Latest & greatest articles for infants

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Top results for infants

21. The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year

The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year 30172426 2018 10 26 1097-6833 2018 Aug 29 The Journal of pediatrics J. Pediatr. The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year. S0022-3476(18)30940-5 10.1016/j.jpeds.2018.07.035 To assess the effect of pulmonary hypertension on neonatal intensive care unit mortality and hospital readmission through 1 year of corrected age (...) in a large multicenter cohort of infants with severe bronchopulmonary dysplasia. This was a multicenter, retrospective cohort study of 1677 infants born <32 weeks of gestation with severe bronchopulmonary dysplasia enrolled in the Children's Hospital Neonatal Consortium with records linked to the Pediatric Health Information System. Pulmonary hypertension occurred in 370 out of 1677 (22%) infants. During the neonatal admission, pulmonary hypertension was associated with mortality (OR 3.15, 95% CI 2.10

EvidenceUpdates2018

22. Effects of a new device for automated closed loop control of inspired oxygen concentration on fluctuations of arterial and different regional organ tissue oxygen saturations in preterm infants

Effects of a new device for automated closed loop control of inspired oxygen concentration on fluctuations of arterial and different regional organ tissue oxygen saturations in preterm infants 30154236 2018 08 29 1468-2052 2018 Aug 28 Archives of disease in childhood. Fetal and neonatal edition Arch. Dis. Child. Fetal Neonatal Ed. Effects of a new device for automated closed loop control of inspired oxygen concentration on fluctuations of arterial and different regional organ tissue oxygen (...) saturations in preterm infants. fetalneonatal-2018-314769 10.1136/archdischild-2018-314769 To assess the efficacy of a newly developed system for closed loop control of the fraction of inspired oxygen (FiO 2 ) on variation of arterial (SpO 2 ) and on regional tissue oxygen saturation (StO 2 ) in preterm infants with fluctuations in SpO 2 . Randomised crossover trial comparing automated (auto) to manual FiO 2 adjustment (manual) during two consecutive 24 hours periods using a Sophie infant ventilator (SPO

EvidenceUpdates2018

23. Effects of Myo-inositol on Type 1 Retinopathy of Prematurity Among Preterm Infants &lt;28 Weeks' Gestational Age: A Randomized Clinical Trial.

Effects of Myo-inositol on Type 1 Retinopathy of Prematurity Among Preterm Infants <28 Weeks' Gestational Age: A Randomized Clinical Trial. Importance: Previous studies of myo-inositol in preterm infants with respiratory distress found reduced severity of retinopathy of prematurity (ROP) and less frequent ROP, death, and intraventricular hemorrhage. However, no large trials have tested its efficacy or safety. Objective: To test the adverse events and efficacy of myo-inositol to reduce type 1 (...) ROP among infants younger than 28 weeks' gestational age. Design, Setting, and Participants: Randomized clinical trial included 638 infants younger than 28 weeks' gestational age enrolled from 18 neonatal intensive care centers throughout the United States from April 17, 2014, to September 4, 2015; final date of follow-up was February 12, 2016. The planned enrollment of 1760 participants would permit detection of an absolute reduction in death or type 1 ROP of 7% with 90% power. The trial

JAMA2018

24. Infant formulas containing hydrolysed protein for prevention of allergic disease.

Infant formulas containing hydrolysed protein for prevention of allergic disease. BACKGROUND: Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants, in place of standard cow's milk formula (CMF). However, it is unclear whether the clinical trial evidence supports this. OBJECTIVES: To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk. If hydrolysed formulas are effective (...) , to determine what type of hydrolysed formula is most effective, including extensively or partially hydrolysed formula (EHF/PHF). To determine whether infants at low or high risk of allergic disease, and whether infants receiving early short-term (first few days after birth) or prolonged formula feeding benefit from hydrolysed formulas. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL 2017, Issue 11), MEDLINE (1948 to 3 November 2017), and Embase (1974 to 3 November

Cochrane2018

25. Creation of the WHO Indicators of Infant and Young Child Development (IYCD): metadata synthesis across 10 countries

Creation of the WHO Indicators of Infant and Young Child Development (IYCD): metadata synthesis across 10 countries 30364327 2018 11 14 2059-7908 3 5 2018 BMJ global health BMJ Glob Health Creation of the WHO Indicators of Infant and Young Child Development (IYCD): metadata synthesis across 10 countries. e000747 10.1136/bmjgh-2018-000747 Renewed global commitment to the improvement of early child development outcomes, as evidenced by the focus of the United Nations Sustainable Development Goal

BMJ global health2018 Full Text: Link to full Text with Trip Pro

26. Naloxone for opioid-exposed newborn infants.

Naloxone for opioid-exposed newborn infants. BACKGROUND: Naloxone, a specific opioid antagonist, is available for the treatment of newborn infants with cardiorespiratory or neurological depression that may be due to intrauterine exposure to opioid. It is unclear whether newborn infants may benefit from this therapy and whether naloxone has any harmful effects. OBJECTIVES: To determine the effect of naloxone on the need for and duration of neonatal unit stay in infants of mothers who received (...) opioid analgesia prior to delivery or of mothers who have used a prescribed or non-prescribed opioid during pregnancy. SEARCH METHODS: We searched the following databases in February 2018: the Cochrane Central Register of Controlled Trials (the Cochrane Library 2018, Issue 1), MEDLINE (OvidSP), MEDLINE In process & Other Non-Indexed Citations (OvidSP), Embase (OvidSP), CINAHL (EBSCO), Maternity and Infant Care (OvidSP), and PubMed. We searched for ongoing and completed trials in the WHO

Cochrane2018

27. Ultrasonography-Guided Lumbar Punctures Effect on Success Rate in Infants

Ultrasonography-Guided Lumbar Punctures Effect on Success Rate in Infants "Ultrasonography-Guided Lumbar Punctures Effect on Success Rate in Infa" by Patricia Dorian < > > > > > Title Author Date of Graduation Summer 8-11-2018 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies Rights . Abstract Background: Lumbar puncture (LP) is a common diagnostic procedure performed in emergency departments for febrile infants in order to rule in or rule out bacterial (...) . The goal of this review is to analyze studies done on infants and discern if they have a similar or better success rate with ultrasonography assistance. Methods: An exhaustive search of the literature was conducted on the following search engines: Web of Science, MEDLINE-Ovid, MEDLINE-PubMed, and Google Scholar. Key terms used included: ultrasonography, infant, lumbar puncture, and randomized control trial . All articles found went through an eligibility criteria and were analyzed using the GRADE

Pacific University EBM Capstone Project2018

28. Hydrocortisone (Alkindi) - replacement therapy of adrenal insufficiency in infants, children and adolescents (from birth to <18 years old)

Hydrocortisone (Alkindi) - replacement therapy of adrenal insufficiency in infants, children and adolescents (from birth to <18 years old) Published 08 October 2018 1 hydrocortisone 0.5mg, 1mg, 2mg and 5mg granules in capsules for opening (Alkindi ® ) SMC2088 Diurnal Limited 7 September 2018 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice (...) is summarized as follows: ADVICE: following a full submission hydrocortisone (Alkindi ® ) is accepted for restricted use within NHSScotland. Indication under review: replacement therapy of adrenal insufficiency in infants, children and adolescents (from birth to <18 years old). SMC restriction: for the first-line treatment of infants and young children with adrenal insufficiency aged from birth to less than six years of age for whom hydrocortisone must otherwise be individually prepared by manipulation

Scottish Medicines Consortium2018

29. A Randomized Controlled Trial of a Barrier Dressing to Reduce Nasal Injury in Preterm Infants Receiving Binasal Noninvasive Respiratory Support

A Randomized Controlled Trial of a Barrier Dressing to Reduce Nasal Injury in Preterm Infants Receiving Binasal Noninvasive Respiratory Support 30251638 2018 09 25 1097-6833 201 2018 Oct The Journal of pediatrics J. Pediatr. A Randomized Controlled Trial of a Barrier Dressing to Reduce Nasal Injury in Preterm Infants Receiving Binasal Noninvasive Respiratory Support. 34-39.e3 S0022-3476(18)30739-X 10.1016/j.jpeds.2018.05.026 To determine whether the use of a hydrocolloid nasal barrier dressing (...) during binasal continuous positive airway pressure (CPAP) therapy, compared with no barrier dressing, reduces the rate of nasal injury in very preterm and/or very low birth weight infants. A single-center randomized controlled trial conducted in the neonatal intensive care unit at The Royal Women's Hospital, Melbourne. Eligible infants were born <30 weeks of gestation and/or with birth weight <1250 g, and had received ≥4 hours, but <48 hours, of CPAP. Infants were randomly allocated to receive either

EvidenceUpdates2018

30. Sociodemographic Factors and Survival of Infants With Congenital Heart Defects

Sociodemographic Factors and Survival of Infants With Congenital Heart Defects 30111552 2018 09 04 1098-4275 142 3 2018 Sep Pediatrics Pediatrics Sociodemographic Factors and Survival of Infants With Congenital Heart Defects. e20180302 10.1542/peds.2018-0302 To examine the first-year survival of infants with congenital heart defects (CHDs) and investigate the potential role of socioeconomic and demographic factors on survival. Subjects included 15 533 infants with CHDs born between 2004 (...) and 2013 ascertained by the NC Birth Defects Monitoring Program. We classified CHDs into the following 3 groups: critical univentricular ( n = 575), critical biventricular ( n = 1494), and noncritical biventricular ( n = 13 345). We determined vital status and age at death through linkage to state vital records and used geocoded maternal residence at birth to obtain census information for study subjects. We calculated Kaplan-Meier survival estimates by maternal and infant characteristics and derived

EvidenceUpdates2018

31. Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (Full Version)

Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (Full Version) CUAJ • February 2018 • Volume 12, Issue 2 © 2018 Canadian Urological Association E76 CUA GUideline Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (full version) Cite as: Can Urol Assoc J 2017;12(2):E76-99. http://dx.doi.org/10.5489/cuaj.5033 Published online December 1, 2017 (...) if the parents so choose. 1 This rec- ommendation was primarily based on the impressive results from African trials demonstrating the protective effect of MC against human immunodeficiency virus (HIV) and sexually transmitted infections (STIs). A review of the literature on MC shows evidence of a vehement debate, often clouded by strong personal biases and lack of high-quality evidence. Creation of a guideline specific to the need of Canadian infant males is, therefore, dif - ficult given the level

Canadian Urological Association2018

32. Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (Abridged Version)

Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (Abridged Version) CUAJ • February 2018 • Volume 12, Issue 2 © 2018 Canadian Urological Association CUA gUideline 18 Cite as: Can Urol Assoc J 2018;12(2):18-28. http://dx.doi.org/10.5489/cuaj.5034 Published online December 1, 2017 See related commentary on page 29 For full version, visit cuaj.ca Introduction Circumcision is the oldest planned operative procedure (...) , Halifax, NS; Canada Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (abridged version)CUAJ • February 2018 • Volume 12, Issue 2 19 guideline: neonatal circumcision and foreskin care Treatment of physiological phimosis Several observational studies and randomized trials have investigated the role of topical steroids and preputial stretch- ing in resolving physiologic phimosis. A recent meta-analysis and several randomized

Canadian Urological Association2018

33. Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.

Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants. BACKGROUND: Indomethacin is used as standard therapy to close a patent ductus arteriosus (PDA) but is associated with reduced blood flow to several organs. Ibuprofen, another cyclo-oxygenase inhibitor, may be as effective as indomethacin with fewer adverse effects. OBJECTIVES: To determine the effectiveness and safety of ibuprofen compared with indomethacin, other cyclo-oxygenase inhibitor (...) (s), placebo, or no intervention for closing a patent ductus arteriosus in preterm, low-birth-weight, or preterm and low-birth-weight infants. SEARCH METHODS: We used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL 2017, Issue 10), MEDLINE via PubMed (1966 to 30 November 2017), Embase (1980 to 30 November 2017), and CINAHL (1982 to 30 November 2017). We searched clinical trials databases, conference proceedings

Cochrane2018

34. Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants.

Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants. BACKGROUND: Placing a small volume of colostrum directly onto the buccal mucosa of preterm infants during the early neonatal period may provide immunological and growth factors that stimulate the immune system and enhance intestinal growth. These benefits could potentially reduce the risk of infection and necrotising enterocolitis (NEC) and improve survival and long-term outcome. OBJECTIVES: To determine if early (...) (within the first 48 hours of life) oropharyngeal administration of mother's own fresh or frozen/thawed colostrum can reduce rates of NEC, late-onset invasive infection, and/or mortality in preterm infants compared with controls. To assess trials for evidence of safety and harm (e.g. aspiration pneumonia). To compare effects of early oropharyngeal colostrum (OPC) versus no OPC, placebo, late OPC, and nasogastric colostrum. SEARCH METHODS: We used the standard search strategy of the Cochrane Neonatal

Cochrane2018

35. A modified developmental care bundle reduces pain and stress in preterm infants undergoing examinations for retinopathy of prematurity: A randomised controlled trial

A modified developmental care bundle reduces pain and stress in preterm infants undergoing examinations for retinopathy of prematurity: A randomised controlled trial 30091495 2018 09 04 1365-2702 2018 Aug 09 Journal of clinical nursing J Clin Nurs A modified developmental care bundle reduces pain and stress in preterm infants undergoing examinations for retinopathy of prematurity: A randomised controlled trial. 10.1111/jocn.14645 To determine the comparative efficacy of developmental care (...) versus standard care for reducing pain and stress in preterm infants during examinations for retinopathy of prematurity (ROP). ROP examinations are routinely performed in neonatal intensive care units to detect these lesions. Pain scores recorded during and after eye examinations have revealed physiological and behavioural manifestations of pain and stress. A randomised crossover trial was conducted. Fourteen preterm infants were evaluated. The modified developmental care bundle included

EvidenceUpdates2018

36. Oral thyroxin supplementation in infants undergoing cardiac surgery: A double-blind placebo-controlled randomized clinical trial

Oral thyroxin supplementation in infants undergoing cardiac surgery: A double-blind placebo-controlled randomized clinical trial 30119284 2018 08 18 1097-685X 156 3 2018 Sep The Journal of thoracic and cardiovascular surgery J. Thorac. Cardiovasc. Surg. Oral thyroxin supplementation in infants undergoing cardiac surgery: A double-blind placebo-controlled randomized clinical trial. 1209-1217.e3 S0022-5223(18)31466-1 10.1016/j.jtcvs.2018.05.044 Decreases in serum total thyroxin and total (...) triiodothyronine occurs after cardiopulmonary bypass, and is reflected as poor immediate outcome. We studied effects of oral thyroxin supplementation in infants who underwent open-heart surgery. In this prospective study, 100 patients were randomized into 2 groups: 50 in the thyroxin group (TH) and 50 in the placebo group (PL). Patients in the TH group received oral thyroxin (5 μg/kg) 12 hours before surgery and once daily for the remainder of their intensive care unit (ICU) stay. Data on intraoperative

EvidenceUpdates2018

37. The Effect of Noninvasive High-Frequency Oscillatory Ventilation on Desaturations and Bradycardia in Very Preterm Infants: A Randomized Crossover Trial

The Effect of Noninvasive High-Frequency Oscillatory Ventilation on Desaturations and Bradycardia in Very Preterm Infants: A Randomized Crossover Trial 29954606 2018 06 29 1097-6833 2018 Jun 25 The Journal of pediatrics J. Pediatr. The Effect of Noninvasive High-Frequency Oscillatory Ventilation on Desaturations and Bradycardia in Very Preterm Infants: A Randomized Crossover Trial. S0022-3476(18)30742-X 10.1016/j.jpeds.2018.05.029 Noninvasive high-frequency oscillatory ventilation compared (...) with nasal continuous positive airway pressure significantly reduced the number of desaturations and bradycardia in preterm infants. However, noninvasive high-frequency oscillatory ventilation was associated with increased oxygen requirements and higher heart rates. Australian and New Zealand Clinical Trial Registry: ACTRN12616001516471. Copyright © 2018 Elsevier Inc. All rights reserved. Rüegger Christoph M CM Newborn Research Center and Neonatal Services, The Royal Women's Hospital, Melbourne, Victoria

EvidenceUpdates2018

38. Cord milking versus immediate clamping in preterm infants: a randomised controlled trial

Cord milking versus immediate clamping in preterm infants: a randomised controlled trial 29903720 2018 06 15 1468-2052 2018 Jun 14 Archives of disease in childhood. Fetal and neonatal edition Arch. Dis. Child. Fetal Neonatal Ed. Cord milking versus immediate clamping in preterm infants: a randomised controlled trial. fetalneonatal-2018-314757 10.1136/archdischild-2018-314757 To investigate whether umbilical cord milking (UCM) at birth improves systemic blood flow and short-term outcomes (...) , as compared with immediate cord clamping (ICC). Randomised clinical trial. Single tertiary care centre. Infants born to eligible women presenting in preterm labour between 24 and 31 weeks' gestation. UCM three times at birth or ICC. Primary outcome included systemic blood flow as represented by echo-derived superior vena cava(SVC) flow at 4-6 hours after birth. The echocardiographer and interpreter were blinded to the randomisation. Secondary outcomes included cardiac output, neonatal morbidities

EvidenceUpdates2018

39. Association of Early Introduction of Solids With Infant Sleep: A Secondary Analysis of a Randomized Clinical Trial

Association of Early Introduction of Solids With Infant Sleep: A Secondary Analysis of a Randomized Clinical Trial 29987321 2018 08 08 2168-6211 172 8 2018 Aug 06 JAMA pediatrics JAMA Pediatr Association of Early Introduction of Solids With Infant Sleep: A Secondary Analysis of a Randomized Clinical Trial. e180739 10.1001/jamapediatrics.2018.0739 The World Health Organization recommends exclusive breastfeeding for 6 months. However, 75% of British mothers introduce solids before 5 months and 26 (...) % report infant waking at night as influencing this decision. To determine whether early introduction of solids influences infant sleep. The Enquiring About Tolerance study was a population-based randomized clinical trial conducted from January 15, 2008, to August 31, 2015, that included 1303 exclusively breastfed 3-month-old infants from England and Wales. Clinical visits took place at St Thomas' Hospital, London, England, and the trial studied the early introduction of solids into the infant diet

EvidenceUpdates2018

40. Treatment of extravasation injuries in infants and young children: a scoping review and survey

Treatment of extravasation injuries in infants and young children: a scoping review and survey Treatment of extravasation injuries in infants and young children: a scoping review and survey Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue

NIHR HTA programme2018