Latest & greatest articles for knee osteoarthritis

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Top results for knee osteoarthritis

21. Gamechanger? The Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients with Knee Osteoarthritis ? A Randomized Clinical Trial

Gamechanger? The Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients with Knee Osteoarthritis ? A Randomized Clinical Trial Gamechanger? The Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients with Knee Osteoarthritis – A Randomized Clinical Trial | Clinical Correlations Gamechanger? The Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients with Knee Osteoarthritis (...) synovitis, as well as the up-regulation of [1]. Based on this proposed pathogenesis, the suppression of inflammatory mechanisms by intra-articular corticosteroids might theoretically reduce the progression of knee OA, with accompanying reduction in pain. This is an important area of study, as the pain associated with OA is the most prominent feature of the disease and is often undertreated. What did we know before? Though intra-articular corticosteroids have long been used to manage the symptoms of knee

Clinical Correlations2018

22. Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial.

Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial. Importance: Limited evidence is available regarding long-term outcomes of opioids compared with nonopioid medications for chronic pain. Objective: To compare opioid vs nonopioid medications over 12 months on pain-related function, pain intensity, and adverse effects. Design, Setting, and Participants: Pragmatic, 12-month (...) , randomized trial with masked outcome assessment. Patients were recruited from Veterans Affairs primary care clinics from June 2013 through December 2015; follow-up was completed December 2016. Eligible patients had moderate to severe chronic back pain or hip or knee osteoarthritis pain despite analgesic use. Of 265 patients enrolled, 25 withdrew prior to randomization and 240 were randomized. Interventions: Both interventions (opioid and nonopioid medication therapy) followed a treat-to-target strategy

JAMA2018 Full Text: Link to full Text with Trip Pro

23. Ultrasound-Guided Genicular Nerve Block for Knee Osteoarthritis: A Double-Blind, Randomized Controlled Trial of Local Anesthetic Alone or in Combination with Corticosteroid

Ultrasound-Guided Genicular Nerve Block for Knee Osteoarthritis: A Double-Blind, Randomized Controlled Trial of Local Anesthetic Alone or in Combination with Corticosteroid 29357330 2018 01 22 2150-1149 21 1 2018 Jan Pain physician Pain Physician Ultrasound-Guided Genicular Nerve Block for Knee Osteoarthritis: A Double-Blind, Randomized Controlled Trial of Local Anesthetic Alone or in Combination with Corticosteroid. 41-52 Recently, several studies suggested that radiofrequency (RF) ablation (...) of the genicular nerves is a safe and effective therapeutic procedure for intractable pain associated with chronic knee osteoarthritis (OA). Diagnostic genicular nerve block (GNB) with local anesthetic has been generally conducted before making decisions regarding RF ablation. Although GNB has been recently performed together with corticosteroid, the analgesic effects of corticosteroids for treating chronic pain remain controversial. The current study aims to assess the effects of combining corticosteroids and

EvidenceUpdates2018

24. Intra-articular ozone or hyaluronic acid injection: Which one is superior in patients with knee osteoarthritis? A 6-month randomized clinical trial

Intra-articular ozone or hyaluronic acid injection: Which one is superior in patients with knee osteoarthritis? A 6-month randomized clinical trial 29379312 2018 02 01 1178-7090 11 2018 Journal of pain research J Pain Res Intra-articular ozone or hyaluronic acid injection: Which one is superior in patients with knee osteoarthritis? A 6-month randomized clinical trial. 111-117 10.2147/JPR.S142755 Knee osteoarthritis (OA) is a common disease, imposing a great burden through pain and decreased (...) function. There are many therapeutic modalities including non-pharmacologic choices and oral, topical, and intra-articular medications. New studies have shown promising results for ozone application in knee OA. Our aim was to compare the effects of ozone therapy versus hyaluronic acid (HA) intra-articular injection in knee OA patients. In this randomized clinical trial, a total of 174 patients with more than 3 months of chronic pain or swelling in the knee joints along with consistent imaging findings

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

25. Growth Factors Levels Determine Efficacy of Platelets Rich Plasma Injection in Knee Osteoarthritis: A Randomized Double Blind Noninferiority Trial Compared With Viscosupplementation

Growth Factors Levels Determine Efficacy of Platelets Rich Plasma Injection in Knee Osteoarthritis: A Randomized Double Blind Noninferiority Trial Compared With Viscosupplementation 29366744 2018 01 25 1526-3231 2018 Jan 20 Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association Arthroscopy Growth Factors Levels Determine Efficacy of Platelets Rich Plasma Injection in Knee (...) Osteoarthritis: A Randomized Double Blind Noninferiority Trial Compared With Viscosupplementation. S0749-8063(17)31481-0 10.1016/j.arthro.2017.11.035 To assess the noninferiority of a single platelet-rich plasma (PRP) injection compared with hyaluronic acid (HA), to alleviate pain and enhance functional capacity in knee osteoarthritis, and identify biological characteristics of PRP that may affect their efficacy. Fifty-four patients with symptomatic knee osteoarthritis received a single injection of either

EvidenceUpdates2018

26. Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction With Bone-Patellar Tendon-Bone Versus Hamstring Tendon Autograft: A Systematic Review of Randomized Controlled Trials

Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction With Bone-Patellar Tendon-Bone Versus Hamstring Tendon Autograft: A Systematic Review of Randomized Controlled Trials 29366740 2018 01 25 1526-3231 2018 Jan 20 Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association Arthroscopy Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction With Bone (...) -Patellar Tendon-Bone Versus Hamstring Tendon Autograft: A Systematic Review of Randomized Controlled Trials. S0749-8063(17)31477-9 10.1016/j.arthro.2017.11.032 The primary purpose of this study was to systematically review high-quality studies in the literature to compare the postoperative radiographic incidence of knee osteoarthritis (OA) after anterior cruciate ligament reconstruction (ACLR) with bone-patellar tendon-bone (BPTB) versus hamstring tendon (HT) autograft. The secondary purpose

EvidenceUpdates2018

27. Self-Acupressure for Older Adults With Symptomatic Knee Osteoarthritis: A Randomized Controlled Trial

Self-Acupressure for Older Adults With Symptomatic Knee Osteoarthritis: A Randomized Controlled Trial 28437570 2018 01 29 2151-4658 70 2 2018 Feb Arthritis care & research Arthritis Care Res (Hoboken) Self-Acupressure for Older Adults With Symptomatic Knee Osteoarthritis: A Randomized Controlled Trial. 221-229 10.1002/acr.23262 This double-blind randomized controlled trial aimed to test the efficacy of self-administered acupressure for pain and physical function improvement for older adults (...) with knee osteoarthritis (OA). Participants were community-dwelling adults with symptomatic knee OA (n = 150, mean age 73 years), randomized to 1 of 3 groups: verum acupressure, sham acupressure, or usual care. Participants in the verum and sham groups, but not those in the usual care group, were taught to self-apply acupressure once daily, 5 days/week for 8 weeks. Assessments were collected during center visits at baseline, and at 4 and 8 weeks. In addition, pain level was assessed weekly by phone

EvidenceUpdates2018

29. Unicompartmental Knee Arthroplasty vs High Tibial Osteotomy for Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Unicompartmental Knee Arthroplasty vs High Tibial Osteotomy for Knee Osteoarthritis: A Systematic Review and Meta-Analysis 29203354 2017 12 05 1532-8406 2017 Dec 01 The Journal of arthroplasty J Arthroplasty Unicompartmental Knee Arthroplasty vs High Tibial Osteotomy for Knee Osteoarthritis: A Systematic Review and Meta-Analysis. S0883-5403(17)30937-3 10.1016/j.arth.2017.10.025 Prior studies have compared unicompartmental knee arthroplasty (UKA) with high tibial osteotomy (HTO) suggesting (...) that both procedures had good clinical outcomes. However, which treatment is more beneficial for unicompartmental knee osteoarthritis is still a controversy. The purpose of our study is to obtain postoperative outcomes of revision rate, complications, function results, range of motion (ROM), and pain between the 2 procedures. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed and study protocol was published online at PROSPERO under registration number

EvidenceUpdates2018

30. A Meta-Analysis of Patellar Replacement in Total Knee Arthroplasty for Patients With Knee Osteoarthritis

A Meta-Analysis of Patellar Replacement in Total Knee Arthroplasty for Patients With Knee Osteoarthritis 29191443 2017 12 01 1532-8406 2017 Oct 16 The Journal of arthroplasty J Arthroplasty A Meta-Analysis of Patellar Replacement in Total Knee Arthroplasty for Patients With Knee Osteoarthritis. S0883-5403(17)30911-7 10.1016/j.arth.2017.10.017 This meta-analysis (MA) aims at comparing the clinical outcomes of resurfacing and nonresurfacing the patella in patients undergoing total knee (...) arthroplasty in the treatment of knee osteoarthritis. Randomized controlled trials were included by retrieving data from electronic English databases. Both fixed and random-effects models were employed, and standardized mean difference and 95% confidence intervals were calculated. Stata13.1 software was used for statistical analysis for all the studies included to compare the differences in improving Knee Society Clinical Score and Knee Society Function Score as well as the reduction in rates of infection

EvidenceUpdates2018

31. Prospective, Multicenter, Randomized, Crossover Clinical Trial Comparing the Safety and Effectiveness of Cooled Radiofrequency Ablation With Corticosteroid Injection in the Management of Knee Pain From Osteoarthritis

Prospective, Multicenter, Randomized, Crossover Clinical Trial Comparing the Safety and Effectiveness of Cooled Radiofrequency Ablation With Corticosteroid Injection in the Management of Knee Pain From Osteoarthritis 29095245 2017 12 20 1532-8651 43 1 2018 Jan Regional anesthesia and pain medicine Reg Anesth Pain Med Prospective, Multicenter, Randomized, Crossover Clinical Trial Comparing the Safety and Effectiveness of Cooled Radiofrequency Ablation With Corticosteroid Injection in (...) the Management of Knee Pain From Osteoarthritis. 84-91 10.1097/AAP.0000000000000690 Osteoarthritis (OA) of the knee affects the aging population and has an associated influence on the health care system. Rigorous studies evaluating radiofrequency ablation for OA-related knee pain are lacking. This study compared long-term clinical safety and effectiveness of cooled radiofrequency ablation (CRFA) with intra-articular steroid (IAS) injection in managing OA-related knee pain. This is a prospective, multicenter

EvidenceUpdates2018

32. Preoperative Pain Neuroscience Education Combined With Knee Joint Mobilization for Knee Osteoarthritis: A Randomized Controlled Trial

Preoperative Pain Neuroscience Education Combined With Knee Joint Mobilization for Knee Osteoarthritis: A Randomized Controlled Trial 28514231 2017 12 04 1536-5409 34 1 2018 Jan The Clinical journal of pain Clin J Pain Preoperative Pain Neuroscience Education Combined With Knee Joint Mobilization for Knee Osteoarthritis: A Randomized Controlled Trial. 44-52 10.1097/AJP.0000000000000511 This study aimed to first compare the effects of a preoperative treatment combining pain neuroscience (...) education (PNE) with knee joint mobilization versus biomedical education with knee joint mobilization on central sensitization (CS) in patients with knee osteoarthritis, both before and after surgery. Second, we wanted to compare the effects of both interventions on knee pain, disability, and psychosocial variables. Forty-four patients with knee osteoarthritis were allocated to receive 4 sessions of either PNE combined with knee joint mobilization or biomedical education with knee joint mobilization

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

33. Internet Cognitive-Behavioral Therapy for Depression in Older Adults With Knee Osteoarthritis: A Randomized Controlled Trial

Internet Cognitive-Behavioral Therapy for Depression in Older Adults With Knee Osteoarthritis: A Randomized Controlled Trial 28426917 2017 12 23 2151-4658 70 1 2018 Jan Arthritis care & research Arthritis Care Res (Hoboken) Internet Cognitive-Behavioral Therapy for Depression in Older Adults With Knee Osteoarthritis: A Randomized Controlled Trial. 61-70 10.1002/acr.23257 To determine the efficacy of an internet-based cognitive-behavioral therapy (iCBT) program for depression in older adults (...) with osteoarthritis (OA) of the knee and comorbid major depressive disorder (MDD). We conducted a randomized controlled trial in 69 adults (ages ≥50 years) meeting criteria for MDD and OA of the knee with 1-week postintervention (week 11) and 3-month followup (week 24) end points. Patients were allocated to either a 10-week iCBT program for depression added to treatment as usual (TAU) or to a TAU control group. Primary outcomes were depression symptoms (9-Item Patient Health Questionnaire [PHQ-9

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

34. Cost-Utility Analysis of High Molecular Weight Hyaluronic Acid for Knee Osteoarthritis in Everyday Clinical Care in Patients at a Working Age: An Economic Evaluation of a Randomized Clinical Trial

Cost-Utility Analysis of High Molecular Weight Hyaluronic Acid for Knee Osteoarthritis in Everyday Clinical Care in Patients at a Working Age: An Economic Evaluation of a Randomized Clinical Trial 28320075 2017 12 23 2151-4658 70 1 2018 Jan Arthritis care & research Arthritis Care Res (Hoboken) Cost-Utility Analysis of High Molecular Weight Hyaluronic Acid for Knee Osteoarthritis in Everyday Clinical Care in Patients at a Working Age: An Economic Evaluation of a Randomized Clinical Trial. 89-97 (...) 10.1002/acr.23242 Knee osteoarthritis (OA) is associated with high medical costs and especially with high productivity costs, in particular in patients in their working years. High molecular weight (HMW) hyaluronic acid (HA) is an alternative treatment for nonsteroidal antiinflammatory drugs, which are known for their serious side-effects. The cost-utility of intraarticular HMW-HA treatment in these patients is unknown, however, and was assessed in this study. Secondary care patients ages 18-65 years

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

35. Exercise, Manual Therapy, and Booster Sessions in Knee Osteoarthritis: Cost-Effectiveness Analysis From a Multicenter Randomized Controlled Trial

Exercise, Manual Therapy, and Booster Sessions in Knee Osteoarthritis: Cost-Effectiveness Analysis From a Multicenter Randomized Controlled Trial 29088393 2017 12 22 1538-6724 98 1 2018 Jan 01 Physical therapy Phys Ther Exercise, Manual Therapy, and Booster Sessions in Knee Osteoarthritis: Cost-Effectiveness Analysis From a Multicenter Randomized Controlled Trial. 16-27 10.1093/ptj/pzx104 Limited information exists regarding the cost-effectiveness of rehabilitation strategies for individuals (...) with knee osteoarthritis (OA). The study objective was to compare the cost-effectiveness of 4 different combinations of exercise, manual therapy, and booster sessions for individuals with knee OA. This economic evaluation involved a cost-effectiveness analysis performed alongside a multicenter randomized controlled trial. The study took place in Pittsburgh, Pennsylvania; Salt Lake City, Utah; and San Antonio, Texas. The study participants were 300 individuals taking part in a randomized controlled trial

EvidenceUpdates2018

36. Comparative effectiveness of intra-articular prolotherapy versus peri-articular prolotherapy on pain reduction and improving function in patients with knee osteoarthritis: A randomized clinical trial

Comparative effectiveness of intra-articular prolotherapy versus peri-articular prolotherapy on pain reduction and improving function in patients with knee osteoarthritis: A randomized clinical trial Electronic Physician (ISSN: 2008-5842) http://www.ephysician.ir November 2017, Volume: 9, Issue: 11, Pages: 5663-5669, DOI: http://dx.doi.org/10.19082/5663 Corresponding author: Assistant Professor Dr. Hamid Reza Farpour, Bone and Joint Diseases Research Center, Department of Physical Medicine (...) -NonCommercial- NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non- commercial and no modifications or adaptations are made. Page 5663 Comparative effectiveness of intra-articular prolotherapy versus peri-articular prolotherapy on pain reduction and improving function in patients with knee osteoarthritis: A randomized clinical trial Hamid Reza Farpour 1 , Farzane Fereydooni 2 1 M.D. Physiatrist, Assistant Professor, Bone and Joint

Electronic physician2017 Full Text: Link to full Text with Trip Pro

37. Treatment of knee osteoarthritis: platelet-derived growth factors vs. hyaluronic acid. A randomized controlled trial

Treatment of knee osteoarthritis: platelet-derived growth factors vs. hyaluronic acid. A randomized controlled trial 28783969 2017 08 08 2017 08 08 1477-0873 2017 Aug 01 Clinical rehabilitation Clin Rehabil Treatment of knee osteoarthritis: platelet-derived growth factors vs. hyaluronic acid. A randomized controlled trial. 269215517724193 10.1177/0269215517724193 Aim of this trial was to compare efficacy of activated platelet-rich plasma against hyaluronic acid as intra-articular injections (...) to people with osteoarthritis of the knee. Phase-2 randomized controlled trial, with blind patients and outcome assessors. Outpatient rehabilitation service; years 2011-2013. Patients with knee osteoarthritis grades 2-3 at magnetic resonance imaging (MRI) were included after consent and randomized. Target sample size was 25 patients per group. Patients received three activated platelet-rich plasma (intervention group) or hyaluronic acid (controls) intra-articular injections at 4-week intervals. Main

EvidenceUpdates2017

38. Clinical Outcomes of Knee Osteoarthritis Treated With an Autologous Protein Solution Injection: A 1-Year Pilot Double-Blinded Randomized Controlled Trial

Clinical Outcomes of Knee Osteoarthritis Treated With an Autologous Protein Solution Injection: A 1-Year Pilot Double-Blinded Randomized Controlled Trial 29016185 2017 10 10 2017 10 16 1552-3365 2017 Oct 01 The American journal of sports medicine Am J Sports Med Clinical Outcomes of Knee Osteoarthritis Treated With an Autologous Protein Solution Injection: A 1-Year Pilot Double-Blinded Randomized Controlled Trial. 363546517732734 10.1177/0363546517732734 Osteoarthritis (OA) is a debilitating (...) disease resulting in substantial pain and functional limitations. A novel blood derivative has been developed to concentrate both growth factors and antagonists of inflammatory cytokines, with promising preliminary findings in terms of safety profile and clinical improvement. To investigate if one intra-articular injection of autologous protein solution (APS) can reduce pain and improve function in patients affected by knee OA in a multicenter, randomized, double-blind, saline-controlled study

EvidenceUpdates2017

39. The effect of self-administered superficial local hot and cold application methods on pain, functional status and quality of life in primary knee osteoarthritis patients

The effect of self-administered superficial local hot and cold application methods on pain, functional status and quality of life in primary knee osteoarthritis patients 28880416 2017 09 07 2017 10 10 1365-2702 2017 Sep 07 Journal of clinical nursing J Clin Nurs The effect of self-administered superficial local hot and cold application methods on pain, functional status and quality of life in primary knee osteoarthritis patients. 10.1111/jocn.14070 To investigate the effect of the self (...) -administered superficial local hot and cold applications on pain, and the functional status and the quality of life in primary knee osteoarthritis patients. Superficial local hot and cold application is used as a nonpharmacological method for the treatment of knee osteoarthritis. However, various guidelines for the management of knee osteoarthritis have conflicting recommendation for hot and cold therapy. A randomised clinical trial design. The sample consisted of patients (n = 96) who were diagnosed

EvidenceUpdates2017

40. Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis

Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis 28975547 2018 11 13 2197-1153 4 1 2017 Oct 03 Journal of experimental orthopaedics J Exp Orthop Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis. 33 10.1186/s40634-017-0108-2 Chondral lesions of the knee represent a challenge for the orthopaedic surgeon. Several treatments have been proposed with variable success rate. Recently (...) Hum Gene Ther. 2011 Jan;22(1):19-26 21028982 Stem Cells Int. 2014;2014:194318 25548573 Cell Stem Cell. 2011 Nov 4;9(5):393-6 22056136 Ann Rheum Dis. 2005 Jan;64(1):29-33 15208174 Bone Res. 2016 Mar 01;4:15040 26962464 Arthritis Care Res (Hoboken). 2011 Nov;63 Suppl 11:S208-28 22588746 Cell Transplant. 2013;22(11):2063-77 23051701 Cell Stem Cell. 2009 Jan 9;4(1):20-6 19058776 Expert Rev Mol Med. 2014 May 09;16:e9 24810570 Adipose tissue Knee Chondropathy MSCs Osteoarthritis 2017 08 02 2017 09 27

Journal of experimental orthopaedics2017 Full Text: Link to full Text with Trip Pro