Latest & greatest articles for ibuprofen

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Top results for ibuprofen

1. Oral ibuprofen may be an option for closing patent ductus arteriosus in premature babies

Oral ibuprofen may be an option for closing patent ductus arteriosus in premature babies Oral ibuprofen may be an option for closing patent ductus arteriosus in premature babies Dissemination Centre Discover Portal NIHR DC Discover Oral ibuprofen may be an option for closing patent ductus arteriosus in premature babies Published on 3 July 2018 doi: A high dose of oral ibuprofen was more likely to close a patent ductus arteriosus in premature babies when compared with standard doses (...) of intravenous ibuprofen or indometacin. Before birth, a baby's lungs aren't needed for breathing. Most blood bypasses the lungs through a large vessel called the ductus arteriosus directly from the pulmonary artery into the aorta to supply the main circulation. Once born, blood flows through the lungs, and the ductus arteriosus usually closes in the first few days. If it doesn't close it is referred to as "patent". This condition is much more common in premature babies and doesn't always need treatment

NIHR Dissemination Centre2018

2. Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.

Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants. BACKGROUND: Indomethacin is used as standard therapy to close a patent ductus arteriosus (PDA) but is associated with reduced blood flow to several organs. Ibuprofen, another cyclo-oxygenase inhibitor, may be as effective as indomethacin with fewer adverse effects. OBJECTIVES: To determine the effectiveness and safety of ibuprofen compared with indomethacin, other cyclo-oxygenase inhibitor (...) , and the reference lists of retrieved articles for randomised controlled trials and quasi-randomised trials. SELECTION CRITERIA: Randomised or quasi-randomised controlled trials of ibuprofen for the treatment of a PDA in preterm, low birth weight, or both preterm and low-birth-weight newborn infants. DATA COLLECTION AND ANALYSIS: Data collection and analysis conformed to the methods of the Cochrane Neonatal Review Group. We used the GRADE approach to assess the quality of evidence. MAIN RESULTS: We included 39

Cochrane2018

3. Ibuprofen

Ibuprofen Top results for ibuprofen - Trip Database or use your Google+ account Turning Research Into Practice My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing (...) the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for ibuprofen The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines

Trip Latest and Greatest2018

4. Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial

Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial 29505772 2018 05 25 1097-6868 218 6 2018 Jun American journal of obstetrics and gynecology Am. J. Obstet. Gynecol. Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial. 616.e1-616.e8 S0002-9378(18)30175-3 10.1016/j.ajog.2018.02.016 (...) Nonsteroidal antiinflammatory drug use has been shown to increase blood pressure in nonpregnant adults. Because of this, the American College of Obstetricians and Gynecologists suggests avoiding their use in women with postpartum hypertension; however, evidence to support this recommendation is lacking. Our goal was to test the hypothesis that nonsteroidal antiinflammatory drugs, such as ibuprofen, adversely affect postpartum blood pressure control in women with preeclampsia with severe features. At delivery, we randomized

EvidenceUpdates2018

5. Ibuprofen versus pivmecillinam for uncomplicated urinary tract infection in women-A double-blind, randomized non-inferiority trial

Ibuprofen versus pivmecillinam for uncomplicated urinary tract infection in women-A double-blind, randomized non-inferiority trial 29763434 2018 05 27 1549-1676 15 5 2018 May PLoS medicine PLoS Med. Ibuprofen versus pivmecillinam for uncomplicated urinary tract infection in women-A double-blind, randomized non-inferiority trial. e1002569 10.1371/journal.pmed.1002569 Although uncomplicated urinary tract infections (UTIs) are often self-limiting, most patients will be prescribed antibiotic (...) treatment. We assessed whether treatment with ibuprofen was non-inferior to pivmecillinam in achieving symptomatic resolution by day 4, with a non-inferiority margin of 10%. This was a randomized, controlled, double-blind non-inferiority trial. We recruited patients from 16 sites in a general practice setting in Norway, Sweden, and Denmark. Non-pregnant women aged 18-60 years presenting with symptoms of uncomplicated UTI were screened for eligibility from 11 April 2013 to 22 April 2016. Patients

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

6. Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis.

Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis. Importance: Despite increasing emphasis on conservative management of patent ductus arteriosus (PDA) in preterm infants, different pharmacotherapeutic interventions are used to treat those developing a hemodynamically significant PDA. Objectives: To estimate the relative likelihood of hemodynamically (...) indomethacin, ibuprofen, or acetaminophen vs each other, placebo, or no treatment for a clinically or echocardiographically diagnosed hemodynamically significant PDA. Data Extraction and Synthesis: Data were independently extracted in pairs by 6 reviewers and synthesized with Bayesian random-effects network meta-analyses. Main Outcomes and Measures: Primary outcome: hemodynamically significant PDA closure; secondary: included surgical closure, mortality, necrotizing enterocolitis, and intraventricular

JAMA2018

7. Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial

Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial 29018084 2017 10 11 2017 10 16 2017 10 18 1488-2329 189 40 2017 Oct 10 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial. E1252-E1258 10.1503/cmaj.170017 Oral morphine for postoperative pain (...) after minor pediatric surgery, while increasingly popular, is not supported by evidence. We evaluated whether oral morphine was superior to ibuprofen for at-home management of children's postoperative pain. We conducted a randomized superiority trial comparing oral morphine (0.5 mg/kg) with ibuprofen (10 mg/kg) in children 5 to 17 years of age who had undergone minor outpatient orthopedic surgery (June 2013 to September 2016). Participants took up to 8 doses of the intervention drug every 6 hours

EvidenceUpdates2017 Full Text: Link to full Text with Trip Pro

8. Pain relief of sore throat with a new anti-inflammatory throat lozenge, ibuprofen 25 mg: A randomised, double-blind, placebo-controlled, international phase III study

Pain relief of sore throat with a new anti-inflammatory throat lozenge, ibuprofen 25 mg: A randomised, double-blind, placebo-controlled, international phase III study 28869722 2017 09 04 2017 09 19 1742-1241 71 9 2017 Sep International journal of clinical practice Int. J. Clin. Pract. Pain relief of sore throat with a new anti-inflammatory throat lozenge, ibuprofen 25 mg: A randomised, double-blind, placebo-controlled, international phase III study. 10.1111/ijcp.12961 The aim of this study (...) was to compare the efficacy and safety of a new oromucosal ibuprofen form, ibuprofen 25 mg lozenge, in single and repeat dosing for up to 4 days, to the matched placebo, in the treatment of acute sore throat pain in adults. In this randomised, double-blind, placebo-controlled trial, adult patients with non-streptococcal sore throat and signs of moderate-to-severe associated pain (≥5 on the objective Tonsillo-Pharyngitis Assessment 21-point scale and ≥60 mm on the subjective 0-100 mm visual analogue Sore

EvidenceUpdates2017

9. Combination Therapy of Acetaminophen and Ibuprofen Is the Most Effective Treatment for Patients with Post-Endodontic Pain

Combination Therapy of Acetaminophen and Ibuprofen Is the Most Effective Treatment for Patients with Post-Endodontic Pain UTCAT3197, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Combination Therapy of Acetaminophen and Ibuprofen Is the Most Effective Treatment for Patients with Post-Endodontic Pain Clinical Question In patients with post-operative endodontic pain, does the combination of non-steroidal anti (...) -inflammatory drugs (NSAIDs) with acetaminophen provide more pain relief than individual NSAIDs or acetaminophen or placebo? Clinical Bottom Line For patients with post-operative endodontic pain, post-operative combination therapy of ibuprofen and acetaminophen provides more pain relief than acetaminophen alone or placebo. Acetaminophen alone did not provide more post-operative endodontic pain relief than placebo, suggesting that acetaminophen should only be used in combination with other NSAIDs for post

UTHSCSA Dental School CAT Library2017

10. Ibuprofen plus paracetamol versus ibuprofen in acute low back pain: a randomized open label multicenter clinical study.

Ibuprofen plus paracetamol versus ibuprofen in acute low back pain: a randomized open label multicenter clinical study. 27978532 2016 12 15 2017 04 03 0303-464X 42 1 2017 Jan-Mar Acta reumatologica portuguesa Acta Reumatol Port Ibuprofen plus paracetamol versus ibuprofen in acute low back pain: a randomized open label multicenter clinical study. 18-25 to estimate whether combination of ibuprofen and paracetamol is more effective than ibuprofen in monotherapy, in the treatment of acute low (...) back pain. 80 adult patients with acute low back pain were randomized into two subgroups. In the first subgroup, 40 patients were treated with ibuprofen 400mg three times a day (TID), whilst patients in the second subgroup (n=40) were treated with a fixed-dose combination tablet of ibuprofen 200mg plus paracetamol 325mg TID, for three consecutive days. Patients were followed for another 7 days. Efficacy and tolerability of both treatment options was assessed. A statistically significant decrease in pain

Acta reumatologica portuguesa2016

11. Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.

Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis. BACKGROUND: The cardiovascular safety of celecoxib, as compared with nonselective nonsteroidal antiinflammatory drugs (NSAIDs), remains uncertain. METHODS: Patients who required NSAIDs for osteoarthritis or rheumatoid arthritis and were at increased cardiovascular risk were randomly assigned to receive celecoxib, ibuprofen, or naproxen. The goal of the trial was to assess the noninferiority of celecoxib with regard (...) , 209±37 mg), the naproxen group (852±103 mg), or the ibuprofen group (2045±246 mg) for a mean treatment duration of 20.3±16.0 months and a mean follow-up period of 34.1±13.4 months. During the trial, 68.8% of the patients stopped taking the study drug, and 27.4% of the patients discontinued follow-up. In the intention-to-treat analyses, a primary outcome event occurred in 188 patients in the celecoxib group (2.3%), 201 patients in the naproxen group (2.5%), and 218 patients in the ibuprofen group

NEJM2016

12. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.

Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. BACKGROUND: Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking. METHODS: In a multicenter, prospective, randomized, double-blind, parallel-group trial, we enrolled 300 (...) children (age range, 12 to 59 months) with mild persistent asthma and assigned them to receive either acetaminophen or ibuprofen when needed for the alleviation of fever or pain over the course of 48 weeks. The primary outcome was the number of asthma exacerbations that led to treatment with systemic glucocorticoids. Children in both groups received standardized asthma-controller therapies that were used in a simultaneous, factorially linked trial. RESULTS: Participants received a median of 5.5 doses

NEJM2016

13. 400 mg Ibuprofen/1000 mg Acetaminophen (Paracetamol) Is Suggested Effective Dosage for Ibuprofen/Acetaminophen Combination Therapy in Postoperative Pain Reduction

400 mg Ibuprofen/1000 mg Acetaminophen (Paracetamol) Is Suggested Effective Dosage for Ibuprofen/Acetaminophen Combination Therapy in Postoperative Pain Reduction UTCAT2994, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title 400 mg Ibuprofen/1000 mg Acetaminophen (Paracetamol) Is Suggested Effective Dosage for Ibuprofen/Acetaminophen Combination Therapy in Postoperative Pain Reduction Clinical Question In patients (...) receiving acetaminophen (paracetamol) and ibuprofen combination therapy, what is the effective dosage to relieve postoperative pain? Clinical Bottom Line For patients with postoperative pain, 400 mg ibuprofen/1000 mg acetaminophen (paracetamol) is the suggested effective dosage for short-term pain management. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Mehlisch/2010 234 patients post extraction

UTHSCSA Dental School CAT Library2016

14. Systematic review with meta analysis: The effectiveness of a single dose of oral ibuprofen plus caffeine in acute postoperative pain in adults

Systematic review with meta analysis: The effectiveness of a single dose of oral ibuprofen plus caffeine in acute postoperative pain in adults The effectiveness of a single dose of oral ibuprofen plus caffeine in acute postoperative pain in adults | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your (...) user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here The effectiveness of a single dose of oral ibuprofen plus caffeine in acute postoperative pain in adults Article Text Therapeutics/Prevention Systematic review with meta analysis The effectiveness of a single dose of oral ibuprofen plus caffeine in acute

Evidence-Based Medicine (Requires free registration)2016

15. Systematic review: Ibuprofen for the treatment of TTH

Systematic review: Ibuprofen for the treatment of TTH Ibuprofen for the treatment of TTH | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers (...) of institutional accounts Username * Password * your user name or password? You are here Ibuprofen for the treatment of TTH Article Text Therapeutics/Prevention Systematic review Ibuprofen for the treatment of TTH Roy G Beran Statistics from Altmetric.com No Altmetric data available for this article. Commentary on: Derry S , Wiffen PJ , Moore RA , et al . Ibuprofen for acute treatment of episodic tension-type headache in adults . Request permissions If you wish to reuse any or all of this article please use

Evidence-Based Medicine (Requires free registration)2016

16. Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen

Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen Prescrire IN ENGLISH - Spotlight ''Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen'', 1 January 2016 {1} {1} {1} | | > > > Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |  (...)  |   |   |   |   |   |   |  Spotlight Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen When pain medication is required, paracetamol (alias acetaminophen) is the reference drug. Among the nonsteroidal anti-inflammatories (NSAIDs), naproxen or ibuprofen (not exceeding 1200 mg a day) are the drugs that carry the least exposure to cardiac disorders. When pain medication is needed

Prescrire2016

17. High-dose ibuprofen (?2400mg/day): small increase in cardiovascular risk

High-dose ibuprofen (?2400mg/day): small increase in cardiovascular risk High-dose ibuprofen (≥2400mg/day): small increase in cardiovascular risk - GOV.UK GOV.UK uses cookies to make the site simpler. Search High-dose ibuprofen (≥2400mg/day): small increase in cardiovascular risk From: Published: 26 June 2015 Therapeutic area: , , , and EU review confirms that the cardiovascular risk of high-dose ibuprofen (≥2400mg/day) is similar to COX 2 inhibitors and diclofenac. Contents When prescribing (...) or dispensing ibuprofen: avoid use of high-dose ibuprofen (≥2400 mg per day) in patients with established: ischaemic heart disease peripheral arterial disease cerebrovascular disease congestive heart failure (New York Heart Association [NYHA] classification II-III) uncontrolled hypertension review the treatment of patients with the above conditions who are taking high-dose ibuprofen at their next routine appointment carefully consider the benefits and risks before starting long-term ibuprofen treatment

MHRA Drug Safety Update2015

18. Fracture pain relief for kids? Ibuprofen does it better

Fracture pain relief for kids? Ibuprofen does it better Fracture pain relief for kids? Ibuprofen does it better Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Fracture pain relief for kids? Ibuprofen does it better View/ Open Date 2010-05 Format Metadata Abstract Use ibuprofen instead of acetaminophen with codeine

PURLS2015

19. Randomised controlled trial: Postfracture pain in children can be adequately managed with ibuprofen

Randomised controlled trial: Postfracture pain in children can be adequately managed with ibuprofen Postfracture pain in children can be adequately managed with ibuprofen | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main (...) menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Postfracture pain in children can be adequately managed with ibuprofen Article Text Therapeutics/Prevention Randomised controlled trial Postfracture pain in children can be adequately managed with ibuprofen Kevin B L Lim Statistics from Altmetric.com No Altmetric data available for this article. Commentary to: Poonai N , Bhullar G

Evidence-Based Medicine (Requires free registration)2015

20. How does the ratio of risk to benefit change with increasing doses of ibuprofen?

How does the ratio of risk to benefit change with increasing doses of ibuprofen? How does the ratio of risk to benefit change with increasing doses of ibuprofen? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics How does the ratio of risk to benefit change with increasing doses of ibuprofen? View/ Open Date 2014-07 (...) Format Metadata Abstract Ibuprofen has greater analgesic efficacy with individual doses of 400 mg compared with 200 mg (SOR: A, systematic review of RCTs), but not at doses of more than 400 mg (SOR: B, single RCT). Higher cumulative daily doses of ibuprofen (>1,200– 1,800 mg/d) are associated with an increased risk of cardiovascular (CV) events and more gastrointestinal (GI) complications (SOR: C, systematic review of case series). URI Part of Part of Citation Evidence Based Practice 17(7): 14

Evidence Based Practice 2014