Latest & greatest articles for morphine

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Top results for morphine

1. Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial.

Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial. BACKGROUND: Infant pain has immediate and long-term effects but is undertreated because of a paucity of evidence-based analgesics. Although morphine is often used to sedate ventilated infants, its analgesic efficacy is unclear. We aimed to establish whether oral morphine could provide effective and safe analgesia in non-ventilated premature infants for acute (...) procedural pain. METHODS: In this single-centre masked trial, 31 infants at the John Radcliffe Hospital, Oxford, UK, were randomly allocated using a web-based facility with a minimisation algorithm to either 100 μg/kg oral morphine sulphate or placebo 1 h before a clinically required heel lance and retinopathy of prematurity screening examination, on the same occasion. Eligible infants were born prematurely at less than 32 weeks' gestation or with a birthweight lower than 1501 g and had a gestational age

Lancet2018

2. Comparison of Safety and Efficacy of Methadone vs Morphine for Treatment of Neonatal Abstinence Syndrome: A Randomized Clinical Trial

Comparison of Safety and Efficacy of Methadone vs Morphine for Treatment of Neonatal Abstinence Syndrome: A Randomized Clinical Trial 29913015 2018 08 08 2168-6211 172 8 2018 Aug 01 JAMA pediatrics JAMA Pediatr Comparison of Safety and Efficacy of Methadone vs Morphine for Treatment of Neonatal Abstinence Syndrome: A Randomized Clinical Trial. 741-748 10.1001/jamapediatrics.2018.1307 Although opioids are used to treat neonatal abstinence syndrome (NAS), the best pharmacologic treatment has (...) not been established. To compare the safety and efficacy of methadone and morphine in NAS. In this randomized, double-blind, intention-to-treat trial, term infants from 8 US newborn units whose mothers received buprenorphine, methadone, or opioids for pain control during pregnancy were eligible. A total of 117 infants were randomized to receive methadone or morphine from February 9, 2014, to March 6, 2017. Mothers who declined randomization could consent to data collection and standard institutional

EvidenceUpdates2018

3. Morphine

Morphine Top results for morphine - Trip Database or use your Google+ account Liberating the literature My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing (...) the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for morphine The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines

Trip Latest and Greatest2018

4. Intravenous Lidocaine Provides Similar Analgesia to Intravenous Morphine for Undifferentiated Severe Pain in the Emergency Department: A Pilot, Unblinded Randomized Controlled Trial

Intravenous Lidocaine Provides Similar Analgesia to Intravenous Morphine for Undifferentiated Severe Pain in the Emergency Department: A Pilot, Unblinded Randomized Controlled Trial 29741660 2018 05 09 1526-4637 2018 May 07 Pain medicine (Malden, Mass.) Pain Med Intravenous Lidocaine Provides Similar Analgesia to Intravenous Morphine for Undifferentiated Severe Pain in the Emergency Department: A Pilot, Unblinded Randomized Controlled Trial. 10.1093/pm/pny031 We compared the analgesic effects (...) of intravenous (IV) lidocaine and IV morphine for the treatment of severe pain in the emergency department (ED). This was a pilot, unblinded randomized controlled study comparing the efficacy of IV lidocaine vs IV morphine for patients aged ≥18 years with severe pain (numerical rating scale [NRS] ≥ 7). Participants were randomized to receive IV lidocaine (75 mg if <50 kg, 100 mg if 50-100 kg, and 150 mg if >100 kg) over 10 minutes, followed by a 50-minute IV lidocaine infusion of the same dose or provider

EvidenceUpdates2018

5. Adductor Canal Block With Continuous Infusion Versus Intermittent Boluses and Morphine Consumption: A Randomized, Blinded, Controlled Clinical Trial

Adductor Canal Block With Continuous Infusion Versus Intermittent Boluses and Morphine Consumption: A Randomized, Blinded, Controlled Clinical Trial 29293181 2018 05 15 1526-7598 126 6 2018 Jun Anesthesia and analgesia Anesth. Analg. Adductor Canal Block With Continuous Infusion Versus Intermittent Boluses and Morphine Consumption: A Randomized, Blinded, Controlled Clinical Trial. 2069-2077 10.1213/ANE.0000000000002747 Based on the assumption that relatively large volumes of local anesthetic

EvidenceUpdates2018

6. Acupuncture versus titrated morphine in acute renal colic: a randomized controlled trial

Acupuncture versus titrated morphine in acute renal colic: a randomized controlled trial 29483783 2018 03 01 1178-7090 11 2018 Journal of pain research J Pain Res Acupuncture versus titrated morphine in acute renal colic: a randomized controlled trial. 335-341 10.2147/JPR.S136299 The objective of this study was to compare the analgesic effect and tolerance profile of acupuncture versus intravenous (IV) titrated morphine in patients presenting to the emergency department (ED) with renal colic (...) . A total of 115 patients were randomized into two groups. Patients in the IV titrated-morphine group (n=61) received 0.1 mg/kg morphine every 5 minutes until pain score dropped by at least 50% of its baseline value. Patients in the acupuncture group (n=54) received an acupuncture session of 30 minutes following a prespecified protocol. The visual analog scale (VAS) was used to assess pain intensity at baseline and at 10, 20, 30, 45, and 60 minutes following the start of the treatment protocol. Possible

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

7. Yokukansan (Kampo medicinal formula) prevents the development of morphine tolerance by inhibiting the secretion of orexin A

Yokukansan (Kampo medicinal formula) prevents the development of morphine tolerance by inhibiting the secretion of orexin A Redirecting

Integrative medicine research2018 Full Text: Link to full Text with Trip Pro

8. Relative Contributions of Adductor Canal Block and Intrathecal Morphine to Analgesia and Functional Recovery After Total Knee Arthroplasty: A Randomized Controlled Trial

Relative Contributions of Adductor Canal Block and Intrathecal Morphine to Analgesia and Functional Recovery After Total Knee Arthroplasty: A Randomized Controlled Trial 29315129 2018 02 07 1532-8651 43 2 2018 Feb Regional anesthesia and pain medicine Reg Anesth Pain Med Relative Contributions of Adductor Canal Block and Intrathecal Morphine to Analgesia and Functional Recovery After Total Knee Arthroplasty: A Randomized Controlled Trial. 154-160 10.1097/AAP.0000000000000724 Effective (...) postoperative analgesia may enhance early rehabilitation after orthopedic surgery. This randomized double-blind trial investigates the relative contributions of adductor canal block and low-dose intrathecal morphine (ITM) to postoperative analgesia and functional recovery after total knee arthroplasty. Two-hundred one patients undergoing elective unilateral total knee arthroplasty under spinal anesthesia were randomized to 3 groups. All patients received standardized intraoperative local infiltration

EvidenceUpdates2018

9. Morphine versus fentanyl for spinal post-caesarean analgesia: a randomised controlled trial.

Morphine versus fentanyl for spinal post-caesarean analgesia: a randomised controlled trial. BACKGROUND: Finding appropriate analgesics is important for a mother's recovery after a caesarean section. The aim of this study was to compare the analgesic effect of spinal morphine and fentanyl for women undergoing a caesarean section. METHODS: In this randomised, unmasked, parallel-group, controlled trial, eligible participants were women undergoing caesarean section with spinal anaesthetic (...) at the Al-Helal Al-Emirati Hospital, Rafah, Gaza Strip, occupied Palestinian territory. Using a manually generated allocation sequence that was independently managed by medical staff, we randomly assigned women (1:1) to receive either 0·2 mg preservative-free morphine or 20 μg fentanyl, spinally, combined with 2 mL of 0·5% hyperbaric bupivacaine for spinal anaesthesia. Pain was recorded by visual analogue scales (VAS; range 0-10, where 0 means no pain and 10 means pain is intolerable) at 1 h, 6 h, 12 h

Lancet2018

10. Intrathecal Morphine for Laparoscopic Segmental Colonic Resection as Part of an Enhanced Recovery Protocol: A Randomized Controlled Trial

Intrathecal Morphine for Laparoscopic Segmental Colonic Resection as Part of an Enhanced Recovery Protocol: A Randomized Controlled Trial 29219935 2017 12 21 1532-8651 2017 Dec 06 Regional anesthesia and pain medicine Reg Anesth Pain Med Intrathecal Morphine for Laparoscopic Segmental Colonic Resection as Part of an Enhanced Recovery Protocol: A Randomized Controlled Trial. 10.1097/AAP.0000000000000703 Management of postoperative pain after laparoscopic segmental colonic resections remains (...) controversial. We compared 2 methods of analgesia within an Enhanced Recovery After Surgery (ERAS) program. The goal of the study was to investigate whether administration of intrathecal bupivacaine/morphine would lead to an enhanced recovery. A single-center, randomized, double-blind controlled trial was performed (NL43488.101.13). Patients scheduled for laparoscopic segmental intestinal resections were considered. Exclusion criteria were patients in whom contraindications to spinal anesthesia were present

EvidenceUpdates2018

11. EVALUATING SLOW-RELEASE ORAL MORPHINE TO NARROW THE TREATMENT GAP FOR OPIOID USE DISORDERS

EVALUATING SLOW-RELEASE ORAL MORPHINE TO NARROW THE TREATMENT GAP FOR OPIOID USE DISORDERS 29277849 2018 11 13 1539-3704 168 2 2018 Jan 16 Annals of internal medicine Ann. Intern. Med. Evaluating Slow-Release Oral Morphine to Narrow the Treatment Gap for Opioid Use Disorders. 141-142 10.7326/M17-2373 Socías M Eugenia ME From University of British Columbia and British Columbia Centre on Substance Use, Vancouver, British Columbia, Canada. Wood Evan E From University of British Columbia

Annals of Internal Medicine2017 Full Text: Link to full Text with Trip Pro

12. Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial

Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial 29018084 2017 10 11 2017 10 16 2017 10 18 1488-2329 189 40 2017 Oct 10 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial. E1252-E1258 10.1503/cmaj.170017 Oral morphine for postoperative pain (...) after minor pediatric surgery, while increasingly popular, is not supported by evidence. We evaluated whether oral morphine was superior to ibuprofen for at-home management of children's postoperative pain. We conducted a randomized superiority trial comparing oral morphine (0.5 mg/kg) with ibuprofen (10 mg/kg) in children 5 to 17 years of age who had undergone minor outpatient orthopedic surgery (June 2013 to September 2016). Participants took up to 8 doses of the intervention drug every 6 hours

EvidenceUpdates2017 Full Text: Link to full Text with Trip Pro

13. Local Efficacy of Periarticular Morphine Injection in Simultaneous Bilateral Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind Trial

Local Efficacy of Periarticular Morphine Injection in Simultaneous Bilateral Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind Trial 28811107 2017 08 16 2017 08 16 1532-8406 2017 Jul 21 The Journal of arthroplasty J Arthroplasty Local Efficacy of Periarticular Morphine Injection in Simultaneous Bilateral Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind Trial. S0883-5403(17)30618-6 10.1016/j.arth.2017.07.020 The periarticular multimodal cocktail injection including (...) morphine is currently commonly used to reduce postoperative pain following total knee arthroplasty (TKA). Despite its analgesic effect, it frequently causes nausea, which is an adverse effect of opioids. It is inconclusive whether the intraoperative injection of periarticular morphine is effective peripherally. The aim of this study was to assess whether the addition of morphine to unilateral periarticular knee injections improves postoperative pain, range of motion, and swelling in patients undergoing

EvidenceUpdates2017

14. Continuous Ropivacaine Subfascial Wound Infusion Compared With Intrathecal Morphine for Postcesarean Analgesia: A Prospective, Randomized Controlled, Double-Blind Study

Continuous Ropivacaine Subfascial Wound Infusion Compared With Intrathecal Morphine for Postcesarean Analgesia: A Prospective, Randomized Controlled, Double-Blind Study 28368941 2017 04 03 2017 09 07 2017 09 07 1526-7598 125 3 2017 Sep Anesthesia and analgesia Anesth. Analg. Continuous Ropivacaine Subfascial Wound Infusion Compared With Intrathecal Morphine for Postcesarean Analgesia: A Prospective, Randomized Controlled, Double-Blind Study. 907-912 10.1213/ANE.0000000000001892 After cesarean (...) delivery, postoperative pain management allows early rehabilitation and helps prevent postpartum depression and chronic pain. Our present prospective, randomized controlled, double-blind study assessed the duration and effect of intrathecal analgesia and continuous ropivacaine wound infiltration versus a control group after cesarean delivery. The primary outcome was analgesia duration, defined as time to first morphine request. Secondary outcomes were cumulative postoperative morphine consumption

EvidenceUpdates2017

15. Intrathecal Morphine Improves Hemodynamic Parameters and Analgesia in Patients Undergoing Aortic Valve Replacement Surgery: A Prospective, Double-Blind, Randomized Trial

Intrathecal Morphine Improves Hemodynamic Parameters and Analgesia in Patients Undergoing Aortic Valve Replacement Surgery: A Prospective, Double-Blind, Randomized Trial 28727703 2017 07 20 2017 07 20 2150-1149 20 5 2017 Jul Pain physician Pain Physician Intrathecal Morphine Improves Hemodynamic Parameters and Analgesia in Patients Undergoing Aortic Valve Replacement Surgery: A Prospective, Double-Blind, Randomized Trial. 405-412 Intrathecal morphine (ITM) has been used in hopes of providing (...) tracheal extubation, and shorter ICU stay. Intrathecal, morphine, fentanyl, analgesia, aortic, cardiac, surgery. Elgendy Hamed H HAMAD Medical Corporation, Doha, Qatar; 2Anesthesia Dept. Assiut University Hospitals, Egypt. Helmy Hatem A R HAR Cardiology Dept. Assiut University Hospitals, Egypt. eng Journal Article United States Pain Physician 100954394 1533-3159 2017 7 21 6 0 2017 7 21 6 0 2017 7 21 6 0 ppublish 28727703

EvidenceUpdates2017

16. A Longitudinal Supra-Inguinal Fascia Iliaca Compartment Block Reduces Morphine Consumption After Total Hip Arthroplasty

A Longitudinal Supra-Inguinal Fascia Iliaca Compartment Block Reduces Morphine Consumption After Total Hip Arthroplasty 28059869 2017 01 06 2017 04 18 1532-8651 42 3 2017 May/Jun Regional anesthesia and pain medicine Reg Anesth Pain Med A Longitudinal Supra-Inguinal Fascia Iliaca Compartment Block Reduces Morphine Consumption After Total Hip Arthroplasty. 327-333 10.1097/AAP.0000000000000543 The role of a fascia iliaca compartment block (FICB) for postoperative analgesia after total hip (...) arthroplasty (THA) remains questionable. High-dose local anesthetics and a proximal injection site may be essential for successful analgesia. High-dose local anesthetics may pose a risk for local anesthetic systemic toxicity. We hypothesized that a high-dose longitudinal supra-inguinal FICB is safe and decreases postoperative morphine consumption after anterior approach THA. We conducted a prospective, double blind, randomized controlled trial. Patients scheduled for THA were randomized to group FICB

EvidenceUpdates2017

17. Parecoxib Supplementation to Morphine Analgesia Decreases Incidence of Delirium in Elderly Patients After Hip or Knee Replacement Surgery: A Randomized Controlled Trial

Parecoxib Supplementation to Morphine Analgesia Decreases Incidence of Delirium in Elderly Patients After Hip or Knee Replacement Surgery: A Randomized Controlled Trial 28525512 2017 05 19 2017 05 19 1526-7598 124 6 2017 Jun Anesthesia and analgesia Anesth. Analg. Parecoxib Supplementation to Morphine Analgesia Decreases Incidence of Delirium in Elderly Patients After Hip or Knee Replacement Surgery: A Randomized Controlled Trial. 1992-2000 10.1213/ANE.0000000000002095 Severe pain and high-dose (...) opioids are both associated with increased risk of postoperative delirium. The authors investigated whether parecoxib-supplemented IV morphine analgesia could decrease the incidence of delirium in elderly patients after total hip or knee replacement surgery. In a randomized, double-blind, 2-center trial, patients of 60 years or older who underwent elective total hip or knee replacement surgery were assigned in a 1:1 ratio to receive either parecoxib (40 mg at the end of surgery and then every 12 hours

EvidenceUpdates2017

18. The improved quality of postoperative analgesia after intrathecal morphine does not result in improved recovery and quality of life in the first 6 months after orthopedic surgery: a randomized controlled pilot study

The improved quality of postoperative analgesia after intrathecal morphine does not result in improved recovery and quality of life in the first 6 months after orthopedic surgery: a randomized controlled pilot study 28533694 2017 05 23 2017 05 26 1178-7090 10 2017 Journal of pain research J Pain Res The improved quality of postoperative analgesia after intrathecal morphine does not result in improved recovery and quality of life in the first 6 months after orthopedic surgery: a randomized (...) controlled pilot study. 1059-1069 10.2147/JPR.S135142 In orthopedic surgery, it is well known that the use of intrathecal morphine (ITM) leads to an improved quality of postoperative analgesia. Little is known how this improved analgesia affects the long-term course after surgery. A randomized, double-blind trial. Academic medical center. Forty-nine patients undergoing total hip or knee replacement surgery in spinal anesthesia. Patients were randomly assigned to receive either 0.1 mg (n=16) or 0.2 mg (n

EvidenceUpdates2017 Full Text: Link to full Text with Trip Pro

19. Effect of Intrathecally Administered Ketamine, Morphine, and Their Combination Added to Bupivacaine in Patients Undergoing Major Abdominal Cancer Surgery a Randomized, Double-Blind Study

Effect of Intrathecally Administered Ketamine, Morphine, and Their Combination Added to Bupivacaine in Patients Undergoing Major Abdominal Cancer Surgery a Randomized, Double-Blind Study 28520955 2017 05 18 2017 05 18 1526-4637 2017 May 17 Pain medicine (Malden, Mass.) Pain Med Effect of Intrathecally Administered Ketamine, Morphine, and Their Combination Added to Bupivacaine in Patients Undergoing Major Abdominal Cancer Surgery a Randomized, Double-Blind Study. 10.1093/pm/pnx105 Effective (...) postoperative pain control reduces postoperative morbidity. In this study, we investigated the effects of intrathecal morphine, ketamine, and their combination with bupivacaine for postoperative analgesia in major abdominal cancer surgery. Prospective, randomized, double-blind. Academic medical center. Ninety ASA I-III patients age 30 to 50 years were divided randomly into three groups: the morphine group (group M) received 10 mg of hyperbaric bupivacaine 0.5% in 2 mL volume and 0.3 mg morphine in 1 mL

EvidenceUpdates2017

20. Intrathecal Morphine Versus Extended-Release Epidural Morphine for Postoperative Pain Control in Pediatric Patients Undergoing Posterior Spinal Fusion

Intrathecal Morphine Versus Extended-Release Epidural Morphine for Postoperative Pain Control in Pediatric Patients Undergoing Posterior Spinal Fusion 28448398 2017 04 27 2017 05 23 1526-7598 124 6 2017 Jun Anesthesia and analgesia Anesth. Analg. Intrathecal Morphine Versus Extended-Release Epidural Morphine for Postoperative Pain Control in Pediatric Patients Undergoing Posterior Spinal Fusion. 2030-2037 10.1213/ANE.0000000000002061 Posterior spinal fusion for scoliosis is one of the most (...) painful elective pediatric surgeries. Good postoperative pain control allows early ambulation and return of ability to tolerate oral intake. Options for analgesia in this patient population are suboptimal. We hypothesized that extended-release epidural morphine (EREM) would provide better pain control and less adverse effects compared to intrathecal (IT) morphine. The primary outcome was total IV morphine consumption during 0-48 hours postoperatively. Secondary outcomes included time until first

EvidenceUpdates2017