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Latest & greatest articles for hypothermia
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Therapeutic hypothermia initiated in the pre-hospital setting: a meta-analysis Therapeutic hypothermia initiated in the pre-hospital setting: a meta-analysis Therapeutic hypothermia initiated in the pre-hospital setting: a meta-analysis Cullen D, Augenstine D, Kaper L, Tinkham S, Utz D CRD summary The review concluded that induced therapeutic hypothermia in the pre-hospital setting was safe and effective after cardiac arrest. Potential for bias and a limited evidence base of unknown quality (...) mean that the authors' conclusions cannot be considered reliable. Authors' objectives To examine the feasibility and safety of pre-hospital hypothermia after cardiac arrest. Searching CINAHL, MEDLINE, EMBASE, The Cochrane Library and Web of Science were searched from 2007 to 2010 for relevant studies published in English; search terms were not reported. Reference lists of retrieved studies were searched. Study selection Randomised controlled trials (RCTs) of patients 15 years or older who received
Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT 20855387 2010 10 05 2010 10 27 2013 11 21 1098-4275 126 4 2010 Oct Pediatrics Pediatrics Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT. e771-8 10.1542/peds.2009-2441 Mild hypothermia after perinatal hypoxic-ischemic encephalopathy (HIE) reduces neurologic sequelae without significant adverse effects, but studies are needed to determine the most-efficacious methods (...) . In the neo.nEURO.network trial, term neonates with clinical and electrophysiological evidence of HIE were assigned randomly to either a control group, with a rectal temperature of 37°C (range: 36.5-37.5°C), or a hypothermia group, cooled and maintained at a rectal temperature of 33.5°C (range: 33-34°C) with a cooling blanket for 72 hours, followed by slow rewarming. All infants received morphine (0.1 mg/kg) every 4 hours or an equivalent dose of fentanyl. Neurodevelopmental outcomes were assessed at the age of 18
Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China 20488453 2010 08 23 2010 09 23 2010 08 23 1097-6833 157 3 2010 Sep The Journal of pediatrics J. Pediatr. Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China. 367-72, 372.e1-3 10.1016/j.jpeds.2010.03.030 To investigate the efficacy and safety (...) of selective head cooling with mild systemic hypothermia in hypoxic-ischemic encephalopathy (HIE) in newborn infants. Infants with HIE were randomly assigned to the selective head cooling or control group. Selective head cooling was initiated within 6 hours after birth to a nasopharyngeal temperature of 34 degrees+/-0.2 degrees C and rectal temperature of 34.5 degrees to 35.0 degrees C for 72 hours. Rectal temperature was maintained at 36.0 degrees to 37.5 degrees C in the control group. Neurodevelopmental
Induction of Therapeutic Hypothermia by Paramedics After Resuscitation From Out-of-Hospital Ventricular Fibrillation Cardiac Arrest. A Randomized Controlled Trial 20679551 2010 08 17 2010 09 15 2010 08 17 1524-4539 122 7 2010 Aug 17 Circulation Circulation Induction of therapeutic hypothermia by paramedics after resuscitation from out-of-hospital ventricular fibrillation cardiac arrest: a randomized controlled trial. 737-42 10.1161/CIRCULATIONAHA.109.906859 Therapeutic hypothermia (...) is recommended for the treatment of neurological injury after resuscitation from out-of-hospital cardiac arrest. Laboratory studies have suggested that earlier cooling may be associated with improved neurological outcomes. We hypothesized that induction of therapeutic hypothermia by paramedics before hospital arrival would improve outcome. In a prospective, randomized controlled trial, we assigned adults who had been resuscitated from out-of-hospital cardiac arrest with an initial cardiac rhythm
Risk of mortality associated with neonatal hypothermia in southern Nepal 20603466 2010 07 06 2010 08 02 2016 10 19 1538-3628 164 7 2010 Jul Archives of pediatrics & adolescent medicine Arch Pediatr Adolesc Med Risk of mortality associated with neonatal hypothermia in southern Nepal. 650-6 10.1001/archpediatrics.2010.103 To quantify the neonatal mortality/hypothermia relationship and develop evidence-based cutoffs for global definitions of neonatal hypothermia. Cohort study. Field workers (...) recorded neonatal axillary temperature at home and recorded vital status at 28 days. Rural Nepal. Twenty-three thousand two hundred forty infants in Sarlahi, Nepal. Hypothermia. Mortality risk was estimated using binomial regression models. Infants were classified using (1) World Health Organization (WHO) cutoffs for mild, moderate, and severe hypothermia; (2) quarter-degree intervals from 32.0 degrees C to 36.5 degrees C; and (3) continuous temperatures. Estimates were adjusted for age, ambient
Therapeutic hypothermia for paediatric traumatic brain injury BestBets: Therapeutic hypothermia for paediatric traumatic brain injury within 8 hr Therapeutic hypothermia for paediatric traumatic brain injury within 8 hr Report By: Gabriel Cade - Emergency Medicine Physician Search checked by Venkatesh Gattu - Senior Emergency Medicine Trainee Institution: Baystate Medical Center aSpringfield, MA 01199, USA nd Manchester Royal Infirmary, Manchester, UK Date Submitted: 12th December 2009 Date (...) Completed: 9th July 2010 Last Modified: 9th July 2010 Status: Green (complete) Three Part Question In [paediatric patients presenting within 8 h of traumatic brain injury (TBI)] are [therapeutic hypothermia regimens better than normothermic care] in [improving patient survival]? Clinical Scenario An 8-year old child presents to the Emergency Department within six hours of an unclear incident at home which left nonspecific bruising and acute change in mental status. Fundoscopic exam reveals retinal
Prophylactic hypothermia for traumatic brain injury: a quantitative systematic review Prophylactic hypothermia for traumatic brain injury: a quantitative systematic review Prophylactic hypothermia for traumatic brain injury: a quantitative systematic review Fox JL, Vu EN, Doyle-Waters M, Brubacher JR, Abu-Laban R, Hu Z CRD summary The review found that early prophylactic mild to moderate hypothermia improved mortality and functional outcomes after severe traumatic brain injury, especially when (...) a long-term or goal-directed cooling strategy was used. In view of limitations in the review, including poor quality studies and possible publication bias (both acknowledged by the authors), some caution may be required in interpreting the findings. Authors' objectives To evaluate the use of prophylactic hypothermia for traumatic brain injury. Searching MEDLINE, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews, PapersFirst
Cost-effectiveness of therapeutic hypothermia to treat neonatal encephalopathy Cost-effectiveness of therapeutic hypothermia to treat neonatal encephalopathy Cost-effectiveness of therapeutic hypothermia to treat neonatal encephalopathy Regier DA, Petrou S, Henderson J, Eddama O, Patel N, Strohm B, Brocklehurst P, Edwards AD, Azzopardi D Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The aim was to estimate the cost-effectiveness of total body hypothermia plus intensive care versus intensive care alone, in the treatment of neonatal encephalopathy. The authors concluded that the likelihood that cooling was cost-effective was finely balanced over the first 18 months after birth, but increased substantially when national incidence data
Hypothermia after cardiac arrest Hypothermia after cardiac arrest Hypothermia after cardiac arrest Flynn K Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Flynn K. Hypothermia after cardiac arrest. Boston: VA Technology Assessment Program (VATAP). 2010 Authors' objectives VHA’s TAAG asked TAP for a review of the literature as support (...) for use of hypothermia after cardiac arrest, initially in 2008 and again in 2010. TAP approached its charge through available systematic reviews, guidelines or technology assessments based on such reviews, and economic evaluations using high quality primary studies or reviews as sources of effectiveness data. This document will refer collectively to these synthesis publication types as “reviews”. We then updated review searches to the present to confirm the presence or absence of subsequently review
Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data Edwards AD (...) caution. Authors' objectives To evaluate whether moderate hypothermia after hypoxic-ischaemic encephalopathy in neonates improves survival and neurological outcomes at 18 months of age. Searching PubMed, Cochrane Central Register of Controlled Trials (CENTRAL) and the Oxford Database of Perinatal Trials were searched to July 2009; search terms were reported. Bibliographies of previous reviews and abstracts (source not specified) were also searched, and trialists contacted. Study selection Studies
Therapeutic hypothermia with intracorporeal temperature monitoring for hypoxic perinatal brain injury (IPG347) Therapeutic hypothermia with intracorporeal temperature monitoring for hypoxic perinatal brain injury | Guidance and guidelines | NICE Therapeutic hypothermia with intracorporeal temperature monitoring for hypoxic perinatal brain injury Interventional procedures guidance [IPG347] Published date: May 2010 Share Save Guidance X51.2 Active cooling Your responsibility This guidance
Therapeutic Hypothermia Therapeutic Hypothermia | Clinical Correlations Therapeutic Hypothermia November 12, 2009 Catherine Lucero, MD Faculty peer reviewed A recent highlighted the remarkable recovery of a doctor who regained essentially all his mental function just six weeks after suffering a cardiac arrest with a post -resuscitation Glasgow coma score of 4.(1) Although the ambulance had originally rushed the doctor to the nearest hospital in Nassau County, he was quickly transferred to New (...) York Presbyterian Hospital, where the receiving team induced hypothermia for the subsequent 24 hours. Five days later, the doctor woke up. Success stories such as these have now prompted the New York City Fire Department to form plans to bypass hospitals that do not have a protocol in place for induced hypothermia following cardiac arrest. Resumption of spontaneous circulation after prolonged ischemia due to cardiac arrest carries significant morbidity and mortality and much effort has been
Does Head Cooling With Mild Systemic Hypothermia Affect Requirement for Blood Pressure Support? 19255036 2009 03 03 2009 03 30 2016 11 22 1098-4275 123 3 2009 Mar Pediatrics Pediatrics Does head cooling with mild systemic hypothermia affect requirement for blood pressure support? 1031-6 10.1542/peds.2008-1610 Our goal was to evaluate whether head cooling with mild systemic hypothermia for neonatal encephalopathy is associated with greater requirement for volume or inotrope support. We studied (...) time and significantly more frequent pressure support in the cooled group than in controls. Mild systemic hypothermia did not affect arterial blood pressure or initial treatment with inotropes or volume in infants with moderate-to-severe encephalopathy but was associated with an apparent change in physician behavior, with slower withdrawal of therapy in cooled infants. Battin Malcolm R MR Newborn Services, National Women's Health, Auckland City Hospital, Private Bag 92 024, Auckland, New Zealand
Hypothermia for traumatic head injury. BACKGROUND: Hypothermia has been used in the treatment of head injury for many years. Encouraging results from small trials and laboratory studies led to renewed interest in the area and some larger trials. OBJECTIVES: To estimate the effect of mild hypothermia for traumatic head injury on mortality and long-term functional outcome complications. SEARCH STRATEGY: We searched the Injuries Group Specialised Register, Current Controlled Trials MetaRegister (...) of trials, Zetoc, Web of Knowledge; Science Citation Index [expanded], CENTRAL, MEDLINE and EMBASE. We handsearched conference proceedings and checked reference lists of relevant articles. The search was updated on 23 May 2008. SELECTION CRITERIA: Randomised controlled trials of hypothermia to a maximum of 35 degrees C for at least 12 hours versus control in patients with any closed traumatic head injury requiring hospitalisation. Two authors independently assessed all trials. DATA COLLECTION
Cost-effectiveness of therapeutic hypothermia after cardiac arrest Cost-effectiveness of therapeutic hypothermia after cardiac arrest Cost-effectiveness of therapeutic hypothermia after cardiac arrest Merchant RM, Becker LB, Abella BS, Asch DA, Groeneveld PW Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical (...) assessment on the reliability of the study and the conclusions drawn. CRD summary This study evaluated the cost-effectiveness of therapeutic hypothermia for patients following witnessed ventricular fibrillation and out-of-hospital cardiac arrest, compared with conventional care. The authors concluded that therapeutic hypothermia improved the clinical outcomes and was cost-effective in the USA. The methods were appropriate and the results were reported in full. The conclusions appear to be appropriate
The use of hypothermia as a treatment for traumatic brain injury The use of hypothermia as a treatment for traumatic brain injury The use of hypothermia as a treatment for traumatic brain injury Rupich K CRD summary This review evaluated hypothermia to treat traumatic brain injuries and concluded that there may be benefits of hypothermia treatment for some patients with severe traumatic head injuries. Insufficient information was presented about the conduct of the review, quality (...) of the included studies and results, so it was difficult to draw any conclusions about the reliability of the author's conclusions. Authors' objectives To evaluate the use of hypothermia as a treatment for traumatic brain injury. Searching MEDLINE, CINAHL, EMBASE and PubMed were searched from 2000 to 2006 for English-language studies. Search terms were reported. Study selection Controlled trials of therapeutic hypothermia used for at least 24 hours compared to normothermia in adults with a closed traumatic