Latest & greatest articles for knee osteoarthritis

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Top results for knee osteoarthritis

41. Efficacy and safety of single injection of cross-linked sodium hyaluronate vs. three injections of high molecular weight sodium hyaluronate for osteoarthritis of the knee: a double-blind, randomized, multi-center, non-inferiority study

Efficacy and safety of single injection of cross-linked sodium hyaluronate vs. three injections of high molecular weight sodium hyaluronate for osteoarthritis of the knee: a double-blind, randomized, multi-center, non-inferiority study 28549436 2017 05 27 2017 06 01 1471-2474 18 1 2017 May 26 BMC musculoskeletal disorders BMC Musculoskelet Disord Efficacy and safety of single injection of cross-linked sodium hyaluronate vs. three injections of high molecular weight sodium hyaluronate (...) for osteoarthritis of the knee: a double-blind, randomized, multi-center, non-inferiority study. 223 10.1186/s12891-017-1591-4 This randomized, double-blind, multi-center, non-inferiority trial was conducted to assess the efficacy and safety of a cross-linked hyaluronate (XLHA, single injection form) compared with a linear high molecular hyaluronate (HMWHA, thrice injection form) in patients with symptomatic knee osteoarthritis. Two hundred eighty seven patients with osteoarthritis (Kellgren-Lawrence grade I

EvidenceUpdates2017 Full Text: Link to full Text with Trip Pro

42. Viscosupplementation for Knee Osteoarthritis: A Review of Clinical and Cost-Effectiveness and Guidelines

Viscosupplementation for Knee Osteoarthritis: A Review of Clinical and Cost-Effectiveness and Guidelines Viscosupplementation for Knee Osteoarthritis: A Review of Clinical and Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Viscosupplementation for Knee Osteoarthritis: A Review of Clinical and Cost-Effectiveness and Guidelines Viscosupplementation for Knee Osteoarthritis: A Review of Clinical and Cost-Effectiveness and Guidelines Published on: June 22, 2017 Project (...) Number: RC0895-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of viscosupplementation for the treatment of adults with osteoarthritis of the knee? What is the cost-effectiveness of viscosupplementation for the treatment of adults with osteoarthritis of the knee? What are the evidence-based guidelines associated with viscosupplementation for the treatment of adults with osteoarthritis of

Canadian Agency for Drugs and Technologies in Health - Rapid Review2017

43. Pharmaceutical-grade Chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis: the ChONdroitin versus CElecoxib versus Placebo Trial (CONCEPT)

Pharmaceutical-grade Chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis: the ChONdroitin versus CElecoxib versus Placebo Trial (CONCEPT) 28533290 2017 05 23 2017 05 23 1468-2060 2017 May 22 Annals of the rheumatic diseases Ann. Rheum. Dis. Pharmaceutical-grade Chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis: the ChONdroitin versus CElecoxib versus Placebo Trial (CONCEPT (...) ). annrheumdis-2016-210860 10.1136/annrheumdis-2016-210860 Chondroitin sulfate 800 mg/day (CS) pharmaceutical-grade in the management of symptomatic knee osteoarthritis consistent with the European Medicines Agency guideline. A prospective, randomised, 6-month, 3-arm, double-blind, double-dummy, placebo and celecoxib (200 mg/day)-controlled trial assessing changes in pain on a Visual Analogue Scale (VAS) and in the Lequesne Index (LI) as coprimary endpoints. Minimal-Clinically Important Improvement (MCII

EvidenceUpdates2017

44. The Main Cause of Death Following Primary Total Hip and Knee Replacement for Osteoarthritis: A Cohort Study of 26,766 Deaths Following 332,734 Hip Replacements and 29,802 Deaths Following 384,291 Knee Replacements

The Main Cause of Death Following Primary Total Hip and Knee Replacement for Osteoarthritis: A Cohort Study of 26,766 Deaths Following 332,734 Hip Replacements and 29,802 Deaths Following 384,291 Knee Replacements 28375889 2017 04 04 2017 04 24 2017 04 24 1535-1386 99 7 2017 Apr 05 The Journal of bone and joint surgery. American volume J Bone Joint Surg Am The Main Cause of Death Following Primary Total Hip and Knee Replacement for Osteoarthritis: A Cohort Study of 26,766 Deaths Following (...) -Shlomo Yoav Y Whitehouse Michael R MR Porter Martyn L ML Blom Ashley W AW eng Journal Article United States J Bone Joint Surg Am 0014030 0021-9355 AIM IM Adult Age Distribution Aged Aged, 80 and over Arthroplasty, Replacement, Hip mortality Arthroplasty, Replacement, Knee mortality Cause of Death Cohort Studies England epidemiology Female Humans Kaplan-Meier Estimate Male Middle Aged Osteoarthritis, Hip mortality surgery Osteoarthritis, Knee mortality surgery Wales epidemiology 2017 4 5 6 0 2017 4 5

EvidenceUpdates2017

45. Treatment of osteoarthritis of the knee: an update review

Treatment of osteoarthritis of the knee: an update review Treatment of osteoarthritis of the knee: an update review Treatment of osteoarthritis of the knee: an update review Newberry SJ, FitzGerald J, SooHoo NF, Booth M, Marks J, Motala A, Apaydin E, Chen C, Raaen L, Shanman R, Shekelle PG. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Newberry SJ, FitzGerald (...) J, SooHoo NF, Booth M, Marks J, Motala A, Apaydin E, Chen C, Raaen L, Shanman R, Shekelle PG.. Treatment of osteoarthritis of the knee: an update review. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 190. 2017 Authors' objectives To assess the evidence for the efficacy of the following interventions for improving clinical outcomes in adults with osteoarthritis (OA) of the knee: cell-based therapies; glucosamine, chondroitin, or glucosamine

Health Technology Assessment (HTA) Database.2017

46. Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial.

Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial. Importance: Synovitis is common and is associated with progression of structural characteristics of knee osteoarthritis. Intra-articular corticosteroids could reduce cartilage damage associated with synovitis but might have adverse effects on cartilage and periarticular bone. Objective: To determine the effects of intra-articular injection of 40 (...) mg of triamcinolone acetonide every 3 months on progression of cartilage loss and knee pain. Design, Setting, and Participants: Two-year, randomized, placebo-controlled, double-blind trial of intra-articular triamcinolone vs saline for symptomatic knee osteoarthritis with ultrasonic features of synovitis in 140 patients. Mixed-effects regression models with a random intercept were used to analyze the longitudinal repeated outcome measures. Patients fulfilling the American College of Rheumatology

JAMA2017

48. The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part one: Introduction, and mind-body exercise programs

The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part one: Introduction, and mind-body exercise programs 28183188 2017 02 10 2017 04 18 1477-0873 31 5 2017 May Clinical rehabilitation Clin Rehabil The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part one: introduction, and mind-body exercise programs. 582-595 10.1177/0269215517691083 To identify effective mind-body exercise programs and provide clinicians (...) and patients with updated, high-quality recommendations concerning non-traditional land-based exercises for knee osteoarthritis. A systematic search and adapted selection criteria included comparative controlled trials with mind-body exercise programs for patients with knee osteoarthritis. A panel of experts reached consensus on the recommendations using a Delphi survey. A hierarchical alphabetical grading system (A, B, C+, C, D, D+, D-) was used, based on statistical significance ( P < 0.5) and clinical

EvidenceUpdates2017

49. Comparison of Single Intra-Articular Injection of Novel Hyaluronan (HYA-JOINT Plus) with Synvisc-One for Knee Osteoarthritis: A Randomized, Controlled, Double-Blind Trial of Efficacy and Safety

Comparison of Single Intra-Articular Injection of Novel Hyaluronan (HYA-JOINT Plus) with Synvisc-One for Knee Osteoarthritis: A Randomized, Controlled, Double-Blind Trial of Efficacy and Safety 28291178 2017 03 14 2017 04 18 2017 04 18 1535-1386 99 6 2017 Mar 15 The Journal of bone and joint surgery. American volume J Bone Joint Surg Am Comparison of Single Intra-Articular Injection of Novel Hyaluronan (HYA-JOINT Plus) with Synvisc-One for Knee Osteoarthritis: A Randomized, Controlled, Double (...) -Blind Trial of Efficacy and Safety. 462-471 10.2106/JBJS.16.00469 Viscosupplementation has been widely used for the treatment of knee osteoarthritis. Because we found no well-controlled trial comparing single-injection regimens of hyaluronan for knee osteoarthritis, we compared the efficacy and safety of a single intra-articular injection of a novel cross-linked hyaluronan (HYA-JOINT Plus) with a single injection of Synvisc-One in patients with knee osteoarthritis. In a prospective, randomized

EvidenceUpdates2017

50. The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part two: Strengthening exercise programs

The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part two: Strengthening exercise programs 28183213 2017 02 10 2017 04 18 1477-0873 31 5 2017 May Clinical rehabilitation Clin Rehabil The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part two: strengthening exercise programs. 596-611 10.1177/0269215517691084 To identify effective strengthening exercise programs and provide rehabilitation teams and patients (...) with updated, high-quality recommendations concerning traditional land-based exercises for knee osteoarthritis. A systematic search and adapted selection criteria included comparative controlled trials with strengthening exercise programs for patients with knee osteoarthritis. A panel of experts reached consensus on the recommendations using a Delphi survey. A hierarchical alphabetical grading system (A, B, C+, C, D, D+ or D-) was based on statistical significance ( p < 0.5) and clinical importance (⩾15

EvidenceUpdates2017

51. The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part three: Aerobic exercise programs

The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part three: Aerobic exercise programs 28183194 2017 02 10 2017 04 18 1477-0873 31 5 2017 May Clinical rehabilitation Clin Rehabil The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part three: aerobic exercise programs. 612-624 10.1177/0269215517691085 To identify effective aerobic exercise programs and provide clinicians and patients with updated, high-quality (...) recommendations concerning traditional land-based exercises for knee osteoarthritis. A systematic search and adapted selection criteria included comparative controlled trials with strengthening exercise programs for patients with knee osteoarthritis. A panel of experts reached consensus on the recommendations using a Delphi survey. A hierarchical alphabetical grading system (A, B, C+, C, D, D+, or D-) was used, based on statistical significance ( P < 0.5) and clinical importance (⩾15% improvement). The five

EvidenceUpdates2017

52. Impact of total knee replacement practice: cost effectiveness analysis of data from the Osteoarthritis Initiative.

Impact of total knee replacement practice: cost effectiveness analysis of data from the Osteoarthritis Initiative. Objectives To evaluate the impact of total knee replacement on quality of life in people with knee osteoarthritis and to estimate associated differences in lifetime costs and quality adjusted life years (QALYs) according to use by level of symptoms. Design Marginal structural modeling and cost effectiveness analysis based on lifetime predictions for total knee replacement and death (...) from population based cohort data. Setting Data from two studies-Osteoarthritis Initiative (OAI) and the Multicenter Osteoarthritis Study (MOST)-within the US health system. Participants 4498 participants with or at high risk for knee osteoarthritis aged 45-79 from the OAI with no previous knee replacement (confirmed by baseline radiography) followed up for nine years. Validation cohort comprised 2907 patients from MOST with two year follow-up. Intervention Scenarios ranging from current practice

BMJ2017

53. Effect of Topical Application of Nigella Sativa Oil and Oral Acetaminophen on Pain in Elderly with Knee Osteoarthritis: A Crossover Clinical Trial.

Effect of Topical Application of Nigella Sativa Oil and Oral Acetaminophen on Pain in Elderly with Knee Osteoarthritis: A Crossover Clinical Trial. 28344755 2017 03 27 2017 08 16 2008-5842 8 11 2016 Nov Electronic physician Electron Physician Effect of Topical Application of Nigella Sativa Oil and Oral Acetaminophen on Pain in Elderly with Knee Osteoarthritis: A Crossover Clinical Trial. 3193-3197 10.19082/3193 Limited evidence supports Nigella sativa's role as an effective complementary (...) and alternative medicine and the anti-inflammatory effects of Nigella sativa on patients with allergic rhinitis. The aim of this study was to investigate the effect of topical application of Nigella sativa oil and oral acetaminophen on pain in the elderly with knee osteoarthritis residing in a parents' home in Sabzevar. This study is done as a crossover clinical trial. After obtaining written consent of elderly patients with osteoarthritis of the knee, they were randomly divided into two groups. In step 1

Electronic physician2017

54. Improving Symptoms in Knee Osteoarthritis: Can We Get There From Here?

Improving Symptoms in Knee Osteoarthritis: Can We Get There From Here? 28241277 2017 12 08 2018 12 02 1539-3704 166 7 2017 04 04 Annals of internal medicine Ann. Intern. Med. Improving Symptoms in Knee Osteoarthritis: Can We Get There From Here? 531-532 10.7326/M17-0330 Mandl Lisa A LA From Hospital for Special Surgery/Weill Cornell Medicine, New York, New York. eng K24 AG053462 AG NIA NIH HHS United States P30 AG022845 AG NIA NIH HHS United States Journal Article Comment 2017 02 21 United (...) States Ann Intern Med 0372351 0003-4819 AIM IM Ann Intern Med. 2017 Apr 4;166(7):453-462 28241215 Humans Osteoarthritis, Knee 2017 2 28 6 0 2017 12 9 6 0 2017 2 28 6 0 ppublish 28241277 2605038 10.7326/M17-0330 PMC5868739 NIHMS951687 Am J Phys Med Rehabil. 2016 May;95(5):372-89 26945211 Arthritis Rheum. 2008 Sep 15;59(9):1207-13 18759314 Clin Ther. 2013 Nov;35(11):1690-702 24145044 Ann Intern Med. 2017 Apr 4;166(7):453-462 28241215 Arthritis Care Res (Hoboken). 2016 Dec;68(12 ):1743-1750 27014966

Annals of Internal Medicine2017 Full Text: Link to full Text with Trip Pro

55. A Prospective Randomized Trial of Prognostic Genicular Nerve Blocks to Determine the Predictive Value for the Outcome of Cooled Radiofrequency Ablation for Chronic Knee Pain Due to Osteoarthritis

A Prospective Randomized Trial of Prognostic Genicular Nerve Blocks to Determine the Predictive Value for the Outcome of Cooled Radiofrequency Ablation for Chronic Knee Pain Due to Osteoarthritis 29300971 2018 03 08 1526-4637 2017 Dec 28 Pain medicine (Malden, Mass.) Pain Med A Prospective Randomized Trial of Prognostic Genicular Nerve Blocks to Determine the Predictive Value for the Outcome of Cooled Radiofrequency Ablation for Chronic Knee Pain Due to Osteoarthritis. 10.1093/pm/pnx286 (...) Genicular nerve radiofrequency ablation is an effective treatment for patients with chronic pain due to knee osteoarthritis; however, little is known about factors that predict procedure success. The current study evaluated the utility of genicular nerve blocks to predict the outcome of genicular nerve cooled radiofrequency ablation (cRFA) in patients with osteoarthritis. This randomized comparative trial included patients with chronic knee pain due to osteoarthritis. Participants were randomized

EvidenceUpdates2017

56. Comparative effectiveness review of platelet-rich plasma for knee osteoarthritis: a review of reviews

Comparative effectiveness review of platelet-rich plasma for knee osteoarthritis: a review of reviews Comparative effectiveness review of platelet-rich plasma for knee osteoarthritis: a review of reviews Comparative effectiveness review of platelet-rich plasma for knee osteoarthritis: a review of reviews HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation (...) HAYES, Inc. Comparative effectiveness review of platelet-rich plasma for knee osteoarthritis: a review of reviews. Lansdale: HAYES, Inc. Directory Publication. 2017 Authors' conclusions Health Problem: Osteoarthritis (OA) is a painful condition in which the cartilage between the bones degenerates, no longer providing a smooth, gliding surface for motion or adequate cushioning. Because OA damages the cartilage and may ultimately damage the bone, it disrupts how components work together, resulting

Health Technology Assessment (HTA) Database.2017

57. Comparative effectiveness review of hyaluronic acid for knee osteoarthritis: a review of reviews

Comparative effectiveness review of hyaluronic acid for knee osteoarthritis: a review of reviews Comparative effectiveness review of hyaluronic acid for knee osteoarthritis: a review of reviews Comparative effectiveness review of hyaluronic acid for knee osteoarthritis: a review of reviews HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc (...) . Comparative effectiveness review of hyaluronic acid for knee osteoarthritis: a review of reviews. Lansdale: HAYES, Inc. Directory Publication. 2017 Authors' conclusions Health Problem: Osteoarthritis (OA) is a painful condition in which the cartilage between the bones degenerates, no longer providing a smooth, gliding surface for motion or adequate cushioning. Because OA damages the cartilage and may ultimately damage the bone, it disrupts how components work together, resulting in pain, swelling

Health Technology Assessment (HTA) Database.2017

59. Intra-articular Corticosteroids for Osteoarthritis of the Knee.

Intra-articular Corticosteroids for Osteoarthritis of the Knee. Clinical Question: Are intra-articular corticosteroids associated with improvement in pain and physical function compared with sham injection or no intervention in patients with knee osteoarthritis? Bottom Line: Intra-articular corticosteroids may be associated with moderate improvement in pain and a small improvement in physical function up to 6 weeks after injection. However, the quality of the evidence is low.

JAMA2016

60. Predictive capacity of thigh muscle strength in symptomatic and/or radiographic knee osteoarthritis progression – data from the FNIH OA Biomarkers Consortium

Predictive capacity of thigh muscle strength in symptomatic and/or radiographic knee osteoarthritis progression – data from the FNIH OA Biomarkers Consortium 27175558 2017 07 17 2018 11 13 1537-7385 95 12 2016 12 American journal of physical medicine & rehabilitation Am J Phys Med Rehabil Predictive Capacity of Thigh Muscle Strength in Symptomatic and/or Radiographic Knee Osteoarthritis Progression: Data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers (...) Consortium. 931-938 Thigh muscle weakness is a risk factor for incident radiographic and symptomatic knee osteoarthritis (KOA). The role of thigh muscle weakness in radiographic and/or symptomatic KOA progression remains elusive. Five hundred twenty-seven knees of 527 Osteoarthritis Initiative participants with baseline Kellgren-Lawrence grades 1 to 3 were included in this nested case-control study evaluating whether baseline muscle strength predicted symptomatic and/or radiographic KOA progression. Case

American journal of physical medicine & rehabilitation2016 Full Text: Link to full Text with Trip Pro