Latest & greatest articles for measles

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Top results for measles

121. Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau: protective efficacy. (Abstract)

Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau: protective efficacy. In a randomised study of 558 children in an urban African community, the protective effect of the Edmonston-Zagreb (EZ) measles vaccine given in a dose of 40,000 plaque forming units from the age of 4 months was compared with the effects of a standard dose (6000 tissue culture infectious units) of Schwarz measles vaccine given from the age of 9 months. During two years of follow-up, all 14 clinical cases (...) of measles occurred in the Schwarz group; 10 of the children contracted measles before vaccination and 4 after measles vaccination. Thus the EZ vaccine provided significant protection against measles both before and after the usual age of vaccination. Among the children who were exposed to measles at home, those given EZ vaccine were better protected than either unvaccinated children or those given the Schwarz vaccine.

1988 Lancet Controlled trial quality: uncertain

122. Trial of high-dose Edmonston-Zagreb measles vaccine in the Gambia: antibody response and side-effects. (Abstract)

Trial of high-dose Edmonston-Zagreb measles vaccine in the Gambia: antibody response and side-effects. In a randomised trial, infants living in a large village in The Gambia were immunised either at 4 months of age with 40,000 plaque forming units (PFU) of the Edmonston-Zagreb (EZ) measles vaccine or at the usual age of 9 months with 6000 TCID50 of a conventional Schwarz measles vaccine. Measles developed in 2 of 119 children who received the EZ vaccine, in 1 before and in the other after 9 (...) months of age. In the Schwarz group measles developed in 7 of 120 children--in 5 before and in 2 after 9 months of age. Serological responses measured at 5 months after vaccination and at 18 months of age were satisfactory in both groups although in the Schwarz group levels were on average 2-fold higher than in the EZ group. The frequencies of fever, cough, vomiting, and diarrhoea were no higher in the EZ vaccinees in the 3 weeks following vaccination than in age-matched non-immunised controls. Long

1988 Lancet Controlled trial quality: uncertain

123. Effects of dose and strain of vaccine on success of measles vaccination of infants aged 4-5 months. (Abstract)

Effects of dose and strain of vaccine on success of measles vaccination of infants aged 4-5 months. Small-scale trials of the Edmonston-Zagreb (E-Z) measles vaccine were undertaken to determine the dose necessary to immunise 4-6-month-old infants. Antibody responses, measured 16 weeks after vaccination, were dose dependent: 40,000 plaque forming units given subcutaneously resulted in positive responses in all infants and higher antibody levels than doses of 20,000 or 10,000 units (10,000 units (...) gave a failure rate of 25%). In further trials the E-Z vaccine was compared with the Schwarz vaccine, both being given in subcutaneous doses of 40,000 plaque forming units. In infants aged 20 weeks the E-Z vaccine produced higher levels of measles antibody and in those aged 18 weeks its superiority showed in a lower proportion failing to respond (3 of 39 versus 19 of 35).

1988 Lancet Controlled trial quality: uncertain

124. Frequency of true adverse reactions to measles-mumps-rubella vaccine. A double-blind placebo-controlled trial in twins. (Abstract)

Frequency of true adverse reactions to measles-mumps-rubella vaccine. A double-blind placebo-controlled trial in twins. The vast majority of adverse reactions following immunisation of children with live measles-mumps-rubella (MMR) vaccine were shown in a double-blind, placebo-controlled, cross-over study in 581 twin pairs to be only temporally but not causally related to the vaccination. The true frequency of side-effects caused by MMR vaccine, estimated from the discordance rates

1986 Lancet Controlled trial quality: uncertain

125. Benefits, risks and costs of immunization for measles, mumps and rubella

Benefits, risks and costs of immunization for measles, mumps and rubella Benefits, risks and costs of immunization for measles, mumps and rubella Benefits, risks and costs of immunization for measles, mumps and rubella White C C, Koplan J P, Orenstein W A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment (...) on the reliability of the study and the conclusions drawn. Health technology Measles, mumps and rubella (MMR) vaccine. Type of intervention Primary prevention. Economic study type Cost-effectiveness analysis. Study population All infants in the United States. Setting The study was set in the USA. Dates to which data relate Price related to 1983. Modelling Epidemiological cohort model (model of survival and disease). Direct costs Direct costs were to the health service, and the patient. The price information

1985 NHS Economic Evaluation Database.

126. Vaccination against measles in the Canadian Arctic. (Abstract)

Vaccination against measles in the Canadian Arctic. 5951890 1966 04 10 2016 10 17 0098-7484 195 5 1966 Jan 31 JAMA JAMA Vaccination against measles in the Canadian Arctic. 342-4 Furesz J J Habgood M M eng Clinical Trial Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 0 Antibodies 0 Measles Vaccine AIM IM Antibodies Arctic Regions Body Temperature Canada Child Child, Preschool European Continental Ancestry Group Hemagglutination Inhibition Tests Humans Infant (...) Inuits Measles immunology Measles Vaccine Neutralization Tests Vaccination 1966 1 31 1966 1 31 0 1 1966 1 31 0 0 ppublish 5951890

1966 JAMA Controlled trial quality: uncertain