in children? Is intranasal fentanyl better than parenteral morphine for managing acute pain in children? Report By: Sandeep Rahul Kusre - Senior House Officer Search checked by Jonathan Costello - Consultant A&E Institution: Royal Free Hospital Current web editor: Stewart Teece - Clinical Research Fellow Date (...) Submitted: 5th April 2009 Date Completed: 30th November 2011 Last Modified: 30th November 2011 Status: Green (complete) Three Part Question In [children presenting to Accident & Emergency in acute pain] is [intranasal fentanyl a better analgesic than intravenous or intramuscular morphine] at [reducing pain] Clinical Scenario A child presents to the paediatric emergency department in acute pain but you cannot give him intranasal diamorphine due to both a departmental and nationwide shortage. You are able

BestBETS2011

57. Systematic review of randomised controlled trials: Only a small reduction in morphine use with adding NSAIDs, paracetamol or COX-2 inhibitors to patient controlled morphine in the 24 h after major surgery

Systematic review of randomised controlled trials: Only a small reduction in morphine use with adding NSAIDs, paracetamol or COX-2 inhibitors to patient controlled morphine in the 24 h after major surgery Only a small reduction in morphine use with adding NSAIDs, paracetamol or COX-2 inhibitors to patient controlled morphine in the 24 h after major surgery | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your (...) Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Only a small reduction in morphine use with adding NSAIDs, paracetamol or COX-2 inhibitors to patient

Evidence-Based Nursing (Requires free registration)2011

58. Comparative clinical effects of hydromorphone and morphine: a meta-analysis

Comparative clinical effects of hydromorphone and morphine: a meta-analysis Comparative clinical effects of hydromorphone and morphine: a meta-analysis Comparative clinical effects of hydromorphone and morphine: a meta-analysis Felden L, Walter C, Harder S, Treede RD, Kayser H, Drover D, Geisslinger G, Lotsch J CRD summary The authors concluded that hydromorphone may have been a slightly more effective pain-killer than morphine, but further studies were needed to confirm this. In view (...) of the limited number and size of the trials, heterogeneity and limited size of the effects, the conclusions may not be sufficiently cautious and it is unclear whether they are reliable. Authors' objectives To compare the clinical benefits of hydromorphone with morphine to relieve pain. Searching PubMed and EMBASE were searched for studies published between 1970 and June 2009. References of included studies were also searched. Authors were contacted for additional data. Search terms were reported. Study

DARE.2011

59. Morphine Sulfate

Morphine Sulfate Drug Approval Package: Morphine Sulfate NDA #202515 Drug Approval Package U.S. Food & Drug Administration Enter Search terms Drug Approval Package - Morphine Sulfate Company: Hospira, Inc. Application No.: 202515 Approval Date: 11/14/2011 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) Date created: June 26, 2012 Vision impaired people having

FDA - Drug Approval Package2011

60. Morphine Sulfate Oral Solution

Morphine Sulfate Oral Solution Drug Approval Package: Morphine Sulfate NDA #201517 Drug Approval Package U.S. Food & Drug Administration Enter Search terms Drug Approval Package - Morphine Sulfate Oral Solution, 100 mg per 5 mL (20 mg per mL) Company: Lannett Holdings, Inc. Application No.: 201517 Approval Date: 06/23/2011 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (P (PDF) (PDF) (PDF) (PDF) (PDF) (PDF

FDA - Drug Approval Package2011