Latest & greatest articles for infection

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Top results for infection

101. Risk of Serious and Opportunistic Infections Associated With Treatment of Inflammatory Bowel Diseases

Risk of Serious and Opportunistic Infections Associated With Treatment of Inflammatory Bowel Diseases 29655835 2018 08 13 2018 08 13 1528-0012 155 2 2018 08 Gastroenterology Gastroenterology Risk of Serious and Opportunistic Infections Associated With Treatment of Inflammatory Bowel Diseases. 337-346.e10 S0016-5085(18)30445-1 10.1053/j.gastro.2018.04.012 The risk of infection associated with tumor necrosis factor antagonists (anti-TNF) and thiopurines (combination therapy) is uncertain. We (...) assessed the risk of serious and opportunistic infections in patients with inflammatory bowel disease (IBD) treated with thiopurine monotherapy, anti-TNF monotherapy, or combination therapy in a large cohort of patients in France. We performed a nationwide population-based study of patients (18 years or older) with a diagnosis of IBD in the French national health insurance database; we collected data from January 1, 2009 until December 31, 2014. The risks of serious and opportunistic infections

EvidenceUpdates2018

102. Prevention of Nosocomial Infections in Critically Ill Patients With Lactoferrin: A Randomized, Double-Blind, Placebo-Controlled Study

Prevention of Nosocomial Infections in Critically Ill Patients With Lactoferrin: A Randomized, Double-Blind, Placebo-Controlled Study 30015668 2018 08 16 1530-0293 46 9 2018 Sep Critical care medicine Crit. Care Med. Prevention of Nosocomial Infections in Critically Ill Patients With Lactoferrin: A Randomized, Double-Blind, Placebo-Controlled Study. 1450-1456 10.1097/CCM.0000000000003294 To obtain preliminary evidence for the efficacy of lactoferrin as a preventative measure for nosocomial (...) infections and inform the conduct of a definitive study. Phase 2, multicenter, randomized, double-blind, placebo-controlled study. Medical-surgical ICUs. Adult, critically ill patients receiving invasive mechanical ventilation. Randomized, eligible, consenting patients expected to require invasive mechanical ventilation more than 48 hours received lactoferrin both enterally and via an oral swab or a placebo of sterile water for up to 28 days. Of the 214 patients who were randomized, 212 received at least

EvidenceUpdates2018

103. Prognostic value of the Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification in patients with no-option chronic limb-threatening ischemia

Prognostic value of the Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification in patients with no-option chronic limb-threatening ischemia 29802042 2018 05 26 1097-6809 2018 May 22 Journal of vascular surgery J. Vasc. Surg. Prognostic value of the Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification in patients with no-option chronic limb-threatening ischemia. S0741-5214(18)30422-1 10.1016/j.jvs.2018.02.028 The Wound, Ischemia (...) , and foot Infection (WIfI) classification was developed to assess amputation risk and hence to aid in clinical decision-making in patients with chronic limb-threatening ischemia (CLTI). WIfI has been validated in multiple CLTI cohorts worldwide. In this study, we examined the relationship between WIfI stage and clinical outcomes in a well-defined subpopulation of CLTI patients considered not eligible for conventional revascularization. The aim of this study was to assess the prognostic value of the WIfI

EvidenceUpdates2018

104. Predicting Failure in Early Acute Prosthetic Joint Infection Treated With Debridement, Antibiotics, and Implant Retention: External Validation of the KLIC Score

Predicting Failure in Early Acute Prosthetic Joint Infection Treated With Debridement, Antibiotics, and Implant Retention: External Validation of the KLIC Score 29691168 2018 07 22 1532-8406 33 8 2018 Aug The Journal of arthroplasty J Arthroplasty Predicting Failure in Early Acute Prosthetic Joint Infection Treated With Debridement, Antibiotics, and Implant Retention: External Validation of the KLIC Score. 2582-2587 S0883-5403(18)30299-7 10.1016/j.arth.2018.03.041 Debridement, antibiotics (...) , and implant retention (DAIR) is a widely used treatment modality for early acute prosthetic joint infection (PJI). A preoperative risk score was previously designed for predicting DAIR failure, consisting of chronic renal failure (K), liver cirrhosis (L), index surgery (I), cemented prosthesis (C), and C-reactive protein >115 mg/L (KLIC). The aim of this study was to validate the KLIC score in an external cohort. We retrospectively evaluated patients with early acute PJI treated with DAIR between 2006

EvidenceUpdates2018

105. HIV Viral Suppression Trends Over Time Among HIV-Infected Patients Receiving Care in the United States, 1997 to 2015: A Cohort Study.

HIV Viral Suppression Trends Over Time Among HIV-Infected Patients Receiving Care in the United States, 1997 to 2015: A Cohort Study. Background: Because HIV viral suppression is essential for optimal outcomes and prevention efforts, understanding trends and predictors is imperative to inform public health policy. Objective: To evaluate viral suppression trends in people living with HIV (PLWH), including the relationship of associated factors, such as demographic characteristics and integrase

Annals of Internal Medicine2018

106. Twelve-Month Outcomes After Transplant of Hepatitis C-Infected Kidneys Into Uninfected Recipients: A Single-Group Trial.

Twelve-Month Outcomes After Transplant of Hepatitis C-Infected Kidneys Into Uninfected Recipients: A Single-Group Trial. Background: Organs from hepatitis C virus (HCV)-infected deceased donors are often discarded. Preliminary data from 2 small trials, including THINKER-1 (Transplanting Hepatitis C kidneys Into Negative KidnEy Recipients), suggested that HCV-infected kidneys could be safely transplanted into HCV-negative patients. However, intermediate-term data on quality of life and renal (...) function are needed to counsel patients about risk. Objective: To describe 12-month HCV treatment outcomes, estimated glomerular filtration rate (eGFR), and quality of life for the 10 kidney recipients in THINKER-1 and 6-month data on 10 additional recipients. Design: Open-label, nonrandomized trial. (ClinicalTrials.gov: NCT02743897 ). Setting: Single center. Participants: 20 HCV-negative transplant candidates. Intervention: Participants underwent transplant with kidneys infected with genotype 1 HCV

Annals of Internal Medicine2018

107. Dalbavancin (Xydalba) - treatment of acute bacterial skin and skin structure infections (ABSSSI) in adults

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All Wales Medicines Strategy Group2018

108. The value of quantitative histology in the diagnosis of fracture-related infection

The value of quantitative histology in the diagnosis of fracture-related infection 29954215 2018 07 10 2018 07 10 2049-4408 100-B 7 2018 07 The bone & joint journal Bone Joint J The value of quantitative histology in the diagnosis of fracture-related infection. 966-972 10.1302/0301-620X.100B7.BJJ-2018-0052.R1 This study aimed to investigate the role of quantitative histological analysis in the diagnosis of fracture-related infection (FRI). The clinical features, microbiology culture results (...) , and histological analysis in 156 surgically treated nonunions were used to stratify the likelihood of associated infection. There were 64 confirmed infected nonunions (one or more confirmatory criteria: pus, sinus, and bacterial growth in two or more samples), 66 aseptic nonunions (no confirmatory criteria), and 26 possibly infected nonunions (pathogen identified from a single specimen and no confirmatory criteria). The histological inflammatory response was assessed by average neutrophil polymorph (NPs

EvidenceUpdates2018

109. Risk of Infective Endocarditis After Invasive Dental Treatments: A Case-Only Study

Risk of Infective Endocarditis After Invasive Dental Treatments: A Case-Only Study 29674326 2018 04 20 1524-4539 2018 Apr 19 Circulation Circulation Risk of Infective Endocarditis After Invasive Dental Treatments: A Case-Only Study. CIRCULATIONAHA.117.033131 10.1161/CIRCULATIONAHA.117.033131 Background -Invasive dental treatments (IDTs) can yield temporary bacteremia and has therefore been considered a potential risk factor of infective endocarditis (IE). It is hypothesized that, through (...) University, Taipei, Taiwan. Tu Yu-Kang YK Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan & Department of Dentistry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan yukangtu@ntu.edu.tw. eng Journal Article 2018 04 19 United States Circulation 0147763 0009-7322 case-crossover design infective endocarditis invasive dental treatments self-controlled case series design 2018 04 09 2017 12 07 2018 03 12 2018 4

EvidenceUpdates2018

111. Does BCG Vaccination Protect Against Non-Tuberculous Mycobacterial Infection? A Systematic Review and Meta-Analysis

Does BCG Vaccination Protect Against Non-Tuberculous Mycobacterial Infection? A Systematic Review and Meta-Analysis 29635431 2018 07 30 1537-6613 218 5 2018 Jul 24 The Journal of infectious diseases J. Infect. Dis. Does BCG Vaccination Protect Against Nontuberculous Mycobacterial Infection? A Systematic Review and Meta-Analysis. 679-687 10.1093/infdis/jiy207 The incidence of nontuberculous mycobacterial (NTM) infections is increasing worldwide, particularly NTM lymphadenitis and skin infections (...) ]). No studies have compared different BCG vaccine strains or the effect of revaccination in this setting. The protective effect of BCG vaccination against NTM should be taken into consideration when deciding on recommendations for discontinuation of universal BCG vaccination programs and in assessing new vaccines designed to replace BCG. Zimmermann Petra P Department of Paediatrics, The University of Melbourne, Parkville, Australia. Infectious Diseases Unit, Royal Children's Hospital Melbourne, Parkville

EvidenceUpdates2018

112. The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system predicts wound healing better than direct angiosome perfusion in diabetic foot wounds

The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system predicts wound healing better than direct angiosome perfusion in diabetic foot wounds 29803684 2018 05 27 1097-6809 2018 May 23 Journal of vascular surgery J. Vasc. Surg. The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system predicts wound healing better than direct angiosome perfusion in diabetic foot wounds. S0741-5214(18)30418-X 10.1016/j.jvs (...) .2018.01.060 Previous studies show conflicting results in wound healing outcomes based on angiosome direct perfusion (DP), but few have adjusted for wound characteristics in their analyses. We have previously shown that the Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification correlates with wound healing in diabetic foot ulcers (DFUs) treated by a multidisciplinary team. The aim of this study was to compare WIfI classification vs DP and pedal arch patency as predictors

EvidenceUpdates2018

114. Urinary tract infection

Urinary tract infection Top results for urinary tract infection - Trip Database or use your Google+ account Liberating the literature My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top (...) search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for urinary tract infection The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection

Trip Latest and Greatest2018

115. Infection

Infection Top results for infection - Trip Database or use your Google+ account Find evidence fast My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search (...) button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for infection The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory

Trip Latest and Greatest2018

117. Treatment for chronic methicillin-sensitive Staphylococcus aureus pulmonary infection in people with cystic fibrosis.

Treatment for chronic methicillin-sensitive Staphylococcus aureus pulmonary infection in people with cystic fibrosis. BACKGROUND: Cystic fibrosis is an inherited life-threatening multisystem disorder with lung disease characterized by abnormally thick airway secretions and persistent bacterial infection. Chronic, progressive lung disease is the most important cause of morbidity and mortality in the condition and is therefore the main focus of clinical care and research. Staphylococcus aureus (...) is a major cause of chest infection in people with cystic fibrosis. Early onset, as well as chronic, lung infection with this organism in young children and adults results in worsening lung function, poorer nutrition and increases the airway inflammatory response, thus leading to a poor overall clinical outcome. There are currently no evidence-based guidelines for chronic suppressive therapy for Staphylococcus aureus infection in cystic fibrosis such as those used for Pseudomonas aeruginosa infection

Cochrane2018

118. Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2018 Recommendations of the International Antiviral Society-USA Panel.

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2018 Recommendations of the International Antiviral Society-USA Panel. Importance: Antiretroviral therapy (ART) is the cornerstone of prevention and management of HIV infection. Objective: To evaluate new data and treatments and incorporate this information into updated recommendations for initiating therapy, monitoring individuals starting therapy, changing regimens, and preventing HIV infection for individuals (...) at risk. Evidence Review: New evidence collected since the International Antiviral Society-USA 2016 recommendations via monthly PubMed and EMBASE literature searches up to April 2018; data presented at peer-reviewed scientific conferences. A volunteer panel of experts in HIV research and patient care considered these data and updated previous recommendations. Findings: ART is recommended for virtually all HIV-infected individuals, as soon as possible after HIV diagnosis. Immediate initiation (eg

JAMA2018

119. Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics.

Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics. Clinical Question: In adults and children prescribed antibiotics, is co-administration of a probiotic associated with a lower risk of symptomatic Clostridium difficile infection without an increase in adverse events? Bottom Line: Moderate-quality evidence suggests that probiotics are associated with a lower risk of C difficile infection and very low-quality evidence suggests that probiotics are associated

JAMA2018

120. Vaginal preparation with antiseptic solution before cesarean section for preventing postoperative infections.

Vaginal preparation with antiseptic solution before cesarean section for preventing postoperative infections. BACKGROUND: Cesarean delivery is one of the most common surgical procedures performed by obstetricians. Infectious morbidity after cesarean delivery can have a tremendous impact on the postpartum woman's return to normal function and her ability to care for her baby. Despite the widespread use of prophylactic antibiotics, postoperative infectious morbidity still complicates cesarean (...) deliveries. This is an update of a Cochrane review first published in 2010 and subsequently updated in 2012, and twice in 2014. OBJECTIVES: To determine if cleansing the vagina with an antiseptic solution before a cesarean delivery decreases the risk of maternal infectious morbidities, including endometritis and wound complications. We also assessed the side effects of vaginal cleansing solutions to determine adverse events associated with the intervention. SEARCH METHODS: We searched Cochrane Pregnancy

Cochrane2018