Latest & greatest articles for methylprednisolone

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on methylprednisolone or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on methylprednisolone and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for methylprednisolone

1. Effect of Methylprednisolone on Pain Management in Total Knee or Hip Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Effect of Methylprednisolone on Pain Management in Total Knee or Hip Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials 29595528 2018 08 27 1536-5409 34 10 2018 Oct The Clinical journal of pain Clin J Pain Effect of Methylprednisolone on Pain Management in Total Knee or Hip Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 967-974 10.1097/AJP.0000000000000614 Total joint arthroplasty (TJA) has been reported to be a successful (...) strategy for patients with advanced osteoarthritis; however, early postoperative pain has become an unresolved issue. Perioperative methylprednisolone (MP) administration in TJA is an important and controversial topic. This study was conducted to assess the efficacy and safety of MP for pain management after total knee or hip arthroplasty (TKA/THA). PubMed, Embase, and the Cochrane Library were searched for randomized controlled trials comparing MP versus placebo for patients undergoing TKA/THA

EvidenceUpdates2018

2. Methylprednisolone

Methylprednisolone Top results for methylprednisolone - Trip Database or use your Google+ account Find evidence fast My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box (...) and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for methylprednisolone The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical

Trip Latest and Greatest2018

3. Randomized Clinical Trial of Preoperative High-Dose Methylprednisolone on Postoperative Pain at Rest After Laparoscopic Appendectomy

Randomized Clinical Trial of Preoperative High-Dose Methylprednisolone on Postoperative Pain at Rest After Laparoscopic Appendectomy 29200067 2018 04 19 1526-7598 126 5 2018 May Anesthesia and analgesia Anesth. Analg. Randomized Clinical Trial of Preoperative High-Dose Methylprednisolone on Postoperative Pain at Rest After Laparoscopic Appendectomy. 1712-1720 10.1213/ANE.0000000000002693 Methylprednisolone administered intravenously preoperatively has been shown to reduce pain, nausea (...) , and fatigue after elective surgery. We aimed to show that 125 mg of methylprednisolone given intravenously 30 minutes before laparoscopic surgery for suspected appendicitis would reduce pain at rest during the first 3 postoperative days. A multicenter, parallel-group, double-blind, placebo-controlled study was conducted including patients 18 years of age and older with an American Society of Anesthesiologist class of I-III undergoing laparoscopic surgery for suspected appendicitis. The primary outcome

EvidenceUpdates2018

4. Methylprednisolone injectable medicine containing lactose (Solu-Medrone 40 mg): do not use in patients with cows? milk allergy

Methylprednisolone injectable medicine containing lactose (Solu-Medrone 40 mg): do not use in patients with cows? milk allergy Methylprednisolone injectable medicine containing lactose (Solu-Medrone 40 mg): do not use in patients with cows’ milk allergy - GOV.UK GOV.UK uses cookies to make the site simpler. Search Methylprednisolone injectable medicine containing lactose (Solu-Medrone 40 mg): do not use in patients with cows’ milk allergy From: Published: 26 October 2017 Therapeutic area (...) : , , and Solu-Medrone 40 mg may contain trace amounts of milk proteins. Do not use in patients with a known or suspected allergy to cows’ milk. Contents Advice for healthcare professionals: Solu-Medrone 40 mg uses lactose produced from cows’ milk as an excipient and may contain trace amounts of milk proteins; other strengths of Solu-Medrone do not contain lactose serious allergic reactions have been reported in patients allergic to cows’ milk proteins do not use injectable methylprednisolone medicines

MHRA Drug Safety Update2017

5. Preoperative methylprednisolone does not reduce loss of knee-extension strength after total knee arthroplastyA randomized, double-blind, placebo-controlled trial of 61 patients

Preoperative methylprednisolone does not reduce loss of knee-extension strength after total knee arthroplastyA randomized, double-blind, placebo-controlled trial of 61 patients 28657396 2017 06 28 2017 08 14 1745-3682 88 5 2017 Oct Acta orthopaedica Acta Orthop Preoperative methylprednisolone does not reduce loss of knee-extension strength after total knee arthroplastyA randomized, double-blind, placebo-controlled trial of 61 patients. 543-549 10.1080/17453674.2017.1345236 Background (...) and purpose - Patients undergoing total knee arthroplasty (TKA) face challenges related to postoperative reduction in knee-extension strength. We evaluated whether inhibition of the inflammatory response by a single preoperative dose of methylprednisolone (MP) reduces the pronounced loss of knee-extension strength at discharge after fast-track TKA. Patients and methods - 70 patients undergoing elective unilateral TKA were randomized (1:1) to preoperative intravenous (IV) MP 125 mg (group MP) or isotonic

EvidenceUpdates2017

6. Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial.

Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial. Importance: Guidelines recommend corticosteroids in patients with IgA nephropathy and persistent proteinuria, but the effects remain uncertain. Objective: To evaluate the efficacy and safety of corticosteroids in patients with IgA nephropathy at risk of progression. Design, Setting, and Participants: The Therapeutic Evaluation of Steroids in IgA Nephropathy Global (...) (TESTING) study was a multicenter, double-blind, randomized clinical trial designed to recruit 750 participants with IgA nephropathy (proteinuria greater than 1 g/d and estimated glomerular filtration rate [eGFR] of 20 to 120 mL/min/1.73 m2 after at least 3 months of blood pressure control with renin-angiotensin system blockade] and to provide follow-up until 335 primary outcomes occurred. Interventions: Patients were randomized 1:1 to oral methylprednisolone (0.6-0.8 mg/kg/d; maximum, 48 mg/d) (n

JAMA2017

7. Tacrolimus Monotherapy after Intravenous Methylprednisolone in Adults with Minimal Change Nephrotic Syndrome

Tacrolimus Monotherapy after Intravenous Methylprednisolone in Adults with Minimal Change Nephrotic Syndrome 27807213 2016 11 03 2017 04 13 1533-3450 28 4 2017 Apr Journal of the American Society of Nephrology : JASN J. Am. Soc. Nephrol. Tacrolimus Monotherapy after Intravenous Methylprednisolone in Adults with Minimal Change Nephrotic Syndrome. 1286-1295 10.1681/ASN.2016030342 Glucocorticoid treatment is the first choice therapy for adults with minimal change nephrotic syndrome; however (...) , this therapy associates with many adverse effects. Tacrolimus may be an alternative to conventional glucocorticoid therapy. To investigate this possibility, we conducted a prospective, randomized, controlled trial (WHO International Clinical Trials Registry Platform: ChiCTR-TRC-11001454) in eight renal units across China. We randomized enrolled patients with adult-onset minimal change nephrotic syndrome (n=119) to receive glucocorticoid therapy or tacrolimus after intravenous methylprednisolone (0.8 mg/kg

EvidenceUpdates2016

8. Intratympanic methylprednisolone versus gentamicin in patients with unilateral Ménière's disease: a randomised, double-blind, comparative effectiveness trial.

Intratympanic methylprednisolone versus gentamicin in patients with unilateral Ménière's disease: a randomised, double-blind, comparative effectiveness trial. BACKGROUND: Ménière's disease is characterised by severe vertigo attacks and hearing loss. Intratympanic gentamicin, the standard treatment for refractory Ménière's disease, reduces vertigo, but damages vestibular function and can worsen hearing. We aimed to assess whether intratympanic administration of the corticosteroid (...) methylprednisolone reduces vertigo compared with gentamicin. METHODS: In this double-blind comparative effectiveness trial, patients aged 18-70 years with refractory unilateral Ménière's disease were enrolled at Charing Cross Hospital (London, UK) and Leicester Royal Infirmary (Leicester, UK). Patients were randomly assigned (1:1) by a block design to two intratympanic methylprednisolone (62·5 mg/mL) or gentamicin (40 mg/mL) injections given 2 weeks apart, and were followed up for 2 years. All investigators

Lancet2016

9. Methylprednisolone Does Not Reduce Persistent Pain after Cardiac Surgery

Methylprednisolone Does Not Reduce Persistent Pain after Cardiac Surgery 26501386 2015 12 15 2016 04 06 2015 12 15 1528-1175 123 6 2015 Dec Anesthesiology Anesthesiology Methylprednisolone Does Not Reduce Persistent Pain after Cardiac Surgery. 1404-10 10.1097/ALN.0000000000000915 Persistent incisional pain is common after cardiac surgery and is believed to be in part related to inflammation and poorly controlled acute pain. Methylprednisolone is a corticosteroid with substantial (...) antiinflammatory and analgesic properties and is thus likely to ameliorate persistent surgical pain. Therefore, the authors tested the primary hypothesis that patients randomized to methylprednisolone have less persistent incisional pain than those given placebo. One thousand forty-three patients having cardiopulmonary bypass for cardiac surgery via a median sternotomy were included in this substudy of Steroids in Cardiac Surgery (SIRS) trial. Patients were randomized to 500 mg intraoperative

EvidenceUpdates2015

10. Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial.

Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial. BACKGROUND: Cardiopulmonary bypass initiates a systemic inflammatory response syndrome that is associated with postoperative morbidity and mortality. Steroids suppress inflammatory responses and might improve outcomes in patients at high risk of morbidity and mortality undergoing cardiopulmonary bypass. We aimed to assess the effects of steroids in patients at high risk (...) of morbidity and mortality undergoing cardiopulmonary bypass. METHODS: The Steroids In caRdiac Surgery (SIRS) study is a double-blind, randomised, controlled trial. We used a central computerised phone or interactive web system to randomly assign (1:1) patients at high risk of morbidity and mortality from 80 hospital or cardiac surgery centres in 18 countries undergoing cardiac surgery with the use of cardiopulmonary bypass to receive either methylprednisolone (250 mg at anaesthetic induction and 250 mg

Lancet2015

11. Randomized clinical trial of prevention of seroma formation after mastectomy by local methylprednisolone injection

Randomized clinical trial of prevention of seroma formation after mastectomy by local methylprednisolone injection 26179672 2015 08 13 2015 11 10 2015 08 13 1365-2168 102 10 2015 Sep The British journal of surgery Br J Surg Randomized clinical trial of prevention of seroma formation after mastectomy by local methylprednisolone injection. 1195-203 10.1002/bjs.9874 Seroma formation, the most prevalent postoperative complication after mastectomy, is an inflammatory process that is potentially (...) preventable via local steroid administration. This study investigated the effect of local steroid administration on seroma formation. This was a double-blind randomized placebo-controlled intervention study of a single dose of 80 mg methylprednisolone versus saline on seroma formation after mastectomy. Patients were further classified according to the surgical axillary procedure: mastectomy with sentinel lymph node biopsy (M + SLNB) or mastectomy with level I-II axillary lymph node dissection (M + ALND

EvidenceUpdates2015

12. Efficacy of Triamcinolone Hexacetonide versus Methylprednisolone Acetate Intraarticular Injections in Knee Osteoarthritis: A Randomized, Double-blinded, 24-week Study

Efficacy of Triamcinolone Hexacetonide versus Methylprednisolone Acetate Intraarticular Injections in Knee Osteoarthritis: A Randomized, Double-blinded, 24-week Study 26136485 2015 09 02 2016 06 06 2015 09 02 0315-162X 42 9 2015 Sep The Journal of rheumatology J. Rheumatol. Efficacy of Triamcinolone Hexacetonide versus Methylprednisolone Acetate Intraarticular Injections in Knee Osteoarthritis: A Randomized, Double-blinded, 24-week Study. 1677-84 10.3899/jrheum.150297 Intraarticular (IA (...) ) corticosteroid injections are broadly used in knee osteoarthritis (OA); however, the best corticosteroid agent is not well defined. The aim of the present study was to compare the efficacy of triamcinolone hexacetonide (TH) and methylprednisolone acetate (MA) injections in knee OA. Patients with symptomatic knee OA and Kellgren-Lawrence grade II or III were randomized to receive 40 mg of IA TH or MA. Evaluations were performed at 4, 12, and 24 weeks. The primary outcome was a change in the patient's

EvidenceUpdates2015

13. Effect of Timing and Route of Methylprednisolone Administration During Pediatric Cardiac Surgical Procedures

Effect of Timing and Route of Methylprednisolone Administration During Pediatric Cardiac Surgical Procedures 25440273 2015 01 03 2015 03 09 2015 01 03 1552-6259 99 1 2015 Jan The Annals of thoracic surgery Ann. Thorac. Surg. Effect of timing and route of methylprednisolone administration during pediatric cardiac surgical procedures. 180-5 10.1016/j.athoracsur.2014.08.042 S0003-4975(14)01744-5 We compared the antiinflammatory and cardioprotective effects of the two most common regimens (...) of corticosteroid administration in pediatric cardiac surgical procedures: a single dose delivered either at anesthesia induction or by cardiopulmonary bypass (CPB) prime. Forty-five children, aged between 1 and 18 months and undergoing ventricular septal or atrioventricular septal defect correction, were randomized in double-blind fashion into three groups. The anesthesia induction group received 30 mg/kg methylprednisolone intravenously after anesthesia induction, and the CPB-prime group received 30 mg/kg

EvidenceUpdates2015

14. Meta-analysis of methylprednisolone pulse therapy for Graves' ophthalmopathy

Meta-analysis of methylprednisolone pulse therapy for Graves' ophthalmopathy Meta-analysis of methylprednisolone pulse therapy for Graves' ophthalmopathy Meta-analysis of methylprednisolone pulse therapy for Graves' ophthalmopathy Gao G, Dai J, Qian Y, Ma F CRD summary The review concluded that intravenous glucocorticoid therapy (steroids injected into the bloodstream) were more efficient in treating people with active and moderate-to-severe Graves’ ophthalmopathy (eye disease linked (...) up. Most of the included trials compared intravenous with oral glucocorticoids. Most included patients had not received any prior treatment. The authors stated that methylprednisolone doses ranged from 4.5g to 12g (but no further details for individual trials were provided). Treatment durations ranged from three to 13 months. Three-quarters of patients were female and most had moderate-to-severe disease (patients had severe disease in one trial). Mean ages ranged from 32 to 56 years. The trials

DARE.2014

15. Clinical findings for fungal infections caused by methylprednisolone injections.

Clinical findings for fungal infections caused by methylprednisolone injections. BACKGROUND: Since September 18, 2012, public health officials have been investigating a large outbreak of fungal meningitis and other infections in patients who received epidural, paraspinal, or joint injections with contaminated lots of methylprednisolone acetate. Little is known about infections caused by Exserohilum rostratum, the predominant outbreak-associated pathogen. We describe the early clinical course

NEJM2013

16. Methylprednisolone injections for the carpal tunnel syndrome: a randomized, placebo-controlled trial.

Methylprednisolone injections for the carpal tunnel syndrome: a randomized, placebo-controlled trial. BACKGROUND: Steroid injections are used in idiopathic carpal tunnel syndrome (CTS), but evidence of efficacy beyond 1 month is lacking. OBJECTIVE: To assess the efficacy of local methylprednisolone injections in CTS. DESIGN: Randomized, placebo-controlled trial. (ClinicalTrials.gov: NCT00806871 ). SETTING: Regional referral orthopedic department in Sweden. PATIENTS: Patients aged 18 to 70 years (...) with CTS but no previous steroid injections. INTERVENTION: Three groups (37 patients each) received 80 mg of methylprednisolone, 40 mg of methylprednisolone, or placebo. The patients and treating surgeons were blinded. MEASUREMENTS: Primary end points were the change in CTS symptom severity scores at 10 weeks (range, 1 to 5) and rate of surgery at 1 year. Three patients had missing 10-week data. All patients had 1-year data. RESULTS: Improvement in CTS symptom severity scores at 10 weeks was greater

Annals of Internal Medicine2013

17. Relapse of Fungal Meningitis Associated with Contaminated Methylprednisolone.

Relapse of Fungal Meningitis Associated with Contaminated Methylprednisolone. Relapse of fungal meningitis associated with contaminated methylprednisolone. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item (...) : 23718153 Format MeSH and Other Data E-mail Subject Additional text E-mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2013 Jun 27;368(26):2535-6. doi: 10.1056/NEJMc1306560. Epub 2013 May 29. Relapse of fungal meningitis associated with contaminated methylprednisolone. , , , , . PMID: 23718153 DOI: [Indexed for MEDLINE] Free full text Publication types MeSH terms Substances Full Text Sources

NEJM2013

18. Cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in systemic lupus erythematosus.

Cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in systemic lupus erythematosus. BACKGROUND: Neuropsychiatric involvement in systemic lupus erythematosus (SLE) is complex and it is an important cause of morbidity and mortality. Management of nervous system manifestations of SLE remains unsatisfactory. This is an update of a Cochrane review first published in 2000 and previously updated in 2006. OBJECTIVES: To assess the benefits and harms of cyclophosphamide (...) and methylprednisolone in the treatment of neuropsychiatric manifestations of SLE. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, LILACS, SCOPUS and WHO up to and including June 2012. We sought additional articles through handsearching in relevant journals as well as contact with experts. There were no language restrictions. SELECTION CRITERIA: We included all randomised controlled trials that compared cyclophosphamide to methylprednisolone in patients

Cochrane2013

19. Pulse methylprednisolone therapy in idiopathic, rapidly progressive glomerulonephritis.

Pulse methylprednisolone therapy in idiopathic, rapidly progressive glomerulonephritis. Pulse methylprednisolone therapy ... preview & related info | Mendeley E-mail address Password ( ) Remember me …or sign in with Search Main Navigation › Short URL Annals of Internal Medicine ( 1980 ) Volume: 92 , Issue: 4 , Pages: 504-506 PubMed: Available from or Find this paper at: Abstract Idiopathic crescentic glomerulonephritis is associated with a 70% to 80% incidence of end-stage renal failure. Oral (...) corticosteroid therapy in combination with immunosuppressive agents or anticoagulants has not altered the prognosis of this disease. We have seen five adults with idiopathic crescentic glomerulonephritis and treated them with intravenous methylprednisolone. Before therapy, the average serum creatinine concentration was 7.4 1.3 mg/dL (chi-square SEM). This value declined to 2.0 0.48 mg/dL within 4 weeks. All patients continue to maintain stable renal function over an average follow-up period of 19 months

Annals of Internal Medicine2013

20. Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis

Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis 22128082 2012 05 08 2012 07 03 2013 11 21 1468-2060 71 6 2012 Jun Annals of the rheumatic diseases Ann. Rheum. Dis. Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis. 966-73 10.1136/annrheumdis-2011-200384 The objectives (...) of this study are to analyse the long-term follow-up of a randomised controlled trial of induction treatment with azathioprine/methylprednisolone (AZA/MP) versus high-dose intravenous cyclophosphamide (ivCY) in patients with proliferative lupus nephritis (LN) and to evaluate the predictive value of clinical, laboratory and renal biopsy parameters regarding renal outcome. 87 patients with biopsy-proven proliferative LN were treated with either AZA/MP (n=37) or ivCY (n=50), both with oral prednisone. After 2

EvidenceUpdates2012