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Latest & greatest articles for knee osteoarthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on knee osteoarthritis or other clinical topics then use Trip today.
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Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. 23299607 2013 01 09 2013 01 10 2016 12 15 1538-3598 309 2 2013 Jan 09 JAMA JAMA Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. 155-62 10.1001/jama.2012.164487 Kneeosteoarthritis (OA), a disorder of cartilage (...) and periarticular bone, is a public health problem without effective medical treatments. Some studies have suggested that vitamin D may protect against structural progression. To determine whether vitamin D supplementation reduces symptom and structural progression of kneeOA. A 2-year randomized, placebo-controlled, double-blind, clinical trial involving 146 participants with symptomatic kneeOA (mean age, 62.4 years [SD, 8.5]; 57 women [61%], 115 white race [79%]). Patients were enrolled at Tufts Medical
A randomised, double-blind, controlled trial comparing two intra-articular hyaluronic acid preparations differing by their molecular weight in symptomatic kneeosteoarthritis 22294639 2012 08 09 2012 10 16 2015 01 28 1468-2060 71 9 2012 Sep Annals of the rheumatic diseases Ann. Rheum. Dis. A randomised, double-blind, controlled trial comparing two intra-articular hyaluronic acid preparations differing by their molecular weight in symptomatic kneeosteoarthritis. 1454-60 10.1136/annrheumdis-2011 (...) -200972 To compare the effects of an intermediate molecular weight (MW) intra-articular hyaluronic acid (HA) with a low MW product on kneeosteoarthritis (OA) symptoms. Patients with symptomatic kneeOA were enrolled inarandomised, controlled, double-blind, parallel-group, non-inferiority trial with the possibility to shift to superiority. Patients were randomised to GO-ON(MW 800-1500 kD, 25 mg/2.5 ml) or Hyalgan(MW 500-730 kD, 20 mg/2 ml) injected at 3-weekly intervals. The primary outcome was 6
Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with kneeosteoarthritis: the IDEA randomized clinical trial. 24065013 2013 09 25 2013 10 25 2017 02 20 1538-3598 310 12 2013 Sep 25 JAMA JAMA Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with kneeosteoarthritis: the IDEA randomized clinical trial. 1263-73 10.1001/jama.2013.277669 (...) Kneeosteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity. To determine whether a ≥10% reduction in body weight induced by diet, with or without exercise, would improve mechanistic and clinical outcomes more than exercise alone. Single-blind, 18-month, randomized clinical trial at Wake Forest University between July 2006 and April 2011. The diet and exercise interventions were center-based with options
Efficacy of strengthening or aerobic exercise on pain relief in people with kneeosteoarthritis: a systematic review and meta-analysis of randomized controlled trials Efficacy of strengthening or aerobic exercise on pain relief in people with kneeosteoarthritis: a systematic review and meta-analysis of randomized controlled trials Efficacy of strengthening or aerobic exercise on pain relief in people with kneeosteoarthritis: a systematic review and meta-analysis of randomized controlled (...) trials Tanaka R, Ozawa J, Kito N, Moriyama H CRD summary This review concluded that muscle-strengthening exercises, with or without weight bearing, and aerobic exercise were effective for pain relief in people with kneeosteoarthritis. Non-weight-bearing strengthening exercise was the most effective. There were method limitations in both the included trials and the meta-analyses, so the authors' conclusions appear to be over-optimistic. Authors' objectives To compare the efficacy of strengthening
The Efficacy of Platelet-rich Plasma Injection in the Treatment of KneeOsteoarthritis: A Systematic Review "The Efficacy of Platelet-rich Plasma Injection in the Treatment of Kne" by Yvonne Howell < > > > > > Title Author Date of Award Summer 8-10-2013 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies Rights . Abstract Background: Increased physical activities and prolonged life expectancies, coupled with biomechanical, metabolic, and biological changes (...) experimental studies have targeted the biomechanical process of OA with the focus on promoting cartilage repair or replacement. Can platelet rich-plasma (PRP) be an effective alternative option in the treatment of kneeOA? Method: An extensive search of the literature using Medline, CINAHL, Web of Science, and Google Scholar was conducted with the help of the following keywords: platelet-rich plasma, cartilage, injections, and osteoarthritis. For the purpose of performing a systematic review, articles
Treatment of Osteoarthritis of the Knee TREATMENT OF OSTEOARTHRITIS OF THE KNEE EVIDENCE-BASED GUIDELINE 2 ND EDITION Adopted by the American Academy of Orthopaedic Surgeons Board of Directors May 18, 2013 i Disclaimer This clinical practice guideline was developed by an AAOS work group comprised of volunteer physicians and interdisciplinary clinicians as well as staff researchers with expertise in systematic reviews and statistical methods used to evaluate empirical evidence (...) (MID) Units 25 Peer Review 26 Public Comment 27 The AAOS Guideline Approval Process 28 Revision Plans 28 Guideline Dissemination Plans 28 AAOS Clinical Guideline on Treating Osteoarthritis of the Knee 31 Guideline Recommendations 31 Recommendation 1 31 Rationale 31 Supporting Evidence 32 Quality 32 Applicability 34 Final Strength of Evidence 35 Results 46 Evidence Tables and Figures 61 Quality and Applicability 61 Findings 98 Recommendation 2 138 Rationale 138 Supporting Evidence 138 Quality 138
Aquatic exercise for knee and hip osteoarthritis RACGP - Aquatic exercise for knee and hip osteoarthritis Username Password Password security changes or call 1800 284 789 Search the RACGP website Your browser has 'Cookies' disabled, alert boxes will continue to appear without this feature. / / / / / Aquatic exercise for knee and hip osteoarthritis HANDI Making non-drug interventions easier to find and use Aquatic exercise for knee and hip osteoarthritis Warm-water therapy is one of the oldest (...) recorded treatments, with effects lasting well beyond the period of immersion. Intervention Physical exercise while immersed in water (typically 32–36°C). Indication People with osteoarthritis (OA) of the knee or hip with the aim of reducing pain and disability and increasing quality of life. These improvements occur through increased muscle strength, balance, coordination and joint mobility. Compared with control groups, the participants who did aquatic exercise showed a 5-point lower mean pain
Physical therapy interventions for knee pain secondary to osteoarthritis: a systematic review Physical therapy interventions for knee pain secondary to osteoarthritis: a systematic review Physical therapy interventions for knee pain secondary to osteoarthritis: a systematic review Wang SY, Olson-Kellogg B, Shamliyan TA, Choi JY, Ramakrishnan R, Kane RL CRD summary This review concluded there was low-strength evidence that aerobic, aquatic, strengthening, and proprioception exercise improved (...) kneeosteoarthritis outcomes. The risk of bias in studies, and variation in populations and interventions, downgraded the strength of most evidence to low or moderate. The authors' conclusions were suitably cautious in reflecting the limited evidence available, and are likely to be reliable. Authors' objectives To evaluate the efficacy and comparative effectiveness of available physical therapy interventions for adults with kneeosteoarthritis. Searching MEDLINE, The Cochrane Library, PEDro, AMED
Comparison of the efficacy of transcutaneous electrical nerve stimulation, interferential currents, and shortwave diathermy in kneeosteoarthritis: a double-blind, randomized, controlled, multicenter study 22459699 2012 04 30 2012 07 24 2013 11 21 1532-821X 93 5 2012 May Archives of physical medicine and rehabilitation Arch Phys Med Rehabil Comparison of the efficacy of transcutaneous electrical nerve stimulation, interferential currents, and shortwave diathermy in kneeosteoarthritis: a double (...) -blind, randomized, controlled, multicenter study. 748-56 10.1016/j.apmr.2011.11.037 To compare the effectiveness of transcutaneous electrical nerve stimulation (TENS), interferential currents (IFCs), and shortwave diathermy (SWD) against each other and sham intervention with exercise training and education as a multimodal package. A double-blind, randomized, controlled, multicenter trial. Departments of physical medicine and rehabilitation in 4 centers. Patients (N=203) with kneeosteoarthritis (OA
Short-term effects of 890-nanometer radiation on pain, physical activity, and postural stability in patients with kneeosteoarthritis: a double-blind, randomized, placebo-controlled study 22459700 2012 04 30 2012 07 24 2012 04 30 1532-821X 93 5 2012 May Archives of physical medicine and rehabilitation Arch Phys Med Rehabil Short-term effects of 890-nanometer radiation on pain, physical activity, and postural stability in patients with kneeosteoarthritis: a double-blind, randomized, placebo (...) -controlled study. 757-64 10.1016/j.apmr.2012.01.003 To investigate the effects of short-term light therapy with 890-nm radiation on pain, physical activity, and postural stability in patients with kneeosteoarthritis (OA). A double-blind, randomized, placebo-controlled study. Rehabilitation clinic. Women (n=62) and men (n=10) with a mean age of 61.2 years (range, 40-88y). All patients fulfilled the combined clinical and radiographic criteria for kneeOA as established by the American College
Viscosupplementation for osteoarthritis of the knee Viscosupplementation for osteoarthritis of the knee Viscosupplementation for osteoarthritis of the knee Rutjes AW, Juni P, da Costa BR, Trelle S, Nuesch E, Reichenbach S CRD summary The authors concluded that the benefit of viscosupplementation on pain and function in patients with symptomatic osteoarthritis of the knee was minimal or nonexistent and their use should be discouraged because of increased risks for serious local adverse events (...) . The authors' conclusions appear appropriate and likely to be reliable, but relatively minor uncertainties exist regarding some of the results. Authors' objectives To assess the benefits and risks of viscosupplementation for adults with symptomatic kneeosteoarthritis. Searching The Cochrane Central Register of Controlled Trials (from inception), MEDLINE (from 1966) and EMBASE (from 1980) were searched without language restrictions to January 2012; search terms were reported in an appendix
Prevalence of abnormalities in knees detected by MRI in adults without kneeosteoarthritis: population based observational study (Framingham Osteoarthritis Study). OBJECTIVE: To examine use of magnetic resonance imaging (MRI) of knees with no radiographic evidence of osteoarthritis to determine the prevalence of structural lesions associated with osteoarthritis and their relation to age, sex, and obesity. DESIGN: Population based observational study. SETTING: Community cohort in Framingham, MA (...) , United States (Framingham osteoarthritis study). PARTICIPANTS: 710 people aged >50 who had no radiographic evidence of kneeosteoarthritis (Kellgren-Lawrence grade 0) and who underwent MRI of the knee. MAIN OUTCOME MEASURES: Prevalence of MRI findings that are suggestive of kneeosteoarthritis (osteophytes, cartilage damage, bone marrow lesions, subchondral cysts, meniscal lesions, synovitis, attrition, and ligamentous lesions) in all participants and after stratification by age, sex
American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee 22563589 2012 05 03 2012 07 02 2013 11 21 2151-4658 64 4 2012 Apr Arthritis care & research Arthritis Care Res (Hoboken) American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. 465-74 To update the American College of Rheumatology (ACR (...) ) 2000 recommendations for hip and kneeosteoarthritis (OA) and develop new recommendations for hand OA. A list of pharmacologic and nonpharmacologic modalities commonly used to manage knee, hip, and hand OA as well as clinical scenarios representing patients with symptomatic hand, hip, and kneeOA were generated. Systematic evidence-based literature reviews were conducted by a working group at the Institute of Population Health, University of Ottawa, and updated by ACR staff to include additions
A Randomized Clinical Trial Evaluating Plasma Rich in Growth Factors (PRGF-Endoret) Versus Hyaluronic Acid in the Short-Term Treatment of Symptomatic KneeOsteoarthritis 22840987 2012 07 30 2012 11 23 2012 07 30 1526-3231 28 8 2012 Aug Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association Arthroscopy A randomized clinical trial evaluating plasma rich in growth factors (PRGF (...) -Endoret) versus hyaluronic acid in the short-term treatment of symptomatic kneeosteoarthritis. 1070-8 10.1016/j.arthro.2012.05.011 This multicenter, double-blind clinical trial evaluated and compared the efficacy and safety of PRGF-Endoret (BTI Biotechnology Institute, Vitoria-Gasteiz, Spain), an autologous biological therapy for regenerative purposes, versus hyaluronic acid (HA) as a short-term treatment for knee pain from osteoarthritis. We randomly assigned 176 patients with symptomatic knee
Duloxetine for the management of pain in older adults with kneeosteoarthritis: randomised placebo-controlled trial 22743149 2012 08 22 2013 04 04 2015 11 19 1468-2834 41 5 2012 Sep Age and ageing Age Ageing Duloxetine for the management of pain in older adults with kneeosteoarthritis: randomised placebo-controlled trial. 646-52 10.1093/ageing/afs072 pain is the leading symptom of osteoarthritis (OA) and is often chronic in nature, leading to significant morbidity and decreased quality (...) of life. Duloxetine, a selective serotonin norepinephrine reuptake inhibitor has been demonstrated to have a centrally acting analgesic effect. the aim of the present study was to investigate the efficacy of duloxetine in reducing pain in older adults with kneeOA. totally, 288 patients aged 65 years and above with primary kneeOA were enrolled in this study. Patients were randomised 1:1. Totally, 144 received 60 mg/day of duloxetine HCL and 144 received placebo for 16 weeks. Outcome measures included pain
Long-Term Comparison of Fixed-Bearing and Mobile-Bearing Total Knee Replacements in Patients Younger Than Fifty-one Years of Age with Osteoarthritis 22617913 2012 05 23 2012 07 19 2016 11 25 1535-1386 94 10 2012 May 16 The Journal of bone and joint surgery. American volume J Bone Joint Surg Am Long-term comparison of fixed-bearing and mobile-bearing total knee replacements in patients younger than fifty-one years of age with osteoarthritis. 866-73 10.2106/JBJS.K.00884 There is limited (...) information comparing the results of fixed-bearing total knee replacement and mobile-bearing total knee replacement in patients with osteoarthritis who are younger than fifty-one years and who have a fixed-bearing implant in one knee and a mobile-bearing implant in the other. The purpose of this study was to compare our long-term clinical and radiographic results of fixed-bearing total knee replacement and mobile-bearing total knee replacement in a group of patients from this population. We prospectively
Physical therapy interventions for knee pain secondary to osteoarthritis Physical therapy interventions for knee pain secondary to osteoarthritis Physical therapy interventions for knee pain secondary to osteoarthritis Shamliyan TA, Wang SY, Olson-Kellogg B, Kane RL Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Shamliyan TA, Wang SY (...) , Olson-Kellogg B, Kane RL. Physical therapy interventions for knee pain secondary to osteoarthritis. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 77. 2012 Authors' objectives To assess the association between intermediate and patient-centered outcomes and harms with physical therapy interventions in community-dwelling adults with chronic knee pain secondary to osteoarthritis and to examine validity and minimum clinically important differences