Latest & greatest articles for insulin

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Top results for insulin

841. Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus. (Abstract)

Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus. We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular

1995 Lancet Controlled trial quality: uncertain

842. Cost-effectiveness analyses of the conversion of patients with non-insulin-dependent diabetes mellitus from glipizide to glyburide and of the accompanying pharmacy follow-up clinic

Cost-effectiveness analyses of the conversion of patients with non-insulin-dependent diabetes mellitus from glipizide to glyburide and of the accompanying pharmacy follow-up clinic Cost-effectiveness analyses of the conversion of patients with non-insulin-dependent diabetes mellitus from glipizide to glyburide and of the accompanying pharmacy follow-up clinic Cost-effectiveness analyses of the conversion of patients with non-insulin-dependent diabetes mellitus from glipizide to glyburide (...) and of the accompanying pharmacy follow-up clinic Law A, Pathak D, Segraves A, Weinstein C, Arneson W Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Treatment for non-insulin-dependent diabetes mellitus. In particular: (1) glipizide therapy; (2

1995 NHS Economic Evaluation Database.

843. Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation

Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation Kiberd B A, Jindal K K Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , macroproteinuria or both (dipstick >0.3 g/l orpositive Albustix confirmed with >300 mg/day or >200 micrograms/minute proteinuria). Type of intervention Screening and secondary prevention. Economic study type Cost-utility analysis. Study population Hypothetical cohort of patients with insulin dependent diabetes for at least five years and patients with hypertension or macroproteinuria. Setting Hospital/primary care. The economic evaluation was carried out in Nova Scotia, Canada. Dates to which data relate

1995 NHS Economic Evaluation Database.

844. A review of the weight loss interventions for obese people with non-insulin-dependent diabetes mellitus

A review of the weight loss interventions for obese people with non-insulin-dependent diabetes mellitus A review of the weight loss interventions for obese people with non-insulin-dependent diabetes mellitus A review of the weight loss interventions for obese people with non-insulin-dependent diabetes mellitus Ciliska D, Kelly C, Petrov N, Chalmers J Authors' objectives To review the literature on the long-term results of weight loss in the non-insulin-dependent diabetes mellitus (NIDDM (...) ) population. Searching MEDLINE, CINAHL and PsycINFO were searched from 1985 using the terms 'non-insulin-dependent diabetes mellitus' combined with 'weight loss' or 'diet'. Reference lists of retrieved articles were searched for additional references, including those before 1985. Two experts in the field were asked to review the list of retrieved articles to identify if any key articles were missing. Study selection Study designs of evaluations included in the review Studies with a comparison group

1995 DARE.

845. Continuous subcutaneous insulin infusion (CSII) in children and adolescents with chronic poorly controlled type 1 diabetes mellitus

Continuous subcutaneous insulin infusion (CSII) in children and adolescents with chronic poorly controlled type 1 diabetes mellitus Continuous subcutaneous insulin infusion (CSII) in children and adolescents with chronic poorly controlled type 1 diabetes mellitus Continuous subcutaneous insulin infusion (CSII) in children and adolescents with chronic poorly controlled type 1 diabetes mellitus Steindel B S, Roe T R, Costin G, Carlson M, Kaufman F R Record Status This is a critical abstract (...) of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Continuous subcutaneous insulin infusion using the MiniMed (Sylmar, CA) CSII system. Type of intervention Secondary prevention, treatment. Economic study type Cost-effectiveness analysis. Study population Children and adolescents

1995 NHS Economic Evaluation Database.

846. Cost-effectiveness of medical nutrition therapy provided by dietitians for persons with non-insulin-dependent diabetes mellitus

Cost-effectiveness of medical nutrition therapy provided by dietitians for persons with non-insulin-dependent diabetes mellitus Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

1995 NHS Economic Evaluation Database.

847. Effect of glycemic control on early diabetic renal lesions. A 5-year randomized controlled clinical trial of insulin-dependent diabetic kidney transplant recipients. (Abstract)

Effect of glycemic control on early diabetic renal lesions. A 5-year randomized controlled clinical trial of insulin-dependent diabetic kidney transplant recipients. To determine whether optimized glycemic control in type I diabetic recipients of renal allografts will prevent or delay diabetic renal lesions in the allograft.Prospective, controlled, and randomized trial of glycemic control in an inception cohort of type I diabetic renal allograft recipients. The experimental group underwent (...) the trial.Subcutaneous insulin given several times a day or continuously (maximized group) and once or twice each day (standard group) was used throughout the trial. A significant difference for hemoglobin A1 level was maintained (mean +/- SD: standard, 0.117 +/- 0.013; maximized, 0.096 +/- 0.016; P < 0.001).The primary end point of this trial was the difference between the groups in renal glomerular mesangial expansion as determined by electron microscopy.There was a more than twofold increase in the volume

1994 JAMA Controlled trial quality: uncertain

848. [Insulin treatment for diabetes on the day of surgery]. (Abstract)

[Insulin treatment for diabetes on the day of surgery]. 1670109 1994 06 09 2011 11 17 0012-7183 106 5 1990 Duodecim; laaketieteellinen aikakauskirja Duodecim [Insulin treatment for diabetes on the day of surgery]. 415-21 Kuusisto A A Jorvin sairaala, Espoo, Finland. fin Clinical Trial Controlled Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't Diabeteksen insuliinihoito leikkauspäivänä. Finland Duodecim 0373207 0012-7183 0 Blood Glucose 0 Insulin IM (...) Blood Glucose metabolism Diabetes Mellitus, Type 1 blood drug therapy Humans Injections, Subcutaneous Insulin administration & dosage Insulin Infusion Systems Preoperative Care 1990 1 1 1990 1 1 0 1 1990 1 1 0 0 ppublish 1670109

1994 Duodecim; laaketieteellinen aikakauskirja Controlled trial quality: uncertain

849. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. (Abstract)

Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. Troglitazone decreases insulin resistance and hyperglycemia in patients with non-insulin-dependent diabetes mellitus (NIDDM), but its effects on subjects without diabetes are not known.We performed oral and intravenous glucose-tolerance tests, studies with the euglycemic-hyperinsulinemic clamp, meal-tolerance tests, and 24-hour blood-pressure measurements at base line and after (...) the administration of troglitazone, 200 mg orally twice daily, or placebo for 12 weeks in 18 nondiabetic obese subjects, 9 of whom had impaired glucose tolerance.The mean (+/- SD) rates of glucose disposal increased from 4.7 +/- 1.7 to 6.0 +/- 1.7 mg per kilogram of body weight per minute (P = 0.004) and from 9.0 +/- 1.8 to 9.9 +/- 1.3 mg per kilogram per minute (P = 0.02) during insulin infusions of 40 and 300 mU per square meter of body-surface area per minute, respectively, in the troglitazone group

1994 NEJM Controlled trial quality: uncertain

850. Effects of low dose versus conventional dose thiazide diuretic on insulin action in essential hypertension. Full Text available with Trip Pro

Effects of low dose versus conventional dose thiazide diuretic on insulin action in essential hypertension. To see whether low dose thiazide diuretics given to patients with essential hypertension might avoid the adverse metabolic consequences seen with conventional doses.Double blind randomised crossover study of two 12 week treatment periods with either low dose (1.25 mg) or conventional dose (5.0 mg) bendrofluazide given after a six week placebo run in period.Outpatient clinics serving (...) the greater Belfast area.16 white non-diabetic patients (9 male) under 65 with essential hypertension recruited from general practices within the greater Belfast area.Systolic and diastolic blood pressure and peripheral and hepatic insulin action.One man failed to complete the study. There were no differences between doses in their effects on systolic and diastolic blood pressure. Bendrofluazide 1.25 mg had substantially less effect on serum potassium concentration than the 5.0 mg dose. There were

1994 BMJ Controlled trial quality: uncertain

851. Effects of varying carbohydrate content of diet in patients with non-insulin-dependent diabetes mellitus. (Abstract)

Effects of varying carbohydrate content of diet in patients with non-insulin-dependent diabetes mellitus. To study effects of variation in carbohydrate content of diet on glycemia and plasma lipoproteins in patients with non-insulin-dependent diabetes mellitus (NIDDM).A four-center randomized crossover trial.Outpatient and inpatient evaluation in metabolic units.Forty-two NIDDM patients receiving glipizide therapy.A high-carbohydrate diet containing 55% of the total energy as carbohydrates (...) and 30% as fats was compared with a high-monounsaturated-fat diet containing 40% carbohydrates and 45% fats. The amounts of saturated fats, polyunsaturated fats, cholesterol, sucrose, and protein were similar. The study diets, prepared in metabolic kitchens, were provided as the sole nutrients to subjects for 6 weeks each. To assess longer-term effects, a subgroup of 21 patients continued the diet they received second for an additional 8 weeks.Fasting plasma glucose, insulin, lipoproteins

1994 JAMA Controlled trial quality: uncertain

852. Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria. European Microalbuminuria Captopril Study Group. (Abstract)

Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria. European Microalbuminuria Captopril Study Group. To study the effect of angiotensin converting enzyme inhibition on the rate of progression to clinical proteinuria and the rate of change of albumin excretion rates in patients with insulin-dependent diabetes mellitus and persistent microalbuminuria.Randomized, double-blind, placebo-controlled clinical trial of 2 (...) years' duration at 12 hospital-based diabetes centers.Ninety-two patients with insulin-dependent diabetes mellitus and persistent microalbuminuria but no hypertension.The patients were randomly allocated in blocks of two to receive either captopril, 50 mg, or placebo twice per day.Albumin excretion rate, blood pressure, glycosylated hemoglobin level, and fructosamine level every 3 months; urinary urea nitrogen excretion every 6 months; and glomerular filtration rate every 12 months.Twelve patients

1994 JAMA Controlled trial quality: predicted high

853. Effectiveness and cost-benefit analysis of intensive treatment and teaching programmes for Type 1 (insulin-dependent) diabetes mellitus in Moscow: blood glucose versus urine glucose self-monitoring

Effectiveness and cost-benefit analysis of intensive treatment and teaching programmes for Type 1 (insulin-dependent) diabetes mellitus in Moscow: blood glucose versus urine glucose self-monitoring Effectiveness and cost-benefit analysis of intensive treatment and teaching programmes for Type 1 (insulin-dependent) diabetes mellitus in Moscow: blood glucose versus urine glucose self-monitoring Effectiveness and cost-benefit analysis of intensive treatment and teaching programmes for Type 1 (...) (insulin-dependent) diabetes mellitus in Moscow: blood glucose versus urine glucose self-monitoring Starostina E G, Antsiferov M, Galstyan G R, Trautner C, Jorgens V, Muhlhauser I, Berger M, Dedov I I Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn

1994 NHS Economic Evaluation Database.

854. Insulin prophylaxis in individuals at high risk of type I diabetes. (Abstract)

Insulin prophylaxis in individuals at high risk of type I diabetes. Prevention of type I diabetes is now a practical goal thanks to the ability to define confidently a high-risk group and the success of preventive strategies in animal models. We describe here a pilot trial of low-dose insulin to prevent diabetes in relatives of patients with type I diabetes.

1993 Lancet

855. Preliminary study of the efficacy of insulin aerosol delivered by oral inhalation in diabetic patients. (Abstract)

Preliminary study of the efficacy of insulin aerosol delivered by oral inhalation in diabetic patients. To maximize deposition of an aerosolized dose of insulin (mean +/- SD = 0.99 +/- 0.06 U/kg of body weight) in the lungs of subjects with non-insulin-dependent diabetes mellitus (NIDDM), and investigate its efficacy in normalizing plasma glucose levels during the fasting state.Nonrandomized, placebo-controlled trial.A primary care facility.Six nonobese, nonsmoking volunteers with NIDDM (...) . No subjects withdrew from the study.Aerosolized insulin was administered by oral inhalation after a 12-hour period of fasting. Aerosol was generated by a raindrop nebulizer from regular 500 U/mL pork insulin. During inhalation, inspiratory flow was regulated at 17 L/min. Plasma samples were collected after inhalation and analyzed for insulin and glucose levels.Plasma insulin and glucose levels.Deposition of the aerosol was maximized within the lungs, with 79% +/- 17% of the inhaled dose depositing below

1993 JAMA

856. The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus. (Abstract)

The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus. A cause-and-effect relation between blood glucose concentrations and microvascular complications in patients with insulin-dependent diabetes mellitus has not been established.We randomly assigned 102 patients with insulin-dependent diabetes mellitus, nonproliferative retinopathy, normal serum creatinine concentrations, and unsatisfactory blood glucose control (...) to intensified insulin treatment (48 patients) or standard insulin treatment (54 patients). We then evaluated them for microvascular complications after 18 months and 3, 5, and 7.5 years.Mean (+/- SD) glycosylated hemoglobin values were reduced from 9.5 +/- 1.3 percent to 7.1 +/- 0.7 percent in the group receiving intensified treatment and from 9.4 +/- 1.4 percent to 8.5 +/- 0.7 percent in the group receiving standard treatment (P = 0.001). In 12 of the patients receiving intensified treatment (27 percent

1993 NEJM Controlled trial quality: uncertain

857. Muslims with non-insulin dependent diabetes fasting during Ramadan: treatment with glibenclamide. Full Text available with Trip Pro

Muslims with non-insulin dependent diabetes fasting during Ramadan: treatment with glibenclamide. To compare the efficacy of two glibenclamide regimens in patients with non-insulin dependent diabetes who were fasting during Ramadan and regular glibenclamide treatment in the non-fasting group.Non-randomised control group of patients who did not fast during Ramadan and two groups of patients who fasted randomised equally to one of two regimens: to take their usual morning dose of glibenclamide (...) the end of Ramadan there were no significant differences between the groups in fructosamine concentration (400 mumol/l in controls and 381 mumol/l and 376 mumol/l in the fasting groups); percentage of glycated haemoglobin (14.7%, 14.0%, and 13.6%); or number of hypoglycaemic events during Ramadan (11, 14, and 10).Glibenclamide is effective and safe for patients with non-insulin dependent diabetes who fast during Ramadan. The easiest regimen is to take the normal morning dose (together with any midday

1993 BMJ Controlled trial quality: uncertain

858. Prompting the clinical care of non-insulin dependent (type II) diabetic patients in an inner city area: one model of community care. Full Text available with Trip Pro

Prompting the clinical care of non-insulin dependent (type II) diabetic patients in an inner city area: one model of community care. To evaluate the effectiveness and acceptability of centrally organised prompting for coordinating community care of non-insulin dependent diabetic patients.Randomised single centre trial. Patients allocated to prompted care in the community or to continued attendance at hospital diabetic clinic (controls). Median follow up two years.Two hospital outpatient clinics (...) differences between the groups in last recorded random plasma glucose concentration, glycated haemoglobin value, numbers admitted to hospital for a diabetes related reason, and number of deaths. Questionnaires revealed a high level of patient, general practitioner, and optometrist satisfaction.Six monthly prompting of non-insulin treated diabetic patients for care by inner city general practitioners and by optometrists is effective and acceptable.

1993 BMJ Controlled trial quality: uncertain

859. Double blind clinical and laboratory study of hypoglycaemia with human and porcine insulin in diabetic patients reporting hypoglycaemia unawareness after transferring to human insulin. Full Text available with Trip Pro

Double blind clinical and laboratory study of hypoglycaemia with human and porcine insulin in diabetic patients reporting hypoglycaemia unawareness after transferring to human insulin. To compare awareness of hypoglycaemia and physiological responses to hypoglycaemia with human and porcine insulin in diabetic patients who reported loss of hypoglycaemia awareness after transferring to human insulin.Double blind randomised crossover study of clinical experience and physiological responses during (...) slow fall hypoglycaemic clamping with porcine and human insulin.Clinical investigation unit of teaching hospital recruiting from diabetes clinics of five teaching hospitals and one district general hospital.17 patients with insulin dependent diabetes mellitus of more than five years' duration who had reported altered hypoglycaemia awareness within three months of transferring to human insulin.Glycaemic control and frequency of hypoglycaemic episodes during two months' treatment with each insulin

1993 BMJ Controlled trial quality: uncertain

860. Comparison of reduction in microalbuminuria by enalapril and hydrochlorothiazide in normotensive patients with insulin dependent diabetes. Full Text available with Trip Pro

Comparison of reduction in microalbuminuria by enalapril and hydrochlorothiazide in normotensive patients with insulin dependent diabetes. To compare the effects of sodium depletion and of angiotensin I converting enzyme inhibition on microalbuminuria in insulin dependent diabetes.Randomised, double blind, double dummy parallel study of normotensive diabetic patients with persistent microalbuminuria (30-300 mg/24 h) treated with enalapril or hydrochlorothiazide for one year after a three month

1993 BMJ Controlled trial quality: uncertain