Latest & greatest articles for insulin

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Top results for insulin

781. Economic evaluation of ACE inhibitor treatment of nephropathy in patients with insulin-dependent diabetes mellitus in Italy

Economic evaluation of ACE inhibitor treatment of nephropathy in patients with insulin-dependent diabetes mellitus in Italy Economic evaluation of ACE inhibitor treatment of nephropathy in patients with insulin-dependent diabetes mellitus in Italy Economic evaluation of ACE inhibitor treatment of nephropathy in patients with insulin-dependent diabetes mellitus in Italy Garattini L, Brunetti M, Salvioni F, Barosi M Record Status This is a critical abstract of an economic evaluation that meets (...) the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology ACE inhibitor (captopril) treatment of nephropathy in patients with insulin-dependent diabetes mellitus (IDDM). Type of intervention Secondary prevention and treatment. Economic study type Cost-effectiveness analysis. Study population Patients aged 18 to 49 years

1997 NHS Economic Evaluation Database.

782. Computer simulated cost effectiveness of care management strategies on reduction of long-term sequelae in patients with non-insulin dependent diabetes mellitus

Computer simulated cost effectiveness of care management strategies on reduction of long-term sequelae in patients with non-insulin dependent diabetes mellitus Computer simulated cost effectiveness of care management strategies on reduction of long-term sequelae in patients with non-insulin dependent diabetes mellitus Computer simulated cost effectiveness of care management strategies on reduction of long-term sequelae in patients with non-insulin dependent diabetes mellitus Demers D, Clark N (...) , Tolzmann G, MacLean C, Benedini K, Farnham P, Plant-DeHayes A, Nagy P Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology A series six care management strategies for the care of patients with non-insulin dependent, or type II, diabetes

1997 NHS Economic Evaluation Database.

783. Implantable insulin pump vs multiple-dose insulin for non-insulin-dependent diabetes mellitus: a randomized clinical trial. Department of Veterans Affairs Implantable Insulin Pump Study Group. (Abstract)

Implantable insulin pump vs multiple-dose insulin for non-insulin-dependent diabetes mellitus: a randomized clinical trial. Department of Veterans Affairs Implantable Insulin Pump Study Group. To determine whether implantable insulin pump (IIP) therapy and multiple daily insulin (MDI) injections could equally attain improved blood glucose control, and to compare the 2 treatments with respect to reducing daily blood glucose fluctuations, reducing serious hypoglycemic insulin reactions (...) , and improving patients' quality of life.Randomized clinical trial.Seven Veterans Affairs medical centers.One hundred twenty-one male type II diabetic patients between the ages of 40 and 69 years, receiving at least 1 injection of insulin per day and having hemoglobin A1c (HbA1c) levels of 8% or above.Intensive therapy (IIP or MDI) for 1 year.Hemoglobin A1c and blood glucose levels.Blood glucose levels declined to 7.96+/-1.08 mmol/L (143.4+/-19.5 mg/dL) and 8.30+/-1.52 mmol/L (149.6+/-27.4 mg/dL) (mean

1996 JAMA Controlled trial quality: uncertain

784. Effect of caffeine on recognition of and physiological responses to hypoglycaemia in insulin-dependent diabetes. (Abstract)

Effect of caffeine on recognition of and physiological responses to hypoglycaemia in insulin-dependent diabetes. For the patient with diabetes, hypoglycaemia unawareness--ie, the warning signs of falling blood glucose are missing--is potentially dangerous. One study has suggested that, in healthy volunteers, caffeine might be a helpful treatment. Our study looked at two effects of caffeine ingestion (250 mg) on the brain--namely, a decrease in cerebral blood flow and an increase in brain (...) glucose use--to see if the recognition of and physiological responses to hypoglycaemia were altered in patients with insulin-dependent diabetes mellitus (IDDM).12 patients were studied twice. A hyperinsulinaemic glucose clamp was used to maintain plasma glucose at 5 mmol/L for 90 min, followed by 60 min at 3.8 mmol/L, and then 2.8 mmol/L for a further hour. After 30 min at 5 mmol/L, patients consumed, in a double-blind, crossover design, 250 mg caffeine or matched placebo. We recorded middle cerebral

1996 Lancet

785. Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome. Full Text available with Trip Pro

Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome. Insulin resistance and increased ovarian cytochrome P450c17 alpha activity are both features of the polycystic ovary syndrome. P450c17 alpha, which is involved in androgen biosynthesis, has both 17 alpha-hydroxylase and 17,20-lyase activities. Increased activity of this enzyme results in exaggerated conversion of progesterone to 17 alpha (...) syndrome.In the 11 women given metformin, the mean (+/- SE) area under the serum insulin curve after oral glucose administration decreased from 9303 +/- 1603 to 4982 +/- 911 microU per milliliter per minute (56 +/- 10 to 30 +/- 6 nmol per liter per minute) (P = 0.004). This decrease was associated with a reduction in the basal serum 17 alpha-hydroxyprogesterone concentration from 135 +/- 21 to 66 +/- 7 ng per deciliter (4.1 +/- 0.6 to 2.0 +/- 0.2 nmol per liter) (P = 0.01) and a reduction

1996 NEJM Controlled trial quality: uncertain

786. Comparison of different insulin regimens in elderly patients with NIDDM

Comparison of different insulin regimens in elderly patients with NIDDM Comparison of different insulin regimens in elderly patients with NIDDM Comparison of different insulin regimens in elderly patients with NIDDM Wolffenbuttel B H, Sels J P, Rondas-Colbers G J, Menheere P P, Kruseman A C Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of twice daily subcutaneous injections of a mixture of fast-acting and NPH insulin 30 minutes before breakfast and dinner, in elderly patients with poorly controlled non insulin dependent diabetes mellitus (NIDDM). Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Elderly NIDDM patients, whose disease state was poorly controlled

1996 NHS Economic Evaluation Database.

787. Efficacy of insulin and sulfonylurea combination therapy in type II diabetes: a meta-analysis of the randomised placebo-controlled trials

Efficacy of insulin and sulfonylurea combination therapy in type II diabetes: a meta-analysis of the randomised placebo-controlled trials Efficacy of insulin and sulfonylurea combination therapy in type II diabetes: a meta-analysis of the randomised placebo-controlled trials Efficacy of insulin and sulfonylurea combination therapy in type II diabetes: a meta-analysis of the randomised placebo-controlled trials Johnson J L, Wolf S L, Kubadi U M Authors' objectives To assess the efficacy (...) of insulin and sulfonylurea combination therapy in type II diabetes mellitus. Searching MEDLINE was searched from January 1980 to March 1992 using the keywords 'sulfonylurea', 'insulin' and 'combination therapy in type II diabetes', and bibliographies of identified papers were examined. Citations reported in non-English language journals, without English translation, were excluded. Study selection Study designs of evaluations included in the review Randomised placebo-controlled trials of the same

1996 DARE.

788. The cost-effectiveness of primary prevention for non-insulin dependent diabetes mellitus

The cost-effectiveness of primary prevention for non-insulin dependent diabetes mellitus The cost-effectiveness of primary prevention for non-insulin dependent diabetes mellitus The cost-effectiveness of primary prevention for non-insulin dependent diabetes mellitus Segal L, Dalton A, Richardson J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Lifestyle and dietary advice, behavioural and surgical interventions for the primary prevention of non insulin dependent diabetes mellitus (NIDDM) as follows: Programme 1 - work site group behavioural programme for overweight men; Programme 2 - media programme for lifestyle change with community support; Programme 3 - bariatric surgery for the seriously obese; Programme 4 - intensive

1996 NHS Economic Evaluation Database.

789. Intensive therapy and progression to clinical albuminuria in patients with insulin dependent diabetes mellitus and microalbuminuria. Microalbuminuria Collaborative Study Group, United Kingdom. Full Text available with Trip Pro

Intensive therapy and progression to clinical albuminuria in patients with insulin dependent diabetes mellitus and microalbuminuria. Microalbuminuria Collaborative Study Group, United Kingdom. To study the effect of intensive therapy of diabetes on the progression to clinical albuminuria in insulin dependent diabetic patients with microalbuminuria.Randomised controlled clinical trial of intensive versus conventional therapy of diabetes for a median of 5 years (range 2-8).Nine hospital based (...) specialist diabetes centres in England and Wales.70 European insulin dependent diabetic patients aged 17-59 years with microalbuminuria (albumin excretion 30-199 micrograms/min), but without arterial hypertension, recruited from the nine hospital based specialist diabetes centres.Intensive diabetic therapy was allocated to 36 patients (27 men, 9 women) and conventional diabetic therapy to 34 (24 men, 10 women).Development of clinical albuminuria, defined as albumin excretion greater than 200 micrograms

1995 BMJ Controlled trial quality: uncertain

790. Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men. Full Text available with Trip Pro

Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men. To investigate whether low vitamin E status is a risk factor for incident non-insulin dependent diabetes mellitus.Population based follow up study with diabetes assessed at baseline and at four years.Eastern Finland.Random sample of 944 men aged 42-60 who had no diabetes at the baseline examination.Oral glucose tolerance test at four year follow up.A man (...) was defined diabetic if he had either (a) a fasting blood glucose concentration > or = 6.7 mmol/l, or (b) a blood glucose concentration > or = 10.0 mmol/l two hours after a glucose load, or (c) a clinical diagnosis of diabetes with either dietary, oral, or insulin treatment.45 men developed diabetes during the follow up period. In a multivariate logistic regression model including the strongest predictors of diabetes, a low lipid standardised plasma vitamin E (below median) concentration was associated

1995 BMJ Controlled trial quality: uncertain

791. United Kingdom Prospective Diabetes Study (UKPDS). 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. Full Text available with Trip Pro

United Kingdom Prospective Diabetes Study (UKPDS). 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. To assess the relative efficacy of treatments for non-insulin dependent diabetes over three years from diagnosis.Multicentre, randomised, controlled trial allocating patients to treatment with diet alone or additional chlorpropamide, glibenclamide, insulin, or metformin (...) (if obese) to achieve fasting plasma glucose concentrations < or = 6 mmol/l.Outpatient diabetic clinics in 15 British hospitals.2520 subjects who, after a three month dietary run in period, had fasting plasma glucose concentrations of 6.1-14.9 mmol/l but no hyperglycaemic symptoms.Fasting plasma glucose, glycated haemoglobin, and fasting plasma insulin concentrations; body weight; compliance; and hypoglycaemia.Median fasting plasma glucose concentrations were significantly lower at three years

1995 BMJ Controlled trial quality: uncertain

792. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. Full Text available with Trip Pro

Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. Sulfonylurea drugs have been the only oral therapy available for patients with non-insulin-dependent diabetes mellitus (NIDDM) in the United States. Recently, however, metformin has been approved for the treatment of NIDDM.We performed two large, randomized, parallel-group, double-blind, controlled studies in which metformin or another treatment was given for 29 weeks (...) to moderately obese patients with NIDDM whose diabetes was inadequately controlled by diet (protocol 1: metformin vs. placebo; 289 patients), or diet plus glyburide (protocol 2: metformin and glyburide vs. metformin vs. glyburide; 632 patients). To determine efficacy we measured plasma glucose (while the patients were fasting and after the oral administration of glucose), lactate, lipids, insulin, and glycosylated hemoglobin before, during, and at the end of the study.In protocol 1, at the end of the study

1995 NEJM Controlled trial quality: uncertain

793. Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy. (Abstract)

Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy. The fetuses of women with gestational diabetes mellitus are at risk for macrosomia and its attendant complications. The best method of achieving euglycemia in these women and reducing morbidity in their infants is not known. We compared the efficacy of postprandial and preprandial monitoring in achieving glycemic control in women with gestational diabetes.We studied 66 (...) women with gestational diabetes mellitus who required insulin therapy at 30 weeks of gestation or earlier. The women were randomly assigned to have their diabetes managed according to the results of preprandial monitoring or postprandial monitoring (one hour after meals) of blood glucose concentrations. Both groups were also monitored with fasting blood glucose measurements. The goal of insulin therapy was a preprandial value of 60 to 105 mg per deciliter (3.3 to 5.9 mmol per liter

1995 NEJM Controlled trial quality: uncertain

794. Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus. (Abstract)

Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus. We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular

1995 Lancet Controlled trial quality: uncertain

795. A review of the weight loss interventions for obese people with non-insulin-dependent diabetes mellitus

A review of the weight loss interventions for obese people with non-insulin-dependent diabetes mellitus A review of the weight loss interventions for obese people with non-insulin-dependent diabetes mellitus A review of the weight loss interventions for obese people with non-insulin-dependent diabetes mellitus Ciliska D, Kelly C, Petrov N, Chalmers J Authors' objectives To review the literature on the long-term results of weight loss in the non-insulin-dependent diabetes mellitus (NIDDM (...) ) population. Searching MEDLINE, CINAHL and PsycINFO were searched from 1985 using the terms 'non-insulin-dependent diabetes mellitus' combined with 'weight loss' or 'diet'. Reference lists of retrieved articles were searched for additional references, including those before 1985. Two experts in the field were asked to review the list of retrieved articles to identify if any key articles were missing. Study selection Study designs of evaluations included in the review Studies with a comparison group

1995 DARE.

796. Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation

Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation Kiberd B A, Jindal K K Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , macroproteinuria or both (dipstick >0.3 g/l orpositive Albustix confirmed with >300 mg/day or >200 micrograms/minute proteinuria). Type of intervention Screening and secondary prevention. Economic study type Cost-utility analysis. Study population Hypothetical cohort of patients with insulin dependent diabetes for at least five years and patients with hypertension or macroproteinuria. Setting Hospital/primary care. The economic evaluation was carried out in Nova Scotia, Canada. Dates to which data relate

1995 NHS Economic Evaluation Database.

797. Cost-effectiveness analyses of the conversion of patients with non-insulin-dependent diabetes mellitus from glipizide to glyburide and of the accompanying pharmacy follow-up clinic

Cost-effectiveness analyses of the conversion of patients with non-insulin-dependent diabetes mellitus from glipizide to glyburide and of the accompanying pharmacy follow-up clinic Cost-effectiveness analyses of the conversion of patients with non-insulin-dependent diabetes mellitus from glipizide to glyburide and of the accompanying pharmacy follow-up clinic Cost-effectiveness analyses of the conversion of patients with non-insulin-dependent diabetes mellitus from glipizide to glyburide (...) and of the accompanying pharmacy follow-up clinic Law A, Pathak D, Segraves A, Weinstein C, Arneson W Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Treatment for non-insulin-dependent diabetes mellitus. In particular: (1) glipizide therapy; (2

1995 NHS Economic Evaluation Database.

798. Continuous subcutaneous insulin infusion (CSII) in children and adolescents with chronic poorly controlled type 1 diabetes mellitus

Continuous subcutaneous insulin infusion (CSII) in children and adolescents with chronic poorly controlled type 1 diabetes mellitus Continuous subcutaneous insulin infusion (CSII) in children and adolescents with chronic poorly controlled type 1 diabetes mellitus Continuous subcutaneous insulin infusion (CSII) in children and adolescents with chronic poorly controlled type 1 diabetes mellitus Steindel B S, Roe T R, Costin G, Carlson M, Kaufman F R Record Status This is a critical abstract (...) of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Continuous subcutaneous insulin infusion using the MiniMed (Sylmar, CA) CSII system. Type of intervention Secondary prevention, treatment. Economic study type Cost-effectiveness analysis. Study population Children and adolescents

1995 NHS Economic Evaluation Database.

799. Cost-effectiveness of medical nutrition therapy provided by dietitians for persons with non-insulin-dependent diabetes mellitus

Cost-effectiveness of medical nutrition therapy provided by dietitians for persons with non-insulin-dependent diabetes mellitus Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

1995 NHS Economic Evaluation Database.

800. Effect of glycemic control on early diabetic renal lesions. A 5-year randomized controlled clinical trial of insulin-dependent diabetic kidney transplant recipients. (Abstract)

Effect of glycemic control on early diabetic renal lesions. A 5-year randomized controlled clinical trial of insulin-dependent diabetic kidney transplant recipients. To determine whether optimized glycemic control in type I diabetic recipients of renal allografts will prevent or delay diabetic renal lesions in the allograft.Prospective, controlled, and randomized trial of glycemic control in an inception cohort of type I diabetic renal allograft recipients. The experimental group underwent (...) the trial.Subcutaneous insulin given several times a day or continuously (maximized group) and once or twice each day (standard group) was used throughout the trial. A significant difference for hemoglobin A1 level was maintained (mean +/- SD: standard, 0.117 +/- 0.013; maximized, 0.096 +/- 0.016; P < 0.001).The primary end point of this trial was the difference between the groups in renal glomerular mesangial expansion as determined by electron microscopy.There was a more than twofold increase in the volume

1994 JAMA Controlled trial quality: uncertain