Latest & greatest articles for metformin

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Top results for metformin

121. [Dapagliflozin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)]

[Dapagliflozin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)] Dapagliflozin/Metformin – Nutzenbewertung gemäß § 35a SGB V [Dapagliflozin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)] Dapagliflozin/Metformin – Nutzenbewertung gemäß § 35a SGB V [Dapagliflozin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)] IQWiG Record Status This is a bibliographic record (...) of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation IQWiG. Dapagliflozin/Metformin – Nutzenbewertung gemäß § 35a SGB V. [Dapagliflozin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)] Cologne: Institut fuer Qualitaet und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). IQWiG-Berichte 220. 2014 Final publication URL Indexing Status Subject indexing assigned

Health Technology Assessment (HTA) Database.2014

122. Saxagliptin + metformin - Diabetes Mellitus, Type 2

Saxagliptin + metformin - Diabetes Mellitus, Type 2 Common Drug Review CDEC Meeting — May 21, 2014 Notice of Final Recommendation — June 20, 2014 Page 1 of 4 © 2014 CADTH CDEC FINAL RECOMMENDATION SAXAGLIPTIN / METFORMIN (Komboglyze — AstraZeneca) Indication: Type 2 Diabetes Mellitus Recommendation: The Canadian Drug Expert Committee (CDEC) recommends that saxagliptin/metformin (Komboglyze) be listed for patients if the following clinical criterion and condition are met: Clinical Criterion (...) : ? Patients for whom insulin is not an option and who are already stabilized on therapy with metformin, a sulfonylurea and saxagliptin, to replace the individual components of saxagliptin and metformin in these patients. Condition: ? Drug plan costs for the saxagliptin/metformin fixed-dose combination (FDC) should not exceed the combined cost of saxagliptin and metformin administered separately. Reason for the Recommendation: At the submitted price, the saxagliptin/metformin FDC ($2.54 per day) is less

Canadian Agency for Drugs and Technologies in Health - Common Drug Review2014

123. Efficacy and safety of initial combination of DPP-IV inhibitors and metformin versus metformin monotherapy in type 2 diabetes: a systematic review of randomized controlled trials

Efficacy and safety of initial combination of DPP-IV inhibitors and metformin versus metformin monotherapy in type 2 diabetes: a systematic review of randomized controlled trials Efficacy and safety of initial combination of DPP-IV inhibitors and metformin versus metformin monotherapy in type 2 diabetes: a systematic review of randomized controlled trials Efficacy and safety of initial combination of DPP-IV inhibitors and metformin versus metformin monotherapy in type 2 diabetes: a systematic (...) review of randomized controlled trials Gao W, Dong J, Liu J, Li Y, Liu F, Yang L, Zhou X, Liao L CRD summary The authors concluded that compared with equal-dosage metformin monotherapy, initial combination of metformin and dipeptidyl peptidase-IV inhibitors was more effective in type 2 diabetes glycaemic control without additional risk of adverse events. Although the authors’ conclusions reflect the results, the varied patients and treatments plus the lack of reporting of trial quality mean

DARE.2014

124. Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone

Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone 24528605 2014 04 16 2015 01 23 2016 12 15 1463-1326 16 5 2014 May Diabetes, obesity & metabolism Diabetes Obes Metab Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone. 467-77 10.1111/dom.12273 The efficacy and safety of canagliflozin, a sodium glucose co-transporter 2 inhibitor, was evaluated (...) in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin and pioglitazone. In this randomized, double-blind, phase 3 study, patients (N = 342) received canagliflozin 100 or 300 mg during a 26-week, placebo-controlled, core period and a 26-week, active-controlled extension in which placebo-treated patients were switched to sitagliptin 100 mg. Efficacy comparisons for canagliflozin versus placebo at week 26 are reported, with no comparisons versus sitagliptin at week 52

EvidenceUpdates2014 Full Text: Link to full Text with Trip Pro

125. Sitagliptin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)

Sitagliptin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment) Sitagliptin/metformin – nutzenbewertung gemäß § 35a SGB V [Sitagliptin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)] Sitagliptin/metformin – nutzenbewertung gemäß § 35a SGB V [Sitagliptin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)] IQWiG Record Status This is a bibliographic record of a published health (...) technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation IQWiG. Sitagliptin/metformin – nutzenbewertung gemäß § 35a SGB V. [Sitagliptin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)] Cologne: Institut fuer Qualitaet und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). IQWiG-Berichte 176. 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Diabetes

Health Technology Assessment (HTA) Database.2014

126. Saxagliptin/Metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)

Saxagliptin/Metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment) Saxagliptin/Metformin (neues anwendungsgebiet) – nutzenbewertung gemäß § 35a SGB V [Saxagliptin/Metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)] Saxagliptin/Metformin (neues anwendungsgebiet) – nutzenbewertung gemäß § 35a SGB V [Saxagliptin/Metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)] IQWiG Record Status (...) This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation IQWiG. Saxagliptin/Metformin (neues anwendungsgebiet) – nutzenbewertung gemäß § 35a SGB V. [Saxagliptin/Metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)] Cologne: Institut fuer Qualitaet und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). IQWiG-Berichte 167. 2013 Final publication URL

Health Technology Assessment (HTA) Database.2014

127. Vildagliptin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)

Vildagliptin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment) Vildagliptin/metformin – nutzenbewertung gemäß § 35a SGB V [Vildagliptin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)] Vildagliptin/metformin – nutzenbewertung gemäß § 35a SGB V [Vildagliptin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)] IQWiG Record Status This is a bibliographic record of a published (...) health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation IQWiG. Vildagliptin/metformin – nutzenbewertung gemäß § 35a SGB V. [Vildagliptin/metformin: benefit assessment according to § 35a Social Code Book V (dossier assessment)] Cologne: Institut fuer Qualitaet und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). IQWiG-Berichte 179. 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH

Health Technology Assessment (HTA) Database.2014

128. Addendum to commission A13-17 (vildagliptin/metformin)

Addendum to commission A13-17 (vildagliptin/metformin) Addendum zum auftrag A13-17 (vildagliptin/metformin) [Addendum to commission A13-17 (vildagliptin/metformin)] Addendum zum auftrag A13-17 (vildagliptin/metformin) [Addendum to commission A13-17 (vildagliptin/metformin)] IQWiG Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation IQWiG (...) . Addendum zum auftrag A13-17 (vildagliptin/metformin). [Addendum to commission A13-17 (vildagliptin/metformin)] Cologne: Institut fuer Qualitaet und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). IQWiG-Berichte 189. 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Adamantane; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Humans; Metformin; Nitriles; Pyrrolidines Language Published German Country of organisation Germany English summary There is no English

Health Technology Assessment (HTA) Database.2014

129. Addendum to commission A13-03 (sitagliptin/metformin)

Addendum to commission A13-03 (sitagliptin/metformin) Addendum zum auftrag A13-03 (sitagliptin/metformin) [Addendum to commission A13-03 (sitagliptin/metformin)] Addendum zum auftrag A13-03 (sitagliptin/metformin) [Addendum to commission A13-03 (sitagliptin/metformin)] IQWiG Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation IQWiG. Addendum (...) zum auftrag A13-03 (sitagliptin/metformin). [Addendum to commission A13-03 (sitagliptin/metformin)] Cologne: Institut fuer Qualitaet und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). IQWiG-Berichte 187. 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Diabetes Mellitus, Type 2; Hypoglycemic Agents; Metformins; Pyrazines; Triazoles Language Published German Country of organisation Germany English summary There is no English language summary available. Address

Health Technology Assessment (HTA) Database.2014

130. Saxagliptin metformin (Kombogylze) - in combination with a sulphonylurea (i.e. triple combination therapy) as an adjunct to diet and exercise to improve glycaemic control in adult patients aged 18 years and older with type 2 diabetes mellitus

Saxagliptin metformin (Kombogylze) - in combination with a sulphonylurea (i.e. triple combination therapy) as an adjunct to diet and exercise to improve glycaemic control in adult patients aged 18 years and older with type 2 diabetes mellitus Published 13 January 2014 Product Update: saxagliptin plus metformin, 2.5mg / 850mg and 2.5mg / 1000mg film- coated tablets (Komboglyze ® ) (No: 929/13) Bristol-Myers Squibb / AstraZeneca 06 December 2013 The Scottish Medicines Consortium (SMC) has (...) completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHS Scotland. The advice is summarised as follows: ADVICE: following an abbreviated submission saxagliptin plus metformin (Komboglyze ® ) is accepted for use within NHS Scotland. Indication under review: in combination with a sulphonylurea (i.e. triple combination therapy) as an adjunct to diet and exercise to improve glycaemic control in adult patients aged 18 years

Scottish Medicines Consortium2014

131. Effect of Metformin on Left Ventricular Function After Acute Myocardial Infarction in Patients Without Diabetes: The GIPS-III Randomized Clinical Trial.

Effect of Metformin on Left Ventricular Function After Acute Myocardial Infarction in Patients Without Diabetes: The GIPS-III Randomized Clinical Trial. 24687169 2014 04 16 2014 04 28 2016 10 17 1538-3598 311 15 2014 Apr 16 JAMA JAMA Effect of metformin on left ventricular function after acute myocardial infarction in patients without diabetes: the GIPS-III randomized clinical trial. 1526-35 10.1001/jama.2014.3315 Metformin treatment is associated with improved outcome after (...) myocardial infarction in patients with diabetes. In animal experimental studies metformin preserves left ventricular function. To evaluate the effect of metformin treatment on preservation of left ventricular function in patients without diabetes presenting with ST-segment elevation myocardial infarction (STEMI). Double-blind, placebo-controlled study conducted among 380 patients who underwent primary percutaneous coronary intervention (PCI) for STEMI at the University Medical Center Groningen, The Netherlands

JAMA2014

132. Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial.

Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial. 25018121 2014 10 13 2015 01 01 2015 11 19 1474-547X 384 9951 2014 Oct 11 Lancet (London, England) Lancet Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial. 1349-57 10.1016/S0140-6736(14)60976-4 S0140 (...) -6736(14)60976-4 Dulaglutide and liraglutide, both glucagon-like peptide-1 (GLP-1) receptor agonists, improve glycaemic control and reduce weight in patients with type 2 diabetes. In a head-to-head trial, we compared the safety and efficacy of once-weekly dulaglutide with that of once-daily liraglutide in metformin-treated patients with uncontrolled type 2 diabetes. We did a phase 3, randomised, open-label, parallel-group study at 62 sites in nine countries between June 20, 2012, and Nov 25, 2013

Lancet2014

133. Xigduo - dapagliflozin / metformin

Xigduo - dapagliflozin / metformin 7 Westferry Circus ? Canary Wharf ? London E14 4HB ? United Kingdom An agency of the European Union Telephone +44 (0)20 7418 8400 Facsimile +44 (0)20 7523 7455 E-mail info@ema.europa.eu Website www.ema.europa.eu 21 November 2013 EMA/620505/2013 Committee for Medicinal Products for Human Use (CHMP) Assessment report Xigduo International non-proprietary name: DAPAGLIFLOZIN / METFORMIN Procedure No. EMEA/H/C/002672/0000 Note Assessment report as adopted (...) by the CHMP with all information of a commercially confidential nature deleted. Assessment report EMA/CHMP/620505/2013 Page 2/105 Product information Name of the medicinal product: Xigduo Applicant: Bristol-Myers Squibb/AstraZeneca EEIG Bristol-Myers Squibb House Uxbridge Business Park Uxbridge UB8 1DH UNITED KINGDOM Active substance: METFORMIN / DAPAGLIFLOZIN International Nonproprietary Name/Common Name: DAPAGLIFLOZIN / METFORMIN Pharmaco-therapeutic group (ATC Code): Drugs used in diabetes

European Medicines Agency - EPARs2014

134. Vokanamet - canagliflozin / metformin

Vokanamet - canagliflozin / metformin 7 Westferry Circus ? Canary Wharf ? London E14 4HB ? United Kingdom An agency of the European Union Telephone +44 (0)20 7418 8400 Facsimile +44 (0)20 7418 8613 E-mail info@ema.europa.eu Website www.ema.europa.eu 20 February 2014 EMA/179391/2014 Committee for Medicinal Products for Human Use (CHMP) Assessment report Vokanamet International non-proprietary name: CANAGLIFLOZIN / METFORMIN Procedure No. EMEA/H/C/002656/0000 Note Assessment report as adopted (...) by the CHMP with all information of a commercially confidential nature deleted. Assessment report EMA/179391/2014 Page 2/130 Product information Name of the medicinal product: Vokanamet Applicant: Janssen-Cilag International N.V. Turnhoutseweg 30 B-2340 Beerse BELGIUM Active substance: CANAGLIFLOZIN / METFORMIN HYDROCHLORIDE International Nonproprietary Name/Common Name: CANAGLIFLOZIN / METFORMIN Pharmaco-therapeutic group (ATC Code): A10BD16 Therapeutic indication(s): Canagliflozin/Metformin is indicated

European Medicines Agency - EPARs2014

135. Metformin

Metformin USE OF METFORMIN IN PREGNANCY 0344 892 0909 USE OF METFORMIN IN PREGNANCY (Date of issue: October 2011 , Version: 1 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . Summary Metformin is an antihyperglycaemic biguanide used in the management of type 2 diabetes. It acts by lowering the basal and postprandial (...) plasma glucose without stimulating insulin secretion thereby reducing the risk of hypoglycaemia associated with insulin therapy. Metformin is also used off-label for the treatment of infertility secondary to polycystic ovarian syndrome (PCOS). The available data does not show an increased risk of congenital malformations or other adverse pregnancy outcomes. Where clinically indicated, use of metformin at any stage of pregnancy may be considered. Inadvertent exposure to metformin at any stage

UK Teratology Information Service2014

136. Invokamet (canagliflozin and metformin hydrochloride)

Invokamet (canagliflozin and metformin hydrochloride) Drug Approval Package: Brand Name (Generic Name) NDA # Drug Approval Package U.S. Food & Drug Administration Enter Search terms Drug Approval Package - Invokamet (canagliflozin and metformin hydrochloride) Tablets Company: Janssen Pharmaceuticals, Inc. Application No.: 204353 Approval Date: 8/08/2014 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF

FDA - Drug Approval Package2014

137. Canagliflozin/metformin - Benefit assessment according to §35a Social Code Book V (dossier assessment)

Canagliflozin/metformin - Benefit assessment according to §35a Social Code Book V (dossier assessment) Extract 1 Translation of Sections 2.1 to 2.6 of the dossier assessment Canagliflozin/Metformin – Nutzenbewertung gemäß § 35a SGB V (Version 1.0; Status: 13 November 2014). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. IQWiG Reports – Commission No. A14-27 (...) Canagliflozin/metformin – Benefit assessment according to §35a Social Code Book V 1 Extract of dossier assessment A14-27 Version 1.0 Canagliflozin/metformin – Benefit assessment acc. to §35a SGB V 13 November 2014 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency in Health Care Topic: Canagliflozin/metformin – Benefit assessment according to §35a Social Code Book V Commissioning agency: Federal Joint Committee Commission

Institute for Quality and Efficiency in Healthcare (IQWiG)2014

138. Metformin for weight loss in schizophrenia: safe but not a panacea

Metformin for weight loss in schizophrenia: safe but not a panacea Metformin for weight loss in schizophrenia: safe but not a panacea | Evidence-Based Mental Health This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Metformin for weight loss in schizophrenia: safe but not a panacea Article Text Pharmacological interventions Metformin for weight loss in schizophrenia: safe but not a panacea Cenk Tek 1 , Lydia Chwastiak 2 Statistics from Altmetric.com No Altmetric data available for this article. What is already known on this topic? Obesity and diabetes rates are two to three times

Evidence-Based Mental Health2014

139. Observational study: Metformin associated with better cardiovascular outcomes than other glycaemic therapies

Observational study: Metformin associated with better cardiovascular outcomes than other glycaemic therapies Metformin associated with better cardiovascular outcomes than other glycaemic therapies | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword (...) Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Metformin associated with better cardiovascular outcomes than other glycaemic therapies Article Text Therapeutics Observational study Metformin associated with better cardiovascular outcomes than other glycaemic therapies Zachary T Bloomgarden Statistics from Altmetric.com No Altmetric data available

Evidence-Based Medicine (Requires free registration)2014

140. Saxagliptin + metformin (Komboglyze ? AstraZeneca) indication: type 2 diabetes mellitus

Saxagliptin + metformin (Komboglyze ? AstraZeneca) indication: type 2 diabetes mellitus Saxagliptin + metformin (Komboglyze — AstraZeneca) indication: type 2 diabetes mellitus Saxagliptin + metformin (Komboglyze — AstraZeneca) indication: type 2 diabetes mellitus CADTH Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Saxagliptin (...) + metformin (Komboglyze — AstraZeneca) indication: type 2 diabetes mellitus. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). CDEC Final Recommendation; SR0348. 2014 Authors' conclusions The Canadian Drug Expert Committee (CDEC) recommends that saxagliptin/metformin (Komboglyze) be listed for patients if clinical criterion and conditions are met. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors

Health Technology Assessment (HTA) Database.2014