Latest & greatest articles for morphine

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on morphine or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on morphine and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for morphine

21. Sustained Release Oral Morphine, Injectable Hydromorphone, and Prescription Diacetylmorphine for Opioid Use Disorder: Clinical and Cost-Effectiveness, and Guidelines

Sustained Release Oral Morphine, Injectable Hydromorphone, and Prescription Diacetylmorphine for Opioid Use Disorder: Clinical and Cost-Effectiveness, and Guidelines Sustained Release Oral Morphine, Injectable Hydromorphone, and Prescription Diacetylmorphine for Opioid Use Disorder: Clinical and Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Sustained Release Oral Morphine, Injectable Hydromorphone, and Prescription Diacetylmorphine for Opioid Use Disorder: Clinical (...) and Cost-Effectiveness, and Guidelines Sustained Release Oral Morphine, Injectable Hydromorphone, and Prescription Diacetylmorphine for Opioid Use Disorder: Clinical and Cost-Effectiveness, and Guidelines Published on: April 13, 2017 Project Number: RB1083-000 Product Line: Research Type: Drugs Report Type: Summary of Abstracts Result type: Report Question What is the comparative clinical effectiveness of sustained release oral morphine (SROM) versus standard of care (i.e., methadone or buprenorphine

Canadian Agency for Drugs and Technologies in Health - Rapid Review2017

22. Oral Morphine Use in South India: A Population-Based Study

Oral Morphine Use in South India: A Population-Based Study 29244992 2018 07 19 2018 11 13 2378-9506 3 6 2017 Dec Journal of global oncology J Glob Oncol Oral Morphine Use in South India: A Population-Based Study. 720-727 10.1200/JGO.2016.007872 Purpose Access to opioids for pain control is recognized as an urgent issue in low- and middle-income countries. Here we report temporal and regional trends in morphine use in Kerala, India. Methods Oral morphine use data for the State of Kerala (2012 (...) to 2015) was used to describe temporal trends, regional variation, and provider characteristics. Total morphine use was calculated for each district of Kerala to derive an annual per capita use rate (milligrams per capita). Each provider was classified as government, private, nongovernment organization (NGO), or NGO partnership. Results Oral morphine use for Kerala was 1.32 mg/capita and increased over the study period 27% (from 1.23 mg/capita to 1.56 mg/capita). There was substantial variation

Journal of global oncology2017 Full Text: Link to full Text with Trip Pro

23. Morphine Post-Conditioning Effect on QT Dispersion in Patients Undergoing Primary Percutaneous Coronary Intervention on Anterior Descending Cardiac Artery: A Cohort Study

Morphine Post-Conditioning Effect on QT Dispersion in Patients Undergoing Primary Percutaneous Coronary Intervention on Anterior Descending Cardiac Artery: A Cohort Study 28243396 2018 11 13 2008-5842 9 1 2017 Jan Electronic physician Electron Physician Morphine Post-Conditioning Effect on QT Dispersion in Patients Undergoing Primary Percutaneous Coronary Intervention on Anterior Descending Cardiac Artery: A Cohort Study. 3468-3474 10.19082/3468 QT dispersion is the difference between (...) the maximum and minimum QTc interval in a 12-lead electrocardiogram (ECG). Some researchers have demonstrated the effects of an increase of QT-d in STEMI and its reduction with successful therapy. The aim of this study was to investigate the morphine post-conditioning effect on the QT dispersion in patients undergoing primary percutaneous coronary intervention (PCI) on anterior descending cardiac artery. This cohort study was conducted on STEMI patients admitted to the Hospital of Imam Reza (AS), Mashhad

Electronic physician2017 Full Text: Link to full Text with Trip Pro

24. Morphine dosing and weaning schedule

Morphine dosing and weaning schedule Queensland Health State of Queensland (Queensland Health) 2016 http://creativecommons.org/licenses/by-nc-nd/3.0/au/deed.en Queensland Clinical Guidelines, Guidelines@health.qld.gov.au Queensland Clinical Guidelines www.health.qld.gov.au/qcg Morphine dosing and weaning schedule Queensland Clinical Guideline: Perinatal substance use: neonatal F16.38-3-V2-R21 Morphine schedule Do not administer Naloxone to babies of known or suspected opioid dependent women (...) during resuscitation or in the newborn period Opioid exposure inutero 2 consecutive Finnegan scores = 12 OR 3 consecutive Finnegan scores average = 8 May require dosing interval reduced to 4 hourly Care Environment: • Ensure close observation • Continue supportive care Medication • Titrate Morphine dose to control NAS • Phenobarbitone if: ? NAS uncontrolled on maximum Morphine dose (1 mg/kg/day) and/or ? History of polydrug use Monitoring • Apnoea monitor: ? When commencing Morphine

Queensland Health2017

25. No Difference in Early Analgesia Between Liposomal Bupivacaine Injection and Intrathecal Morphine After TKA

No Difference in Early Analgesia Between Liposomal Bupivacaine Injection and Intrathecal Morphine After TKA 27339124 2016 07 21 2017 03 16 2017 04 18 1528-1132 475 1 2017 Jan Clinical orthopaedics and related research Clin. Orthop. Relat. Res. No Difference in Early Analgesia Between Liposomal Bupivacaine Injection and Intrathecal Morphine After TKA. 94-105 10.1007/s11999-016-4931-z Opioid analgesics have been a standard modality for postoperative pain management after total knee arthroplasty (...) (TKA) but are also associated with increased risk of nausea, pruritus, vomiting, respiratory depression, prolonged ileus, and cognitive dysfunction. There is still a need for a method of anesthesia that can deliver effective long-term postoperative pain relief without incurring the high cost and health burden of opioids and nerve blocks. (1) Is liposomal bupivacaine-based periarticular injection (PAI) more effective than morphine-based spinal anesthesia or ropivacaine-based PAI in controlling

EvidenceUpdates2016

26. Impact of morphine use in reducing the need for CT scan in patients with cervical spine trauma: a double blinded randomized clinical trial.

Impact of morphine use in reducing the need for CT scan in patients with cervical spine trauma: a double blinded randomized clinical trial. 27382455 2016 07 06 2016 07 06 2017 02 20 8 5 2016 May Electronic physician Electron Physician Impact of morphine use in reducing the need for CT scan in patients with cervical spine trauma: a double blinded randomized clinical trial. 2432-5 10.19082/2432 Cervical spine trauma occurs mostly among young males due to falls and car accidents. The CT scan (...) technology is replacing radiography in many medical clinics as it is very capable in detecting subtle cervical spine injuries. However, the use of CT scan for routine screening in patients with cervical spine trauma remains controversial due to its radiation risks and relatively high cost. The focus of this research was on using morphine in patients with cervical spine trauma. The objective was to determine the ability of morphine to reduce the number of patients in need of CT scans. This double-blinded

Electronic physician2016 Full Text: Link to full Text with Trip Pro

27. Comparison of Intravenous Morphine vs Paracetamol in Sciatica: A Randomized Placebo Controlled Trial

Comparison of Intravenous Morphine vs Paracetamol in Sciatica: A Randomized Placebo Controlled Trial 26938140 2016 06 09 2017 03 29 1553-2712 23 6 2016 06 Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Acad Emerg Med Comparison of Intravenous Morphine Versus Paracetamol in Sciatica: A Randomized Placebo Controlled Trial. 674-8 10.1111/acem.12956 The objective was to compare intravenous morphine and intravenous acetaminophen (paracetamol) for pain (...) treatment in patients presenting to the emergency department with sciatica. Patients, between the ages of 21 and 65 years, suffering from pain in the sciatic nerve distribution and a positive straight leg-raise test composed the study population. Study patients were assigned to one of three intravenous interventions: morphine (0.1 mg/kg), acetaminophen (1 g), or placebo. Physicians, nurses, and patients were blinded to the study drug. Changes in pain intensity were measured at 15 and 30 minutes using

EvidenceUpdates2016

28. Oral morphine for cancer pain.

Oral morphine for cancer pain. BACKGROUND: This is the third updated version of a Cochrane review first published in Issue 4, 2003 of The Cochrane Library and first updated in 2007. Morphine has been used for many years to relieve pain. Oral morphine in either immediate release or modified release form remains the analgesic of choice for moderate or severe cancer pain. OBJECTIVES: To determine the efficacy of oral morphine in relieving cancer pain, and to assess the incidence and severity (...) of adverse events. SEARCH METHODS: We searched the following databases: Cochrane Central Register of Controlled Trials (CENTRAL 2015, Issue 9); MEDLINE (1966 to October 2015); and EMBASE (1974 to October 2015). We also searched ClinicalTrials.gov (1 October 2015). SELECTION CRITERIA: Published randomised controlled trials (RCTs) using placebo or active comparators reporting on the analgesic effect of oral morphine in adults and children with cancer pain. We excluded trials with fewer than 10 participants

Cochrane2016

29. "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine

"Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine Prescrire IN ENGLISH - Spotlight ''"Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine'', 1 February 2016 {1} {1} {1} | | > > > "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |    (...) |   |   |   |   |  Spotlight "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine FEATURED REVIEW When opioid therapy is needed, there is no evidence that codeine, dihydrocodeine or tramadol is less risky than morphine at its lowest effective dose. The efficacy of these drugs varies more from one patient to another, and their multiple pharmacokinetic interactions can be difficult to manage. Weak opioids require at least

Prescrire2016

30. Morphine In Myocardial Infarction: Delay In Platelet Inhibition Due To Morphine Administered To Patients Presenting With Acute Coronary Syndrome

Morphine In Myocardial Infarction: Delay In Platelet Inhibition Due To Morphine Administered To Patients Presenting With Acute Coronary Syndrome "Morphine In Myocardial Infarction: Delay In Platelet Inhibition Due To" by Stacy R. Joyce < > > > > > Title Author Date of Award Summer 8-13-2016 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Jennifer VanAtta Rights . Abstract Background: The American College of Cardiology Foundation/American (...) Heart Association Task Force recommends morphine for patients with ST-elevation myocardial infarction and for patients undergoing primary percutaneous coronary intervention (PPCI). A drug-to-drug interaction between morphine and the preferred antiplatelets have been studied to determine the adverse effects on such a combination in antiplatelets. There is an increase risk of thrombic events if platelets are not effectively inhibited during PPCI. The primary aim of this systematic review is to clarify

Pacific University EBM Capstone Project2016

31. Cohort study: Morphine exposure in preterm infants correlates with impaired cerebellar growth and poorer neurodevelopmental outcome

Cohort study: Morphine exposure in preterm infants correlates with impaired cerebellar growth and poorer neurodevelopmental outcome Morphine exposure in preterm infants correlates with impaired cerebellar growth and poorer neurodevelopmental outcome | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your (...) user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Morphine exposure in preterm infants correlates with impaired cerebellar growth and poorer neurodevelopmental outcome Article Text Aetiology/Harm Cohort study Morphine exposure in preterm infants correlates with impaired cerebellar growth and poorer

Evidence-Based Medicine (Requires free registration)2016

32. Systematic review with meta analysis: In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery

Systematic review with meta analysis: In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery Article Text

Evidence-Based Medicine (Requires free registration)2016

33. Yokukansan, a Kampo medicine, prevents the development of morphine tolerance through the inhibition of spinal glial cell activation in rats

Yokukansan, a Kampo medicine, prevents the development of morphine tolerance through the inhibition of spinal glial cell activation in rats 28462096 2018 11 13 2213-4220 5 1 2016 Mar Integrative medicine research Integr Med Res Yokukansan, a Kampo medicine, prevents the development of morphine tolerance through the inhibition of spinal glial cell activation in rats. 41-47 10.1016/j.imr.2015.12.003 Animal models have shown that glial cells (microglia and astrocytes) in the spinal cord undergo (...) activation following peripheral injury associated with chronic pain, suggesting the involvement of these cells in pain diseases. We have previously reported that Yokukansan (YKS), a Japanese traditional herbal (Kampo) medicine, is effective against chronic pain through the suppression of spinal glial cell activation. Morphine is a widely-used opioid analgesic for relieving severe pain, but its repeated administration leads to the development of antinociceptive tolerance. The development of morphine

Integrative medicine research2015 Full Text: Link to full Text with Trip Pro

34. Efficacy of Low-Dose Oral Liquid Morphine for Elderly Patients with Chronic Non-Cancer Pain: Retrospective Chart Review

Efficacy of Low-Dose Oral Liquid Morphine for Elderly Patients with Chronic Non-Cancer Pain: Retrospective Chart Review 26688789 2018 11 13 2199-1154 2 4 2015 Drugs - real world outcomes Drugs Real World Outcomes Efficacy of Low-Dose Oral Liquid Morphine for Elderly Patients with Chronic Non-Cancer Pain: Retrospective Chart Review. 369-376 The use of medications among older persons can often be challenging as physiological changes may affect metabolism and cognitive abilities. Several studies (...) show that the elderly with chronic pain are seriously undertreated or inappropriately treated, particularly with respect to opioids. To determine whether very low doses of oral liquid morphine (LM) in patients over 65 years of age with chronic non-cancer pain provides meaningful pain improvement. A retrospective chart review was conducted for ten carefully selected older patients seen at a tertiary care pain clinic in Toronto Ontario (2009-2011) with serious biomedical painful conditions

Drugs - real world outcomes2015 Full Text: Link to full Text with Trip Pro

35. Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial

Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2014

36. Morphine

Morphine USE OF MORPHINE IN PREGNANCY 0344 892 0909 USE OF MORPHINE IN PREGNANCY (Date of issue: March 2016 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Morphine is a natural opioid analgesic derived from the poppy ( Papaver (...) somniferum ) and is typically administered orally, intravenously, or rectally for the treatment of severe or intractable pain. No recent data relating specifically to morphine exposure in human pregnancy have been published. Very limited data from 1977 did not demonstrate an increased risk of congenital malformation following first trimester morphine exposure in 70 cases. Increased rates of specific malformations have been observed in some studies analysing opioids as a class, but the data

UK Teratology Information Service2014

37. The efficacy of 2 doses of epidural morphine for postcesarean delivery analgesia: a randomized noninferiority trial

The efficacy of 2 doses of epidural morphine for postcesarean delivery analgesia: a randomized noninferiority trial 23921652 2013 08 22 2013 10 28 2015 07 14 1526-7598 117 3 2013 Sep Anesthesia and analgesia Anesth. Analg. The efficacy of 2 doses of epidural morphine for postcesarean delivery analgesia: a randomized noninferiority trial. 677-85 10.1213/ANE.0b013e31829cfd21 A single dose of epidural morphine is effective in reducing pain after cesarean delivery but is associated with adverse (...) effects. In this study, we sought to establish whether half the traditional dose of epidural morphine, when administered as part of a multimodal analgesia regimen after cesarean delivery, was associated with noninferior analgesia and fewer adverse effects. Ninety term parturients undergoing cesarean delivery under epidural anesthesia were enrolled in this randomized, double-blinded, noninferiority study. Patients were randomly allocated to receive either 3 mg epidural morphine or, half this dose, 1.5

EvidenceUpdates2013

38. Oral morphine for cancer pain.

Oral morphine for cancer pain. BACKGROUND: This is the second updated version of a Cochrane review first published in Issue 4, 2003 of The Cochrane Library and first updated in 2007. Morphine has been used for many years to relieve pain. Oral morphine in either immediate release or modified release form remains the analgesic of choice for moderate or severe cancer pain. OBJECTIVES: To determine the efficacy of oral morphine in relieving cancer pain, and assess the incidence and severity (...) of adverse effects. SEARCH METHODS: We searched the following databases: Cochrane Pain, Palliative and Supportive Care Group Trials Register (June 2013); Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2013, Issue 5, May); MEDLINE (1966 to June 2013); and EMBASE (1974 to June 2013). SELECTION CRITERIA: Published randomised controlled trials (RCTs) using placebo or active comparators reporting on the analgesic effect of oral morphine in adults and children with cancer pain

Cochrane2013

39. Is Pain After TKA Better with Periarticular Injection or Intrathecal Morphine?

Is Pain After TKA Better with Periarticular Injection or Intrathecal Morphine? 23397315 2013 05 02 2013 06 25 2017 02 20 1528-1132 471 6 2013 Jun Clinical orthopaedics and related research Clin. Orthop. Relat. Res. Is pain after TKA better with periarticular injection or intrathecal morphine? 1992-9 10.1007/s11999-013-2826-9 Postoperative pain after TKA is a major concern to patients. The best technique to control pain is still controversial. Intrathecal morphine or periarticular multimodal (...) drug injection are both commonly used and both appear to provide better pain control than placebo, but it is unclear whether one or the other provides better pain control. We asked whether intrathecal morphine or periarticular multimodal drug injection provides better pain control with fewer adverse events. In a prospective, double-blind, randomized controlled trial we randomized 57 patients with osteoarthritic knees who underwent TKAs into two groups. Group M (n = 28) received 0.2 mg intrathecal

EvidenceUpdates2013 Full Text: Link to full Text with Trip Pro

40. Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis

Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis Engelman E, Marsala C CRD summary The authors concluded that the addition of intrathecal clonidine to intrathecal morphine provided small clinical benefits, but increased the frequency of hypotension. The (...) results were heavily influenced by one trial, with an additional treatment.There were some limitations in the review, but the cautious conclusions reflect the evidence presented and seem reliable. Authors' objectives To evaluate the efficacy of adding intrathecal clonidine to intrathecal morphine for acute postoperative pain. Searching Seven databases, including EMBASE and PubMed, were searched in January 2012, for relevant studies. Search terms were reported. The references of the included articles

DARE.2013