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Latest & greatest articles for ketamine
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The relationship between subjective effects induced by a single dose of ketamine and treatment response in patients with major depressive disorder: A systematic review. The relationship between ketamine's hallucinogenic- and dissociative-type effects and antidepressant mechanism of action is poorly understood. This paper reviewed the correlation between subjective effects defined by various psychometric scales and observed clinical outcomes in the treatment of patients with Major Depressive (...) Disorder (MDD).Based on PRISMA guidelines, we reviewed the dissociative and psychotomimetic mental state induced with ketamine during MDD treatment. Our selected studies correlated depression rating with validated scales collected at regular intervals throughout the study period such as the Clinician-Administered Dissociative States Scale (CADSS), Brief Psychiatric Rating Scale (BPRS), and the 5-Dimensional Altered States of Consciousness Rating Scale (5D-ASC). We excluded studies with bipolar
The effect of ketamine on emergence agitation in children: A systematic review and meta-analysis. Ketamine is believed to reduce the incidence of emergence agitation in children undergoing surgery or procedure. However, recent randomized controlled trials reported conflicting findings.To investigate the effect of ketamine on emergence agitation in children.Databases of MEDLINE, EMBASE, and CENTRAL were systematically searched from their start date until February 2019. Randomized controlled (...) trials comparing intravenous ketamine and placebo in children were sought. The primary outcome was the incidence of emergence agitation. Secondary outcomes included postoperative pain score, duration of discharge time, and the adverse effects associated with the use of ketamine, namely postoperative nausea and vomiting, desaturation, and laryngospasm.Thirteen studies (1125 patients) were included in the quantitative meta-analysis. The incidence of emergence agitation was 14.7% in the ketamine group
Reply letter to: "Commentary on: Ketamine reduces pain and opioid consumption after total knee arthroplasty: A meta-analysis of randomized controlled studies". 31639452 2020 02 06 2020 02 06 1743-9159 72 2019 12 International journal of surgery (London, England) Int J Surg Reply letter to: "Commentary on: Ketamine reduces pain and opioid consumption after total knee arthroplasty: A meta-analysis of randomized controlled studies". 43-44 S1743-9191(19)30282-1 10.1016/j.ijsu.2019.09.034 Wang (...) Chenxi C Department of Orthopedics and Traumatology, Yuncheng County Hospital of Traditional Chinese Medicine, Shandong Province, 274700, China. Electronic address: firstname.lastname@example.org. Zhang Jian J Department of Orthopedics and Traumatology, Yuncheng County Hospital of Traditional Chinese Medicine, Shandong Province, 274700, China. Electronic address: email@example.com. eng Editorial Comment 2019 10 19 England Int J Surg 101228232 1743-9159 0 Analgesics, Opioid 690G0D6V8H Ketamine IM Int J Surg. 2019 Oct
Ketamine for emergency sedation of agitated patients: A systematic review and meta-analysis Prior studies suggest that ketamine is effective for acute agitation in the emergency department (ED) and prehospital settings. This systematic review and meta-analysis aims to evaluate the rate of sedation and need for airway management in patients given ketamine for management of acute agitation. Methods: We performed a systematic review of publications describing the use of ketamine to control (...) agitation in the ED and prehospital settings. Studies were included if they included agitated patients, used ketamine to control agitation, occurred in the ED and prehospital setting and measured sedation status or need for airway management. Following data abstraction, a meta-analysis was performed to synthesize the rate of effective sedation and the need for airway management. Result: 13 studies met the inclusion criteria. 10 studies were conducted in the prehospital setting and 3 in the ED setting
Use of ketamine for prehospital pain control on the battlefield: A systematic review. Intravenous ketamine is commonly used for pain management in the civilian prehospital setting. Several studies have evaluated its effectiveness in the military setting. To date, there has been no report reviewing the published data on the use of ketamine in this context. The objective of this systematic review was to analyze the content and quality of published data on the use of ketamine for prehospital pain (...) management in military trauma.The MEDLINE database was searched for studies on ketamine use in combat prehospital settings, at point of injury or during evacuation, published between 2000 and 2019. The systematic review was conducted following PRISMA guidelines, and the protocol was registered on PROSPERO (CRD42019115728). Civilian reports and case series lacking systematic data collection were excluded.Eight studies were included with 2029 casualties receiving ketamine. All but one were American reports
In Search of Solutions for Chronic Pain: A Meta-analysis of Ketamine Infusions. 31206441 2020 01 06 1526-7598 129 1 2019 07 Anesthesia and analgesia Anesth. Analg. In Search of Solutions for Chronic Pain: A Meta-analysis of Ketamine Infusions. 1 10.1213/ANE.0000000000004244 Nathan Naveen N Northwestern University Feinberg School of Medicine (firstname.lastname@example.org). eng Journal Article United States Anesth Analg 1310650 0003-2999 AIM IM 2019 6 18 6 0 2019 6 18 6 0 2019 6 18 6 1 ppublish
Ketamine reduces pain and opioid consumption after total knee arthroplasty: A meta-analysis of randomized controlled studies. To examine the analgesic efficacy and safety of ketamine after total knee arthroplasty.We searched for all articles on ketamine in patients with total knee arthroplasty in electronic databases, including PubMed, Embase, Ovid, Cochrane Library, Web of Science, CNKI, Wanfang Data, and VIP, up to the February 2019. Randomized controlled trials comparing ketamine (...) regarding the pain score within the first 24 postoperative hours. Ketamine was associated with a significant reduction of cumulative morphine consumption. Notably, ketamine could significantly decrease the incidence of nausea and vomiting without increasing the risk of thrombosis.Ketamine is effective in reducing pain and cumulative morphine consumption during the early post-operative period after total knee arthroplasty. In addition, the use of ketamine is associated with a lower incidence of adverse
Commentary on "Ketamine reduces pain and opioid consumption after total knee arthroplasty: A meta-analysis of randomized controlled studies" (Int J Surg 2019;70:70-83). 31600568 2019 11 25 2019 11 25 1743-9159 71 2019 11 International journal of surgery (London, England) Int J Surg Commentary on "Ketamine reduces pain and opioid consumption after total knee arthroplasty: A meta-analysis of randomized controlled studies" (Int J Surg 2019;70:70-83). 172-173 S1743-9191(19)30259-6 10.1016/j.ijsu (...) .2019.09.028 Ding Weizhong W Department of Orthopedic Surgery, The Second Affiliated Hospital, Chongqing Medical University, 400010, China. Chen Shirong S Department of Orthopedic Surgery, The Second Affiliated Hospital, Chongqing Medical University, 400010, China. Electronic address: email@example.com. eng Editorial Comment 2019 10 07 England Int J Surg 101228232 1743-9159 0 Analgesics, Opioid 690G0D6V8H Ketamine IM Int J Surg. 2019 Oct;70:70-83 31446006 Int J Surg. 2019 Dec;72:43-44 31639452 Analgesics
Corrigendum to 'Ketamine in electroconvulsive therapy for depressive disorder: A systematic review and meta-analysis' [Journal of Psychiatric Research 104 (2018) 144-156]. 30408654 2019 11 20 1879-1379 108 2019 01 Journal of psychiatric research J Psychiatr Res Corrigendum to 'Ketamine in electroconvulsive therapy for depressive disorder: A systematic review and meta-analysis' [Journal of Psychiatric Research 104 (2018) 144-156]. 1 S0022-3956(18)31110-5 10.1016/j.jpsychires.2018.09.009 Ren Li L
The efficacy of ketamine supplementation on pain management for knee arthroscopy: A meta-analysis of randomized controlled trials: Erratum. 31415441 2019 11 12 2019 11 20 1536-5964 98 33 2019 08 Medicine Medicine (Baltimore) The efficacy of ketamine supplementation on pain management for knee arthroscopy: A meta-analysis of randomized controlled trials: Erratum. e16918 10.1097/MD.0000000000016918 eng Journal Article Published Erratum United States Medicine (Baltimore) 2985248R 0025-7974 AIM IM
Effects of Ketamine Anesthesia on Efficacy, Tolerability, Seizure Response, and Neurocognitive Outcomes in Electroconvulsive Therapy: A Comprehensive Meta-analysis of Double-Blind Randomized Controlled Trials. Electroconvulsive therapy (ECT) remains the most effective treatment for major depressive disorder. Ketamine is an anesthetic gaining attention for its rapid antidepressant effect. Numerous randomized controlled trials have investigated the effect of ketamine anesthesia in ECT on various (...) clinical outcomes. Previous systematic reviews have not found benefit for overall depression response, although some have found evidence of benefit early in the ECT course. Clear quantitative conclusions have not been established regarding other outcomes, particularly while only using data from high-quality studies. We aimed to examine all data from double-blind randomized controlled trials comparing ketamine to other anesthetics via meta-analysis, to make recommendations regarding ECT practice
A meta-analysis of pharmacological neuroprotection in noncardiac surgery: focus on statins, lidocaine, ketamine, and magnesium sulfate. Non-cardiac surgery is associated with perioperative cerebral complications (delirium, postoperative cognition dysfunction, stroke). While rare, these complications can lead to disabilities and deaths. Information is ambiguous as to whether pharmacological preoperative treatment exerts neuroprotection. We wished to systematically assess potential modulation (...) by statins, lidocaine, ketamine or magnesium sulfate of the relative risk of cerebral complications in noncardiac surgery. Selection of these pharmacological agents was based on their known neuroprotective abilities.By searching Medline, EMBASE and Cochrane databases, we identified 4 suitable publications that collectively enrolled 1358 patients (intent-to-treat population), of which 679 patients were treated preoperatively with statins (404 patients on atorvastatin and 275 on rosuvastatin) and 679
Dexamethasone Versus Ketamine in the Interscalene Block in Patients Undergoing Arthroscopic Shoulder Surgery: A Randomized Double-Blinded Study. Arthroscopic shoulder surgery (ASS) is often followed by severe pain. Interscalene brachial plexus block (ISB) was used to relieve such pain. The aim of the study was to compare the effect of adding either dexamethasone or ketamine to ISB on time to the fi rst request for analgesia.Sixty patients scheduled for ASS were enrolled in this study. Before (...) induction of general anaesthesia, patients were randomly allocated to two groups; in Group D, patients received ISB with bupivacaine 0.3%, 5 mL lidocaine 2% plus 8 mg dexamethasone. Whereas in Group K, patients received ISB with bupivacaine 0.3%, 5 mL lidocaine 2% plus 50 mg ketamine. Time to the fi rst administration of supplemental analgesic postoperative was our primary concern. Secondary outcomes included pain score, patient satisfaction, and side effects of either block or drugs. Student's t-test
Ketamine for Refractory Status Epilepticus: A Systematic Review. Ketamine is an emerging third-line medication for refractory status epilepticus, a medical and neurological emergency requiring prompt and appropriate treatment. Owing to its pharmacological properties, ketamine represents a practical alternative to conventional anaesthetics.The objective of this study was to assess the efficacy and safety of ketamine to treat refractory status epilepticus in paediatric and adult populations.We (...) of the status epilepticus type, ketamine was twice as effective if administered early, with an efficacy rate as high as 64% in refractory status epilepticus lasting 3 days and dropping to 32% when the mean refractory status epilepticus duration was 26.5 days. Ketamine doses were extremely heterogeneous and did not appear to be an independent prognostic factor. Endotracheal intubation, a negative prognostic factor for status epilepticus, was unnecessary in 12 individuals (10 children), seven of whom were
Ketamine for Pharmacological Management of Aggression and Agitation in Pre-Hospital Settings: A Review of Comparative Clinical Effectiveness, Safety and Guidelines Ketamine for Pharmacological Management of Aggression and Agitation in Pre-Hospital Settings: A Review of Comparative Clinical Effectiveness, Safety and Guidelines | CADTH.ca Find the information you need Ketamine for Pharmacological Management of Aggression and Agitation in Pre-Hospital Settings: A Review of Comparative Clinical (...) Effectiveness, Safety and Guidelines Ketamine for Pharmacological Management of Aggression and Agitation in Pre-Hospital Settings: A Review of Comparative Clinical Effectiveness, Safety and Guidelines Last updated: May 13, 2019 Project Number: RC1118-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the comparative evidence regarding safety of ketamine administration performed in pre-hospital settings versus by a physician
Ketamine in electroconvulsive therapy for depressive disorder: A systematic review and meta-analysis. Electroconvulsive therapy (ECT) is one of the most effective treatments for depressive disorder. Sub-anesthetic dose of ketamine exerts a rapid and robust antidepressive effect. However, it is still unclear whether ketamine usage in ECT is efficacious as an antidepressant. We aimed to conduct a systematic review and meta-analysis on the effects of ketamine in ECT among patients with depressive (...) disorder. MEDLINE, EMBASE, the CENTRAL and PsycINFO for randomized controlled trials were searched to assess the effects of ketamine used in ECT until 31 Mar 2018 (PROSPERO: CRD42018081024). Sixteen studies including 928 patients were enrolled. At the end of ECT, no significant standardized mean difference (SMD) was observed in favor of the ketamine group. Depressive scores were lower in the ketamine group after 1st ECT and 3rd to 6th ECTs. The depressive scores were lower after 2nd, 3rd, 4th and 6th
Analgesic efficacy and safety of ketamine after total knee or hip arthroplasty: a meta-analysis of randomised placebo-controlled studies. To examine the analgesic efficacy and safety of ketamine after total knee or hip arthroplasty.Systematic review and meta-analysis.PubMed, EMBASE and Cochrane Library from inception to 22 May 2019.Randomised controlled trials comparing the efficacy and safety of ketamine with placebo for postoperative pain relief in patients undergoing total knee or hip (...) arthroplasty.Data (ie, pain intensity, morphine consumption, gastrointestinal and psychotic adverse effects) were extracted by two reviewers independently. The Cochrane Collaboration's recommended tool was used to determine the methodological quality of included studies.A total of 10 studies were included. One of them was rated as low quality. Compared with placebo, intravenous ketamine was effective for pain relief during 0-8-hour (weighted mean difference (WMD) -1.21, 95% CI -1.45 to -0.98, p<0.001; three
A meta-analysis of randomized controlled trials: combination of ketamine and propofol versus ketamine alone for procedural sedation and analgesia in children. Although ketamine has been used for procedural sedation and analgesia, some researchers have assessed ketamine-propofol as a better alternative because of its reduced adverse events. The goal of this review was to compare adverse events between ketamine-propofol and ketamine for procedural sedation and analgesia in children. We searched (...) the literature from their inception to May 2018 without the restriction of language. We included all randomized controlled trials comparing ketamine-propofol with ketamine for procedural sedation and analgesia in children. The meta-analysis was conducted using the Stata software. A total of six studies involving 693 individuals were included. Pooling of data showed that subjects with ketamine-propofol had similar incidence of respiratory adverse events compared to those with ketamine (RR 1.16, 95% CI 0.68