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Latest & greatest articles for knee osteoarthritis
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Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of KneeOsteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled Trial 30545242 2018 12 14 1552-3365 2018 Dec 13 The American journal of sports medicine Am J Sports Med Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of KneeOsteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled Trial. 363546518814532 10.1177/0363546518814532 Platelet-rich plasma (PRP (...) controlled trial; Level of evidence, 1. Patients with a history of chronic symptomatic knee degenerative changes and osteoarthritis (Kellgren-Lawrence grade 0-3) were enrolled: 192 patients were randomized to undergo 3 blinded weekly intra-articular injections of either PRP or HA. Patients were prospectively evaluated before the injection and then at 2, 6, 12, and 24 months and a mean of 64.3 months (SD, 7.8 months) of follow-up. Evaluation was based on International Knee Documentation Committee (IKDC
The efficacy of electromyographic biofeedback on pain, function, and maximal thickness of vastus medialis oblique muscle in patients with kneeosteoarthritis: a randomized clinical trial 30519081 2018 12 17 1178-7090 11 2018 Journal of pain research J Pain Res The efficacy of electromyographic biofeedback on pain, function, and maximal thickness of vastus medialis oblique muscle in patients with kneeosteoarthritis: a randomized clinical trial. 2781-2789 10.2147/JPR.S169613 The aim (...) of this survey was to examine the effect of adding electromyographic biofeedback (EMGBF) to isometric exercise, on pain, function, thickness, and maximal electrical activity in isometric contraction of the vastus medialis oblique (VMO) muscle in patients with kneeosteoarthritis (OA). In this clinical trial, 46 patients with a diagnosis of kneeOA were recruited and assigned to two groups. The case group consisted of 23 patients with EMGBF-associated exercise, and the control group was made up of 23 patients
Association of Pharmacological Treatments With Long-term Pain Control in Patients With KneeOsteoarthritis: A Systematic Review and Meta-analysis. Importance: Even though osteoarthritis is a chronic and progressive disease, pharmacological agents are mainly studied over short-term periods, resulting in unclear recommendations for long-term disease management. Objective: To search, review, and analyze long-term (≥12 months) outcomes (symptoms, joint structure) from randomized clinical trials (...) (RCTs) of medications for kneeosteoarthritis. Data Sources and Study Selection: The databases of MEDLINE, Scopus, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials were searched until June 30, 2018 (MEDLINE alerts through August 31, 2018) for RCTs of patients with kneeosteoarthritis that had treatment and follow-up lasting 1 year or longer. Data Extraction and Synthesis: Data at baseline and at the longest available treatment and follow-up of 12 months' duration
Intra-articular Mesenchymal Stem Cells in Osteoarthritis of the Knee: A Systematic Review of Clinical Outcomes and Evidence of Cartilage Repair 30455086 2018 11 20 1526-3231 2018 Nov 16 Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association Arthroscopy Intra-articular Mesenchymal Stem Cells in Osteoarthritis of the Knee: A Systematic Review of Clinical Outcomes and Evidence (...) of Cartilage Repair. S0749-8063(18)30616-9 10.1016/j.arthro.2018.07.028 To provide a systematic review of the clinical literature reporting the efficacy of mesenchymal stem cells (MSCs) in terms of clinical outcomes including pain and function and cartilage repair in patients with osteoarthritis. We systematically reviewed any studies investigating clinical outcomes and cartilage repair after the clinical application of cell populations containing MSCs in human subjects with kneeosteoarthritis through
Clinic-Based Patellar Mobilization Therapy for KneeOsteoarthritis: A Randomized Clinical Trial 30420367 2018 12 07 1544-1717 16 6 2018 Nov Annals of family medicine Ann Fam Med Clinic-Based Patellar Mobilization Therapy for KneeOsteoarthritis: A Randomized Clinical Trial. 521-529 10.1370/afm.2320 We performed a phase 2 randomized clinical trial to evaluate the preliminary effectiveness of a clinic-based patellar mobilization therapy (PMT) in patients with kneeosteoarthritis. We recruited 208 (...) patients with kneeosteoarthritis at primary care clinics in Hong Kong. Patients were randomly assigned (1:1) to the intervention group or the control group. The intervention group received 3 PMT treatment sessions from primary care physicians at 2-month intervals, with concomitant prescription of a home-based vastus medialis oblique muscle exercise. The control group received PMT after the study period. The primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC
Periosteal Electrical Dry Needling as an Adjunct to Exercise and Manual Therapy for KneeOsteoarthritis: A Multicenter Randomized Clinical Trial 29864043 2018 12 11 1536-5409 34 12 2018 Dec The Clinical journal of pain Clin J Pain Periosteal Electrical Dry Needling as an Adjunct to Exercise and Manual Therapy for KneeOsteoarthritis: A Multicenter Randomized Clinical Trial. 1149-1158 10.1097/AJP.0000000000000634 To compare the effects of adding electrical dry needling into a manual therapy (MT (...) ) and exercise program on pain, stiffness, function, and disability in individuals with painful kneeosteoarthritis (OA). In total, 242 participants (n=242) with painful kneeOA were randomized to receive 6 weeks of electrical dry needling, MT, and exercise (n=121) or MT and exercise (n=121). The primary outcome was related-disability as assessed by the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index at 3 months. Individuals receiving the combination of electrical dry needling, MT
Structured Education and Neuromuscular Exercise Program for Hip and/or KneeOsteoarthritis Public Comment: Held July 19 to August 9, 2018. Structured Education and Neuromuscular Exercise Program for Hip and/or KneeOsteoarthritis: Health Quality Ontario Recommendation FINAL RECOMMENDATION • Health Quality Ontario, under the guidance of the Ontario Health Technology Advisory Committee, recommends publicly funding a structured education and neuromuscular exercise program for the management (...) of people with osteoarthritis of the hip and/or knee RATIONALE FOR THE RECOMMENDATION The Ontario Health Technology Advisory Committee has reviewed the findings of the health technology assessment 1 and concluded that a structured education and neuromuscular exercise program provides clinical benefit in the management of hip and/or kneeosteoarthritis and is consistent with patient values and preferences. The Ontario Health Technology Advisory Committee supported data collection and outcome monitoring
Effectiveness of low-dose radiation therapy on symptoms in patients with kneeosteoarthritis: a randomised, double-blinded, sham-controlled trial 30366945 2018 10 27 1468-2060 2018 Oct 26 Annals of the rheumatic diseases Ann. Rheum. Dis. Effectiveness of low-dose radiation therapy on symptoms in patients with kneeosteoarthritis: a randomised, double-blinded, sham-controlled trial. annrheumdis-2018-214104 10.1136/annrheumdis-2018-214104 Low-dose radiation therapy (LDRT) for benign disorders (...) such as kneeosteoarthritis (OA) is widely used in some parts of the world, despite absence of controlled studies. We evaluated the effect of LDRT on symptoms and inflammation in patients with kneeOA. In this randomised, double-blinded, sham-controlled clinical trial (RCT), we recruited patients with kneeOA (clinical ACR criteria) in the Netherlands, aged ≥50 years, pain score ≥5/10 and non-responding to analgesics and exercise therapy. Patients were randomised 1:1 to receive LDRT (1 Gray per fraction
Smoothness of the knee joint movement during the stance phase in patients with severe kneeosteoarthritis 30202737 2018 11 14 2214-6873 14 2018 Oct Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology Asia Pac J Sports Med Arthrosc Rehabil Technol Smoothness of the knee joint movement during the stance phase in patients with severe kneeosteoarthritis. 1-5 10.1016/j.asmart.2018.08.002 Patients with kneeosteoarthritis can significantly affect the function (...) jerk value is linked with a decrease in smoothness. However few have reported to evaluate the smoothness of the knee joint movement during walking in patients with kneeosteoarthritis. The purpose of the present study was to quantify the smoothness of the knee joint movement during walking in people with kneeosteoarthritis. Patients were classified as having early or severe kneeosteoarthritis. There were eight patients in each group (16 knees; three males, five females). The normalized angular
Effectiveness and feasibility of acupuncture for kneeosteoarthritis: a pilot randomized controlled trial 30037276 2018 07 24 1477-0873 2018 Jul 01 Clinical rehabilitation Clin Rehabil Effectiveness and feasibility of acupuncture for kneeosteoarthritis: a pilot randomized controlled trial. 269215518790632 10.1177/0269215518790632 To evaluate the effectiveness of acupuncture for pain relief and function improvement in patients with kneeosteoarthritis and to determine the feasibility (...) of an eight-week acupuncture intervention. Pilot randomized controlled trial. Three teaching hospitals in China. Patients with kneeosteoarthritis (Kellgren grade II or III). Patients were randomly assigned to an eight-week (three sessions per week) intervention of either traditional Chinese acupuncture or sham acupuncture. The primary outcome was response rate-the proportion of patients achieving score ⩾36% decrease in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain
Is four-week underwater treadmill exercise regimen compared to home exercise efficacious for pain relief and functional improvement in obese patients with kneeosteoarthritis? A randomized controlled trial 30064262 2018 08 01 1477-0873 2018 Aug 01 Clinical rehabilitation Clin Rehabil Is four-week underwater treadmill exercise regimen compared to home exercise efficacious for pain relief and functional improvement in obese patients with kneeosteoarthritis? A randomized controlled trial (...) . 269215518792041 10.1177/0269215518792041 To investigate the efficacy of a four-week underwater treadmill exercise regimen compared to a home exercise regimen relative to pain relief and functional improvement in obese patients with kneeosteoarthritis. Single-blind randomized controlled trial. Outpatient. Eighty primary kneeosteoarthritis with pain ⩾5/10 and body mass index ⩾25 kg/m 2 . Daily quadriceps exercise at home for 30 minutes (control group) or underwater treadmill exercise (study group) for 30
Kneeosteoarthritis Top results for kneeosteoarthritis - Trip Database or use your Google+ account Find evidence fast My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box (...) and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for kneeosteoarthritis The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical
Kneeosteoarthritis in professional football is related to severe knee injury and knee surgery 29911282 2018 11 14 2197-1714 5 1 2018 Jun 18 Injury epidemiology Inj Epidemiol Kneeosteoarthritis in professional football is related to severe knee injury and knee surgery. 26 10.1186/s40621-018-0157-8 As a consequence of severe knee injuries, kneeosteoarthritis (OA) seems prevalent in retired professional footballers. However, some epidemiological data remain missing, for instance whether kneeOA (...) is also prevalent in current professional footballers, whether kneeOA is associated with knee injuries and surgeries, and whether kneeOA leads to a lower level of functioning. Therefore, three research questions were answered: (i) what is the prevalence of kneeosteoarthritis (OA) among current and retired professional footballers? (ii) is severe knee injury or knee surgery associated with kneeOA among current and retired professional footballers? (iii) what are the consequences of kneeOA on
MMP-3 in the peripheral serum as a biomarker of kneeosteoarthritis, 40Â years after open total knee meniscectomy 29904905 2018 11 14 2197-1153 5 1 2018 Jun 15 Journal of experimental orthopaedics J Exp Orthop MMP-3 in the peripheral serum as a biomarker of kneeosteoarthritis, 40 years after open total knee meniscectomy. 21 10.1186/s40634-018-0132-x To explore potential biomarkers in a meniscectomy-induced kneeosteoarthritis model, at forty years after meniscectomy. We carried out a forty (...) and peripheral serum was measured using Alcian blue precipitation and ELISA quantification, respectively. Patients also had their knee radiographs assessed and their radiographic osteoarthritis classified as per the Kellgren-Lawrence and Ahlbӓck systems. At forty years after meniscectomy, synovial MMP-3 levels remain increased (p = 0.0132) while GAG levels were reduced (p = 0.0487) when compared to controls and these two levels correlate inversely. Furthermore, levels of synovial MMP-3 significantly
Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on KneeOsteoarthritis Pain: A Double-Blinded, Randomized, Placebo-Controlled, Multinational Study 29664853 2018 06 15 1535-1386 100 8 2018 Apr 18 The Journal of bone and joint surgery. American volume J Bone Joint Surg Am Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on KneeOsteoarthritis Pain: A Double-Blinded, Randomized, Placebo (...) , double-blinded, 24-week study, adults ≥40 years of age with kneeosteoarthritis (Kellgren-Lawrence grade 2 or 3) and average-daily-pain (ADP)-intensity scores of ≥5 and ≤9 (0 to 10 numeric rating scale) were centrally randomized (1:1:1) to a single intra-articular injection of FX006 (32 mg), saline-solution placebo, or TAcs (40 mg). The primary end point was change from baseline to week 12 in weekly mean ADP-intensity scores for FX006 compared with saline-solution placebo. Secondary end points were
The effect of 12-week garlic supplementation on symptom relief in overweight or obese women with kneeosteoarthritis 29790635 2018 05 23 1742-1241 2018 May 23 International journal of clinical practice Int. J. Clin. Pract. The effect of 12-week garlic supplementation on symptom relief in overweight or obese women with kneeosteoarthritis. e13208 10.1111/ijcp.13208 Chronic joint pain and stiffness, and functional disability, are the major debilitating features of osteoarthritis (OA). The aim (...) of this study was to assess the effect of 12-week supplementation with a garlic supplement on kneeosteoarthritis outcomes in overweight or obese women. Seventy-six postmenopausal overweight or obese women (25≤BMI≤40 kg/m 2 ) with medically diagnosed kneeOA participated in this randomised double-blind, placebo-controlled, parallel-design trial. After randomisation into 2 groups, patients received a daily dose of either 1000 mg odourless garlic tablet, or placebo, for 12 weeks. The total Western Ontario
Systematic clinical evidence review of NASHA (Durolane hyaluronic acid) for the treatment of kneeosteoarthritis 29849470 2018 11 14 1179-156X 10 2018 Open access rheumatology : research and reviews Open Access Rheumatol Systematic clinical evidence review of NASHA (Durolane hyaluronic acid) for the treatment of kneeosteoarthritis. 43-54 10.2147/OARRR.S162127 Pain and limitations in joint mobility associated with kneeosteoarthritis (OA) are clinically challenging to manage, and advanced (...) progression of disease can often lead to total knee arthroplasty. Intra-articular injection of hyaluronic acid (HA), also referred to as viscosupplementation, is a non-surgical treatment approach for OA, the effectiveness of which may depend on the HA composition, and the length of time over which it resides in the joint. One of the available options for such therapies includes NASHA (Durolane HA), a non-animal, biofermentation-derived product, which is manufactured using a process that stabilizes the HA
A randomized, double-blind, placebo-controlled Phase III trial of duloxetine in Japanese patients with knee pain due to osteoarthritis 29713194 2018 05 03 1178-7090 11 2018 Journal of pain research J Pain Res A randomized, double-blind, placebo-controlled Phase III trial of duloxetine in Japanese patients with knee pain due to osteoarthritis. 809-821 10.2147/JPR.S164128 To examine the efficacy and safety of duloxetine in Japanese patients with knee pain due to osteoarthritis. Patients were (...) more frequent in the duloxetine than placebo group were somnolence, constipation, dry mouth, nausea, malaise, and decreased appetite. There were no marked changes in range of motion of the knee joint (efficacy), X-ray images, or Kellgren-Lawrence grade (safety) in either group. Duloxetine reduced pain and improved function in patients with kneeosteoarthritis, without causing X-ray abnormalities or altered knee joint mobility. Reduced pain was associated with improved HRQoL. Adverse events were
Fluoroscopic Guided Radiofrequency of Genicular Nerves for Pain Alleviation in Chronic KneeOsteoarthritis: A Single-Blind Randomized Controlled Trial 29565947 2018 03 22 2150-1149 21 2 2018 Mar Pain physician Pain Physician Fluoroscopic Guided Radiofrequency of Genicular Nerves for Pain Alleviation in Chronic KneeOsteoarthritis: A Single-Blind Randomized Controlled Trial. 169-177 Nowadays, pain and disability due to chronic knee arthritis is a very common problem in middle aged people. A lot (...) of modalities for management are available, including conservative analgesics and up to surgical interventions. Radiofrequency ablation of genicular nerves is assumed to be an effective less invasive and safe pain alleviation modality. To evaluate the efficacy of fluoroscopic guided radiofrequency neurotomy of the genicular nerves for alleviation of chronic pain and improvement of function in patients with kneeosteoarthritis. A single-blind randomized controlled trial. Pain management unit