Latest & greatest articles for insulin

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Top results for insulin

801. [Insulin treatment for diabetes on the day of surgery]. (Abstract)

[Insulin treatment for diabetes on the day of surgery]. 1670109 1994 06 09 2011 11 17 0012-7183 106 5 1990 Duodecim; laaketieteellinen aikakauskirja Duodecim [Insulin treatment for diabetes on the day of surgery]. 415-21 Kuusisto A A Jorvin sairaala, Espoo, Finland. fin Clinical Trial Controlled Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't Diabeteksen insuliinihoito leikkauspäivänä. Finland Duodecim 0373207 0012-7183 0 Blood Glucose 0 Insulin IM (...) Blood Glucose metabolism Diabetes Mellitus, Type 1 blood drug therapy Humans Injections, Subcutaneous Insulin administration & dosage Insulin Infusion Systems Preoperative Care 1990 1 1 1990 1 1 0 1 1990 1 1 0 0 ppublish 1670109

1994 Duodecim; laaketieteellinen aikakauskirja Controlled trial quality: uncertain

802. Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria. European Microalbuminuria Captopril Study Group. (Abstract)

Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria. European Microalbuminuria Captopril Study Group. To study the effect of angiotensin converting enzyme inhibition on the rate of progression to clinical proteinuria and the rate of change of albumin excretion rates in patients with insulin-dependent diabetes mellitus and persistent microalbuminuria.Randomized, double-blind, placebo-controlled clinical trial of 2 (...) years' duration at 12 hospital-based diabetes centers.Ninety-two patients with insulin-dependent diabetes mellitus and persistent microalbuminuria but no hypertension.The patients were randomly allocated in blocks of two to receive either captopril, 50 mg, or placebo twice per day.Albumin excretion rate, blood pressure, glycosylated hemoglobin level, and fructosamine level every 3 months; urinary urea nitrogen excretion every 6 months; and glomerular filtration rate every 12 months.Twelve patients

1994 JAMA Controlled trial quality: predicted high

803. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. (Abstract)

Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. Troglitazone decreases insulin resistance and hyperglycemia in patients with non-insulin-dependent diabetes mellitus (NIDDM), but its effects on subjects without diabetes are not known.We performed oral and intravenous glucose-tolerance tests, studies with the euglycemic-hyperinsulinemic clamp, meal-tolerance tests, and 24-hour blood-pressure measurements at base line and after (...) the administration of troglitazone, 200 mg orally twice daily, or placebo for 12 weeks in 18 nondiabetic obese subjects, 9 of whom had impaired glucose tolerance.The mean (+/- SD) rates of glucose disposal increased from 4.7 +/- 1.7 to 6.0 +/- 1.7 mg per kilogram of body weight per minute (P = 0.004) and from 9.0 +/- 1.8 to 9.9 +/- 1.3 mg per kilogram per minute (P = 0.02) during insulin infusions of 40 and 300 mU per square meter of body-surface area per minute, respectively, in the troglitazone group

1994 NEJM Controlled trial quality: uncertain

804. Effects of varying carbohydrate content of diet in patients with non-insulin-dependent diabetes mellitus. (Abstract)

Effects of varying carbohydrate content of diet in patients with non-insulin-dependent diabetes mellitus. To study effects of variation in carbohydrate content of diet on glycemia and plasma lipoproteins in patients with non-insulin-dependent diabetes mellitus (NIDDM).A four-center randomized crossover trial.Outpatient and inpatient evaluation in metabolic units.Forty-two NIDDM patients receiving glipizide therapy.A high-carbohydrate diet containing 55% of the total energy as carbohydrates (...) and 30% as fats was compared with a high-monounsaturated-fat diet containing 40% carbohydrates and 45% fats. The amounts of saturated fats, polyunsaturated fats, cholesterol, sucrose, and protein were similar. The study diets, prepared in metabolic kitchens, were provided as the sole nutrients to subjects for 6 weeks each. To assess longer-term effects, a subgroup of 21 patients continued the diet they received second for an additional 8 weeks.Fasting plasma glucose, insulin, lipoproteins

1994 JAMA Controlled trial quality: uncertain

805. Effects of low dose versus conventional dose thiazide diuretic on insulin action in essential hypertension. Full Text available with Trip Pro

Effects of low dose versus conventional dose thiazide diuretic on insulin action in essential hypertension. To see whether low dose thiazide diuretics given to patients with essential hypertension might avoid the adverse metabolic consequences seen with conventional doses.Double blind randomised crossover study of two 12 week treatment periods with either low dose (1.25 mg) or conventional dose (5.0 mg) bendrofluazide given after a six week placebo run in period.Outpatient clinics serving (...) the greater Belfast area.16 white non-diabetic patients (9 male) under 65 with essential hypertension recruited from general practices within the greater Belfast area.Systolic and diastolic blood pressure and peripheral and hepatic insulin action.One man failed to complete the study. There were no differences between doses in their effects on systolic and diastolic blood pressure. Bendrofluazide 1.25 mg had substantially less effect on serum potassium concentration than the 5.0 mg dose. There were

1994 BMJ Controlled trial quality: uncertain

806. Effectiveness and cost-benefit analysis of intensive treatment and teaching programmes for Type 1 (insulin-dependent) diabetes mellitus in Moscow: blood glucose versus urine glucose self-monitoring

Effectiveness and cost-benefit analysis of intensive treatment and teaching programmes for Type 1 (insulin-dependent) diabetes mellitus in Moscow: blood glucose versus urine glucose self-monitoring Effectiveness and cost-benefit analysis of intensive treatment and teaching programmes for Type 1 (insulin-dependent) diabetes mellitus in Moscow: blood glucose versus urine glucose self-monitoring Effectiveness and cost-benefit analysis of intensive treatment and teaching programmes for Type 1 (...) (insulin-dependent) diabetes mellitus in Moscow: blood glucose versus urine glucose self-monitoring Starostina E G, Antsiferov M, Galstyan G R, Trautner C, Jorgens V, Muhlhauser I, Berger M, Dedov I I Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn

1994 NHS Economic Evaluation Database.

807. Insulin prophylaxis in individuals at high risk of type I diabetes. (Abstract)

Insulin prophylaxis in individuals at high risk of type I diabetes. Prevention of type I diabetes is now a practical goal thanks to the ability to define confidently a high-risk group and the success of preventive strategies in animal models. We describe here a pilot trial of low-dose insulin to prevent diabetes in relatives of patients with type I diabetes.

1993 Lancet

808. Preliminary study of the efficacy of insulin aerosol delivered by oral inhalation in diabetic patients. (Abstract)

Preliminary study of the efficacy of insulin aerosol delivered by oral inhalation in diabetic patients. To maximize deposition of an aerosolized dose of insulin (mean +/- SD = 0.99 +/- 0.06 U/kg of body weight) in the lungs of subjects with non-insulin-dependent diabetes mellitus (NIDDM), and investigate its efficacy in normalizing plasma glucose levels during the fasting state.Nonrandomized, placebo-controlled trial.A primary care facility.Six nonobese, nonsmoking volunteers with NIDDM (...) . No subjects withdrew from the study.Aerosolized insulin was administered by oral inhalation after a 12-hour period of fasting. Aerosol was generated by a raindrop nebulizer from regular 500 U/mL pork insulin. During inhalation, inspiratory flow was regulated at 17 L/min. Plasma samples were collected after inhalation and analyzed for insulin and glucose levels.Plasma insulin and glucose levels.Deposition of the aerosol was maximized within the lungs, with 79% +/- 17% of the inhaled dose depositing below

1993 JAMA

809. The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus. (Abstract)

The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus. A cause-and-effect relation between blood glucose concentrations and microvascular complications in patients with insulin-dependent diabetes mellitus has not been established.We randomly assigned 102 patients with insulin-dependent diabetes mellitus, nonproliferative retinopathy, normal serum creatinine concentrations, and unsatisfactory blood glucose control (...) to intensified insulin treatment (48 patients) or standard insulin treatment (54 patients). We then evaluated them for microvascular complications after 18 months and 3, 5, and 7.5 years.Mean (+/- SD) glycosylated hemoglobin values were reduced from 9.5 +/- 1.3 percent to 7.1 +/- 0.7 percent in the group receiving intensified treatment and from 9.4 +/- 1.4 percent to 8.5 +/- 0.7 percent in the group receiving standard treatment (P = 0.001). In 12 of the patients receiving intensified treatment (27 percent

1993 NEJM Controlled trial quality: uncertain

810. Double blind clinical and laboratory study of hypoglycaemia with human and porcine insulin in diabetic patients reporting hypoglycaemia unawareness after transferring to human insulin. Full Text available with Trip Pro

Double blind clinical and laboratory study of hypoglycaemia with human and porcine insulin in diabetic patients reporting hypoglycaemia unawareness after transferring to human insulin. To compare awareness of hypoglycaemia and physiological responses to hypoglycaemia with human and porcine insulin in diabetic patients who reported loss of hypoglycaemia awareness after transferring to human insulin.Double blind randomised crossover study of clinical experience and physiological responses during (...) slow fall hypoglycaemic clamping with porcine and human insulin.Clinical investigation unit of teaching hospital recruiting from diabetes clinics of five teaching hospitals and one district general hospital.17 patients with insulin dependent diabetes mellitus of more than five years' duration who had reported altered hypoglycaemia awareness within three months of transferring to human insulin.Glycaemic control and frequency of hypoglycaemic episodes during two months' treatment with each insulin

1993 BMJ Controlled trial quality: uncertain

811. Comparison of reduction in microalbuminuria by enalapril and hydrochlorothiazide in normotensive patients with insulin dependent diabetes. Full Text available with Trip Pro

Comparison of reduction in microalbuminuria by enalapril and hydrochlorothiazide in normotensive patients with insulin dependent diabetes. To compare the effects of sodium depletion and of angiotensin I converting enzyme inhibition on microalbuminuria in insulin dependent diabetes.Randomised, double blind, double dummy parallel study of normotensive diabetic patients with persistent microalbuminuria (30-300 mg/24 h) treated with enalapril or hydrochlorothiazide for one year after a three month

1993 BMJ Controlled trial quality: uncertain

812. Prompting the clinical care of non-insulin dependent (type II) diabetic patients in an inner city area: one model of community care. Full Text available with Trip Pro

Prompting the clinical care of non-insulin dependent (type II) diabetic patients in an inner city area: one model of community care. To evaluate the effectiveness and acceptability of centrally organised prompting for coordinating community care of non-insulin dependent diabetic patients.Randomised single centre trial. Patients allocated to prompted care in the community or to continued attendance at hospital diabetic clinic (controls). Median follow up two years.Two hospital outpatient clinics (...) differences between the groups in last recorded random plasma glucose concentration, glycated haemoglobin value, numbers admitted to hospital for a diabetes related reason, and number of deaths. Questionnaires revealed a high level of patient, general practitioner, and optometrist satisfaction.Six monthly prompting of non-insulin treated diabetic patients for care by inner city general practitioners and by optometrists is effective and acceptable.

1993 BMJ Controlled trial quality: uncertain

813. Muslims with non-insulin dependent diabetes fasting during Ramadan: treatment with glibenclamide. Full Text available with Trip Pro

Muslims with non-insulin dependent diabetes fasting during Ramadan: treatment with glibenclamide. To compare the efficacy of two glibenclamide regimens in patients with non-insulin dependent diabetes who were fasting during Ramadan and regular glibenclamide treatment in the non-fasting group.Non-randomised control group of patients who did not fast during Ramadan and two groups of patients who fasted randomised equally to one of two regimens: to take their usual morning dose of glibenclamide (...) the end of Ramadan there were no significant differences between the groups in fructosamine concentration (400 mumol/l in controls and 381 mumol/l and 376 mumol/l in the fasting groups); percentage of glycated haemoglobin (14.7%, 14.0%, and 13.6%); or number of hypoglycaemic events during Ramadan (11, 14, and 10).Glibenclamide is effective and safe for patients with non-insulin dependent diabetes who fast during Ramadan. The easiest regimen is to take the normal morning dose (together with any midday

1993 BMJ Controlled trial quality: uncertain

814. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. (Abstract)

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. Long-term microvascular and neurologic complications cause major morbidity and mortality in patients with insulin-dependent diabetes mellitus (IDDM). We examined whether intensive treatment with the goal of maintaining blood glucose concentrations close to the normal range could decrease (...) the frequency and severity of these complications.A total of 1441 patients with IDDM--726 with no retinopathy at base line (the primary-prevention cohort) and 715 with mild retinopathy (the secondary-intervention cohort) were randomly assigned to intensive therapy administered either with an external insulin pump or by three or more daily insulin injections and guided by frequent blood glucose monitoring or to conventional therapy with one or two daily insulin injections. The patients were followed

1993 NEJM Controlled trial quality: uncertain

815. Double-blind crossover comparison of human and porcine insulins in patients reporting lack of hypoglycaemia awareness. (Abstract)

Double-blind crossover comparison of human and porcine insulins in patients reporting lack of hypoglycaemia awareness. There has been much debate about reports that some insulin-treated diabetic patients lose awareness of hypoglycaemic symptoms on changing from porcine to human insulin. In a double-blind, crossover study, we sought differences between porcine and human insulin in the frequency and characteristics of hypoglycaemic episodes among patients who reported a reduction of awareness (...) of hypoglycaemia after changing treatment. We studied 50 patients referred by their physicians because of complaints of lack of awareness of hypoglycaemia on human insulin. They had had diabetes for a mean of 20 (SD 12) years and 70% had good or acceptable glycaemic control. Each patient was treated in a double-blind manner for four 1-month periods, two with human and two with porcine insulin, in random order. Only 2 patients correctly identified the sequence of insulin treatments used; 8 or 9 would have been

1992 Lancet Controlled trial quality: uncertain

816. Coronary revascularisation in insulin-dependent diabetic patients with chronic renal failure. (Abstract)

Coronary revascularisation in insulin-dependent diabetic patients with chronic renal failure. Insulin-dependent diabetic patients found to have substantial coronary artery disease at the time of assessment for renal transplantation have 2-year survival of less than 50%. Because most of these patients have no angina symptoms their management is controversial. We tried to find out whether coronary artery revascularisation in such patients might decrease the combined incidence of unstable angina (...) , myocardial infarction, and cardiac death. 151 consecutive insulin-dependent diabetic candidates for renal transplantation underwent coronary angiography. 31 had stenoses greater than 75% in one or more coronary arteries, atypical chest pain or no chest pain, and a left ventricular ejection fraction greater than 0.35. Of these, 26 agreed to be randomly assigned medical treatment (a calcium-channel-blocking drug plus aspirin) or revascularisation (angioplasty or coronary bypass surgery). 10 of 13 medically

1992 Lancet Controlled trial quality: uncertain

817. Comparison of enalapril and nifedipine in treating non-insulin dependent diabetes associated with hypertension: one year analysis. Full Text available with Trip Pro

Comparison of enalapril and nifedipine in treating non-insulin dependent diabetes associated with hypertension: one year analysis. To compare the efficacy, safety, and tolerance of enalapril and nifedipine in hypertensive patients with non-insulin dependent diabetes.One year double blind follow up of patients randomly allocated to either enalapril or nifedipine with matching placebos for the alternative drug.Metabolic Investigation Unit, Hong Kong.102 patients were randomised: 52 to nifedipine

1992 BMJ Controlled trial quality: uncertain

818. Somatostatin analogue, octreotide, reduces increased glomerular filtration rate and kidney size in insulin-dependent diabetes. (Abstract)

Somatostatin analogue, octreotide, reduces increased glomerular filtration rate and kidney size in insulin-dependent diabetes. To determine whether treatment with a somatostatin analogue can reduce kidney hyperfiltration and hypertrophy in insulin-dependent diabetes mellitus, we studied 11 patients with insulin-dependent diabetes mellitus and glomerular hyperfiltration. The patients were assigned randomly to receive continuous subcutaneous infusion of either octreotide, 300 micrograms/24 h (...) was significantly lower after treatment in the octreotide group (379 mL/1.73 m2; range, 307 to 454 mL/1.73 m2) than in the placebo group (389 mL/1.73 m2; range, 347 to 465 mL/1.73 m2). Glycemic control did not change significantly in either group. We conclude that subcutaneous infusion of octreotide for 12 weeks reduces increased glomerular filtration rate and kidney size in patients with insulin-dependent diabetes mellitus despite the fact that glycemic control remains unchanged.

1991 JAMA Controlled trial quality: uncertain

819. Effect of restricting dietary protein on the progression of renal failure in patients with insulin-dependent diabetes mellitus. (Abstract)

Effect of restricting dietary protein on the progression of renal failure in patients with insulin-dependent diabetes mellitus. Restriction of dietary protein may slow the progression of renal failure in diverse renal diseases, but the extent to which such a diet is beneficial in patients with diabetic nephropathy is uncertain.We studied the effect of reduced intake of protein and phosphorus on the progression of renal disease in 35 patients with insulin-dependent (Type I) diabetes mellitus

1991 NEJM Controlled trial quality: uncertain

820. Efficacy of captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria. Full Text available with Trip Pro

Efficacy of captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria. To assess the effectiveness of angiotensin converting enzyme inhibition in preventing the development of diabetic nephropathy (albuminuria greater than 300 mg/24h).Open randomised controlled study of four years' duration.Outpatient diabetic clinic in tertiary referral centre.44 normotensive (mean blood pressure 127/78 (SD 12/10) mm Hg) insulin dependent diabetic patients (...) , and urinary excretion of sodium and urea remained practically unchanged in the two groups.The findings suggest that angiotensin converting enzyme inhibition postpones the development of clinical overt diabetic nephropathy in normotensive insulin dependent diabetic patients with persistent microalbuminuria.

1991 BMJ Controlled trial quality: uncertain