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Latest & greatest articles for magnesium
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Combined vitamin B6-magnesium treatment in autism spectrum disorder. The use of mega-vitamin intervention began in the 1950s with the treatment of schizophrenic patients. Pyroxidine (vitamin B6) was first used with children diagnosed with "autism syndrome" when speech and language improvement was observed in some children as a result of large doses of B6. A number of studies attempted to assess the effects of vitamin B6-Magnesium (Mg) was found to reduce undesirable side effects from B6 (...) ) on characteristics such as verbal communication, non-verbal communication, interpersonal skills, and physiological function, in individuals with autism.To determine the efficacy of vitamin B6 and magnesium (B6-Mg) for treating social, communication, and behavioural responses of children and adults with autism.We searched the Cochrane Controlled Trials Register (Cochrane Library, Issue 2, 2002), MEDLINE (1966 to January 2002), EMBASE (1980 to January 2002), PsycINFO (1887 to January 2002), Dissertation Abstracts
Does magnesium offer any additional benefit in patients having anti-arrhythmic treatment for atrial fibrillation following cardiac surgery? BestBets: Does magnesium offer any additional benefit in patients having anti-arrhythmic treatment for atrial fibrillation following cardiac surgery? Does magnesium offer any additional benefit in patients having anti-arrhythmic treatment for atrial fibrillation following cardiac surgery? Report By: Anish Patel, Jagan Rao - Cardiothoracic Registrars Search (...) checked by J Desmond - Cardiothoracic Registrar RCS Institution: Department of Cardiothoracic Surgery, Freeman Hospital, Freeman Road, Newcastle-upon-Tyne Date Submitted: 15th April 2003 Date Completed: 29th July 2005 Last Modified: 6th May 2003 Status: Green (complete) Three Part Question In [patients undergoing cardiac surgery, going into atrial fibrillation] is [the addition of magnesium] more effective than standard therapy alone in [cardioverting or controlling ventricular rate]. Clinical
Magnesium intake in relation to risk of colorectal cancer in women. Animal studies have suggested that dietary magnesium may play a role in the prevention of colorectal cancer, but data in humans are lacking.To evaluate the hypothesis that a high magnesium intake reduces the risk of colorectal cancer in women.The Swedish Mammography Cohort, a population-based prospective cohort of 61,433 women aged 40 to 75 years without previous diagnosis of cancer at baseline from 1987 to 1990.Incident (...) invasive colorectal cancer.During a mean of 14.8 years (911 042 person-years) of follow-up, 805 incident colorectal cancer cases were diagnosed. After adjustment for potential confounders, we observed an inverse association of magnesium intake with the risk of colorectal cancer (P for trend = .006). Compared with women in the lowest quintile of magnesium intake, the multivariate rate ratio (RR) was 0.59 (95% confidence interval [CI], 0.40-0.87) for those in the highest quintile. The inverse association
A meta-analysis on intravenous magnesium sulphate for treating acute asthma Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Intravenous magnesium for prevention of atrial fibrillation after coronary artery bypass surgery: a systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Effects of magnesium on atrial fibrillation after cardiac surgery: a meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Nebulised magnesium in asthma BestBets: Nebulised magnesium in asthma Nebulised magnesium in asthma Report By: Craig Ferguson - Clinical Research Fellow Search checked by Marten Howes - SpR Emergency Medicine Institution: Manchester Royal Infirmary Original author: Jonathan Costello Original institution: Royal Preston Hospital Date Submitted: 28th April 2003 Date Completed: 1st September 2004 Last Modified: 21st August 2006 Status: Green (complete) Three Part Question In [an adult with asthma (...) ] is [nebulised beta-agonist with nebulised magnesium sulphate better than nebulsed beta-agonist alone] at [improving airflow and reducing morbidity]? Clinical Scenario A known asthmatic patient is brought into the emergency department with signs consistent with acute asthma. Little improvement is noted with nebulised beta-agonist therapy. You wonder if adjunctive nebulised magnesium sulphate would provide any benefit. Search Strategy Medline 1966-05/04 using the Ovid interface. Repeated August 06 using Ovid
Magnesium prophylaxis for arrhythmias after cardiac surgery: a meta-analysis of randomized controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Cost effectiveness of ibutilide with prophylactic magnesium in the treatment of atrial fibrillation Cost effectiveness of ibutilide with prophylactic magnesium in the treatment of atrial fibrillation Cost effectiveness of ibutilide with prophylactic magnesium in the treatment of atrial fibrillation Coleman C I, Kalus J S, White C M, Spencer A P, Tsikouris J P, Chung J O, Kenyon K W, Ziska M, Kluger J, Reddy P Record Status This is a critical abstract of an economic evaluation that meets (...) the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study compared the use of ibutilide in the presence and absence of magnesium prophylaxis for the conversion of atrial fibrillation (AF). The mean dose of ibutilide was 2.2 (+/- 1) g. Type of intervention Treatment. Economic study type Cost-effectiveness analysis
Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial. Magnesium is neuroprotective in animal models of stroke, and findings of small clinical pilot trials suggest potential benefit in people. We aimed to test whether intravenous magnesium sulphate, given within 12 h of stroke onset, reduces death or disability at 90 days.2589 patients were randomised within 12h of acute stroke to receive 16 mmol MgSO4 intravenously over 15 min and then 65 mmol (...) , and cortical stroke syndromes versus non-cortical strokes. Intention-to-treat and efficacy analyses were done.The efficacy dataset included 2386 patients. Primary outcome was not improved by magnesium (odds ratio 0.95, 95% CI 0.80-1.13, p=0.59). Mortality was slightly higher in the magnesium-treated group than in the placebo group (hazard ratio 1.18, 95% CI 0.97-1.42, p=0.098). Secondary outcomes did not show any treatment effect. Planned subgroup analyses showed benefit of magnesium in non-cortical
2004LancetControlled trial quality: predicted high
Effect of magnesium sulfate given for neuroprotection before preterm birth: a randomized controlled trial. Prenatal magnesium sulfate may reduce the risk of cerebral palsy or death in very preterm infants.To determine the effectiveness of magnesium sulfate given for neuroprotection to women at risk of preterm birth before 30 weeks' gestation in preventing pediatric mortality and cerebral palsy.Randomized controlled trial at 16 tertiary hospitals in Australia and New Zealand with stratification (...) by center and multiple pregnancy. A total of 1062 women with fetuses younger than 30 weeks' gestation for whom birth was planned or expected within 24 hours were enrolled from February 1996 to September 2000 with follow-up of surviving children at a corrected age of 2 years.Women were randomly assigned to receive a loading infusion of 8 mL (4 g [16 mmol] of 0.5 g/mL of magnesium sulfate solution or isotonic sodium chloride solution [0.9%]) for 20 minutes followed by a maintenance infusion of 2 mL/h
Magnesium prophylaxis in cardiac surgery patients Magnesium prophylaxis in cardiac surgery patients Magnesium prophylaxis in cardiac surgery patients Higgins S Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Higgins S. Magnesium prophylaxis in cardiac surgery patients. Clayton, Victoria: Centre for Clinical Effectiveness (CCE) 2003: 30 Authors' objectives (...) This aim of this report was to assess whether, in patients undergoing cardiac surgery, prophylactic administration of magnesium reduces the incidence of adverse outcomes. Project page URL Indexing Status Subject indexing assigned by CRD MeSH Heart Diseases /surgery; Magnesium; Thoracic Surgery /adverse effects Language Published English Country of organisation Australia Address for correspondence Monash Institute of Health Services Research, Block E, Monash Medical Centre, Locked Bag 29, Clayton
Use of isotonic nebulised magnesium sulphate as an adjuvant to salbutamol in treatment of severe asthma in adults: randomised placebo-controlled trial. Intravenous magnesium can cause bronchodilation in treatment of severe asthma, however its effect by the nebulised route is uncertain. We aimed to assess the effectiveness of isotonic magnesium sulphate as an adjuvant to nebulised salbutamol in severe attacks of asthma.We enrolled 52 patients with severe exacerbations of asthma presenting (...) to the emergency departments at two hospitals in New Zealand. A severe exacerbation was defined as a forced expiratory volume at 1 s (FEV(1)) of less than 50% predicted 30 min after initial administration of 2.5 mg salbutamol via nebulisation. In this randomised double-blind placebo-controlled trial patients received 2.5 mg nebulised salbutamol mixed with either 2.5 mL isotonic magnesium sulphate or isotonic saline on three occasions at 30 min intervals. The primary outcome measure was FEV(1) at 90 min
2003LancetControlled trial quality: predicted high
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia. Magnesium sulfate may prevent eclampsia by reducing cerebral vasoconstriction and ischemia. Nimodipine is a calcium-channel blocker with specific cerebral vasodilator activity. Our objective was to determine whether nimodipine is more effective than magnesium sulfate for seizure prophylaxis in women with severe preeclampsia.We conducted an unblinded, multicenter trial in which 1650 women with severe preeclampsia (...) were randomly assigned to receive either nimodipine (60 mg orally every 4 hours) or intravenous magnesium sulfate (given according to the institutional protocol) from enrollment until 24 hours post partum. High blood pressure was controlled with intravenous hydralazine as needed. The primary outcome measure was the development of eclampsia, as defined by a witnessed tonic-clonic seizure.Demographic and clinical characteristics were similar in the two groups. The women who received nimodipine were
Magnesium sulphate versus diazepam for eclampsia. Eclampsia, the occurrence of a convulsion in association with pre-eclampsia, remains a rare but serious complication of pregnancy. A number of different anticonvulsants are used to control eclamptic fits and to prevent further fits.The objective of this review was to assess the effects of magnesium sulphate compared with diazepam when used for the care of women with eclampsia. Magnesium sulphate is compared with phenytoin and with lytic cocktail (...) in other Cochrane reviews.We searched the Cochrane Pregnancy and Childbirth trials register (28 November 2002) and the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 4, 2002).Randomised trials comparing magnesium sulphate (intravenous or intramuscular administration) with diazepam for women with a clinical diagnosis of eclampsia.Both reviewers assessed and extracted data.Seven trials involving 1441 women are included. Most of the data are from trials of good quality
The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials Jee S H, Miller E R, Guallar E, Singh V K, Appel L J, Klag M J Authors' objectives The objectives were to determine whether magnesium supplementation reduces blood-pressure (BP (...) ), to identify the dose-response relationship, and to determine trial characteristics associated with the greatest BP reductions. Searching MEDLINE was searched for articles published before May 2001 using the MeSH terms 'magnesium' and 'BP' in clinical trials. The authors also searched the reference lists from original and review articles and reviewed their own reference files. The search was restricted to articles published in English. Study selection Study designs of evaluations included in the review
Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Anticonvulsants are used for pre-eclampsia in the belief they prevent eclamptic convulsions, and so improve outcome. Evidence supported magnesium sulphate as the drug to evaluate.Eligible women (n=10141) had not given birth or were 24 h or less postpartum; blood pressure of 140/90 mm Hg or more, and proteinuria of 1+ (30 mg/dL) or more; and there was clinical (...) uncertainty about magnesium sulphate. Women were randomised in 33 countries to either magnesium sulphate (n=5071) or placebo (n=5070). Primary outcomes were eclampsia and, for women randomised before delivery, death of the baby. Follow up was until discharge from hospital after delivery. Analyses were by intention to treat.Follow-up data were available for 10,110 (99.7%) women, 9992 (99%) of whom received the allocated treatment. 1201 of 4999 (24%) women given magnesium sulphate reported side-effects
2002LancetControlled trial quality: predicted high
Early administration of intravenous magnesium to high-risk patients with acute myocardial infarction in the Magnesium in Coronaries (MAGIC) Trial: a randomised controlled trial. The benefits of supplemental administration of intravenous magnesium in patients with ST-elevation myocardial infarction (STEMI) are controversial. Despite promising results from work in animals and the ready availability of this simple, inexpensive treatment, conflicting results have been reported in clinical trials (...) . Our aim was to compare short-term mortality in patients with STEMI who received either intravenous magnesium sulphate or placebo.We did a randomised, double-blind trial in 6213 patients with acute STEMI who were assigned a 2 g intravenous bolus of magnesium sulphate administered over 15 min, followed by a 17 g infusion of magnesium sulphate over 24 h (n=3113), or matching placebo (n=3100). Our primary endpoint was 30-day all-cause mortality. At randomisation, patients were stratified
2002LancetControlled trial quality: predicted high
The use of magnesium sulfate to prevent seizures in the pre-eclamptic gravida: a cost-effectiveness analysis The use of magnesium sulfate to prevent seizures in the pre-eclamptic gravida: a cost-effectiveness analysis The use of magnesium sulfate to prevent seizures in the pre-eclamptic gravida: a cost-effectiveness analysis Blackwell S C, Tomlinson M W, Berman S, Redman M E, Hassan S S, Berry S M, Hallak M, Sorokin Y, Cotton D B Record Status This is a critical abstract of an economic (...) evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of magnesium sulphate (MgSO4) seizure prophylaxis for pre-eclamptic women. MgSO4 therapy was given as a 6.g bolus followed by a 2 g/hour continuous infusion. Type of intervention Treatment. Economic study type Cost-effectiveness analysis