Latest & greatest articles for ibuprofen

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on ibuprofen or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on ibuprofen and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for ibuprofen

41. Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen

Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen Prescrire IN ENGLISH - Spotlight ''Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen'', 1 January 2016 {1} {1} {1} | | > > > Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |  (...)  |   |   |   |   |   |   |  Spotlight Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen When pain medication is required, paracetamol (alias acetaminophen) is the reference drug. Among the nonsteroidal anti-inflammatories (NSAIDs), naproxen or ibuprofen (not exceeding 1200 mg a day) are the drugs that carry the least exposure to cardiac disorders. When pain medication is needed

2016 Prescrire

42. Effect of ibuprofen vs. other drugs such as premedication in the risk and intensity of postoperative pain resulting from endodontic treatment in adult patients: a systematic review

Effect of ibuprofen vs. other drugs such as premedication in the risk and intensity of postoperative pain resulting from endodontic treatment in adult patients: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2016 PROSPERO

43. Ibuprofen Versus Indomethacin for Medical Closure of the Patent Arterial Duct: A Pooled Analysis by Route of Administration. Full Text available with Trip Pro

Ibuprofen Versus Indomethacin for Medical Closure of the Patent Arterial Duct: A Pooled Analysis by Route of Administration. Preterm infants are at increased risk of having a patent arterial duct (PAD). PADs may cause congestive heart failure, respiratory distress, necrotizing enterocolitis, and renal impairment. Consequently, in some infants, it becomes necessary to attempt closure of the PAD. Surgical closure can be difficult in small infants and is not without its risks; thus, medical (...) closure offers advantages. Cyclooxygenase inhibitors have been used for medical closure of the PAD with both ibuprofen and indomethacin having been used clinically.We performed a systematic review of the literature to identify all studies comparing ibuprofen and indomethacin. Studies comparing ibuprofen and indomethacin for closure of the PAD in premature infants were included in the meta-analysis. A subanalysis was performed to compare the route of administration. Efficacy endpoints studied were PAD

2015 Curēus

44. Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults. Full Text available with Trip Pro

Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults. There is good evidence that combining two different analgesics in fixed doses in a single tablet can provide better pain relief in acute pain and headache than either drug alone, and that the drug-specific benefits are essentially additive. This appears to be broadly true in postoperative pain and migraine headache across a range of different drug combinations, and when tested in the same and different trials (...) . Adding caffeine to analgesics also increases the number of people obtaining good pain relief. Combinations of ibuprofen and caffeine are available without prescription in some parts of the world.To assess the analgesic efficacy and adverse effects of a single oral dose of ibuprofen plus caffeine for moderate to severe postoperative pain, using methods that permit comparison with other analgesics evaluated in standardised trials using almost identical methods and outcomes.We searched the Cochrane

2015 Cochrane

45. High-dose ibuprofen (?2400mg/day): small increase in cardiovascular risk

High-dose ibuprofen (?2400mg/day): small increase in cardiovascular risk High-dose ibuprofen (≥2400mg/day): small increase in cardiovascular risk - GOV.UK GOV.UK uses cookies to make the site simpler. or Search High-dose ibuprofen (≥2400mg/day): small increase in cardiovascular risk EU review confirms that the cardiovascular risk of high-dose ibuprofen (≥2400mg/day) is similar to COX 2 inhibitors and diclofenac. Published 26 June 2015 From: Therapeutic area: , , , Contents When prescribing (...) or dispensing ibuprofen: avoid use of high-dose ibuprofen (≥2400 mg per day) in patients with established: ischaemic heart disease peripheral arterial disease cerebrovascular disease congestive heart failure (New York Heart Association [NYHA] classification II-III) uncontrolled hypertension review the treatment of patients with the above conditions who are taking high-dose ibuprofen at their next routine appointment carefully consider the benefits and risks before starting long-term ibuprofen treatment

2015 MHRA Drug Safety Update

46. Fracture pain relief for kids? Ibuprofen does it better

Fracture pain relief for kids? Ibuprofen does it better Fracture pain relief for kids? Ibuprofen does it better Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Fracture pain relief for kids? Ibuprofen does it better View/ Open Date 2010-05 Format Metadata Abstract Use ibuprofen instead of acetaminophen with codeine

2015 PURLS

47. Ibuprofen for acute treatment of episodic tension-type headache in adults [Cochrane Protocol]

Ibuprofen for acute treatment of episodic tension-type headache in adults [Cochrane Protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address

2015 PROSPERO

48. Systematic review and network meta-analysis of IV indomethacin versus IV Ibuprofen versus oral Ibuprofen versus oral acetaminophen versus placebo for treatment of symptomatic patent ductus arteriosus in preterm infants

Systematic review and network meta-analysis of IV indomethacin versus IV Ibuprofen versus oral Ibuprofen versus oral acetaminophen versus placebo for treatment of symptomatic patent ductus arteriosus in preterm infants Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any

2015 PROSPERO

49. Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults [Cochrane Protocol]

Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults [Cochrane Protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web

2015 PROSPERO

50. Randomised controlled trial: Postfracture pain in children can be adequately managed with ibuprofen

Randomised controlled trial: Postfracture pain in children can be adequately managed with ibuprofen Postfracture pain in children can be adequately managed with ibuprofen | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers (...) of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Postfracture pain in children can be adequately managed with ibuprofen Article Text Therapeutics/Prevention Randomised controlled trial Postfracture pain in children can be adequately managed with ibuprofen Kevin B L

2015 Evidence-Based Medicine

51. For Post-Dental Extraction Pain, Co-therapy with Acetaminophen and Ibuprofen is More Effective in Pain Management than Acetaminophen or Ibuprofen Alone

For Post-Dental Extraction Pain, Co-therapy with Acetaminophen and Ibuprofen is More Effective in Pain Management than Acetaminophen or Ibuprofen Alone UTCAT2734, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title For Post-Dental Extraction Pain, Co-therapy with Acetaminophen and Ibuprofen is More Effective in Pain Management than Acetaminophen or Ibuprofen Alone Clinical Question In patients following a dental extraction (...) is the post-operative administration of combined acetaminophen and ibuprofen better than therapy with acetaminophen or ibuprofen alone for pain management? Clinical Bottom Line The post-operative use combined acetaminophen and ibuprofen provides superior pain relief compared to acetaminophen or ibuprofen alone. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Bailey/2013 Patient Group 2,241 patients ages 16-65

2014 UTHSCSA Dental School CAT Library

52. Ibuprofen

Ibuprofen USE OF IBUPROFEN IN PREGNANCY 0344 892 0909 USE OF IBUPROFEN IN PREGNANCY (Date of issue: December 2013 , Version: 1.1 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used (...) to treat acute and chronic pain, and in the management of rheumatoid arthritis. Studies of NSAIDs as a group have identified an association between use in pregnancy and congenital malformation, specifically cardiovascular defects. However, the available data are conflicting and limited, and firm associations are yet to be concluded. Data specifically relating to maternal ibuprofen use in pregnancy are confounded and conflicting. Studies which have investigated overall rates of malformation have

2014 UK Teratology Information Service

53. Randomised controlled trial: Neither ibuprofen nor steam improves symptom control compared with paracetamol in patients with acute respiratory tract infections in primary care

Randomised controlled trial: Neither ibuprofen nor steam improves symptom control compared with paracetamol in patients with acute respiratory tract infections in primary care Neither ibuprofen nor steam improves symptom control compared with paracetamol in patients with acute respiratory tract infections in primary care | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser (...) at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Neither ibuprofen nor steam improves symptom control compared

2014 Evidence-Based Medicine

54. Cohort study: Ibuprofen does not seem to increase global malformation risk but NSAID use in late pregnancy remains a concern

Cohort study: Ibuprofen does not seem to increase global malformation risk but NSAID use in late pregnancy remains a concern Ibuprofen does not seem to increase global malformation risk but NSAID use in late pregnancy remains a concern | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Ibuprofen does not seem to increase global malformation risk but NSAID use in late pregnancy remains a concern Article Text Aetiology Cohort study

2014 Evidence-Based Medicine

55. Systematic review and meta-analysis: Limited evidence that single-dose oral ibuprofen plus codeine is more effective for postoperative pain than either drug alone Full Text available with Trip Pro

Systematic review and meta-analysis: Limited evidence that single-dose oral ibuprofen plus codeine is more effective for postoperative pain than either drug alone Limited evidence that single-dose oral ibuprofen plus codeine is more effective for postoperative pain than either drug alone | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use (...) cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Limited evidence that single-dose oral ibuprofen plus codeine is more effective for postoperative pain than

2014 Evidence-Based Nursing

56. Single dose oral dexibuprofen [S(+)-ibuprofen] for acute postoperative pain in adults. Full Text available with Trip Pro

Single dose oral dexibuprofen [S(+)-ibuprofen] for acute postoperative pain in adults. This review is an update of a previously published review in The Cochrane Database of Systematic Reviews Issue 3, 2009 on single dose oral dexibuprofen (S(+)-ibuprofen) for acute postoperative pain in adults.Dexibuprofen is a non-steroidal anti-inflammatory drug (NSAID) licensed for use in rheumatic disease and other musculoskeletal disorders in the UK, and widely available in other countries worldwide (...) . It is an active isomer of ibuprofen. This review sought to evaluate the efficacy and safety of oral dexibuprofen in acute postoperative pain, using clinical studies in patients with established pain, and with outcomes measured primarily over four to six hours, using standard methods. This type of study has been used for many decades to establish that drugs have analgesic properties.To assess the efficacy and adverse effects of single dose oral dexibuprofen for acute postoperative pain using methods

2013 Cochrane

57. A Prophylactic Single Dose of 200mg Ibuprofen or 20mg Tenoxicam Administration Before Endodontic Treatment reduces Postoperative Pain at 6 hours after Treatment

A Prophylactic Single Dose of 200mg Ibuprofen or 20mg Tenoxicam Administration Before Endodontic Treatment reduces Postoperative Pain at 6 hours after Treatment UTCAT2593, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title A Prophylactic Single Dose of 200mg Ibuprofen or 20mg Tenoxicam Administration Before Endodontic Treatment Reduces Postoperative Pain at 6 Hours After Treatment Clinical Question Do preoperative pain (...) medications reduce pain in patients with endodontic treatment compared with patients with no postoperative pain? Clinical Bottom Line 200mg Ibuprofen or 20mg of tenoxicam reduces postoperative pain at 6 hours after Endodontic treatment but no significant difference at 12,24,48 and 72 hours. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Arslan/2011 48 Randomized double-blinded clinical trail Key results 48

2013 UTHSCSA Dental School CAT Library

58. Prophylactic Compared With Therapeutic Ibuprofen Analgesia in First-Trimester Medical Abortion: A Randomized Controlled Trial (Abstract)

Prophylactic Compared With Therapeutic Ibuprofen Analgesia in First-Trimester Medical Abortion: A Randomized Controlled Trial To compare the effectiveness of two oral analgesic regimens in first-trimester medical abortion.We randomly assigned 250 participants undergoing first-trimester abortion with mifepristone and misoprostol at three clinics to two ibuprofen regimens: therapeutic (800 mg every 4-6 hours as needed for pain) or prophylactic (800 mg starting 1 hour before the misoprostol dose (...) , then every 4-6 hours for 48 hours regardless of pain, then as needed). We asked each participant to record her maximum pain on a scale of 0-10 daily thereafter.Of participants assigned to the prophylactic and therapeutic regimens, 111 of 123 (90%) and 117 of 127 (92%), respectively, provided follow-up data. More than 80% of the participants in each group complied with their assigned treatment. Participants in the prophylactic group used substantially more ibuprofen than those in the therapeutic group

2013 EvidenceUpdates Controlled trial quality: predicted high

59. Enteral Feeding during Indomethacin and Ibuprofen Treatment of a Patent Ductus Arteriosus Full Text available with Trip Pro

Enteral Feeding during Indomethacin and Ibuprofen Treatment of a Patent Ductus Arteriosus To test the hypothesis that infants who are just being introduced to enteral feedings will advance to full enteral nutrition at a faster rate if they receive "trophic" (15 mL/kg/d) enteral feedings while receiving indomethacin or ibuprofen treatment for patent ductus arteriosus.Infants were eligible for the study if they were 23(1/7)-30(6/7) weeks' gestation, weighed 401-1250 g at birth, received maximum (...) enteral volumes ≤60 mL/kg/d, and were about to be treated with indomethacin or ibuprofen. A standardized "feeding advance regimen" and guidelines for managing feeding intolerance were followed at each site (N = 13).Infants (N = 177, 26.3 ± 1.9 weeks' mean ± SD gestation) were randomized at 6.5 ± 3.9 days to receive "trophic" feeds ("feeding" group, n = 81: indomethacin 80%, ibuprofen 20%) or no feeds ("fasting [nil per os]" group, n = 96: indomethacin 75%, ibuprofen 25%) during the drug administration

2013 EvidenceUpdates Controlled trial quality: uncertain

60. Single dose oral ibuprofen plus codeine for acute postoperative pain in adults. (Abstract)

Single dose oral ibuprofen plus codeine for acute postoperative pain in adults. There is good evidence that combining two different analgesics in fixed doses in a single tablet can provide better pain relief in acute pain and headache than either drug alone, and that the drug-specific effects are essentially additive. This appears to be broadly true in postoperative pain and migraine headache across a range of different drug combinations and when tested in the same and different trials. Some (...) combinations of ibuprofen and codeine are available without prescription (but usually only from a pharmacy) where the dose of codeine is lower, and with a prescription when the dose of codeine is higher.To assess the analgesic efficacy and adverse effects of a single oral dose of ibuprofen plus codeine for moderate to severe postoperative pain. We compared ibuprofen plus codeine with placebo and with the same dose of ibuprofen alone.We searched the Cochrane Central Register of Controlled Trials (CENTRAL

2013 Cochrane