Latest & greatest articles for infection

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Top results for infection

1. Leukomed Sorbact for preventing surgical site infection

Leukomed Sorbact for preventing surgical site infection Leukomed Sorbact for preventing surgical site infection Medtech innovation briefing Published: 14 November 2019 www.nice.org.uk/guidance/mib197 pathways Summary Summary The technology technology described in this briefing is Leukomed Sorbact. It is used for preventing surgical site infection (SSI) in closed surgical incisions with up to moderate exudate levels. The inno innovativ vative aspect e aspect is the hydrophobic dialkylcarbamoyl (...) ), also known as Sorbact surgical dressing, is a sterile, single-use, bacteria- binding, adhesive-bordered wound dressing. It is to prevent surgical site infection (SSI) in closed surgical wounds that have low to moderate levels of exudate. The dressing comprises an absorbent non-woven wound contact pad and an adhesive polyurethane film. The pad is made of white viscose polypropylene and polyester laminated to the proprietary dialkylcarbamoyl chloride (DACC)-coated Sorbact mesh. DACC's hydrophobicity

2019 National Institute for Health and Clinical Excellence - Advice

2. Rapid tests for group A streptococcal infections in people with a sore throat

Rapid tests for group A streptococcal infections in people with a sore throat Rapid tests for group A streptococcal infections in people with a sore throat Diagnostics guidance Published: 13 November 2019 www.nice.org.uk/guidance/dg38 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility This guidance represents the view of NICE, arrived at after careful consideration (...) infections in people with a sore throat (DG38) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 47Contents Contents 1 Recommendations 4 2 The diagnostic tests 6 Clinical need and practice 6 The condition 6 The care pathway 7 The interventions 8 The comparator 11 Reference standard 11 3 Evidence 12 Clinical effectiveness 12 Cost effectiveness 17 4 Committee discussion 35 Clinical need and practice 35 Clinical

2019 National Institute for Health and Clinical Excellence - Diagnostics Guidance

3. Prophylactic levofloxacin to prevent infections in newly diagnosed symptomatic myeloma: the TEAMM RCT

Prophylactic levofloxacin to prevent infections in newly diagnosed symptomatic myeloma: the TEAMM RCT Prophylactic levofloxacin to prevent infections in newly diagnosed symptomatic myeloma: the TEAMM RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need (...) . >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} During the 12 weeks from new diagnosis, the addition of prophylactic levofloxacin to active myeloma treatment significantly reduced febrile episodes and deaths without increasing healthcare associated infections or carriage. {{author}} {{($index , , , , , , , , , , , , , , & . Mark T Drayson 1, * , Stella Bowcock 2 , Tim Planche 3 , Gulnaz Iqbal 4 , Guy Pratt 5 , Kwee Yong 6 , Jill Wood 4 , Kerry Raynes 4

2019 NIHR HTA programme

4. Nivolumab (Opdivo): reports of cytomegalovirus (CMV) gastrointestinal infection or reactivation

Nivolumab (Opdivo): reports of cytomegalovirus (CMV) gastrointestinal infection or reactivation Nivolumab (Opdivo): reports of cytomegalovirus (CMV) gastrointestinal infection or reactivation - GOV.UK GOV.UK uses cookies which are essential for the site to work. We also use non-essential cookies to help us improve government digital services. Any data collected is anonymised. By continuing to use this site, you agree to our use of cookies. Accept cookies You’ve accepted all cookies. You can (...) at any time. Hide Search Register by 26 November to vote in the General Election on 12 December. Nivolumab (Opdivo): reports of cytomegalovirus (CMV) gastrointestinal infection or reactivation Patients on nivolumab who present with diarrhoea or other symptoms of colitis, and those who do not respond to steroid treatment for immune-related colitis, should be investigated to exclude other causes, including infections such as cytomegalovirus (CMV). Published 18 October 2019 From: Therapeutic area

2019 MHRA Drug Safety Update

5. Glecaprevir/pibrentasvir (Maviret) - chronic hepatitis C virus (HCV) infection in adolescents

Glecaprevir/pibrentasvir (Maviret) - chronic hepatitis C virus (HCV) infection in adolescents Published 11 November 2019 1 Product update SMC2214 glecaprevir/pibrentasvir 100mg/40mg film-coated tablets (Maviret®) AbbVie Ltd 04 October 2019 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following an abbreviated (...) submission glecaprevir/pibrentasvir (Maviret®) is accepted for use within NHSScotland. Indication under review: treatment of chronic hepatitis C virus (HCV) infection in adolescents aged 12 to <18 years. SMC has previously accepted glecaprevir/pibrentasvir for the treatment of chronic HCV infection in adults. This SMC advice takes account of the benefits of a Patient Access Scheme (PAS) that improves the cost-effectiveness of glecaprevir/pibrentasvir. This advice is contingent upon the continuing

2019 Scottish Medicines Consortium

6. Dolutegravir + rilpivirine (Juluca) dual therapy in HIV infection

Dolutegravir + rilpivirine (Juluca) dual therapy in HIV infection Prescrire IN ENGLISH - Spotlight ''Dolutegravir + rilpivirine (Juluca°) dual therapy in HIV infection'', 1 November 2019 {1} {1} {1} | | > > > Dolutegravir + rilpivirine (Juluca°) dual therapy in HIV infection Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Dolutegravir (...) + rilpivirine (Juluca°) dual therapy in HIV infection FEATURED REVIEW First-line therapy for patients with HIV infection is usually based on triple therapy. When sustained virological suppression has been achieved, treatment "simplification" can sometimes be considered. Is the two-drug regimen dolutegravir + rilpivirine (Juluca°) any better than other treatment options? Full review (3 pages) available for download by subscribers. Prescrire's rating NOTHING NEW In patients who have an undetectable viral load

2019 Prescrire

7. Hepatitis E: health protection response to reports of infection

Hepatitis E: health protection response to reports of infection Hepatitis E: health protection response to reports of infection - GOV.UK GOV.UK uses cookies which are essential for the site to work. We also use non-essential cookies to help us improve government digital services. Any data collected is anonymised. By continuing to use this site, you agree to our use of cookies. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Register by 26 November to vote (...) in the General Election on 12 December. Guidance Hepatitis E: health protection response to reports of infection Guidance on low public health risk, surveillance process and follow up with contacts. Published 14 June 2012 Last updated 8 November 2019 — From: Documents Ref: PHE publications gateway number: GW-698 If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email . Please tell us what format you need. It will help us if you

2019 Public Health England

8. Dilute Betadine Lavage Reduces the Risk of Acute Postoperative Periprosthetic Joint Infection in Aseptic Revision Total Knee and Hip Arthroplasty: A Randomized Controlled Trial

Dilute Betadine Lavage Reduces the Risk of Acute Postoperative Periprosthetic Joint Infection in Aseptic Revision Total Knee and Hip Arthroplasty: A Randomized Controlled Trial The purpose of this randomized, controlled trial is to determine whether dilute betadine lavage compared to normal saline lavage reduces the rate of acute postoperative periprosthetic joint infection (PJI) in aseptic revision total knee (TKA) and hip arthroplasty (THA).A total of 478 patients undergoing aseptic revision (...) -day wound complications. A priori power analysis determined that 285 patients per group were needed to detect a reduction in the rate of PJI from 5% to 1% with 80% power and alpha of 0.05.There were eight infections in the saline group and 1 in the betadine group (3.4% vs 0.4%, P = .038). There was no difference in wound complications between groups (1.3% vs 0%, P = .248). There were no differences in any baseline demographics or type of revision procedure between groups, suggesting appropriate

2019 EvidenceUpdates

9. Daptomycin and linezolid for vancomycin-resistant enterococci bloodstream infections

Daptomycin and linezolid for vancomycin-resistant enterococci bloodstream infections '); } else { document.write(' '); } ACE | Daptomycin and linezolid for treating vancomycin-resistant enterococci bloodstream infections Search > > Daptomycin and linezolid for treating vancomycin-resistant enterococci bloodstream infections - Daptomycin and linezolid for treating vancomycin-resistant enterococci bloodstream infections Published on 2 January 2019 Guidance Recommendations The Ministry of Health's (...) Drug Advisory Committee has recommended: Linezolid 600 mg tablet and 2 mg/ml solution for infusion for treating patients with culture-positive vancomycin-resistant enterococci (VRE) bloodstream infections. Subsidy status Linezolid 600 mg tablet and 2 mg/ml solution for infusion are recommended for inclusion on the Medication Assistance Fund (MAF) for the abovementioned indication. Treatment with linezolid should be initiated and monitored by an infectious disease specialist. MAF assistance does

2019 Appropriate Care Guides, Agency for Care Effectiveness (Singapore)

11. Prophylactic Postoperative Measures to Minimize Surgical Site Infections in Spine Surgery: Systematic Review and Evidence Summary

Prophylactic Postoperative Measures to Minimize Surgical Site Infections in Spine Surgery: Systematic Review and Evidence Summary There are three phases in prophylaxis of surgical site infections (SSI): preoperative, intraoperative and postoperative. There is lack of consensus and paucity of evidence with SSI prophylaxis in the postoperative period.To systematically evaluate the literature, and provide evidence-based summaries on postoperative measures for SSI prophylaxis in spine (...) idiopathic scoliosis corrective surgery does not seem to alter the overall rate of SSI in spine surgery. Concomitant administration of AMP in the presence of a wound drain does not seem to reduce the overall rate of SSI, deep SSI, or superficial SSI in thoracolumbar fusion performed for degenerative and deformity spine pathologies, and in adolescent idiopathic scoliosis corrective surgery. Enhanced-recovery after surgery clinical pathways and infection-specific protocols do not seem to reduce rate of SSI

2019 EvidenceUpdates

12. Reduction of Postoperative Wound Infections by Antiseptica (RECIPE)?: A Randomized Controlled Trial

Reduction of Postoperative Wound Infections by Antiseptica (RECIPE)?: A Randomized Controlled Trial To evaluate whether intraoperative subcutaneous wound irrigation with 0.04% polyhexanide can reduce surgical site infection (SSI) in elective laparotomies compared to saline.SSI is a common complication after gastrointestinal surgery. To date, there is a lack of evidence whether subcutaneous wound irrigation is beneficial in terms of reduction of SSI.The RECIPE trial was an investigator initiated

2019 EvidenceUpdates

13. Risk of Infections and Cancer in Patients With Rheumatologic Diseases Receiving Interleukin Inhibitors: A Systematic Review and Meta-analysis

Risk of Infections and Cancer in Patients With Rheumatologic Diseases Receiving Interleukin Inhibitors: A Systematic Review and Meta-analysis The safety profile of interleukin (IL) inhibitors is not well established.To assess the risk of serious infections, opportunistic infections, and cancer in patients with rheumatologic diseases treated with IL inhibitors.Ovid MEDLINE and Epub Ahead of Print, In-Process & Other Non-Indexed Citations; Ovid MEDLINE Daily; Ovid Embase; Ovid Cochrane Central (...) and certainty in the evidence. Fixed-effects meta-analysis was conducted to pool odds ratios (ORs) for serious infections, opportunistic infections, and cancers for IL inhibitors vs placebo.The outcomes of interest were the number of serious infections, opportunistic infections, and cancers in individuals receiving IL inhibitor therapies compared with placebo.In this meta-analysis, 74 studies comprising 29 214 patients (24 236 patients for serious infections, 9998 for opportunistic infections, and 21 065

2019 EvidenceUpdates

14. Glecaprevir/pibrentasvir (Maviret) - chronic hepatitis C virus (HCV) infection in adolescents

Glecaprevir/pibrentasvir (Maviret) - chronic hepatitis C virus (HCV) infection in adolescents Final Appraisal Recommendation Advice No: 1319 – October 2019 Glecaprevir/pibrentasvir (Maviret ® ) 100 mg/40 mg film-coated tablets Limited submission by AbbVie Ltd. Additional note(s): • Please refer to the Summary of Product Characteristics for the full licensed indication. In reaching the above recommendation AWMSG has taken account of the appraisal documentation prepared by the AWMSG Secretariat (...) as an option for use within NHS Wales for the treatment of chronic hepatitis C virus (HCV) infection in adolescents aged 12 to < 18 years. This recommendation applies only in circumstances where the approved Wales Patient Access Scheme (WPAS) is utilised or where the list/contract price is equivalent or lower than the WPAS price. Statement of use: No part of this recommendation may be reproduced without the whole recommendation being quoted in full and cited as: All Wales Medicines Strategy Group Final

2019 All Wales Medicines Strategy Group

15. The Effect of Prolonged Postoperative Antibiotic Administration on the Rate of Infection in Patients Undergoing Posterior Spinal Surgery Requiring a Closed-Suction Drain: A Randomized Controlled Trial

The Effect of Prolonged Postoperative Antibiotic Administration on the Rate of Infection in Patients Undergoing Posterior Spinal Surgery Requiring a Closed-Suction Drain: A Randomized Controlled Trial Closed-suction drains are frequently used following posterior spinal surgery. The optimal timing of antibiotic discontinuation in this population may influence infection risk, but there is a paucity of evidence. The aim of this study was to determine whether postoperative antibiotic administration (...) for 72 hours (24 hours after drain removal as drains were removed on the second postoperative day) decreases the incidence of surgical site infection compared with postoperative antibiotic administration for 24 hours.Patients undergoing posterior thoracolumbar spinal surgery managed with a closed-suction drain were prospectively randomized into 1 of 2 groups of postoperative antibiotic durations: (1) 24 hours, or (2) 24 hours after drain removal (72 hours). Drains were discontinued on the second

2019 EvidenceUpdates

16. Isoniazid Preventive Therapy in HIV-Infected Pregnant and Postpartum Women. (PubMed)

Isoniazid Preventive Therapy in HIV-Infected Pregnant and Postpartum Women. The safety, efficacy, and appropriate timing of isoniazid therapy to prevent tuberculosis in pregnant women with human immunodeficiency virus (HIV) infection who are receiving antiretroviral therapy are unknown.In this multicenter, double-blind, placebo-controlled, noninferiority trial, we randomly assigned pregnant women with HIV infection to receive isoniazid preventive therapy for 28 weeks, initiated either during

2019 NEJM

17. Radiologic Management of Infected Fluid Collections

Radiologic Management of Infected Fluid Collections Date of origin: 1996 Last review date: 2014 ACR Appropriateness Criteria ® 1 Radiologic Management of Infected Fluid Collections American College of Radiology ACR Appropriateness Criteria ® Clinical Condition: Radiologic Management of Infected Fluid Collections Variant 1: Patient with right lower quadrant abdominal pain, fever, and leukocytosis for 7 days. Physical examination shows no peritoneal signs. CT scan shows a thin-walled, 3 × 4 cm (...) be appropriate; 7,8,9 Usually appropriate ACR Appropriateness Criteria ® 2 Radiologic Management of Infected Fluid Collections Clinical Condition: Radiologic Management of Infected Fluid Collections Variant 3: Patient who is an IV drug abuser presents with fever and tachycardia and on imaging is found to have 2 noncommunicating splenic abscesses measuring 4 cm in diameter, accessible percutaneously through a 1 cm rim of normal splenic tissue. Appropriate management includes antibiotics. Treatment/Procedure

2019 American College of Radiology

18. Fluoroquinolones for the Treatment of Respiratory Tract Infections: A Review of Clinical Effectiveness,

Fluoroquinolones for the Treatment of Respiratory Tract Infections: A Review of Clinical Effectiveness, Fluoroquinolones for the Treatment of Respiratory Tract Infections: A Review of Clinical Effectiveness, | CADTH.ca Find the information you need Fluoroquinolones for the Treatment of Respiratory Tract Infections: A Review of Clinical Effectiveness, Fluoroquinolones for the Treatment of Respiratory Tract Infections: A Review of Clinical Effectiveness, Last updated: May 6, 2019 Project Number (...) : RC1093-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of fluoroquinolones for the treatment of respiratory tract infections? What is the cost-effectiveness of fluoroquinolones for the treatment of respiratory tract infections? What are the evidence-based guidelines for the use of fluoroquinolones for the treatment of respiratory tract infections? Key Message Overall, 15 publications met the eligibility

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

19. Ivermectin for Parasitic Skin Infections of Lice: A Review of Comparative Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Ivermectin for Parasitic Skin Infections of Lice: A Review of Comparative Clinical Effectiveness, Cost-Effectiveness, and Guidelines Ivermectin for Parasitic Skin Infections of Lice: A Review of Comparative Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Ivermectin for Parasitic Skin Infections of Lice: A Review of Comparative Clinical Effectiveness, Cost-Effectiveness, and Guidelines Ivermectin for Parasitic Skin Infections of Lice: A Review (...) of Comparative Clinical Effectiveness, Cost-Effectiveness, and Guidelines Last updated: May 14, 2019 Project Number: RC1115-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the comparative clinical effectiveness of oral versus topical ivermectin for parasitic skin infections of lice? What is the comparative clinical effectiveness of oral ivermectin versus pediculicides for parasitic skin infections of lice? What is the comparative

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

20. Lyophilized versus Frozen Fecal Microbiota Transplant for Recurrent Clostridium Difficile Infection, Inflammatory Bowel Disease, and Irritable Bowel Syndrome: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Lyophilized versus Frozen Fecal Microbiota Transplant for Recurrent Clostridium Difficile Infection, Inflammatory Bowel Disease, and Irritable Bowel Syndrome: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Lyophilized versus Frozen Fecal Microbiota Transplant for Recurrent Clostridium Difficile Infection, Inflammatory Bowel Disease, and Irritable Bowel Syndrome: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you (...) need Lyophilized versus Frozen Fecal Microbiota Transplant for Recurrent Clostridium Difficile Infection, Inflammatory Bowel Disease, and Irritable Bowel Syndrome: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Lyophilized versus Frozen Fecal Microbiota Transplant for Recurrent Clostridium Difficile Infection, Inflammatory Bowel Disease, and Irritable Bowel Syndrome: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Last updated: August 14, 2019 Project

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review