Latest & greatest articles for ibuprofen

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Top results for ibuprofen

62. A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery

A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery 18308218 2008 02 29 2008 03 27 2013 11 21 1879-1190 206 3 2008 Mar Journal of the American College of Surgeons J. Am. Coll. Surg. A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery. 472-9 10.1016/j.jamcollsurg.2007.09.006 Narcotics are used (...) extensively in outpatient general surgery but are often poorly tolerated with variable efficacy. Acetaminophen combined with NSAIDs is a possible alternative. The objective of this study was to compare the efficacy of acetaminophen, codeine, and caffeine (Tylenol No. 3) with acetaminophen and ibuprofen for management of pain after outpatient general surgery procedures. A double-blind randomized controlled trial was performed in patients undergoing outpatient inguinal/umbilical/ventral hernia repair

EvidenceUpdates2008

63. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): economic evaluation of a randomised controlled trial.

Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): economic evaluation of a randomised controlled trial. 18782838 2008 09 10 2008 09 26 2016 11 22 1756-1833 337 2008 Sep 09 BMJ (Clinical research ed.) BMJ Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): economic evaluation of a randomised controlled trial. a1490 10.1136/bmj.a1490 337/sep09_3/a1490 To estimate the cost to the NHS and to parents and carers of treating febrile preschool children (...) with paracetamol, ibuprofen, or both, and to compare these costs with the benefits of each treatment regimen. Cost consequences analysis and cost effectiveness analysis conducted as part of a three arm, randomised controlled trial. Children between the ages of 6 months and 6 years recruited from primary care and the community with axillary temperatures >or=37.8 degrees C and ibuprofen, or both drugs. Costs to the NHS and to parents and carers. Cost consequences analysis at 48

BMJ2008 Full Text: Link to full Text with Trip Pro

64. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial.

Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. 18765450 2008 09 03 2008 09 15 2016 11 22 1756-1833 337 2008 Sep 02 BMJ (Clinical research ed.) BMJ Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. a1302 10.1136/bmj.a1302 337/sep02_2/a1302 To investigate whether paracetamol (acetaminophen) plus ibuprofen are superior to either drug alone for increasing time without fever and the relief (...) of fever associated discomfort in febrile children managed at home. Individually randomised, blinded, three arm trial. Primary care and households in England. Children aged between 6 months and 6 years with axillary temperatures of at least 37.8 degrees C and up to 41.0 degrees C. Advice on physical measures to reduce temperature and the provision of, and advice to give, paracetamol plus ibuprofen, paracetamol alone, or ibuprofen alone. Primary outcomes were the time without fever (<37.2 degrees C

BMJ2008 Full Text: Link to full Text with Trip Pro

65. Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomised controlled trial and patient preference study.

Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomised controlled trial and patient preference study. 18056743 2008 01 18 2008 03 03 2016 11 22 1756-1833 336 7636 2008 Jan 19 BMJ (Clinical research ed.) BMJ Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomised controlled trial and patient preference study. 138-42 To determine whether older patients with chronic knee pain should be advised to use topical or oral non-steroidal (...) anti-inflammatory drugs (NSAIDs). Randomised controlled trial and patient preference study. 26 general practices. People aged > or =50 with knee pain: 282 in randomised trial and 303 in preference study. Advice to use topical or oral ibuprofen. Primary outcome measures WOMAC (Western Ontario and McMaster Universities) osteoarthritis index, major and minor adverse effects. Changes in global WOMAC scores at 12 months were equivalent. In the randomised trial the difference (topical minus oral) was two

BMJ2008 Full Text: Link to full Text with Trip Pro

66. Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization

Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization Manley J, Taddio A CRD summary This review investigated use of acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunisation. The authors concluded (...) that acetaminophen and ibuprofen may prevent adverse events in young infants receiving diphtheria-tetanus toxoids-whole pertussis vaccine. No benefits were demonstrated for the diphtheria-tetanusoxides acellular pertussis vaccine. The conclusions may not be reliable due to methodological limitations. Authors' objectives To evaluate prophylactic use of acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunisation. Searching MEDLINE (1966 to February 2007), PubMed (1966

DARE.2007

67. Drugs - Ibuprofen

Drugs - Ibuprofen PRESENTATION A solution or suspension containing ibuprofen 100 milligrams in 5ml or tablet form containing 200 milligrams, 400 milligrams, and 600 milligrams. ACTIONS Analgesic (pain relieving) and antipyretic (temperature reducing) drug. Anti-in?ammatory (in?ammation reducing). SIDE EFFECTS Ibuprofen may cause nausea, vomiting, and tinnitus. DOSAGE AND ADMINISTRATION Route: Oral INDICATIONS Relief of mild to moderate pain and/or high temperature. Pain and in?ammation of soft (...) tissue injuries. CONTRA-INDICATIONS Should not be administered to dehydrated patients. Asthma Known allergy or hypersensitivity to non-steroidal anti-in?ammatory drugs (NSAIDs). Active upper gastro-intestinal disturbance (e.g. oesophagitis, peptic ulcer, dyspepsia). If a product containing NSAID properties (e.g. Diclofenac, Naproxen) has been given within the last four hours or if the maximum cumulative daily dose has been given then further NSAID i.e. ibuprofen should NOT be given. AGE DOSE VOLUME

Joint Royal Colleges Ambulance Liaison Committee2007

68. Ibuprofen

Ibuprofen PRESENTATION A solution or suspension containing ibuprofen 100 milligrams in 5ml or tablet form containing 200 milligrams, 400 milligrams, and 600 milligrams. ACTIONS Analgesic (pain relieving) and antipyretic (temperature reducing) drug. Anti-in?ammatory (in?ammation reducing). SIDE EFFECTS Ibuprofen may cause nausea, vomiting, and tinnitus. DOSAGE AND ADMINISTRATION Route: Oral INDICATIONS Relief of mild to moderate pain and/or high temperature. Pain and in?ammation of soft tissue (...) injuries. CONTRA-INDICATIONS Should not be administered to dehydrated patients. Asthma Known allergy or hypersensitivity to non-steroidal anti-in?ammatory drugs (NSAIDs). Active upper gastro-intestinal disturbance (e.g. oesophagitis, peptic ulcer, dyspepsia). If a product containing NSAID properties (e.g. Diclofenac, Naproxen) has been given within the last four hours or if the maximum cumulative daily dose has been given then further NSAID i.e. ibuprofen should NOT be given. AGE DOSE VOLUME Adults >12

Joint Royal Colleges Ambulance Liaison Committee2006

70. Review: no evidence exists that paracetamol and ibuprofen differ for short term pain relief or safety in children, but ibuprofen more effectively reduces fever

Review: no evidence exists that paracetamol and ibuprofen differ for short term pain relief or safety in children, but ibuprofen more effectively reduces fever Review: no evidence exists that paracetamol and ibuprofen differ for short term pain relief or safety in children, but ibuprofen more effectively reduces fever | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: no evidence exists that paracetamol and ibuprofen differ for short term pain relief or safety in children, but ibuprofen more

Evidence-Based Mental Health2006

71. Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): randomised controlled trial.

Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): randomised controlled trial. 16885182 2006 09 08 2006 09 26 2016 12 15 1756-1833 333 7567 2006 Sep 09 BMJ (Clinical research ed.) BMJ Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): randomised controlled trial. 519 To determine the benefits (...) and risks of a non-steroidal anti-inflammatory drug (NSAID) as prophylaxis for ectopic bone formation in patients undergoing total hip replacement (or revision) surgery. Double blind randomised placebo controlled clinical trial, stratified by treatment site and surgery (primary or revision). 20 orthopaedic surgery centres in Australia and New Zealand. 902 patients undergoing elective primary or revision total hip replacement surgery. 14 days' treatment with ibuprofen (1200 mg daily) or matching placebo

BMJ2006 Full Text: Link to full Text with Trip Pro

72. Brief communication: duration of platelet dysfunction after a 7-day course of Ibuprofen.

Brief communication: duration of platelet dysfunction after a 7-day course of Ibuprofen. BACKGROUND: Despite a paucity of evidence, clinicians routinely advise that patients discontinue using nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, at least 1 week before most surgical procedures. OBJECTIVE: To define the duration of ibuprofen-induced platelet dysfunction. DESIGN: Prospective cohort study. SETTING: Denver/Aurora, Colorado. PARTICIPANTS: 11 healthy adult volunteers (...) . MEASUREMENTS: Individuals were tested at baseline and serially after completion of a 7-day course of ibuprofen (600 mg orally every 8 hours). The platelet function analyzer (PFA-100, Dade Behring, Newark, Delaware), a test that has replaced the bleeding time in many clinical settings, was used. RESULTS: All participants exhibited normal platelet function before starting ibuprofen. Platelet dysfunction was apparent after completion of the ibuprofen course in 7 of the 11 participants and normalized by 24

Annals of Internal Medicine2005

73. A meta-analysis of ibuprofen versus indomethacin for closure of patent ductus arteriosus

A meta-analysis of ibuprofen versus indomethacin for closure of patent ductus arteriosus A meta-analysis of ibuprofen versus indomethacin for closure of patent ductus arteriosus A meta-analysis of ibuprofen versus indomethacin for closure of patent ductus arteriosus Thomas R L, Parker G C, Van Overmeire B, Aranda J V CRD summary This review assessed the efficacy and safety of ibuprofen and indomethacin for closure of patent ductus arteriosus (PDA). The authors concluded that ibuprofen (...) and indomethacin have similar rates of PDA closure, but renal dysfunction is less likely with ibuprofen. This was generally a well-conducted review and the authors' conclusions are likely to be reliable. Authors' objectives To compare the effects of ibuprofen (IBU) and indomethacin (INDO) for closure of patent ductus arteriosus (PDA). Searching MEDLINE, (1966 to 2003), EMBASE (1980 to 2003), the Cochrane Controlled Trials Register (2003) and abstracts published in Pediatric Research (1991 to 2003) were

DARE.2005

74. Prophylactic ibuprofen versus placebo in very premature infants: a randomised, double-blind, placebo-controlled trial.

Prophylactic ibuprofen versus placebo in very premature infants: a randomised, double-blind, placebo-controlled trial. 15567009 2004 11 29 2004 12 15 2015 06 16 1474-547X 364 9449 2004 Nov 27-Dec 3 Lancet (London, England) Lancet Prophylactic ibuprofen versus placebo in very premature infants: a randomised, double-blind, placebo-controlled trial. 1939-44 Patent ductus arteriosus is a common complication of prematurity that frequently requires surgical or medical treatment. The benefit (...) of prophylactic treatment by indometacin, a cyclo-oxygenase inhibitor, remains uncertain compared with curative treatment. This benefit could be improved with ibuprofen, another cyclo-oxygenase inhibitor with fewer adverse effects than indometacin on renal, mesenteric, and cerebral perfusion. We aimed to compare prophylactic and curative ibuprofen in the treatment of this abnormality in very premature infants. We did a randomised controlled trial in infants younger than 28 weeks of gestation, who were

Lancet2004

75. Prophylactic ibuprofen in premature infants: a multicentre, randomised, double-blind, placebo-controlled trial.

Prophylactic ibuprofen in premature infants: a multicentre, randomised, double-blind, placebo-controlled trial. 15567010 2004 11 29 2004 12 15 2015 06 16 1474-547X 364 9449 2004 Nov 27-Dec 3 Lancet (London, England) Lancet Prophylactic ibuprofen in premature infants: a multicentre, randomised, double-blind, placebo-controlled trial. 1945-9 Ibuprofen is used for treatment and prevention of patent ductus arteriosus in low-birthweight infants. Its effects on regional circulations differ from those (...) of indometacin. Because prophylactic indometacin reduces the frequency of severe intraventricular haemorrhage and patent ductus arteriosus, we aimed to study the efficacy of early ibuprofen in reducing these outcomes in a double-blind, multicentre trial. Within 6 h after birth, 415 low-birthweight infants (gestational age <31 weeks) were randomly allocated ibuprofen-lysine (10 mg/kg then two doses of 5 mg/kg after 24 h and 48 h) or placebo intravenously. The primary outcome was occurrence of severe

Lancet2004

76. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial.

Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial. 15325831 2004 08 24 2004 09 02 2016 11 24 1474-547X 364 9435 2004 Aug 21-27 Lancet (London, England) Lancet Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled (...) , naproxen and ibuprofen. 18325 patients age 50 years or older with osteoarthritis were randomised to lumiracoxib 400 mg once daily (n=9156), naproxen 500 mg twice daily (4754), or ibuprofen 800 mg three times daily (4415) for 52 weeks, in two substudies of identical design (lumiracoxib vs ibuprofen or naproxen). Randomisation was stratified for low-dose aspirin use and age. The primary endpoint was the difference in time-to-event distribution of upper gastrointestinal ulcer complications (bleeding

Lancet2004

77. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial.

Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial. 15325832 2004 08 24 2004 09 02 2016 11 24 1474-547X 364 9435 2004 Aug 21-27 Lancet (London, England) Lancet Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial. 675-84 (...) The potential for cyclo-oxygenase 2 (COX2)-selective inhibitors to increase the risk for myocardial infarction is controversial. The Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET) aimed to assess gastrointestinal and cardiovascular safety of the COX2 inhibitor lumiracoxib compared with two non-steroidal anti-inflammatory drugs, naproxen and ibuprofen. 18325 patients age 50 years or older with osteoarthritis were randomised to lumiracoxib 400 mg once daily (n=9156), naproxen 500 mg

Lancet2004

78. Is indomethacin or ibuprofen better for medical closure of the patent ductus arteriosus?

Is indomethacin or ibuprofen better for medical closure of the patent ductus arteriosus? BestBets: Is ibuprofen or indomethacin better for medical closure of the patent ductus arterious? Is ibuprofen or indomethacin better for medical closure of the patent ductus arterious? Report By: Erik N Swartz - Pediatric Cardiology Fellow Institution: University of Alberta, Edmonton, Canada Date Submitted: 10th March 2003 Date Completed: 15th July 2004 Last Modified: 15th July 2004 Status: Green (complete (...) ) Three Part Question In [a preterm baby of gestational age less than or equal to 34 weeks] is [ibuprofen compared with indomethacin] equally efficacious at [treating echocardiographically proven patent ductus arteriosus and have fewer side effects]? Clinical Scenario A preterm baby of 28 weeks gestation with respiratory distress syndrome is admitted to the neonatal intensive care unit. On day 2 of life, the characteristic murmur or a patent ductus arteriosus (PDA) is heard, with the diagnosis

BestBETS2004

79. Effect of ibuprofen on cardioprotective effect of aspirin.

Effect of ibuprofen on cardioprotective effect of aspirin. Treatment with ibuprofen might limit the cardioprotective effects of aspirin. We aimed to assess whether patients with known cardiovascular disease who take low-dose aspirin and ibuprofen have increased risk of cardiovascular mortality. We studied 7107 patients who were discharged after first admission for cardiovascular disease between April, 1989, and April, 1997, and who were prescribed low-dose aspirin (<325 mg/day) and survived (...) for at least 1 month. Compared with those who used aspirin alone, patients taking aspirin plus ibuprofen had an increased risk of all-cause mortality (adjusted hazard ratio 1.93, 95% CI 1.30-2.87, p=0.0011) and cardiovascular mortality (1.73, 1.05-2.84, p=0.0305). Our finding lends support to the hypothesis that ibuprofen may interact with the cardioprotective effects of aspirin, at least in patients with established cardiovascular disease.

Lancet2003

80. Ibuprofen for the treatment of a patent ductus arteriosus in preterm and/or low birth weight infants.

Ibuprofen for the treatment of a patent ductus arteriosus in preterm and/or low birth weight infants. BACKGROUND: A patent ductus arteriosus (PDA) complicates the clinical course of preterm infants, increasing their risks of developing chronic lung disease (CLD), necrotizing enterocolitis (NEC), and intraventricular hemorrhage (IVH). Indomethacin is used as standard therapy to close a PDA, but is associated with reduced blood flow to the brain, kidneys and gut. Ibuprofen, another cyclo (...) -oxygenase inhibitor, may be as effective with fewer side effects. OBJECTIVES: To determine the effectiveness and safety of ibuprofen compared to placebo or no intervention for closing a PDA in preterm and/or low birth weight infants. To determine the effectiveness and safety of ibuprofen compared to other cyclo-oxygenase inhibitors (including indomethacin, mefenamic acid) for closing a PDA in preterm and/or low birth weight infants. SEARCH STRATEGY: Randomized (or quasi-randomized) controlled trials

Cochrane2003