Latest & greatest articles for insulin

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on insulin or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on insulin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for insulin

801. Health care for persons with non-insulin-dependent diabetes mellitus. The German experience.

Health care for persons with non-insulin-dependent diabetes mellitus. The German experience. Health care for persons with non-... preview & related info | Mendeley E-mail address Password ( ) Remember me …or sign in with Search Main Navigation › Short URL Annals of Internal Medicine ( 1996 ) Volume: 124 , Issue: 1 Pt 2 , Pages: 153-155 PubMed: Available from or Find this paper at: Abstract A structured treatment and education program for patients with non-insulin-dependent diabetes mellitus (...) (NIDDM) who are not taking insulin was developed, evaluated, and implemented at the primary health care level throughout Germany. The program is based on the definition of individual and pragmatic therapeutic goals for each patient, primarily using nondrug treatment, which includes systematic glycosuria self-monitoring by the patients and four structured sessions of group education held in a general practitioner's office. After documentation of the program's efficacy in a randomized, controlled trial

Annals of Internal Medicine1996

802. Efficacy of insulin and sulfonylurea combination therapy in type II diabetes: a meta-analysis of the randomised placebo-controlled trials

Efficacy of insulin and sulfonylurea combination therapy in type II diabetes: a meta-analysis of the randomised placebo-controlled trials Efficacy of insulin and sulfonylurea combination therapy in type II diabetes: a meta-analysis of the randomised placebo-controlled trials Efficacy of insulin and sulfonylurea combination therapy in type II diabetes: a meta-analysis of the randomised placebo-controlled trials Johnson J L, Wolf S L, Kubadi U M Authors' objectives To assess the efficacy (...) of insulin and sulfonylurea combination therapy in type II diabetes mellitus. Searching MEDLINE was searched from January 1980 to March 1992 using the keywords 'sulfonylurea', 'insulin' and 'combination therapy in type II diabetes', and bibliographies of identified papers were examined. Citations reported in non-English language journals, without English translation, were excluded. Study selection Study designs of evaluations included in the review Randomised placebo-controlled trials of the same

DARE.1996

803. Comparison of different insulin regimens in elderly patients with NIDDM

Comparison of different insulin regimens in elderly patients with NIDDM Comparison of different insulin regimens in elderly patients with NIDDM Comparison of different insulin regimens in elderly patients with NIDDM Wolffenbuttel B H, Sels J P, Rondas-Colbers G J, Menheere P P, Kruseman A C Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of twice daily subcutaneous injections of a mixture of fast-acting and NPH insulin 30 minutes before breakfast and dinner, in elderly patients with poorly controlled non insulin dependent diabetes mellitus (NIDDM). Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Elderly NIDDM patients, whose disease state was poorly controlled

NHS Economic Evaluation Database.1996

804. The cost-effectiveness of primary prevention for non-insulin dependent diabetes mellitus

The cost-effectiveness of primary prevention for non-insulin dependent diabetes mellitus The cost-effectiveness of primary prevention for non-insulin dependent diabetes mellitus The cost-effectiveness of primary prevention for non-insulin dependent diabetes mellitus Segal L, Dalton A, Richardson J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Lifestyle and dietary advice, behavioural and surgical interventions for the primary prevention of non insulin dependent diabetes mellitus (NIDDM) as follows: Programme 1 - work site group behavioural programme for overweight men; Programme 2 - media programme for lifestyle change with community support; Programme 3 - bariatric surgery for the seriously obese; Programme 4 - intensive

NHS Economic Evaluation Database.1996

805. Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome.

Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome. 8687515 1996 08 29 1996 08 29 2016 11 23 0028-4793 335 9 1996 Aug 29 The New England journal of medicine N. Engl. J. Med. Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome. 617-23 Insulin resistance and increased ovarian cytochrome P450c17 alpha (...) -hydroxyprogesterone to leuprolide, a gonadotrophin-releasing hormone agonist, and performed oral glucose-tolerance tests before and after oral administration of either metformin (500 mg three times daily) or placebo for four to eight weeks in 24 obese women with the polycystic ovary syndrome. In the 11 women given metformin, the mean (+/- SE) area under the serum insulin curve after oral glucose administration decreased from 9303 +/- 1603 to 4982 +/- 911 microU per milliliter per minute (56 +/- 10 to 30 +/- 6

NEJM1996

806. Effect of caffeine on recognition of and physiological responses to hypoglycaemia in insulin-dependent diabetes.

Effect of caffeine on recognition of and physiological responses to hypoglycaemia in insulin-dependent diabetes. 8531542 1996 02 01 1996 02 01 2015 06 16 0140-6736 347 8993 1996 Jan 06 Lancet (London, England) Lancet Effect of caffeine on recognition of and physiological responses to hypoglycaemia in insulin-dependent diabetes. 19-24 For the patient with diabetes, hypoglycaemia unawareness--ie, the warning signs of falling blood glucose are missing--is potentially dangerous. One study has (...) suggested that, in healthy volunteers, caffeine might be a helpful treatment. Our study looked at two effects of caffeine ingestion (250 mg) on the brain--namely, a decrease in cerebral blood flow and an increase in brain glucose use--to see if the recognition of and physiological responses to hypoglycaemia were altered in patients with insulin-dependent diabetes mellitus (IDDM). 12 patients were studied twice. A hyperinsulinaemic glucose clamp was used to maintain plasma glucose at 5 mmol/L for 90 min

Lancet1996

807. Abnormal rheologic effects of glyceryl trinitrate in patients with non-insulin-dependent diabetes mellitus and reversal by antioxidants.

Abnormal rheologic effects of glyceryl trinitrate in patients with non-insulin-dependent diabetes mellitus and reversal by antioxidants. Abnormal rheologic effects of gly... preview & related info | Mendeley E-mail address Password ( ) Remember me …or sign in with Search Main Navigation › Short URL Annals of Internal Medicine ( 1995 ) Volume: 96 , Issue: 5 , Pages: 338-343 PubMed: Available from or Find this paper at: Abstract The purpose of this study was to investigate the triglyceride (...) -lowering effect of fluvastatin, a new 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, in the combined hyperlipidemia of non-insulin-dependent diabetes mellitus (NIDDM). In this double-blind trial, 66 patients with NIDDM (24 men and 42 women, age 37-71), with low-density lipoprotein cholesterol (LDL-C) levels of 130-300 mg/dL (3.4-7.8 mmol/L) and triglyceride (TG) levels of 200-1,000 mg/dL (2.3-11.3 mmol/L) despite an 8-week period of diet modification, were randomized to receive

Annals of Internal Medicine1995

808. A review of the weight loss interventions for obese people with non-insulin-dependent diabetes mellitus

A review of the weight loss interventions for obese people with non-insulin-dependent diabetes mellitus A review of the weight loss interventions for obese people with non-insulin-dependent diabetes mellitus A review of the weight loss interventions for obese people with non-insulin-dependent diabetes mellitus Ciliska D, Kelly C, Petrov N, Chalmers J Authors' objectives To review the literature on the long-term results of weight loss in the non-insulin-dependent diabetes mellitus (NIDDM (...) ) population. Searching MEDLINE, CINAHL and PsycINFO were searched from 1985 using the terms 'non-insulin-dependent diabetes mellitus' combined with 'weight loss' or 'diet'. Reference lists of retrieved articles were searched for additional references, including those before 1985. Two experts in the field were asked to review the list of retrieved articles to identify if any key articles were missing. Study selection Study designs of evaluations included in the review Studies with a comparison group

DARE.1995

809. Cost-effectiveness of medical nutrition therapy provided by dietitians for persons with non-insulin-dependent diabetes mellitus

Cost-effectiveness of medical nutrition therapy provided by dietitians for persons with non-insulin-dependent diabetes mellitus Cost-effectiveness of medical nutrition therapy provided by dietitians for persons with non-insulin-dependent diabetes mellitus Cost-effectiveness of medical nutrition therapy provided by dietitians for persons with non-insulin-dependent diabetes mellitus Franz M J, Splett P L, Monk A, Barry B, McClain K, Weaver T, Upham P, Bergenstal R, Mazze R S Record Status (...) This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Nutrition care of non-insulin-dependent diabetic patients as laid down by practice guidelines (practice guidelines care or PGC) was compared with basic nutrition care (BC). The PGC strategy consisted

NHS Economic Evaluation Database.1995

810. Continuous subcutaneous insulin infusion (CSII) in children and adolescents with chronic poorly controlled type 1 diabetes mellitus

Continuous subcutaneous insulin infusion (CSII) in children and adolescents with chronic poorly controlled type 1 diabetes mellitus Continuous subcutaneous insulin infusion (CSII) in children and adolescents with chronic poorly controlled type 1 diabetes mellitus Continuous subcutaneous insulin infusion (CSII) in children and adolescents with chronic poorly controlled type 1 diabetes mellitus Steindel B S, Roe T R, Costin G, Carlson M, Kaufman F R Record Status This is a critical abstract (...) of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Continuous subcutaneous insulin infusion using the MiniMed (Sylmar, CA) CSII system. Type of intervention Secondary prevention, treatment. Economic study type Cost-effectiveness analysis. Study population Children and adolescents

NHS Economic Evaluation Database.1995

811. Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation

Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation Kiberd B A, Jindal K K Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , macroproteinuria or both (dipstick >0.3 g/l orpositive Albustix confirmed with >300 mg/day or >200 micrograms/minute proteinuria). Type of intervention Screening and secondary prevention. Economic study type Cost-utility analysis. Study population Hypothetical cohort of patients with insulin dependent diabetes for at least five years and patients with hypertension or macroproteinuria. Setting Hospital/primary care. The economic evaluation was carried out in Nova Scotia, Canada. Dates to which data relate

NHS Economic Evaluation Database.1995

812. Cost-effectiveness analyses of the conversion of patients with non-insulin-dependent diabetes mellitus from glipizide to glyburide and of the accompanying pharmacy follow-up clinic

Cost-effectiveness analyses of the conversion of patients with non-insulin-dependent diabetes mellitus from glipizide to glyburide and of the accompanying pharmacy follow-up clinic Cost-effectiveness analyses of the conversion of patients with non-insulin-dependent diabetes mellitus from glipizide to glyburide and of the accompanying pharmacy follow-up clinic Cost-effectiveness analyses of the conversion of patients with non-insulin-dependent diabetes mellitus from glipizide to glyburide (...) and of the accompanying pharmacy follow-up clinic Law A, Pathak D, Segraves A, Weinstein C, Arneson W Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Treatment for non-insulin-dependent diabetes mellitus. In particular: (1) glipizide therapy; (2

NHS Economic Evaluation Database.1995

813. Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men.

Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men. 7580706 1995 12 18 1995 12 18 2016 10 19 0959-8138 311 7013 1995 Oct 28 BMJ (Clinical research ed.) BMJ Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men. 1124-7 To investigate whether low vitamin E status is a risk factor for incident non-insulin dependent diabetes mellitus (...) , or insulin treatment. 45 men developed diabetes during the follow up period. In a multivariate logistic regression model including the strongest predictors of diabetes, a low lipid standardised plasma vitamin E (below median) concentration was associated with a 3.9-fold (95% confidence interval 1.8-fold to 8.6-fold) risk of incident diabetes. A decrement of 1 mumol/l of uncategorised unstandardised vitamin E concentration was associated with an increment of 22% in the risk of diabetes when allowing

BMJ1995 Full Text: Link to full Text with Trip Pro

814. Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus.

Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus. 7853952 1995 03 10 1995 03 10 2015 06 16 0140-6736 345 8947 1995 Feb 18 Lancet (London, England) Lancet Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus. 421-2 We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were

Lancet1995

815. Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy.

Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy. 7565999 1995 11 09 1995 11 09 2011 11 17 0028-4793 333 19 1995 Nov 09 The New England journal of medicine N. Engl. J. Med. Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy. 1237-41 The fetuses of women with gestational diabetes mellitus are at risk for macrosomia and its attendant (...) complications. The best method of achieving euglycemia in these women and reducing morbidity in their infants is not known. We compared the efficacy of postprandial and preprandial monitoring in achieving glycemic control in women with gestational diabetes. We studied 66 women with gestational diabetes mellitus who required insulin therapy at 30 weeks of gestation or earlier. The women were randomly assigned to have their diabetes managed according to the results of preprandial monitoring or postprandial

NEJM1995

816. Intensive therapy and progression to clinical albuminuria in patients with insulin dependent diabetes mellitus and microalbuminuria. Microalbuminuria Collaborative Study Group, United Kingdom.

Intensive therapy and progression to clinical albuminuria in patients with insulin dependent diabetes mellitus and microalbuminuria. Microalbuminuria Collaborative Study Group, United Kingdom. 7580637 1995 12 01 1995 12 01 2013 09 22 0959-8138 311 7011 1995 Oct 14 BMJ (Clinical research ed.) BMJ Intensive therapy and progression to clinical albuminuria in patients with insulin dependent diabetes mellitus and microalbuminuria. Microalbuminuria Collaborative Study Group, United Kingdom. 973-7 (...) To study the effect of intensive therapy of diabetes on the progression to clinical albuminuria in insulin dependent diabetic patients with microalbuminuria. Randomised controlled clinical trial of intensive versus conventional therapy of diabetes for a median of 5 years (range 2-8). Nine hospital based specialist diabetes centres in England and Wales. 70 European insulin dependent diabetic patients aged 17-59 years with microalbuminuria (albumin excretion 30-199 micrograms/min), but without arterial

BMJ1995 Full Text: Link to full Text with Trip Pro

817. United Kingdom Prospective Diabetes Study (UKPDS). 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years.

United Kingdom Prospective Diabetes Study (UKPDS). 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. 7833731 1995 02 27 1995 02 27 2013 11 21 0959-8138 310 6972 1995 Jan 14 BMJ (Clinical research ed.) BMJ United Kingdom Prospective Diabetes Study (UKPDS). 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly (...) diagnosed non-insulin dependent diabetes followed for three years. 83-8 To assess the relative efficacy of treatments for non-insulin dependent diabetes over three years from diagnosis. Multicentre, randomised, controlled trial allocating patients to treatment with diet alone or additional chlorpropamide, glibenclamide, insulin, or metformin (if obese) to achieve fasting plasma glucose concentrations < or = 6 mmol/l. Outpatient diabetic clinics in 15 British hospitals. 2520 subjects who, after a three

BMJ1995 Full Text: Link to full Text with Trip Pro

818. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group.

Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. 7623902 1995 08 31 1995 08 31 2013 11 21 0028-4793 333 9 1995 Aug 31 The New England journal of medicine N. Engl. J. Med. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. 541-9 Sulfonylurea drugs have been the only oral therapy available for patients with non-insulin-dependent diabetes mellitus (NIDDM) in the (...) United States. Recently, however, metformin has been approved for the treatment of NIDDM. We performed two large, randomized, parallel-group, double-blind, controlled studies in which metformin or another treatment was given for 29 weeks to moderately obese patients with NIDDM whose diabetes was inadequately controlled by diet (protocol 1: metformin vs. placebo; 289 patients), or diet plus glyburide (protocol 2: metformin and glyburide vs. metformin vs. glyburide; 632 patients). To determine efficacy

NEJM1995

819. Effect of glycemic control on early diabetic renal lesions. A 5-year randomized controlled clinical trial of insulin-dependent diabetic kidney transplant recipients.

Effect of glycemic control on early diabetic renal lesions. A 5-year randomized controlled clinical trial of insulin-dependent diabetic kidney transplant recipients. 8057515 1994 09 12 1994 09 12 2016 10 17 0098-7484 272 8 1994 Aug 24-31 JAMA JAMA Effect of glycemic control on early diabetic renal lesions. A 5-year randomized controlled clinical trial of insulin-dependent diabetic kidney transplant recipients. 600-6 To determine whether optimized glycemic control in type I diabetic recipients (...) and Clinic and the Clinical Research Center and Hennepin County Medical Center, Minneapolis. Type I diabetics with terminal diabetic renal failure undergoing renal transplantation. Forty-eight patients randomized to maximized or standard control completed the trial. Subcutaneous insulin given several times a day or continuously (maximized group) and once or twice each day (standard group) was used throughout the trial. A significant difference for hemoglobin A1 level was maintained (mean +/- SD: standard

JAMA1994

820. Effectiveness and cost-benefit analysis of intensive treatment and teaching programmes for Type 1 (insulin-dependent) diabetes mellitus in Moscow: blood glucose versus urine glucose self-monitoring

Effectiveness and cost-benefit analysis of intensive treatment and teaching programmes for Type 1 (insulin-dependent) diabetes mellitus in Moscow: blood glucose versus urine glucose self-monitoring Effectiveness and cost-benefit analysis of intensive treatment and teaching programmes for Type 1 (insulin-dependent) diabetes mellitus in Moscow: blood glucose versus urine glucose self-monitoring Effectiveness and cost-benefit analysis of intensive treatment and teaching programmes for Type 1 (...) (insulin-dependent) diabetes mellitus in Moscow: blood glucose versus urine glucose self-monitoring Starostina E G, Antsiferov M, Galstyan G R, Trautner C, Jorgens V, Muhlhauser I, Berger M, Dedov I I Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn

NHS Economic Evaluation Database.1994