Latest & greatest articles for ketamine

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Top results for ketamine

41. Adjunctive Atropine Versus Metoclopramide: Can We Reduce Ketamine-associated Vomiting in Young Children? A Prospective, Randomized, Open, Controlled Study

Adjunctive Atropine Versus Metoclopramide: Can We Reduce Ketamine-associated Vomiting in Young Children? A Prospective, Randomized, Open, Controlled Study 23009186 2012 10 16 2013 04 10 2013 11 21 1553-2712 19 10 2012 Oct Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Acad Emerg Med Adjunctive atropine versus metoclopramide: can we reduce ketamine-associated vomiting in young children? a prospective, randomized, open, controlled study. 1128-33 (...) 10.1111/j.1553-2712.2012.01457.x Pediatric procedural sedation and analgesia (PPSA) with ketamine administration occurs commonly in the emergency department (ED). Although ketamine-associated vomiting (KAV) is a less serious complication of ketamine administration, it seems to be cumbersome and not uncommon. The authors evaluated the incidence of KAV and the prophylactic effect of adjunctive atropine and metoclopramide in children receiving ketamine sedation in the ED setting. This prospective

EvidenceUpdates2012

42. Ketamine as an adjuvant to opioids for cancer pain.

Ketamine as an adjuvant to opioids for cancer pain. BACKGROUND: This is an update of the original review published in Issue 1, 2003. Ketamine is a commonly used anaesthetic agent, and in subanaesthetic doses is also given as an adjuvant to opioids for the treatment of cancer pain, particularly when opioids alone prove to be ineffective. Ketamine is known to have psychotomimetic (including hallucinogenic), urological and hepatic adverse effects. OBJECTIVES: To determine the effectiveness (...) and adverse effects of ketamine as an adjuvant to opioids in the treatment of cancer pain. SEARCH METHODS: Studies were originally identified from MEDLINE (1966 to 2002), EMBASE (1980 to 2002), CancerLit (1966 to 2002), The Cochrane Library (Issue 1, 2001); by handsearching reference lists from review articles, trials, and chapters from standard textbooks on pain and palliative care. The manufacturer of ketamine (Pfizer Parke-Davis) provided search results from their in-house database, PARDLARS.An

Cochrane2012

43. Ketamine for management of acute exacerbations of asthma in children.

Ketamine for management of acute exacerbations of asthma in children. BACKGROUND: Asthma is the most common chronic disease in children, and children with asthma frequently visit the paediatric emergency departments with acute exacerbations. Some of these children fail to respond to standard therapy (aerosol beta(2)-agonist with or without aerosol anticholinergic and oral or parenteral corticosteroids) for acute asthma leading to prolonged emergency department stay, hospitalisation, morbidity (...) (e.g. barotrauma, intubation) and death, albeit rarely. Ketamine may relieve bronchospasm and is a potentially promising therapy for children with acute asthma who fail to respond to standard treatment. OBJECTIVES: To evaluate the efficacy of ketamine compared to placebo, no intervention or standard care for management of severe acute asthma in children who had not responded to standard therapy. SEARCH METHODS: We identified trials from the Cochrane Airways Group Specialised Register of trials

Cochrane2012

44. The effect of perioperative intravenous lidocaine and ketamine on recovery after abdominal hysterectomy

The effect of perioperative intravenous lidocaine and ketamine on recovery after abdominal hysterectomy 23011561 2012 10 24 2013 01 01 2013 11 21 1526-7598 115 5 2012 Nov Anesthesia and analgesia Anesth. Analg. The effect of perioperative intravenous lidocaine and ketamine on recovery after abdominal hysterectomy. 1078-84 10.1213/ANE.0b013e3182662e01 Perioperative ketamine infusion reduces postoperative pain; perioperative lidocaine infusion reduces postoperative narcotic consumption, speeds (...) recovery of intestinal function, improves postoperative fatigue, and shortens hospital stay. However, it is unknown whether perioperative IV lidocaine and/or ketamine enhances acute functional recovery. We therefore tested the primary hypothesis that perioperative IV lidocaine and/or ketamine in patients undergoing open abdominal hysterectomy improves rehabilitation as measured by a 6-minute walk distance (6-MWD) on the second postoperative morning. Women having open hysterectomy were anesthetized

EvidenceUpdates2012

45. Ketamine-propofol combination (ketofol) versus propofol alone for emergency department procedural sedation and analgesia: a randomized double-blind trial

Ketamine-propofol combination (ketofol) versus propofol alone for emergency department procedural sedation and analgesia: a randomized double-blind trial 22401952 2012 05 25 2012 08 09 2013 11 21 1097-6760 59 6 2012 Jun Annals of emergency medicine Ann Emerg Med Ketamine-propofol combination (ketofol) versus propofol alone for emergency department procedural sedation and analgesia: a randomized double-blind trial. 504-12.e1-2 10.1016/j.annemergmed.2012.01.017 We determine whether a 1:1 mixture (...) of ketamine and propofol (ketofol) for emergency department (ED) procedural sedation results in a 13% or more absolute reduction in adverse respiratory events compared with propofol alone. Participants were randomized to receive either ketofol or propofol in a double-blind fashion. Inclusion criteria were aged 14 years or older and American Society of Anesthesiology class 1 to 3 status. The primary outcome was the number and proportion of patients experiencing an adverse respiratory event as defined

EvidenceUpdates2012

46. Morphine and Ketamine Is Superior to Morphine Alone for Out-of-Hospital Trauma Analgesia: A Randomized Controlled Trial

Morphine and Ketamine Is Superior to Morphine Alone for Out-of-Hospital Trauma Analgesia: A Randomized Controlled Trial 22243959 2012 05 25 2012 08 09 2013 11 21 1097-6760 59 6 2012 Jun Annals of emergency medicine Ann Emerg Med Morphine and ketamine is superior to morphine alone for out-of-hospital trauma analgesia: a randomized controlled trial. 497-503 10.1016/j.annemergmed.2011.11.012 We assess the efficacy of intravenous ketamine compared with intravenous morphine in reducing pain (...) in adults with significant out-of-hospital traumatic pain. This study was an out-of-hospital, prospective, randomized, controlled, open-label study. Patients with trauma and a verbal pain score of greater than 5 after 5 mg intravenous morphine were eligible for enrollment. Patients allocated to the ketamine group received a bolus of 10 or 20 mg, followed by 10 mg every 3 minutes thereafter. Patients allocated to the morphine alone group received 5 mg intravenously every 5 minutes until pain free. Pain

EvidenceUpdates2012

47. The Reduction Of The Adverse Effects Of Ketamine When Combined With Midazolam During Anesthesia

The Reduction Of The Adverse Effects Of Ketamine When Combined With Midazolam During Anesthesia UTCAT2287, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title The Reduction Of The Adverse Effects Of Ketamine When Combined With Midazolam During Anesthesia Clinical Question In the anesthetized patient, does the combination of ketamine (Ketalar) with midazolam (Versed) reduce the adverse effects (hallucinations) produced (...) by ketamine when it is used alone? Clinical Bottom Line The combination of ketamine and midazolam reduces the adverse effects produced by ketamine when it is used alone. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Sener/2011 182 adult emergency department patients; 18-50 years old Randomized double blind trial Key results Less recovery agitation was shown in patients receiving midazolam (8% versus 25

UTHSCSA Dental School CAT Library2012

48. Procedural sedation with propofol for painful orthopaedic manipulation in the emergency department expedites patient management compared with a midazolam/ketamine regimen: a randomized prospective study

Procedural sedation with propofol for painful orthopaedic manipulation in the emergency department expedites patient management compared with a midazolam/ketamine regimen: a randomized prospective study 22258771 2012 01 19 2012 03 12 2016 05 12 1535-1386 93 24 2011 Dec 21 The Journal of bone and joint surgery. American volume J Bone Joint Surg Am Procedural sedation with propofol for painful orthopaedic manipulation in the emergency department expedites patient management compared (...) with a midazolam/ketamine regimen: a randomized prospective study. 2255-62 10.2106/JBJS.J.01307 The use of procedural sedation and analgesia to allow painful orthopaedic manipulations in the emergency department has become a standard practice over the last decade. Both propofol and midazolam/ketamine are attractive sedative regimens for routine use in the emergency department. We hypothesized that sedation with propofol as compared with midazolam/ketamine will save time in the emergency department. The purpose

EvidenceUpdates2012

49. Ketamine for depression: where do we go from here?

Ketamine for depression: where do we go from here? Ketamine for depression: where do we go from here? Ketamine for depression: where do we go from here? aan het Rot M, Zarate CA, Charney DS, Mathew SJ CRD summary The review concluded that ketamine seemed a reasonable treatment option for most patients with treatment resistant depression when administered by trained clinicians in appropriate settings. This was a poorly reported review that was at risk of various forms of bias. The synthesis (...) was limited which suggests that definitive conclusions cannot be drawn, and the authors’ conclusions cannot be considered reliable. Authors' objectives To evaluate the antidepressant effects of ketamine for patients with major depressive episodes. Searching PubMed was searched to January 2012 for relevant articles; search terms were reported. ClinicalTrials.gov was also searched for studies that were unpublished, currently recruiting participants or not yet enrolling. Additional relevant studies cited

DARE.2012

50. Ketamine for mood disorders

Ketamine for mood disorders Ketamine for mood disorders Ketamine for mood disorders Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Ketamine for mood disorders. Lansdale: HAYES, Inc.. Directory Publication. 2012 Authors' conclusions Intravenous injection of ketamine hydrochloride is intended to reduce symptoms of depression in patients with treatment-resistant (...) depression. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Humans; Ketamine; Mood Disorders Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218 Email: hayesinfo@hayesinc.com AccessionNumber 32013000192 Date abstract record published 25/03

Health Technology Assessment (HTA) Database.2012

51. The Use of Ketamine to Decrease Depressive Symptoms in Adults With Major Depressive Disorder

The Use of Ketamine to Decrease Depressive Symptoms in Adults With Major Depressive Disorder "The Use of Ketamine to Decrease Depressive Symptoms in Adults With Maj" by Jessica Otis < > > > > > Title Author Date of Award Summer 8-11-2012 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Annjanette Sommers PA-C, MS Rights . Abstract Background: Mental Health Conditions including Major Depressive Disorders cause many emergency department (...) visits and hospital admissions with few acute treatment options. The use of N-methyl-D-aspartate antagonist drugs such as Ketamine show promise in treatment of these patients. Method: Exhaustive search of medical literature using MEDLINE, CINAHL, PsychInfo, and EBM multifiles was conducted, using search terms Ketamine, Major Depressive Disorder, N-methyl-D-aspartate Antagonist, Excitatory Amino Acid Antagonist. Articles that were not randomized control trials or were duplicates were excluded. Results

Pacific University EBM Capstone Project2012

52. Is ketamine a viable induction agent for the trauma patient with potential brain injury.

Is ketamine a viable induction agent for the trauma patient with potential brain injury. BestBets: Is ketamine a viable induction agent for the trauma patient with potential brain injury. Is ketamine a viable induction agent for the trauma patient with potential brain injury. Report By: Sian Hughes - CT3 Emergency Medicine Search checked by Dan Horner and Janos Baombe - Research Fellow / Senior Emergency Trainee Institution: Morriston Hospital Swansea NHS Trust Original institution: Central (...) Manchester University Hospitals NHS Foundation Trust Current web editor: Stewart Teece - Clinical Research Fellow Date Submitted: 30th April 2011 Date Completed: 30th November 2011 Last Modified: 30th November 2011 Status: Green (complete) Three Part Question In [adults with head injury necessitating emergency intubation] does [the use of ketamine as an induction agent, compared to any other standard agent] lead to [increased morbidity/mortality]? Clinical Scenario A 26 year-old male is brought

BestBETS2011

53. Intravenous ketamine for chronic nonmalignant pain

Intravenous ketamine for chronic nonmalignant pain Intravenous ketamine for chronic nonmalignant pain Intravenous ketamine for chronic nonmalignant pain Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Intravenous ketamine for chronic nonmalignant pain. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2011 Authors' objectives Chronic pain, or pain (...) or a multidisciplinary plan including physical therapy, drug therapy, sympathetic nerve block, spinal cord stimulation, and intrathecal drug pumps to deliver opioids and local anesthetic agents via the spinal cord. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Infusions, Intravenous; Ketamine; Pain Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES

Health Technology Assessment (HTA) Database.2011

54. A randomized controlled trial of ketamine/propofol versus propofol alone for emergency department procedural sedation

A randomized controlled trial of ketamine/propofol versus propofol alone for emergency department procedural sedation 21256626 2011 04 25 2011 06 29 2013 11 21 1097-6760 57 5 2011 May Annals of emergency medicine Ann Emerg Med A randomized controlled trial of ketamine/propofol versus propofol alone for emergency department procedural sedation. 435-41 10.1016/j.annemergmed.2010.11.025 We compare the frequency of respiratory depression during emergency department procedural sedation with ketamine (...) plus propofol versus propofol alone. Secondary outcomes are provider satisfaction, sedation quality, and total propofol dose. In this randomized, double-blind, placebo-controlled trial, healthy children and adults undergoing procedural sedation were pretreated with intravenous fentanyl and then randomized to receive either intravenous ketamine 0.5 mg/kg or placebo. In both groups, this procedure was immediately followed by intravenous propofol 1 mg/kg, with repeated doses of 0.5 mg/kg as needed

EvidenceUpdates2011

55. Brief report: the effect of suggestion on unpleasant dreams induced by ketamine administration

Brief report: the effect of suggestion on unpleasant dreams induced by ketamine administration 21346162 2011 04 25 2012 07 13 2013 11 21 1526-7598 112 5 2011 May Anesthesia and analgesia Anesth. Analg. Brief report: the effect of suggestion on unpleasant dreams induced by ketamine administration. 1082-5 10.1213/ANE.0b013e31820eeb0e The use of ketamine may be associated with the recall of unpleasant dreams after sedation. We hypothesized that a positive suggestion before sedation could reduce (...) the incidence of ketamine-induced unpleasant dreams. To test this hypothesis, we randomized 100 patients receiving sedation with ketamine for their procedure into 2 groups with 1 group having an anesthesiologist provide a mood-elevating suggestion to the patient before ketamine administration (suggestion group), whereas in the control group no suggestion was provided. Patients were provided with a pleasantness/unpleasantness scale to rate "the overall mood of the dream" as very unpleasant (grade 1), quite

EvidenceUpdates2011

56. Ketamine, but not priming, improves intubating conditions during a propofol-rocuronium induction

Ketamine, but not priming, improves intubating conditions during a propofol-rocuronium induction 19908105 2010 01 22 2010 04 05 2013 11 21 1496-8975 57 2 2010 Feb Canadian journal of anaesthesia = Journal canadien d'anesthesie Can J Anaesth Ketamine, but not priming, improves intubating conditions during a propofol-rocuronium induction. 113-9 10.1007/s12630-009-9217-4 Both ketamine and priming may shorten the onset time of rocuronium. This study investigates the effects of ketamine and priming (...) as components of a propofol induction on intubating conditions and onset of neuromuscular block. This prospective randomized double-blind study was performed in 120 American Society of Anesthesiologists (ASA) I-II patients who were assigned to one of four groups of 30 patients each: control, priming, ketamine, and ketamine-priming. Ketamine 0.5 mg x kg(-1) or saline was given before priming and induction. Rocuronium 0.06 mg x kg(-1) or saline was injected 2 min before propofol 2.5 mg x kg(-1

EvidenceUpdates2010

57. Preemptive analgesic effect of ketamine in patients undergoing elective cesarean section

Preemptive analgesic effect of ketamine in patients undergoing elective cesarean section 20173436 2010 02 22 2010 05 13 2013 11 21 1536-5409 26 3 2010 Mar-Apr The Clinical journal of pain Clin J Pain Preemptive analgesic effect of ketamine in patients undergoing elective cesarean section. 223-6 10.1097/AJP.0b013e3181bff86d In this study, the preemptive effect of a small dose of ketamine on postoperative wound pain and morphine consumption in patients undergoing elective cesarean section (...) was evaluated. In a randomized, double-blind clinical trial, 60 women with American Society of Anesthesiologists class I and II identification undergoing elective cesarean section were enrolled. In the case group, the patients received 0.5 mg/kg ketamine, and in the control group, they received isotonic saline, 5 minutes before the induction of anesthesia. Anesthesia was induced with 4 mg/kg thiopental followed by 1.5 mg/kg succinylcholine. A further neuromuscular block was achieved by using 0.2 mg/kg

EvidenceUpdates2010

58. The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study

The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study 19923527 2009 11 20 2009 12 03 2013 11 21 1526-7598 109 6 2009 Dec Anesthesia and analgesia Anesth. Analg. The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. 1963-71 10.1213/ANE.0b013e3181bdc8a0 Ketamine has been shown to have a morphine-sparing effect soon after (...) surgery. Nevertheless, whether this effect still exists after being combined with nonsteroidal antiinflammatory drugs and acetaminophen, and whether ketamine can decrease chronic pain after nononcologic surgery remain unclear. Thus, we designed a study to assess ketamine's effect on acute and chronic postoperative pain when combined with multimodal analgesia after total hip arthroplasty (THA). Patients scheduled for primary nononcologic THA using standardized general anesthesia were randomized

EvidenceUpdates2010

59. Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1

Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1 19604642 2009 09 11 2009 12 07 2013 11 21 1872-6623 145 3 2009 Oct Pain Pain Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1. 304-11 10.1016/j.pain.2009.06.023 Complex Regional Pain Syndrome Type 1 (CRPS-1) responds poorly to standard pain treatment. We evaluated if the N-methyl-D-aspartate receptor antagonist S(+)-ketamine (...) improves pain in CRPS-1 patients. Sixty CRPS-1 patients (48 females) with severe pain participated in a double-blind randomized placebo-controlled parallel-group trial. Patients were given a 4.2-day intravenous infusion of low-dose ketamine (n=30) or placebo (n=30) using an individualized stepwise tailoring of dosage based on effect (pain relief) and side effects (nausea/vomiting/psychomimetic effects). The primary outcome of the study was the pain score (numerical rating score: 0-10) during the 12

EvidenceUpdates2010

60. Postoperative analgesia and early rehabilitation after total knee replacement: a comparison of continuous low-dose intravenous ketamine versus nefopam

Postoperative analgesia and early rehabilitation after total knee replacement: a comparison of continuous low-dose intravenous ketamine versus nefopam 18793861 2009 06 09 2009 08 12 2013 11 21 1532-2149 13 6 2009 Jul European journal of pain (London, England) Eur J Pain Postoperative analgesia and early rehabilitation after total knee replacement: a comparison of continuous low-dose intravenous ketamine versus nefopam. 613-9 10.1016/j.ejpain.2008.08.003 The effects of nefopam and ketamine (...) on pain control and rehabilitation after total knee replacement were compared in a prospective, double blinded study. Seventy-five patients were randomly assigned to receive a 0.2mg kg(-1) bolus of nefopam or ketamine, followed by a 120microg kg(-1) h(-1) continuous infusion until the end of surgery, and 60microg kg(-1) h(-1) until the second postoperative day, or an equal volume of saline considered as placebo. Pain scores measured on a visual analog scale at rest and on mobilization, and patient

EvidenceUpdates2009