Latest & greatest articles for morphine

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Top results for morphine

41. Sustained Release Oral Morphine, Injectable Hydromorphone, and Prescription Diacetylmorphine for Opioid Use Disorder: Clinical and Cost-Effectiveness, and Guidelines

Sustained Release Oral Morphine, Injectable Hydromorphone, and Prescription Diacetylmorphine for Opioid Use Disorder: Clinical and Cost-Effectiveness, and Guidelines Sustained Release Oral Morphine, Injectable Hydromorphone, and Prescription Diacetylmorphine for Opioid Use Disorder: Clinical and Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Sustained Release Oral Morphine, Injectable Hydromorphone, and Prescription Diacetylmorphine for Opioid Use Disorder: Clinical (...) and Cost-Effectiveness, and Guidelines Sustained Release Oral Morphine, Injectable Hydromorphone, and Prescription Diacetylmorphine for Opioid Use Disorder: Clinical and Cost-Effectiveness, and Guidelines Published on: April 13, 2017 Project Number: RB1083-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the comparative clinical effectiveness of sustained release oral morphine (SROM) versus standard of care (i.e., methadone or buprenorphine

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

42. Impact of tramadol and morphine abuse on the activities of acetylcholine esterase, Na+/K+-ATPase and related parameters in cerebral cortices of male adult rats (PubMed)

Impact of tramadol and morphine abuse on the activities of acetylcholine esterase, Na+/K+-ATPase and related parameters in cerebral cortices of male adult rats To determine the effect of the most commonly abused drugs (tramadol and morphine), on acetylcholine esterase (AChE), Na+/K+-ATPase activities and related parameters, Na+ and K+ as biomarkers of neurotoxicity.Tramadol - as a weak μ opioid receptor agonist- and morphine - as opiate analgesic drugs, were chosen for the present study. Four (...) series of experimental animals were conducted for either tramadol or morphine: control series; repeated single equal doses (therapeutic dose) series; cumulative increasing doses series and delay (withdrawal) series (96 hours withdrawal period after last administration), at time period intervals 7, 14 and 21 days. Acetylcholine esterase (AChE), Na+/K+-ATPase activities and related parameters, Na+ and K+ were measured in cerebral cortices of experimental rats.Acetylcholine esterase (AChE) activity

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2017 Electronic physician

43. Oral Morphine Use in South India: A Population-Based Study (PubMed)

Oral Morphine Use in South India: A Population-Based Study Purpose Access to opioids for pain control is recognized as an urgent issue in low- and middle-income countries. Here we report temporal and regional trends in morphine use in Kerala, India. Methods Oral morphine use data for the State of Kerala (2012 to 2015) was used to describe temporal trends, regional variation, and provider characteristics. Total morphine use was calculated for each district of Kerala to derive an annual per (...) capita use rate (milligrams per capita). Each provider was classified as government, private, nongovernment organization (NGO), or NGO partnership. Results Oral morphine use for Kerala was 1.32 mg/capita and increased over the study period 27% (from 1.23 mg/capita to 1.56 mg/capita). There was substantial variation in morphine use across districts (range, 0.49 mg/capita to 2.97 mg/capita; six-fold difference). This variation increased over time (19-fold difference in 2015). In 2015, 31% of morphine

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2017 Journal of global oncology

44. Morphine Post-Conditioning Effect on QT Dispersion in Patients Undergoing Primary Percutaneous Coronary Intervention on Anterior Descending Cardiac Artery: A Cohort Study (PubMed)

Morphine Post-Conditioning Effect on QT Dispersion in Patients Undergoing Primary Percutaneous Coronary Intervention on Anterior Descending Cardiac Artery: A Cohort Study QT dispersion is the difference between the maximum and minimum QTc interval in a 12-lead electrocardiogram (ECG). Some researchers have demonstrated the effects of an increase of QT-d in STEMI and its reduction with successful therapy. The aim of this study was to investigate the morphine post-conditioning effect on the QT (...) dispersion in patients undergoing primary percutaneous coronary intervention (PCI) on anterior descending cardiac artery.This cohort study was conducted on STEMI patients admitted to the Hospital of Imam Reza (AS), Mashhad, Iran, from March 2015 to February 2016 who were undergoing primary angioplasty on the anterior descending cardiac artery. The patients were divided into two groups based on the intake or non-intake of morphine (5 mg morphine for the period of 30 minutes prior to PCI). Parameters

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2017 Electronic physician

45. Morphine dosing and weaning schedule

Morphine dosing and weaning schedule Queensland Health State of Queensland (Queensland Health) 2016 http://creativecommons.org/licenses/by-nc-nd/3.0/au/deed.en Queensland Clinical Guidelines, Guidelines@health.qld.gov.au Queensland Clinical Guidelines www.health.qld.gov.au/qcg Morphine dosing and weaning schedule Queensland Clinical Guideline: Perinatal substance use: neonatal F16.38-3-V2-R21 Morphine schedule Do not administer Naloxone to babies of known or suspected opioid dependent women (...) during resuscitation or in the newborn period Opioid exposure inutero 2 consecutive Finnegan scores = 12 OR 3 consecutive Finnegan scores average = 8 May require dosing interval reduced to 4 hourly Care Environment: • Ensure close observation • Continue supportive care Medication • Titrate Morphine dose to control NAS • Phenobarbitone if: ? NAS uncontrolled on maximum Morphine dose (1 mg/kg/day) and/or ? History of polydrug use Monitoring • Apnoea monitor: ? When commencing Morphine

2017 Queensland Health

46. The effect of low-dose ketamine via patient-controlled analgesic pump on morphine consumption in the postoperative period in thoracotomies: a systematic review protocol. (PubMed)

The effect of low-dose ketamine via patient-controlled analgesic pump on morphine consumption in the postoperative period in thoracotomies: a systematic review protocol. The objective of this systematic review is to determine if adding low-dose ketamine to a morphine patient-controlled analgesic pump will have an impact on the total consumption of morphine during the first 72 hours postoperative in patients over the age of 15 undergoing surgery involving thoracotomy. In addition, secondary

2016 JBI database of systematic reviews and implementation reports

47. No Difference in Early Analgesia Between Liposomal Bupivacaine Injection and Intrathecal Morphine After TKA (PubMed)

No Difference in Early Analgesia Between Liposomal Bupivacaine Injection and Intrathecal Morphine After TKA Opioid analgesics have been a standard modality for postoperative pain management after total knee arthroplasty (TKA) but are also associated with increased risk of nausea, pruritus, vomiting, respiratory depression, prolonged ileus, and cognitive dysfunction. There is still a need for a method of anesthesia that can deliver effective long-term postoperative pain relief without incurring (...) the high cost and health burden of opioids and nerve blocks.(1) Is liposomal bupivacaine-based periarticular injection (PAI) more effective than morphine-based spinal anesthesia or ropivacaine-based PAI in controlling postoperative pain after TKA? (2) Do patients treated with liposomal bupivacaine-based PAI experience fewer opioid-related adverse events compared with patients treated with morphine-based spinal anesthesia or ropivacaine-based PAI in controlling postoperative pain after TKA

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2016 EvidenceUpdates Controlled trial quality: predicted high

48. Impact of morphine use in reducing the need for CT scan in patients with cervical spine trauma: a double blinded randomized clinical trial. (PubMed)

Impact of morphine use in reducing the need for CT scan in patients with cervical spine trauma: a double blinded randomized clinical trial. Cervical spine trauma occurs mostly among young males due to falls and car accidents. The CT scan technology is replacing radiography in many medical clinics as it is very capable in detecting subtle cervical spine injuries. However, the use of CT scan for routine screening in patients with cervical spine trauma remains controversial due to its radiation (...) risks and relatively high cost.The focus of this research was on using morphine in patients with cervical spine trauma. The objective was to determine the ability of morphine to reduce the number of patients in need of CT scans.This double-blinded randomized clinical trial study was conducted from April 2014 to March 2015 in Hasheminejad Hospital in Mashhad, Iran. We enrolled 67 patients with cervical spine trauma and normal radiography in the study. They were divided randomly into two groups

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2016 Electronic physician Controlled trial quality: uncertain

49. Comparison of Intravenous Morphine vs Paracetamol in Sciatica: A Randomized Placebo Controlled Trial (PubMed)

Comparison of Intravenous Morphine vs Paracetamol in Sciatica: A Randomized Placebo Controlled Trial The objective was to compare intravenous morphine and intravenous acetaminophen (paracetamol) for pain treatment in patients presenting to the emergency department with sciatica.Patients, between the ages of 21 and 65 years, suffering from pain in the sciatic nerve distribution and a positive straight leg-raise test composed the study population. Study patients were assigned to one of three (...) intravenous interventions: morphine (0.1 mg/kg), acetaminophen (1 g), or placebo. Physicians, nurses, and patients were blinded to the study drug. Changes in pain intensity were measured at 15 and 30 minutes using a visual analog scale. Rescue drug (fentanyl) use and adverse effects were also recorded.Three-hundred patients were randomized. The median change in pain intensity between treatment arms at 30 minutes were as follows: morphine versus acetaminophen 25 mm (95% confidence interval [CI] = 20 to 29

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2016 EvidenceUpdates Controlled trial quality: predicted high

50. Single dose intra-articular morphine for pain control after knee arthroscopy. (PubMed)

Single dose intra-articular morphine for pain control after knee arthroscopy. Knee arthroscopy is a common procedure and is associated with postoperative pain. Intra-articular (IA) injection of morphine for pain control has been widely studied, but its analgesic effect after knee arthroscopy is uncertain.To evaluate the relative effects on pain relief and adverse events of IA morphine given for pain control after knee arthroscopy compared with placebo, other analgesics (local anaesthetics, non (...) -steroidal anti-inflammatory drugs (NSAIDs), other opioids) and other routes of morphine administration.We searched CENTRAL (The Cochrane Library Issue 4, 2015), MEDLINE via Ovid (January 1966 to May 2015), EMBASE via Ovid (January 1988 to May 2015), and the reference lists of included articles. We also searched the metaRegister of controlled trials, clinicaltrials.gov and the World Health Organization (WHO) International Clinical Trials Registry Platform for ongoing trials.We identified all

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2016 Cochrane

51. Oral morphine for cancer pain. (PubMed)

Oral morphine for cancer pain. This is the third updated version of a Cochrane review first published in Issue 4, 2003 of The Cochrane Library and first updated in 2007. Morphine has been used for many years to relieve pain. Oral morphine in either immediate release or modified release form remains the analgesic of choice for moderate or severe cancer pain.To determine the efficacy of oral morphine in relieving cancer pain, and to assess the incidence and severity of adverse events.We searched (...) the following databases: Cochrane Central Register of Controlled Trials (CENTRAL 2015, Issue 9); MEDLINE (1966 to October 2015); and EMBASE (1974 to October 2015). We also searched ClinicalTrials.gov (1 October 2015).Published randomised controlled trials (RCTs) using placebo or active comparators reporting on the analgesic effect of oral morphine in adults and children with cancer pain. We excluded trials with fewer than 10 participants.One review author extracted data, which were checked by another review

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2016 Cochrane

52. "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine

"Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine Prescrire IN ENGLISH - Spotlight ''"Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine'', 1 February 2016 {1} {1} {1} | | > > > "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |    (...) |   |   |   |   |  Spotlight "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine FEATURED REVIEW When opioid therapy is needed, there is no evidence that codeine, dihydrocodeine or tramadol is less risky than morphine at its lowest effective dose. The efficacy of these drugs varies more from one patient to another, and their multiple pharmacokinetic interactions can be difficult to manage. Weak opioids require at least

2016 Prescrire

53. Morphine In Myocardial Infarction: Delay In Platelet Inhibition Due To Morphine Administered To Patients Presenting With Acute Coronary Syndrome

Morphine In Myocardial Infarction: Delay In Platelet Inhibition Due To Morphine Administered To Patients Presenting With Acute Coronary Syndrome "Morphine In Myocardial Infarction: Delay In Platelet Inhibition Due To" by Stacy R. Joyce < > > > > > Title Author Date of Graduation Summer 8-13-2016 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Jennifer VanAtta Rights . Abstract Background: The American College of Cardiology Foundation (...) /American Heart Association Task Force recommends morphine for patients with ST-elevation myocardial infarction and for patients undergoing primary percutaneous coronary intervention (PPCI). A drug-to-drug interaction between morphine and the preferred antiplatelets have been studied to determine the adverse effects on such a combination in antiplatelets. There is an increase risk of thrombic events if platelets are not effectively inhibited during PPCI. The primary aim of this systematic review

2016 Pacific University EBM Capstone Project

54. Cohort study: Morphine exposure in preterm infants correlates with impaired cerebellar growth and poorer neurodevelopmental outcome

Cohort study: Morphine exposure in preterm infants correlates with impaired cerebellar growth and poorer neurodevelopmental outcome Morphine exposure in preterm infants correlates with impaired cerebellar growth and poorer neurodevelopmental outcome | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Morphine exposure in preterm infants correlates with impaired cerebellar growth and poorer neurodevelopmental outcome Article Text Aetiology

2016 Evidence-Based Medicine (Requires free registration)

55. Systematic review with meta analysis: In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery

Systematic review with meta analysis: In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie (...) fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery Article Text Therapeutics/Prevention Systematic review with meta analysis In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery Christoph Bührer Statistics from Altmetric.com Commentary on: Ohlsson A , Shah PS . Paracetamol (acetaminophen) for prevention or treatment of pain in newborns

2016 Evidence-Based Medicine (Requires free registration)

56. Yokukansan, a Kampo medicine, prevents the development of morphine tolerance through the inhibition of spinal glial cell activation in rats (PubMed)

Yokukansan, a Kampo medicine, prevents the development of morphine tolerance through the inhibition of spinal glial cell activation in rats Animal models have shown that glial cells (microglia and astrocytes) in the spinal cord undergo activation following peripheral injury associated with chronic pain, suggesting the involvement of these cells in pain diseases. We have previously reported that Yokukansan (YKS), a Japanese traditional herbal (Kampo) medicine, is effective against chronic pain (...) through the suppression of spinal glial cell activation. Morphine is a widely-used opioid analgesic for relieving severe pain, but its repeated administration leads to the development of antinociceptive tolerance. The development of morphine tolerance is also reported to be caused by spinal glial cells activation. In the present study, we investigated the inhibitory effects of YKS on the development of morphine tolerance and the activation of the spinal microglia and astrocytes using a rat model.Male

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2015 Integrative medicine research

57. Efficacy of Low-Dose Oral Liquid Morphine for Elderly Patients with Chronic Non-Cancer Pain: Retrospective Chart Review (PubMed)

Efficacy of Low-Dose Oral Liquid Morphine for Elderly Patients with Chronic Non-Cancer Pain: Retrospective Chart Review The use of medications among older persons can often be challenging as physiological changes may affect metabolism and cognitive abilities. Several studies show that the elderly with chronic pain are seriously undertreated or inappropriately treated, particularly with respect to opioids.To determine whether very low doses of oral liquid morphine (LM) in patients over 65 years

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2015 Drugs - real world outcomes

58. Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain. (PubMed)

Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain. There is increasing focus on providing high quality care for people at the end of life, irrespective of disease or cause, and in all settings. In the last ten years the use of care pathways to aid those treating patients at the end of life has become common worldwide. The use of the Liverpool Care Pathway in the UK has been criticised. In England the LCP (...) to an earlier death, and that effects of opioids on appetite and thirst may result in unnecessary suffering. This rapid review, commissioned by the National Institute for Health Research, used standard Cochrane methodology to examine adverse effects of morphine, fentanyl, oxycodone, and codeine in cancer pain studies as a close approximation to possible effects in the dying patient.To determine the impact of opioid treatment on patient consciousness, appetite and thirst in randomised controlled trials

2014 Cochrane

59. Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial

Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2014 PedsCCM Evidence-Based Journal Club

60. Morphine

Morphine USE OF MORPHINE IN PREGNANCY 0344 892 0909 USE OF MORPHINE IN PREGNANCY (Date of issue: March 2016 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Morphine is a natural opioid analgesic derived from the poppy ( Papaver (...) somniferum ) and is typically administered orally, intravenously, or rectally for the treatment of severe or intractable pain. No recent data relating specifically to morphine exposure in human pregnancy have been published. Very limited data from 1977 did not demonstrate an increased risk of congenital malformation following first trimester morphine exposure in 70 cases. Increased rates of specific malformations have been observed in some studies analysing opioids as a class, but the data

2014 UK Teratology Information Service