Latest & greatest articles for influenza

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Top results for influenza

41. Blockage of regulatory T cells augments induction of protective immune responses by influenza virus-like particles in aged mice

Blockage of regulatory T cells augments induction of protective immune responses by influenza virus-like particles in aged mice 28899815 2018 07 10 2018 12 01 1769-714X 19 12 2017 12 Microbes and infection Microbes Infect. Blockage of regulatory T cells augments induction of protective immune responses by influenza virus-like particles in aged mice. 626-634 S1286-4579(17)30144-2 10.1016/j.micinf.2017.08.013 Elderly humans over 65 years old are at great risk to pathogenesis by influenza virus (...) infection. However, although influenza vaccines provide effective protection in healthy young adults, protection of elderly adults is substantially lower even with a good match between the vaccine and the circulating influenza virus. To gain insight of the underlying mechanism for the reduced immunogenicity of influenza vaccines in the aged population, we investigated immunogenicity of influenza virus-like particle vaccines in aged mice, which represent a useful model for studying aging associated

Microbes and infection2017 Full Text: Link to full Text with Trip Pro

42. Influenza.

Influenza. Influenza is an acute viral respiratory disease that affects persons of all ages and is associated with millions of medical visits, hundreds of thousands of hospitalizations, and thousands of deaths during annual winter epidemics of variable severity in the United States. Elderly persons have the highest influenza-associated hospitalization and mortality rates. The primary method of prevention is annual vaccination. Early antiviral treatment has the greatest clinical benefit

Annals of Internal Medicine2017

43. Influenza Vaccine Effectiveness in the United States during the 2015-2016 Season.

Influenza Vaccine Effectiveness in the United States during the 2015-2016 Season. BACKGROUND: The A(H1N1)pdm09 virus strain used in the live attenuated influenza vaccine was changed for the 2015-2016 influenza season because of its lack of effectiveness in young children in 2013-2014. The Influenza Vaccine Effectiveness Network evaluated the effect of this change as part of its estimates of influenza vaccine effectiveness in 2015-2016. METHODS: We enrolled patients 6 months of age or older who (...) presented with acute respiratory illness at ambulatory care clinics in geographically diverse U.S. sites. Using a test-negative design, we estimated vaccine effectiveness as (1-OR)×100, in which OR is the odds ratio for testing positive for influenza virus among vaccinated versus unvaccinated participants. Separate estimates were calculated for the inactivated vaccines and the live attenuated vaccine. RESULTS: Among 6879 eligible participants, 1309 (19%) tested positive for influenza virus

NEJM2017 Full Text: Link to full Text with Trip Pro

44. First Trimester Influenza Vaccination and Risks for Major Structural Birth Defects in Offspring

First Trimester Influenza Vaccination and Risks for Major Structural Birth Defects in Offspring 28550954 2017 05 28 2017 07 28 1097-6833 187 2017 Aug The Journal of pediatrics J. Pediatr. First Trimester Influenza Vaccination and Risks for Major Structural Birth Defects in Offspring. 234-239.e4 S0022-3476(17)30586-3 10.1016/j.jpeds.2017.04.039 To examine risks for major structural birth defects in infants after first trimester inactivated influenza vaccine (IIV) exposures. In this observational

EvidenceUpdates2017

45. History and current trends in influenza virus infections with special reference to Sri Lanka

History and current trends in influenza virus infections with special reference to Sri Lanka 29291207 2018 11 13 2347-3584 28 3 2017 Sep Virusdisease Virusdisease History and current trends in influenza virus infections with special reference to Sri Lanka. 225-232 10.1007/s13337-017-0390-8 The World Health Organization (WHO) estimates that approximately one billion people are infected and up to 500,000 people die from influenza each year in the world. Influenza is considered to be the greatest (...) killer of the human populations, due to the 1918 Spanish flu, which killed millions around the world. Despite the effective treatment available against influenza, it still contributes to significant morbidity and mortality. Currently circulating influenza strains in humans include influenza A (H1N1)pdm09, influenza A (H3N2) and influenza B viruses, (B/Victoria and B/Yamagata). Influenza has been prevalent in Sri Lanka from 1969, since then it continued to cause morbidity and mortality in children

Virusdisease2017 Full Text: Link to full Text with Trip Pro

46. The Use of Antivirals for Influenza Prophylaxis: A Review of the Clinical Effectiveness

The Use of Antivirals for Influenza Prophylaxis: A Review of the Clinical Effectiveness The Use of Antivirals for Influenza Prophylaxis: A Review of the Clinical Effectiveness | CADTH.ca Find the information you need The Use of Antivirals for Influenza Prophylaxis: A Review of the Clinical Effectiveness The Use of Antivirals for Influenza Prophylaxis: A Review of the Clinical Effectiveness Published on: July 5, 2017 Project Number: RC0890-000 Product Line: Research Type: Drug Report Type (...) : Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness regarding the use of antivirals for seasonal influenza? What is the clinical effectiveness regarding the use of antivirals for pandemic influenza? Key Message The evidence suggested that influenza prophylaxis with oseltamivir or zanamivir was effective in preventing symptomatic influenza at the individual and household levels, including healthy individuals of various ages exposed to seasonal or pandemic

Canadian Agency for Drugs and Technologies in Health - Rapid Review2017

47. The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial.

The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial. BACKGROUND: Microneedle patches provide an alternative to conventional needle-and-syringe immunisation, and potentially offer improved immunogenicity, simplicity, cost-effectiveness, acceptability, and safety. We describe safety, immunogenicity, and acceptability of the first-in-man study on single (...) , dissolvable microneedle patch vaccination against influenza. METHODS: The TIV-MNP 2015 study was a randomised, partly blinded, placebo-controlled, phase 1, clinical trial at Emory University that enrolled non-pregnant, immunocompetent adults from Atlanta, GA, USA, who were aged 18-49 years, naive to the 2014-15 influenza vaccine, and did not have any significant dermatological disorders. Participants were randomly assigned (1:1:1:1) to four groups and received a single dose of inactivated influenza

Lancet2017 Full Text: Link to full Text with Trip Pro

48. Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older.

Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older. BACKGROUND: Improved influenza vaccines are needed to control seasonal epidemics. This trial compared the protective efficacy in older adults of a quadrivalent, recombinant influenza vaccine (RIV4) with a standard-dose, egg-grown, quadrivalent, inactivated influenza vaccine (IIV4) during the A/H3N2-predominant 2014-2015 influenza season, when antigenic mismatch between circulating and vaccine influenza strains (...) resulted in the reduced effectiveness of many licensed vaccines. METHODS: We conducted a randomized, double-blind, multicenter trial of RIV4 (45 μg of recombinant hemagglutinin [HA] per strain, 180 μg of protein per dose) versus standard-dose IIV4 (15 μg of HA per strain, 60 μg of protein per dose) to compare the relative vaccine efficacy against reverse-transcriptase polymerase-chain-reaction (RT-PCR)-confirmed, protocol-defined, influenza-like illness caused by any influenza strain starting 14 days

NEJM2017

49. Seasonal Influenza Immunization of Health Care Workers for the Prevention of Influenza in Patients: A Review of the Clinical Effectiveness

Seasonal Influenza Immunization of Health Care Workers for the Prevention of Influenza in Patients: A Review of the Clinical Effectiveness Seasonal Influenza Immunization of Health Care Workers for the Prevention of Influenza in Patients: A Review of the Clinical Effectiveness | CADTH.ca Find the information you need Seasonal Influenza Immunization of Health Care Workers for the Prevention of Influenza in Patients: A Review of the Clinical Effectiveness Seasonal Influenza Immunization of Health (...) Care Workers for the Prevention of Influenza in Patients: A Review of the Clinical Effectiveness Published on: June 19, 2017 Project Number: RC0889-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of seasonal influenza immunization of health care workers to prevent the spread of influenza to patients? Key Message One overview of systematic reviews and two non-randomized studies were

Canadian Agency for Drugs and Technologies in Health - Rapid Review2017

50. Canadian immunization guide chapter on influenza and statement on seasonal influenza vaccine for 2017-2018

Canadian immunization guide chapter on influenza and statement on seasonal influenza vaccine for 2017-2018 | STATEMENT ON SEASONAL INFLUENZA VACCINE FOR 2017–2018 An Advisory Committee Statement (ACS) National Advisory Committee on Immunization (NACI) Canadian Immunization Guide Chapter on Influenza and Statement on Seasonal Influenza Vaccine for 2017–2018 TO PROMOTE AND PROTECT THE HEALTH OF CANADIANS THROUGH LEADERSHIP, PARTNERSHIP, INNOVATION AND ACTION IN PUBLIC HEALTH. —Public Health (...) Agency of Canada Également disponible en français sous le titre : Une déclaration d’un comité consultatif (DCC) Comité consultatif national de l’immunisation (CCNI) Chapitre sur la grippe du Guide canadien d’immunisation et Déclaration sur la vaccination antigrippale pour la saison 2017-2018 This publication can be made available in alternative formats upon request. © Her Majesty the Queen in Right of Canada, as represented by the Minister of Health, 2017 Publication date: May 2017 This publication

CMA Infobase (Canada)2017

51. Synergistic effects of influenza and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be eliminated by the use of influenza therapeutics: experimental evidence for the multi-hit hypothesis

Synergistic effects of influenza and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be eliminated by the use of influenza therapeutics: experimental evidence for the multi-hit hypothesis 28649618 2018 11 13 2373-8057 3 2017 NPJ Parkinson's disease NPJ Parkinsons Dis Synergistic effects of influenza and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be eliminated by the use of influenza therapeutics: experimental evidence for the multi-hit hypothesis. 18 10.1038/s41531-017-0019 (...) -z Central Nervous System inflammation has been implicated in neurodegenerative disorders including Parkinson's disease (Ransohoff, Science 353: 777-783, 2016; Kannarkat et al. J. Parkinsons Dis. 3: 493-514, 2013). Here, we examined if the H1N1 influenza virus (Studahl et al. Drugs 73: 131-158, 2013) could synergize with the parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (Jackson-Lewis et al. in Mark LeDoux (ed) Movement Disorders: Genetics and Models : 287-306, Elsevier, 2015

NPJ Parkinson's disease2017 Full Text: Link to full Text with Trip Pro

52. Mutation signature in neuraminidase gene of avian influenza H9N2/G1 in Egypt

Mutation signature in neuraminidase gene of avian influenza H9N2/G1 in Egypt 28770242 2018 11 13 2347-3584 28 2 2017 Jun Virusdisease Virusdisease Mutation signature in neuraminidase gene of avian influenza H9N2/G1 in Egypt. 164-173 10.1007/s13337-017-0367-7 The low pathogenic avian influenza (LPAI) H9N2 subtype has become the most prevalent and widespread in many Asian and Middle Eastern countries. It causes an enzootic situation in commercial poultry and known as a potential facilitator virus (...) these substitutions were a distinctive feature resembling to human H9N2, H2N2 and H3N2 viruses but differs from the other avian influenza viruses. These Special features of surface glycoproteins of LPAI-H9N2 viruses refer to the tendency for enhanced introductions into humans and ensuring the importance of poultry in the transfer influenza viruses. Mosaad Zienab Z National Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, P.O. Box 264, Dokki, Giza, 12618 Egypt

Virusdisease2017 Full Text: Link to full Text with Trip Pro

53. Pulmonary immune cells and inflammatory cytokine dysregulation are associated with mortality of IL-1R1-/-mice infected with influenza virus (H1N1)

Pulmonary immune cells and inflammatory cytokine dysregulation are associated with mortality of IL-1R1-/-mice infected with influenza virus (H1N1) 28585438 2018 03 01 2018 11 13 2095-8137 38 3 2017 May 18 Zoological research Zool Res Pulmonary immune cells and inflammatory cytokine dysregulation are associated with mortality of IL-1R1 -/- mice infected with influenza virus (H1N1). 146-154 10.24272/j.issn.2095-8137.2017.035 Respirovirus infection can cause viral pneumonia and acute lung injury (...) (ALI). The interleukin-1 (IL-1) family consists of proinflammatory cytokines that play essential roles in regulating immune and inflammatory responses in vivo . IL-1 signaling is associated with protection against respiratory influenza virus infection by mediation of the pulmonary anti-viral immune response and inflammation. We analyzed the infiltration lung immune leukocytes and cytokines that contribute to inflammatory lung pathology and mortality of fatal H1N1 virus-infected IL-1 receptor 1 (IL

Zoological research2017 Full Text: Link to full Text with Trip Pro

54. Do statins reduce the effectiveness of the influenza vaccine?

Do statins reduce the effectiveness of the influenza vaccine? Do statins reduce the effectiveness of the influenza vaccine? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Do statins reduce the effectiveness of the influenza vaccine? View/ Open Date 2017-03 Format Metadata Abstract Do statins reduce the effectiveness (...) of the influenza vaccine? Evidence-based answer: Statin therapy is associated with reduced response to influenza vaccine and decreased protection against acute respiratory illness (SOR: B, large, cross-sectional observational study and retrospective cohort study). URI Part of Citation Evidence-based practice 20, no. 3 (2017): 9 Collections hosted by hosted by

Evidence Based Practice 2017

55. Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 14, April 3 to 9, 2017

Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 14, April 3 to 9, 2017 WHO IRIS: Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 14, April 3 to 9, 2017 Browse Related links Files in This Item: File Description Size Format 614.1 kB Adobe PDF Title: Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 14, April 3 to 9, 2017 Authors: Issue Date: 15-Apr-2017 Publisher: World Health Organization (...) . Regional Office for Africa Relation: Influenza Surveillance in the WHO African Region 14 3 Place of publication: Brazzaville Language: English Subject: URI: Appears in Collections: Items in WHO IRIS are protected by copyright, with all rights reserved, unless otherwise indicated. |

WHO2017

56. Presumed acute fatty liver of pregnancy following influenza A hepatitis

Presumed acute fatty liver of pregnancy following influenza A hepatitis 29225680 2018 12 01 1753-495X 10 4 2017 Dec Obstetric medicine Obstet Med Presumed acute fatty liver of pregnancy following influenza A hepatitis. 186-188 10.1177/1753495X17695173 Acute fatty liver of pregnancy is a rare mitochondrial hepatopathy characterised by microvesicular fatty infiltration, and is believed to be due to impaired fatty acid oxidation. Hepatitis following influenza virus infection is uncommon. Rarely (...) influenza virus infection may be complicated by Reye's syndrome, another hepatic microvesicular fat disease. A case of influenza A hepatitis in third trimester of pregnancy, followed by the evelopment of presumed acute fatty liver of pregnancy is described in this report and a potential mechanism why this may have occurred is discussed. Morton Adam A Mater Health and University of Queensland, South Brisbane, Queensland, Australia. eng Journal Article 2017 04 11 England Obstet Med 101464191 1753-495X

Obstetric medicine2017 Full Text: Link to full Text with Trip Pro

57. Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 13, March 27 to April 2, 2017

Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 13, March 27 to April 2, 2017 WHO IRIS: Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 13, March 27 to April 2, 2017 Browse Related links Files in This Item: File Description Size Format 608.36 kB Adobe PDF Title: Influenza Virological Surveillance in the WHO African Region: Epidemiological Week 13, March 27 to April 2, 2017 Authors: Issue Date: 4-Apr-2017 Publisher: World (...) Health Organization. Regional Office for Africa Relation: Influenza Virological Surveillance in the WHO African Region 13 3 Place of publication: Brazzaville Language: English Subject: URI: Appears in Collections: Items in WHO IRIS are protected by copyright, with all rights reserved, unless otherwise indicated. |

WHO2017

58. Taiwan's Public Health National Laboratory System: Success in Influenza Diagnosis and Surveillance

Taiwan's Public Health National Laboratory System: Success in Influenza Diagnosis and Surveillance 28418742 2017 10 31 2018 11 13 2326-5108 15 2 2017 Mar/Apr Health security Health Secur Taiwan's Public Health National Laboratory System: Success in Influenza Diagnosis and Surveillance. 154-164 10.1089/hs.2016.0104 Taiwan's National Laboratory System is one of the action packages of the Global Health Security Agenda, which was launched by the World Health Organization (WHO) to promote health (...) the national laboratory system for public health in Taiwan. We provide additional information on the national influenza laboratory surveillance network to demonstrate how our national laboratory systems work in practice, including descriptions of long-term seasonal influenza characterization and successful experiences identifying novel H7N9 and H6N1 influenza viruses. Yang Ji-Rong JR Teng Hwa-Jen HJ Liu Ming-Tsan MT Li Shu-Ying SY eng Journal Article United States Health Secur 101654694 2326-5094 IM

Health security2017 Full Text: Link to full Text with Trip Pro

59. Analyzing the clinical profile of swine flu/influenza A H1N1 infection in central India: a retrospective study

Analyzing the clinical profile of swine flu/influenza A H1N1 infection in central India: a retrospective study 28466053 2018 11 13 2347-3584 28 1 2017 Mar Virusdisease Virusdisease Analyzing the clinical profile of swine flu/influenza A H1N1 infection in central India: a retrospective study. 33-38 10.1007/s13337-017-0363-y Recently, India reported an increase in swine flu (influenza A H1N1) activity. There are limited studies on epidemiology of swine flu in Indian context. This study aims (...) to analyze clinical and epidemiological profile of suspected swine flu cases in central India. 171 cases were included in a hospital based, observational, descriptive study conducted from December 2014 to April 2015. Demographics, clinical presentation and outcome of positive and negative cases were compared. Data was analyzed using STATA software. Distribution by age, sex and residence was found similar ( p > 0.05) in positive and negative cases. Cough (89%), fever (85%) and throat irritation (51%) were

Virusdisease2017 Full Text: Link to full Text with Trip Pro

60. Recommended composition of influenza virus vaccines for use in the 2017–2018 northern hemisphere influenza season – Composition recommandée des vaccins antigrippaux pour la saison grippale 2017-2018 dans l’hémisphère Nord

Recommended composition of influenza virus vaccines for use in the 2017–2018 northern hemisphere influenza season – Composition recommandée des vaccins antigrippaux pour la saison grippale 2017-2018 dans l’hémisphère Nord WHO IRIS: Recommended composition of influenza virus vaccines for use in the 2017–2018 northern hemisphere influenza season – Composition recommandée des vaccins antigrippaux pour la saison grippale 2017-2018 dans l’hémisphère Nord Browse Related links Files in This Item: File (...) Description Size Format 1.2 MB Adobe PDF Title: Recommended composition of influenza virus vaccines for use in the 2017–2018 northern hemisphere influenza season – Composition recommandée des vaccins antigrippaux pour la saison grippale 2017-2018 dans l’hémisphère Nord Authors: Issue Date: 17-Mar-2017 Publisher: World Health Organization = Organisation mondiale de la Santé Journal: 92 (11): 117-128 Place of publication: Geneva = Genève Language: English French Description: 12 p Subject: URI: Appears

WHO2017