Latest & greatest articles for lorazepam

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Top results for lorazepam

1. Lorazepam confirmed as first-line treatment for stopping prolonged seizures in children

Lorazepam confirmed as first-line treatment for stopping prolonged seizures in children Lorazepam confirmed as first-line treatment for stopping prolonged seizures in children Dissemination Centre Discover Portal NIHR DC Discover Lorazepam confirmed as first-line treatment for stopping prolonged seizures in children Published on 17 April 2018 Intravenous lorazepam is as effective as intravenous diazepam for stopping children’s tonic-clonic seizures in hospital. Lorazepam also results in fewer (...) trials comparing buccal midazolam with rectal diazepam were graded as low to very low evidence, and because of the uncertainty, the authors considered that the new evidence did not support the use of buccal midazolam when intravenous access was difficult. What did it find? Intravenous lorazepam appears to be as effective as intravenous diazepam in stopping acute tonic-clonic seizures, (risk ratio [RR] 1.04, 95% confidence interval [CI] 0.94 to 1.16; three trials, 414 children). Compared to other

NIHR Dissemination Centre2018

2. Lorazepam

Lorazepam Top results for lorazepam - Trip Database or use your Google+ account Liberating the literature My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing (...) the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for lorazepam The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines

Trip Latest and Greatest2018

3. Effect of Lorazepam With Haloperidol vs Haloperidol Alone on Agitated Delirium in Patients With Advanced Cancer Receiving Palliative Care: A Randomized Clinical Trial.

Effect of Lorazepam With Haloperidol vs Haloperidol Alone on Agitated Delirium in Patients With Advanced Cancer Receiving Palliative Care: A Randomized Clinical Trial. Importance: The use of benzodiazepines to control agitation in delirium in the last days of life is controversial. Objective: To compare the effect of lorazepam vs placebo as an adjuvant to haloperidol for persistent agitation in patients with delirium in the setting of advanced cancer. Design, Setting, and Participants: Single (...) -center, double-blind, parallel-group, randomized clinical trial conducted at an acute palliative care unit at MD Anderson Cancer Center, Texas, enrolling 93 patients with advanced cancer and agitated delirium despite scheduled haloperidol from February 11, 2014, to June 30, 2016, with data collection completed in October 2016. Interventions: Lorazepam (3 mg) intravenously (n = 47) or placebo (n = 43) in addition to haloperidol (2 mg) intravenously upon the onset of an agitation episode. Main Outcomes

JAMA2017

4. Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial.

Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. IMPORTANCE: Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam may be more effective or safer than diazepam, but lorazepam is not Food and Drug Administration approved for this indication. OBJECTIVE: To test the hypothesis that lorazepam has better efficacy and safety than diazepam for treating pediatric status epilepticus. DESIGN, SETTING (...) , AND PARTICIPANTS: This double-blind, randomized clinical trial was conducted from March 1, 2008, to March 14, 2012. Patients aged 3 months to younger than 18 years with convulsive status epilepticus presenting to 1 of 11 US academic pediatric emergency departments were eligible. There were 273 patients; 140 randomized to diazepam and 133 to lorazepam. INTERVENTIONS: Patients received either 0.2 mg/kg of diazepam or 0.1 mg/kg of lorazepam intravenously, with half this dose repeated at 5 minutes if necessary

JAMA2014

5. Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial.

Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. 24756515 2014 04 23 2014 05 01 2016 10 17 1538-3598 311 16 2014 Apr 23-30 JAMA JAMA Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. 1652-60 10.1001/jama.2014.2625 Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam may be more effective or safer than diazepam, but lorazepam is not Food and Drug (...) Administration approved for this indication. To test the hypothesis that lorazepam has better efficacy and safety than diazepam for treating pediatric status epilepticus. This double-blind, randomized clinical trial was conducted from March 1, 2008, to March 14, 2012. Patients aged 3 months to younger than 18 years with convulsive status epilepticus presenting to 1 of 11 US academic pediatric emergency departments were eligible. There were 273 patients; 140 randomized to diazepam and 133 to lorazepam

JAMA2014

6. Intranasal Lorazepam Is an Acceptable Alternative To Intravenous Lorazepam In The Control Of Acute Seizures In Children

Intranasal Lorazepam Is an Acceptable Alternative To Intravenous Lorazepam In The Control Of Acute Seizures In Children BestBets: Intranasal Lorazepam Is an Acceptable Alternative To Intravenous Lorazepam In The Control Of Acute Seizures In Children Intranasal Lorazepam Is an Acceptable Alternative To Intravenous Lorazepam In The Control Of Acute Seizures In Children Report By: Anna Allan, Jayne Cullen - Final Year Medical Students Search checked by Dr Adrian Boyle - Emergency Department (...) Consultant Institution: University of Cambridge School of Clinical Medicine, Cambridge, UK Date Submitted: 2nd December 2011 Date Completed: 30th August 2013 Last Modified: 30th August 2013 Status: Green (complete) Three Part Question In [children presenting to the ED with seizures] is [intranasal Lorazepam an acceptable intervention] for achieving [termination of seizures]? Clinical Scenario A 4 year old child is brought to the Emergency Department by her parents. She presents with protracted seizures

BestBETS2013

7. Randomised controlled trial: Pregabalin similar to lorazepam for alcohol withdrawal symptoms

Randomised controlled trial: Pregabalin similar to lorazepam for alcohol withdrawal symptoms Pregabalin similar to lorazepam for alcohol withdrawal symptoms | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Pregabalin similar to lorazepam for alcohol withdrawal symptoms Article Text Therapeutics Randomised controlled trial Pregabalin similar to lorazepam for alcohol withdrawal symptoms Giovanni Addolorato 1 , Lorenzo Leggio 1 , 2 Statistics from Altmetric.com No Altmetric data available for this article. Commentary on: Martinotti G , di Nicola M

Evidence-Based Medicine (Requires free registration)2010

8. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial

Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2008

9. Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation

Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation Cox C E, Reed S D, Govert J A, Rodgers J E, Campbell-Bright S, Kress J P, Carson S S Record Status This is a critical abstract of an economic evaluation that meets (...) in significantly lower overall costs and a greater number of ventilator-free days in comparison with intermittent lorazepam. The methodology and results were clearly reported and appear to have been valid. The authors' conclusions appear to be appropriate. Type of economic evaluation Cost-effectiveness analysis Study objective The objective was to assess the cost-effectiveness of the most commonly prescribed sedatives for mechanically ventilated, critically ill patients. Interventions In the base-case analysis

NHS Economic Evaluation Database.2008

10. Review: lorazepam provides the best control for status epilepticus

Review: lorazepam provides the best control for status epilepticus Review: lorazepam provides the best control for status epilepticus | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in via (...) your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: lorazepam provides the best control for status epilepticus Article Text Treatment Review: lorazepam provides the best control for status epilepticus Statistics from Altmetric.com No Altmetric data available for this article. Request permissions If you wish to reuse any or all of this article please use the link below

Evidence-Based Nursing (Requires free registration)2007

11. Review: lorazepam provides the best control for status epilepticus

Review: lorazepam provides the best control for status epilepticus Review: lorazepam provides the best control for status epilepticus | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: lorazepam provides the best control for status epilepticus Article Text Therapeutics Review: lorazepam provides the best control for status epilepticus Free J Craig Henry , MD , Robert Holloway , MD, MPH Statistics from Altmetric.com No Altmetric data available for this article. Prasad K, Al-Roomi K, Krishnan P, et al. Anticonvulsant therapy for status epilepticus

Evidence-Based Medicine (Requires free registration)2007

12. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial

Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial Pandharipande PP, Pun BT, Herr DL (...) of dexmedetomidine for sedation of adult medical and surgical intensive care unit patients who required mechanical ventilation for more than 24 hours. The authors concluded that compared with lorazepam, dexmedetomidine reduced duration of delirium and coma and increased time at the targeted level of sedation at no added cost. Reporting and methodology were satisfactory. The authors' conclusions appear appropriate but readers should take into account the limited generalisability and lack of uncertainty assessment

NHS Economic Evaluation Database.2007

13. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial.

Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. 18073360 2007 12 12 2007 12 14 2016 10 17 1538-3598 298 22 2007 Dec 12 JAMA JAMA Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. 2644-53 Lorazepam is currently recommended for sustained sedation of mechanically ventilated intensive (...) sedation as compared with lorazepam. Double-blind, randomized controlled trial of 106 adult mechanically ventilated medical and surgical ICU patients at 2 tertiary care centers between August 2004 and April 2006. Patients were sedated with dexmedetomidine or lorazepam for as many as 120 hours. Study drugs were titrated to achieve the desired level of sedation, measured using the Richmond Agitation-Sedation Scale (RASS). Patients were monitored twice daily for delirium using the Confusion Assessment

JAMA2007

14. Lorazepam or diazepam in paediatric status epilepticus

Lorazepam or diazepam in paediatric status epilepticus BestBets: Lorazepam or diazepam in paediatric status elipticus Lorazepam or diazepam in paediatric status elipticus Report By: Vince Choudhery - Specialist Registrar Search checked by Will Townend - Specialist Registrar Emergency Medicine Institution: North Western Emergency Medicine Specialist Registrar NW Rotation Current web editor: Richard Body - Clinical Research Fellow Date Submitted: 1st March 2000 Date Completed: 24th May 2006 Last (...) Modified: 21st April 2006 Status: Green (complete) Three Part Question In [children in status epilepticus] is [lorazepam better than diazepam] at [safely terminating the seizure]? Clinical Scenario A 2 year old is brought to the emergency department with a first presentation of fitting secondary to febrile illness. She has been fitting for >30 minutes. You obtain intravenous access and wonder if lorazepam or diazepam would be best at terminating the fit safely. Search Strategy Medline 1966-9/99 using

BestBETS2006

15. Intramuscular haloperidol-promethazine sedates violent or agitated patients more quickly than intramuscular lorazepam

Intramuscular haloperidol-promethazine sedates violent or agitated patients more quickly than intramuscular lorazepam Intramuscular haloperidol-promethazine sedates violent or agitated patients more quickly than intramuscular lorazepam | Evidence-Based Mental Health This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user (...) name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Intramuscular haloperidol-promethazine sedates violent or agitated patients more quickly than intramuscular lorazepam Article Text Therapeutics Intramuscular haloperidol-promethazine sedates violent or agitated patients more quickly than intramuscular lorazepam

Evidence-Based Mental Health2006

16. Efficacy and safety of intranasal lorazepam versus intramuscular paraldehyde for protracted convulsions in children: an open randomised trial.

Efficacy and safety of intranasal lorazepam versus intramuscular paraldehyde for protracted convulsions in children: an open randomised trial. 16698412 2006 05 15 2006 05 25 2015 06 16 1474-547X 367 9522 2006 May 13 Lancet (London, England) Lancet Efficacy and safety of intranasal lorazepam versus intramuscular paraldehyde for protracted convulsions in children: an open randomised trial. 1591-7 In sub-Saharan Africa, rectal diazepam or intramuscular paraldehyde are commonly used as first-line (...) anticonvulsant agents in the emergency treatment of seizures in children. These treatments can be expensive and sometimes toxic. We aimed to assess a drug and delivery system that is potentially more effective, safer, and easier to administer than those presently in use. We did an open randomised trial in a paediatric emergency department of a tertiary hospital in Malawi. 160 children aged over 2 months with seizures persisting for more than 5 min were randomly assigned to receive either intranasal lorazepam

Lancet2006

17. A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus

A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus Cock H R, Schapira A H Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Lorazepam was compared with diazepam as first-line treatment for convulsive status epilepticus (CSE). The dose of lorazepam was 4 mg intravenously (i.v.), repeated up to 2 times. The dose of diazepam was 10 mg i.v., repeated up to 3 times. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients aged over

NHS Economic Evaluation Database.2002

18. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus.

A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. 11547716 2001 08 15 2001 09 13 2013 11 21 0028-4793 345 9 2001 Aug 30 The New England journal of medicine N. Engl. J. Med. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. 631-7 It is uncertain whether the administration of benzodiazepines by paramedics is an effective and safe treatment for out-of-hospital status epilepticus. We (...) conducted a randomized, double-blind trial to evaluate intravenous benzodiazepines administered by paramedics for the treatment of out-of-hospital status epilepticus. Adults with prolonged (lasting five minutes or more) or repetitive generalized convulsive seizures received intravenous diazepam (5 mg), lorazepam (2 mg), or placebo. An identical second injection was given if needed. Of the 205 patients enrolled, 66 received lorazepam, 68 received diazepam, and 71 received placebo. Status epilepticus had

NEJM2001

19. Continuous infusion of lorazepam versus midazolam in patients in the intensive care unit: sedation with lorazepam is easier to manage and is more cost-effective

Continuous infusion of lorazepam versus midazolam in patients in the intensive care unit: sedation with lorazepam is easier to manage and is more cost-effective Continuous infusion of lorazepam versus midazolam in patients in the intensive care unit: sedation with lorazepam is easier to manage and is more cost-effective Continuous infusion of lorazepam versus midazolam in patients in the intensive care unit: sedation with lorazepam is easier to manage and is more cost-effective Swart E L, van (...) Schijndel R J, van Loenen A C, Thijs L G Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of long term sedation, specifically using either lorazepam (maximum dose of 4mg/h) and midazolam (maximum dose of 60 mg/h), to accommodate

NHS Economic Evaluation Database.1999

20. Continuous infusions of lorazepam, midazolam, and propofol for sedation of the critically ill surgery trauma patient: a prospective, randomized comparison

Continuous infusions of lorazepam, midazolam, and propofol for sedation of the critically ill surgery trauma patient: a prospective, randomized comparison Continuous infusions of lorazepam, midazolam, and propofol for sedation of the critically ill surgery trauma patient: a prospective, randomized comparison Continuous infusions of lorazepam, midazolam, and propofol for sedation of the critically ill surgery trauma patient: a prospective, randomized comparison McCollam J S, O'Neil M G, Norcross (...) E D, Byrne T K, Reeves S T Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study compared continuous infusions of lorazepam, midazolam and propofol for the sedation of mechanically-ventilated, critically ill trauma

NHS Economic Evaluation Database.1999