Latest & greatest articles for migraine

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Top results for migraine

1. Intravenous metoclopramide versus dexketoprofen trometamol versus metoclopramide+ dexketoprofen trometamol in acute migraine attack in the emergency department: A randomized double-blind controlled trial

Intravenous metoclopramide versus dexketoprofen trometamol versus metoclopramide+ dexketoprofen trometamol in acute migraine attack in the emergency department: A randomized double-blind controlled trial Intravenous Metoclopramide Versus Dexketoprofen Trometamol Versus metoclopramide+ Dexketoprofen Trometamol in Acute Migraine Attack in the Emergency Department: A Randomized Double-Blind Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage (...) Migraine Attack in the Emergency Department: A Randomized Double-Blind Controlled Trial , , , Affiliations Expand Affiliations 1 Department of Emergency Medicine, Adiyaman University Training and Research Hospital, Adiyaman, Turkey. 2 Department of Emergency Medicine, Adiyaman University Training and Research Hospital, Adiyaman, Turkey. Electronic address: umutgulacti@gmail.com. PMID: 32359776 DOI: Item in Clipboard Intravenous Metoclopramide Versus Dexketoprofen Trometamol Versus metoclopramide

2020 EvidenceUpdates

2. Efficacy and safety of eptinezumab in patients with chronic migraine: PROMISE-2 Full Text available with Trip Pro

Efficacy and safety of eptinezumab in patients with chronic migraine: PROMISE-2 Efficacy and Safety of Eptinezumab in Patients With Chronic Migraine: PROMISE-2 - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center for Biotechnology Information Show account info (...) Permalink Copy Page navigation Neurology Actions . 2020 Mar 31;94(13):e1365-e1377. doi: 10.1212/WNL.0000000000009169. Epub 2020 Mar 24. Efficacy and Safety of Eptinezumab in Patients With Chronic Migraine: PROMISE-2 , , , , , , , , Affiliations Expand Affiliations 1 From the Montefiore Headache Center (R.B.L.); Department of Neurology (R.B.L.), Albert Einstein College of Medicine, Bronx, NY; NIHR-Wellcome Trust King's Clinical Research Facility (P.J.G.), SLaM Biomedical Research Centre, King's College

2020 EvidenceUpdates

3. Enhanced mindfulness-based stress reduction in episodic migraine: a randomized clinical trial with magnetic resonance imaging outcomes

Enhanced mindfulness-based stress reduction in episodic migraine: a randomized clinical trial with magnetic resonance imaging outcomes Enhanced Mindfulness-Based Stress Reduction in Episodic Migraine: A Randomized Clinical Trial With Magnetic Resonance Imaging Outcomes - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National (...) RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Pain Actions . 2020 Mar 13. doi: 10.1097/j.pain.0000000000001860. Online ahead of print. Enhanced Mindfulness-Based Stress Reduction in Episodic Migraine: A Randomized Clinical Trial With Magnetic Resonance Imaging Outcomes , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Department of Neural and Pain Sciences, School of Dentistry, University

2020 EvidenceUpdates

4. Fremanezumab for preventing migraine

Fremanezumab for preventing migraine Fremanezumab for preventing migraine T echnology appraisal guidance Published: 3 June 2020 www.nice.org.uk/guidance/ta631 © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Your responsibility Your responsibility The recommendations in this guidance represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health (...) system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Fremanezumab for preventing migraine (TA631) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 33Contents Contents 1 Recommendations 4 2 Information about fremanezumab 6 Marketing authorisation indication 6 Dosage in the marketing authorisation 6 Price 6 3 Committee discussion 7 The condition 7

2020 National Institute for Health and Clinical Excellence - Technology Appraisals

5. Acute Treatments for Migraine

Acute Treatments for Migraine ©Institute for Clinical and Economic Review, 2020 Acute Treatments for Migraine Final Evidence Report February 25, 2020 Prepared for ©Institute for Clinical and Economic Review, 2020 Page i Final Evidence Report- Acute Treatments for Migraine ICER Staff and Consultants The University of Illinois at Chicago College of Pharmacy’s Center for Pharmacoepidemiology and Pharmacoeconomic Research* Steven J. Atlas, MD, MPH Associate Professor of Medicine Harvard Medical (...) of the University of Illinois at Chicago College of Pharmacy’s Center for Pharmacoepidemiology and Pharmacoeconomic Research is limited to the development of the cost-effectiveness model, and the resulting ICER reports do not necessarily represent the views of the UIC. DATE OF PUBLICATION: February 25, 2020 How to cite this document: Atlas S, Touchette D, Agboola F, Lee T, Chapman R, Pearson S D, Rind D M. Acute Treatments for Migraine: Effectiveness and Value. Institute for Clinical and Economic Review

2020 California Technology Assessment Forum

6. Rimegepant (Nurtec ODT) - To treat migraine

Rimegepant (Nurtec ODT) - To treat migraine Drug Approval Package: NURTEC ODT NURTEC ODT " /> U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: NURTEC ODT Company: Biohaven Pharmaceuticals Application Number: 212728 Approval Date: 02/27/2020 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application Review Files (PDF) (PDF) (PDF) (PDF) (PDF

2020 FDA - Drug Approval Package

7. Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: multicentre, randomised clinical trial. Full Text available with Trip Pro

Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: multicentre, randomised clinical trial. To assess the efficacy of manual acupuncture as prophylactic treatment for acupuncture naive patients with episodic migraine without aura.Multicentre, randomised, controlled clinical trial with blinded participants, outcome assessment, and statistician.Seven hospitals in China, 5 June 2016 to 15 November 2018.150 acupuncture naive patients (...) with episodic migraine without aura.20 sessions of manual acupuncture at true acupuncture points plus usual care, 20 sessions of non-penetrating sham acupuncture at heterosegmental non-acupuncture points plus usual care, or usual care alone over 8 weeks.Change in migraine days and migraine attacks per four weeks during weeks 1-20 after randomisation compared with baseline (four weeks before randomisation).Among 150 randomised patients (mean age 36.5 (SD 11.4) years; 123 (82%) women), 147 were included

2020 BMJ

8. Ubrogepant (Ubrelvy) - acute treatment of migraine with or without aura in adults

Ubrogepant (Ubrelvy) - acute treatment of migraine with or without aura in adults Drug Approval Package: UBRELVY UBRELVY " /> U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: UBRELVY Company: Allergan Sales, Inc. Application Number: 211765 Approval Date: 12/23/2019 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application Review Files

2020 FDA - Drug Approval Package

9. Fremanezumab (Ajovy) - chronic and episodic migraine

Fremanezumab (Ajovy) - chronic and episodic migraine 1 Published 13 January 2020 1 SMC2226 fremanezumab 225mg solution for injection in pre- filled syringe (Ajovy®) Teva UK Limited 6 December 2019 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following a full submission fremanezumab (Ajovy ® ) is accepted (...) for restricted use within NHSScotland. Indication under review: For prophylaxis of migraine in adults who have at least four migraine days per month. SMC restriction: for the treatment of patients with chronic and episodic migraine who have had prior failure on three or more migraine preventive treatments. Three phase III studies demonstrated superiority of fremanezumab over placebo in reducing the number of monthly migraine days in patients with chronic and episodic migraine. This advice applies only

2020 Scottish Medicines Consortium

10. Galcanezumab (Emgality) - migraine

Galcanezumab (Emgality) - migraine Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Expand all Summary Basis of Decision (SBD) for Contact: Summary Basis of Decision (SBD) documents provide information related to the original authorization of a product. The for is located below. Recent Activity for SBDs written for approved after September 1, 2012 will be updated

2020 Health Canada - Drug and Health Product Register

11. Acute Treatments for Migraine

Acute Treatments for Migraine ©Institute for Clinical and Economic Review, 2020 Acute Treatments for Migraine Evidence Report January 10, 2020 Prepared for ©Institute for Clinical and Economic Review, 2020 Page i Evidence Report- Acute Treatments for Migraine ICER Staff and Consultants The University of Illinois at Chicago College of Pharmacy’s Center for Pharmacoepidemiology and Pharmacoeconomic Research* Steven J. Atlas, MD, MPH Associate Professor of Medicine Harvard Medical School, Boston (...) , and the resulting ICER reports do not necessarily represent the views of the UIC. DATE OF PUBLICATION: January 10, 2020 How to cite this document: Atlas S, Touchette D, Agboola F, Lee T, Chapman R, Pearson S D, Rind D M. Acute Treatments for Migraine: Effectiveness and Value. Institute for Clinical and Economic Review, January 8,2020. http://icer-review.org/material/acute-migraine-evidence-report/ Steven Atlas served as the lead author for the report. Foluso Agboola led the systematic review and authorship

2020 California Technology Assessment Forum

12. Vascular safety of erenumab for migraine prevention Full Text available with Trip Pro

Vascular safety of erenumab for migraine prevention Vascular Safety of Erenumab for Migraine Prevention - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health U.S. National Library of Medicine National Center for Biotechnology Information Show account info (...) to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Neurology Actions 2019 Dec 18 [Online ahead of print] Vascular Safety of Erenumab for Migraine Prevention , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 From California Medical Clinic for Headache (D.K.), Santa Monica, CA; Department of Neurology (J.P.), University Hospital Marqués de Valdecilla and IDIVAL, Santander, Spain; Premiere Research Institute (P.K.W.), Nova Southeastern University, West Palm Beach, FL

2020 EvidenceUpdates

13. Ubrogepant for the Treatment of Migraine. (Abstract)

Ubrogepant for the Treatment of Migraine. Ubrogepant is an oral, small-molecule calcitonin gene-related peptide receptor antagonist for acute migraine treatment.We conducted a randomized trial to evaluate the efficacy, safety, and side-effect profile of ubrogepant. We assigned adults with migraine, with or without aura, in a 1:1:1 ratio to receive an initial dose of placebo, ubrogepant at a dose of 50 mg, or ubrogepant at a dose of 100 mg for treatment of a single migraine attack (...) , with the option to take a second dose. The coprimary efficacy end points were freedom from pain at 2 hours after the initial dose and absence of the most bothersome migraine-associated symptom at 2 hours. Secondary end points included pain relief (at 2 hours), sustained pain relief (from 2 to 24 hours), sustained freedom from pain (from 2 to 24 hours), and absence of symptoms associated with migraine (photophobia, phonophobia, and nausea) at 2 hours.A total of 1672 participants were enrolled; 559 were

2019 NEJM

14. Galcanezumab (migraine) - Benefit assessment according to §35a Social Code Book V

Galcanezumab (migraine) - Benefit assessment according to §35a Social Code Book V Extract 1 Translation of Sections 2.1 to 2.7 of the dossier assessment Galcanezumab (Migräne) – Nutzenbewertung gemäß § 35a SGB V (Version 1.0; Status: 27 June 2019). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. IQWiG Reports – Commission No. A19-28 Galcanezumab (migraine (...) ) – Benefit assessment according to §35a Social Code Book V 1 Extract of dossier assessment A19-28 Version 1.0 Galcanezumab (migraine) 27 June 2019 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency in Health Care Topic: Galcanezumab (migraine) – Benefit assessment according to §35a Social Code Book V Commissioning agency: Federal Joint Committee Commission awarded on: 29 March 2019 Internal Commission No.: A19-28 Address

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

15. Lasmiditan (Reyvow) - For the acute treatment of migraine with or without aura, in adults

Lasmiditan (Reyvow) - For the acute treatment of migraine with or without aura, in adults Drug Approval Package: REYVOW (lasmitidan) U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: REYVOW (lasmitidan) Company: Eli Lilly Application Number: 211280 Orig 1 Approval Date: 10/11/2019 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application

2019 FDA - Drug Approval Package

16. Effect of Ubrogepant vs Placebo on Pain and the Most Bothersome Associated Symptom in the Acute Treatment of Migraine: The ACHIEVE II Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Ubrogepant vs Placebo on Pain and the Most Bothersome Associated Symptom in the Acute Treatment of Migraine: The ACHIEVE II Randomized Clinical Trial. Ubrogepant is an oral calcitonin gene-related peptide receptor antagonist under investigation for acute treatment of migraine.To evaluate the efficacy and tolerability of ubrogepant compared with placebo for acute treatment of a single migraine attack.Phase 3, multicenter, randomized, double-blind, placebo-controlled, single-attack (...) , clinical trial (ACHIEVE II) conducted in the United States (99 primary care and research clinics; August 26, 2016-February 26, 2018). Participants were adults with migraine with or without aura experiencing 2 to 8 migraine attacks per month.Ubrogepant 50 mg (n = 562), ubrogepant 25 mg (n = 561), or placebo (n = 563) for a migraine attack of moderate or severe pain intensity.Co-primary efficacy outcomes were pain freedom and absence of the participant-designated most bothersome migraine-associated

2019 JAMA

17. Targeting calcitonin gene-related peptide: a new era in migraine therapy. (Abstract)

Targeting calcitonin gene-related peptide: a new era in migraine therapy. Migraine is one of the most prevalent and disabling diseases worldwide, but until recently, few migraine-specific therapies had been developed. Extensive basic and clinical scientific investigation has provided strong evidence that the neuropeptide calcitonin gene-related peptide (CGRP) has a key role in migraine. This evidence led to the development of small molecule CGRP receptor antagonists and monoclonal antibodies (...) targeting either CGRP or its receptor. Clinical trials investigating these therapies have consistently shown statistically significant efficacy for either the acute or preventive treatment of migraine. No serious safety or tolerability issues have been identified in the trials of the monoclonal antibody therapies. Although the appropriate place of these new migraine-specific therapies relative to other available acute and preventive treatments remains to be determined, a growing body of evidence shows

2019 Lancet

18. Acupuncture for migraine headaches

Acupuncture for migraine headaches Acupuncture for migraine headaches Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Acupuncture for migraine headaches View/ Open Date 2010-04 Format Metadata Abstract Acupuncture reduces the frequency of migraine headaches when used as an adjunct to, or in place of, medical management

2019 Clinical Inquiries

19. Erenumab (Aimovig) - Migraine

Erenumab (Aimovig) - Migraine erenumab | CADTH.ca Find the information you need erenumab erenumab Last Updated: October 3, 2019 Result type: Reports Project Number: SR0578-000 Product Line: Generic Name: erenumab Brand Name: Aimovig Manufacturer: Novartis Pharmaceuticals Canada Inc. Indications: Migraine Manufacturer Requested Reimbursement Criteria 1 : For prevention of migraine in adults who have at least 8 migraine days per month and who have previously failed, are intolerant, or have (...) a contraindication to at least two migraine preventive therapies Submission Type: New Project Status: Active Biosimilar: No Fee Schedule: Schedule A The requested reimbursement criteria are provided by the applicant and do not necessarily reflect the views of CADTH. Reimbursement criteria from CADTH will be documented in the final recommendation, if applicable. Key Milestones 2 Call for patient input posted April 04, 2019 Clarification: CADTH initially posted the call for patient from July 12, 2018 to August 31

2019 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

20. Fremanezumab versus placebo for migraine prevention in patients with documented failure to up to four migraine preventive medication classes (FOCUS): a randomised, double-blind, placebo-controlled, phase 3b trial. (Abstract)

Fremanezumab versus placebo for migraine prevention in patients with documented failure to up to four migraine preventive medication classes (FOCUS): a randomised, double-blind, placebo-controlled, phase 3b trial. Antibodies targeting calcitonin gene-related peptide (CGRP) or its receptor have shown efficacy in the prevention of migraine attacks. We investigated the efficacy and tolerability of fremanezumab, a fully humanised CGRP antibody, in patients with migraine who had previously (...) not responded to two to four classes of migraine preventive medications.The randomised, double-blind, placebo-controlled, parallel-group, phase 3b FOCUS trial was done at 104 sites (including hospitals, medical centres, research institutes, and group practice clinics) across Belgium, the Czech Republic, Denmark, Finland, France, Germany, Italy, the Netherlands, Poland, Spain, Sweden, Switzerland, the UK, and the USA. We enrolled participants aged 18-70 years with episodic or chronic migraine who had

2019 Lancet Controlled trial quality: predicted high